作者: 植物學(xué) 時(shí)間: 2025-3-21 21:34
https://doi.org/10.1007/978-3-540-79478-3Biomarkers; Cancer Research; Metabolic Profiling; Metabonomics; Warburg Effect; cells; diagnostics; physiol作者: bile648 時(shí)間: 2025-3-22 03:24 作者: Cardiac 時(shí)間: 2025-3-22 07:59
Oncogenes Meet Metabolism978-3-540-79478-3Series ISSN 0947-6075 作者: 敲竹杠 時(shí)間: 2025-3-22 10:45
Mitochondria and Cancer,brane permeabilization (MMP), which is the rate-limiting step of the intrinsic pathway of apoptosis. The mechanisms of MMP resistance have come under close scrutiny because apoptosis resistance constitutes one of the essential hallmarks of cancer. Second, cancer cell mitochondria often exhibit a?red作者: 整體 時(shí)間: 2025-3-22 13:04
Role of the Metabolic Stress Responses of Apoptosis and Autophagy in Tumor Suppression,that include insufficient nutrient supply caused by deficient angiogenesis and high metabolic demand of unrestrained cell proliferation. The high metabolic demand of tumor cells is only exacerbated by reliance on the inefficient process of glycolysis for energy production. Recently it has become cle作者: 本能 時(shí)間: 2025-3-22 17:02
The Interplay Between MYC and HIF in the Warburg Effect, MYC involves the induction of cell proliferation and enhancement of cellular metabolism, the function of HIF, particularly HIF-1, involves adaptation to the hypoxic microenvironment, including activation of anaerobic glycolysis. When MYC-dependent tumors grow, the hypoxic tumor microenvironment ele作者: Immobilize 時(shí)間: 2025-3-22 21:39
Using Metabolomics to Monitor Anticancer Drugs,tinue treatment or, in the context of a?drug trial, to indicate whether the drug is working and perhaps its mechanism of action. (Nuclear) magnetic resonance spectroscopy (NMR/MRS) methods can offer important insights into novel anticancer agents in order to accelerate the drug development process i作者: arbovirus 時(shí)間: 2025-3-23 02:07 作者: Interregnum 時(shí)間: 2025-3-23 07:36 作者: GEM 時(shí)間: 2025-3-23 12:57 作者: BUOY 時(shí)間: 2025-3-23 17:21
Minimally Invasive Biomarkers for Therapy Monitoring,y, these biomarkers would stratify patients so that only those patients likely to respond to a?particular therapy receive that therapy. However, that is not always feasible, and an alternative is to make use of early response biomarkers to determine the responding population. In this paper, a?number作者: Needlework 時(shí)間: 2025-3-23 20:28
Use of Metabolic Pathway Flux Information in Anticancer Drug Design, of specific metabolic substrate channels toward nucleic acid synthesis and (b) increased expression phosphorylation, allosteric or transcriptional regulation of intermediary metabolic enzymes and their substrate availability together mediate unlimited growth. It is evident that cell transformation 作者: 恫嚇 時(shí)間: 2025-3-24 01:08
Cancer Diagnostics Using 1H-NMR-Based Metabonomics,s. Metabonomics, the study of metabolic processes in biologic systems, is based on the use of .H-NMR spectroscopy and multivariate statistics for biochemical data generation and interpretation and may provide a?characteristic fingerprint in disease. Here we review our initial experiences utilizing t作者: 團(tuán)結(jié) 時(shí)間: 2025-3-24 04:22
Human Metabolic Phenotyping and Metabolome Wide Association Studies,l factors with regard to the prevalence and risk of chronic diseases. Spectroscopic technologies such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) can be used to generate multi-parameter profiles of biological samples and together with automated sample delivery and mat作者: Thyroiditis 時(shí)間: 2025-3-24 09:05
Defining Personal Nutrition and Metabolic Health Through Metabonomics,signed to maintain individual health free of disease. Nutrigenomic techniques have been developed to generate information at various levels of biological organization, i.e. genes, proteins, and metabolites. Within this frame, metabonomics targets the molecular characterization of a?living system thr作者: 勤勉 時(shí)間: 2025-3-24 12:09 作者: 取之不竭 時(shí)間: 2025-3-24 14:59
Conference proceedings 2008interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics)..作者: 木訥 時(shí)間: 2025-3-24 22:54
Conference proceedings 2008 normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the 作者: 牙齒 時(shí)間: 2025-3-25 01:11
Molecular Imaging of Tumor Metabolism and Apoptosis,presentation and/or caspase activation as surrogate markers for therapeutic efficacy. Finally, the evaluation of hypoxia with nitroimidazoles may be a?valuable tool for prognosis and therapy planning.作者: 剛開始 時(shí)間: 2025-3-25 06:08 作者: 相反放置 時(shí)間: 2025-3-25 08:55
0947-6075 cts on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics)..978-3-642-09840-6978-3-540-79478-3Series ISSN 0947-6075 作者: Dissonance 時(shí)間: 2025-3-25 14:19 作者: 宣傳 時(shí)間: 2025-3-25 16:46 作者: 造反,叛亂 時(shí)間: 2025-3-25 23:13 作者: 脆弱帶來 時(shí)間: 2025-3-26 01:14
The Interplay Between MYC and HIF in the Warburg Effect, concurrent decrease in mitochondrial respiration. Target genes that are common to both HIF and MYC, such as PDK1, LDHA, HK2, and TFRC, are therefore attractive therapeutic targets, because their coordinate induction by HIF and MYC widens the therapeutic window between cancer and normal tissues.作者: 生命 時(shí)間: 2025-3-26 06:31
Using Metabolomics to Monitor Anticancer Drugs, of such drugs in early-phase clinical trials. This review focuses on the use of ex vivo NMR and in vivo MRS methods for monitoring the effect of some novel anticancer drugs on the cancer metabolome. Ex vivo NMR methods are complementary to in vivo measurements, as they can provide additional inform作者: carotid-bruit 時(shí)間: 2025-3-26 09:02 作者: 努力趕上 時(shí)間: 2025-3-26 14:35
Minimally Invasive Biomarkers for Therapy Monitoring, the minimally invasive WIN method for measuring tumour interstitial pressure (IFP). The data show that drug-induced changes in IFP (ΔIFP) involve mechanism-dependent changes in the tumour vascular architecture, and that ΔIFP may be considered a?universal generic early-response marker of tumour resp作者: monologue 時(shí)間: 2025-3-26 17:47 作者: affluent 時(shí)間: 2025-3-26 22:01
Cancer Diagnostics Using 1H-NMR-Based Metabonomics,om patients with benign ovarian disease (100%). In addition, it was possible to correctly separate 37 of 38 (97.4%) cancer specimens from 31 of 32 (97%) postmenopausal control sera. ROC analysis indicated that the sera from patients with and without disease could be identified with 100% sensitivity 作者: 無意 時(shí)間: 2025-3-27 03:16
Defining Personal Nutrition and Metabolic Health Through Metabonomics,tal factors. In particular, metabolic profiles encapsulate information on the metabolic activity of symbiotic partners, i.e. gut microflora, in complex organisms, which represent a?major determinant in nutrition and health. Therefore, applications of metabonomics to nutrition sciences led to the nut作者: 懶惰人民 時(shí)間: 2025-3-27 08:35
P. McSheehy,P. Allegrini,S. Ametaby,M. Becquet,T. Ebenhan,M. Honer,S. Ferretti,H. Lane,P. Schubiger,作者: 喊叫 時(shí)間: 2025-3-27 11:22
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