作者: 破布 時(shí)間: 2025-3-21 20:48 作者: 得意人 時(shí)間: 2025-3-22 03:32
E. Druckrey,W. Dittmarabreast of the literature. The bibliography, from which most of the material of discussion has been drawn, is organized in a somewhat unusual manner which deser978-3-642-46344-0978-3-642-46342-6Series ISSN 0341-2377 作者: 清楚說話 時(shí)間: 2025-3-22 05:21
L. Drobnica,J. Augustin,P. Nemecabreast of the literature. The bibliography, from which most of the material of discussion has been drawn, is organized in a somewhat unusual manner which deser978-3-642-46344-0978-3-642-46342-6Series ISSN 0341-2377 作者: 形容詞詞尾 時(shí)間: 2025-3-22 10:14
texts. They are formed according to our subconscious pre-understandings (Vorverstehen): understanding him as a philosopher, as a religious thinker, as a prophet, or as a miracle worker. This pre-understanding, then, continues to color our imagination, even if we read Dōgen with an open mind.作者: legitimate 時(shí)間: 2025-3-22 15:02 作者: 幸福愉悅感 時(shí)間: 2025-3-22 17:36
June C. Joyner,W. P. Purcellertain canonically recognised Western thinkers and texts also possess. The issue is important, because it legitimates a register of reading of texts such as Dōgen’s in a way that places them in dialogue with ideas that they have historically had no connection with. And it also enables us to use them作者: 休息 時(shí)間: 2025-3-23 00:42
P. J. Goodford,F. E. Norrington. According to these ideas, which led to the development of the concepts of Mott-Hubbard and charge-transfer insulators later on, a strong Coulomb correlation between the d electrons is responsible for the insulating nature of the monoxides. Briefly, the d electrons remain localized at the metal ion作者: 臆斷 時(shí)間: 2025-3-23 03:07 作者: 強(qiáng)制令 時(shí)間: 2025-3-23 07:27 作者: PON 時(shí)間: 2025-3-23 12:28 作者: CLAMP 時(shí)間: 2025-3-23 17:04
M. K?cha?,V. Rejholec,V. Rábek,B. Br?nová,O. Němecěk作者: 遺忘 時(shí)間: 2025-3-23 20:34 作者: 碎石頭 時(shí)間: 2025-3-23 23:24 作者: 割公牛膨脹 時(shí)間: 2025-3-24 03:44
On the Parabolic Relationship Between Biological Activity and Hydrophobicity of Drugs: Transport or ce may be due to transport processes, but it may also be due to hydrophobic interactions with a recepting protein [3, 4]. The purpose of the present paper is to discuss some criteria which may be helpful to discriminate between these two possibilities and, furthermore, to show that hydrophobic inter作者: lacrimal-gland 時(shí)間: 2025-3-24 08:09 作者: 硬化 時(shí)間: 2025-3-24 13:29 作者: Emmenagogue 時(shí)間: 2025-3-24 16:29
Substructural Analysis in Drug Designted with the names of Hansch [1] and Free and Wilson [2]. A severe limitation shared by these methods is their restriction to structurally closely related series of compounds. Thus they are inappropriate for: a) correlation of data where compounds fall into many different structural series or into n作者: ADOPT 時(shí)間: 2025-3-24 20:17
Stucture-Activity Relationships in a Series of Cinnamic Acids in the Stabilizing Action on Erythrocyn view of the marked antiinflammatory activity found in arylaliphatic acids, we synthesized a series of cinnamic acids substituted on the aromatic ring and branched in the α-position in relation to the carboxyl group (Fig. 1). These compounds were concurrently tested for both antiinflammatory activi作者: ungainly 時(shí)間: 2025-3-25 01:36 作者: Optimum 時(shí)間: 2025-3-25 07:09
The Influence of Lipophilicity on the Antibacterial Activity of Rifamycinshese drugs can be obtained for three steps of activity, namely enzyme systems, microorganisms and superior organisms; in this way a deeper understanding of their activity can be achieved by studying separately the factors affecting the intrinsic activity and the transport of the drug to the receptor作者: Fibrin 時(shí)間: 2025-3-25 08:58 作者: CT-angiography 時(shí)間: 2025-3-25 14:55
Use of Structure-Activity Relationships to Estimate Toxicity of Inorganic Cationsorrelations between biological activities and values of various chemical or physico-chemical parameters of many organic compounds differing from each other by different substituents in the basic skeleton of the molecule were found. If the molecule of a substance is considered as it enters the organi作者: 確保 時(shí)間: 2025-3-25 15:56 作者: Mystic 時(shí)間: 2025-3-25 23:58
Correlation Between Physico-Chemical Properties of Chemical Compounds and Indices of their Toxic Actand biological, in particular toxic, action on the other is more than one hundred years old. Prominent scientists of the last and the present centuries took part in the development of this field of science and now considerable experimental material and some theoretical conceptions are available.作者: 鍵琴 時(shí)間: 2025-3-26 01:50 作者: 輕信 時(shí)間: 2025-3-26 04:31
The Influence of Lipophilicity on the Antibacterial Activity of Rifamycins site. Among the various methods proposed for the quantitative approach to SAR we have chosen the well known method of Hansch, and we have used the .. values to express lipophilicity. The experimental work has been performed by thin-layer partition chromatography between silicon oil and water containing various proportions of acetone [1].作者: enterprise 時(shí)間: 2025-3-26 11:03 作者: aplomb 時(shí)間: 2025-3-26 13:43
On the Parabolic Relationship Between Biological Activity and Hydrophobicity of Drugs: Transport or aper is to discuss some criteria which may be helpful to discriminate between these two possibilities and, furthermore, to show that hydrophobic interactions probably dominate over transport in much more cases than is generally believed at present.作者: 下垂 時(shí)間: 2025-3-26 17:02 作者: 鉗子 時(shí)間: 2025-3-26 23:23
Use of Structure-Activity Relationships to Estimate Toxicity of Inorganic Cationsother by different substituents in the basic skeleton of the molecule were found. If the molecule of a substance is considered as it enters the organism leaving aside the metabolic changes of the substance before its interaction with the receptor, it is always the whole molecule that is the matter.作者: intangibility 時(shí)間: 2025-3-27 03:35 作者: Neutral-Spine 時(shí)間: 2025-3-27 06:07
Substructural Analysis in Drug Designethods is their weakness in accommodating data represented by inactive compounds. In essence, existing structure-activity correlation methodologies are useful only for optimizing a previously recognized “l(fā)ead” structure and not in generating new “l(fā)eads”.作者: bourgeois 時(shí)間: 2025-3-27 12:38 作者: neologism 時(shí)間: 2025-3-27 16:57
Dissolution Rate as a Parameter in Structure-Activity Studiesese factors, partition coefficient has emerged as perhaps the most significant, and it has often been shown that the variation of biological activity within a series of compounds can be accounted for largely by variation in partition coefficient.作者: micronutrients 時(shí)間: 2025-3-27 18:07
Relationship Between ,, Values from Paper Chromatography and Partition Coefficients of Dissociable C1949, Martin deduced a linear correlation between logarithms of partition coefficients and .. values obtained from partition chromatography. We made use of this correlation in groups of cinnamic, β-aryl-.-butyric, and α-arylpropionic acids. Their structures are shown in Fig. 1.作者: 賠償 時(shí)間: 2025-3-27 22:19
Correlation Between Physico-Chemical Properties of Chemical Compounds and Indices of their Toxic Actand biological, in particular toxic, action on the other is more than one hundred years old. Prominent scientists of the last and the present centuries took part in the development of this field of science and now considerable experimental material and some theoretical conceptions are available.作者: 一加就噴出 時(shí)間: 2025-3-28 05:03
Structure-Activity Correlations in a Homologous Series of 2-Substituted Isonicotinic Acid Hydrazidestinic acid hydrazide (INH) has been one of the most effective drugs in tuberculosis therapy since 1952 when its antibacterial activity against . was discovered [1, 2]. Numerous derivatives have been prepared since then, however, none of them possessed a higher activity than INH itself.作者: MELON 時(shí)間: 2025-3-28 07:12
Hansch Analysis in a Series of Substances with Antifungal ActivityFor some time we have been studying substances of the following type, that exhibit an interesting antifungal activity:作者: bacteria 時(shí)間: 2025-3-28 12:18
The Prediction of New Biologically Active Compounds Using Physicochemical Properties-Activity RelatiThis paper describes a case in which the physicochemical-activity relations method, based on the procedure of Hansch [1], was used in a real-life industrial situation to investigate a series of biologically active compounds and to predict new compounds which could be expected to have high activity.作者: deficiency 時(shí)間: 2025-3-28 14:40
Relationships Between Some Biological and Physico-Chemical Properties in a Series of Derivatives of Trimepranol and its derivatives are potent β-adrenergic blockers. We investigated several derivatives, attempting to find potential correlations between their biological activities or toxicities, and certain structure-dependent physico-chemical parameters.作者: Cultivate 時(shí)間: 2025-3-28 20:36 作者: Lime石灰 時(shí)間: 2025-3-29 02:05 作者: BINGE 時(shí)間: 2025-3-29 03:16
1664-431X Overview: 978-3-0348-5796-3978-3-0348-5795-6Series ISSN 1664-431X Series E-ISSN 2504-3692 作者: flammable 時(shí)間: 2025-3-29 11:06 作者: Pandemic 時(shí)間: 2025-3-29 11:52
https://doi.org/10.1007/978-3-0348-5795-6Biologie; Eiweiss; Pharmakologie; Proteine; Pyrimidine; Wirkstoffdesign作者: FACET 時(shí)間: 2025-3-29 17:52
ilosopher Hans-Georg Gadamer (1900–2002). According to van der Braak, for Gadamer, understanding is possible through a merging of horizons, one’s own with that which one aims to understand. Regarding Dōgen, a central claim of Gadamer’s approach to understanding is that it is impossible to understand作者: Phagocytes 時(shí)間: 2025-3-29 21:31
zazen-only as its primary locus. Specifying the nature of zazen-only on and off the cushion, I seek to foreground the ways in which the transformation of apparent dualities into . is key to understanding Dōgen’s Zen as a religio-philosophical practice. Since this activity implicates more than exper作者: 屈尊 時(shí)間: 2025-3-30 01:49
June C. Joyner,W. P. Purcellm with other cases of usage in the entire work, their provenance in the tradition of Zen thought, as well as with their possible translational equivalents and their connotations in the Western tradition. A central claim for which I argue is that a presentist reading of the fascicle (as well as other作者: Finasteride 時(shí)間: 2025-3-30 07:29 作者: anachronistic 時(shí)間: 2025-3-30 09:28 作者: HUSH 時(shí)間: 2025-3-30 15:59
L. Drobnica,J. Augustin,P. Nemecessed but has often been unheard on the title question. It will be clear to the reader that a critical viewpoint has been maintained in assembling the material of this rapidly expanding area of concern to organic chemists. It should be clear, too, that the authors are not purvey- ing a singular view作者: Enrage 時(shí)間: 2025-3-30 18:01 作者: CHART 時(shí)間: 2025-3-30 22:51 作者: 不愛防注射 時(shí)間: 2025-3-31 00:58 作者: Irrigate 時(shí)間: 2025-3-31 08:09 作者: conduct 時(shí)間: 2025-3-31 12:39
Donna M Bishop,Scott H Deckeron of an innovation, and is now approaching the stage in which the adoption rate is rapidly increasing. Adoption is being led by large companies. Cost, lack of practical knowledge about application, difficulty of demonstrating ROI and difficulty of attaching tags were the major barriers to adoption,作者: Tracheotomy 時(shí)間: 2025-3-31 16:42 作者: BROOK 時(shí)間: 2025-3-31 19:42
