作者: fulmination 時(shí)間: 2025-3-21 21:21
cently uniform measures reemerged in new results in abstract harmonic analysis. Until now, results about uniform measures have been scattered through many papers written by a number of authors, some unpublished, written using a variety of definitions and notations. Uniform measures are certain funct作者: 廚師 時(shí)間: 2025-3-22 00:29
Introduction: Strategies and Realities,m has blossomed to such an extent that it has now reached the stage of popularization (Chase, 1988; Kolata, 1988). But the basis for this approach, and the many assumptions and pitfalls involved in it, cannot be dealt with in a limited popular treatment.作者: 煞費(fèi)苦心 時(shí)間: 2025-3-22 07:06
Synthesis of Oligonucleotides and Oligonucleotide Analogues,e expression. As a consequence, several DNA chemical synthesis methodologies such as the phosphate diester and phosphate triester approaches, which are now primarily only of historical interest, will not be discussed, even though they contributed significantly towards solving many important biologic作者: 濕潤(rùn) 時(shí)間: 2025-3-22 12:48 作者: gorgeous 時(shí)間: 2025-3-22 14:42 作者: 攤位 時(shí)間: 2025-3-22 17:40 作者: Glucose 時(shí)間: 2025-3-23 00:37
Control of Gene Expression by Oligodeoxynucleotides Covalently Linked to Intercalating Agents and Ning of mRNA precursors; post-transcriptional modifications of mRNAs (capping, polyadenylation); transfer of mRNAs from the nucleus to the cytoplasm; translation of mRNA; mRNA stability …. In most cases this regulation is achieved by proteins that bind to specific regions of DNA or RNA and either blo作者: 露天歷史劇 時(shí)間: 2025-3-23 05:19
Oligonucleotides Linked to Reactive Groups,of gene expression. Reactive oligonucleotide derivatives represent the affinity reagents capable of bringing about chemical modification of the target nucleic acid residues in the vicinity of the oligonucleotide binding area. In many cases reactive oligonucleotide derivatives are advantageous over t作者: 讓空氣進(jìn)入 時(shí)間: 2025-3-23 08:10
Oligonucleotide Recognition of Double-helical DNA by Triple-helix Formation,ing transcription, replication and cell division. The ability to design synthetic molecules that bind sequence-specifically to unique sites on human DNA has major implications for the treatment of genetic, oncogenic and viral diseases. A detailed understanding of the chemical principles for binding 作者: 昆蟲(chóng) 時(shí)間: 2025-3-23 10:02 作者: Minutes 時(shí)間: 2025-3-23 15:05 作者: PURG 時(shí)間: 2025-3-23 20:24
Textbook 1989Latest editionll areas of current knowledge and includes new results. The principle of the antisense approach is that an antisense mRNA base sequence will bind to its target mRNA base sequence and thus bring about the selective inhibition of gene expression. The antisense approach is important in general in under作者: 復(fù)習(xí) 時(shí)間: 2025-3-23 22:53 作者: Endometrium 時(shí)間: 2025-3-24 02:41 作者: insightful 時(shí)間: 2025-3-24 10:24
Textbook 1989Latest editionts target mRNA base sequence and thus bring about the selective inhibition of gene expression. The antisense approach is important in general in understanding gene function, and more specifically as a potential basis for new drugs, notably against cancer and viral genes.作者: 地名表 時(shí)間: 2025-3-24 12:27
bind to its target mRNA base sequence and thus bring about the selective inhibition of gene expression. The antisense approach is important in general in understanding gene function, and more specifically as a potential basis for new drugs, notably against cancer and viral genes.作者: glans-penis 時(shí)間: 2025-3-24 18:35 作者: 可憎 時(shí)間: 2025-3-24 19:52 作者: tic-douloureux 時(shí)間: 2025-3-25 02:56
Pharmaceutical Considerations,oach which was taken addresses principal issues, such as pharmacokinetics, ‘packaging’, targeting, toxicity and mutagenicity, either in an . manner, if experimental data were unavailable, or with reference to existing data for antisense oligomers, which were usually of a preliminary nature.作者: modifier 時(shí)間: 2025-3-25 06:37
Oligonucleotide Recognition of Double-helical DNA by Triple-helix Formation,specific sites on double-helical DNA with oligodeoxynucleotides (or their analogues) by . would provide a pivotal first step in the development of a novel chemotherapeutic strategy of .. This could ultimately enable precise inactivation of undesirable DNA sequences within the human genome.作者: Leisureliness 時(shí)間: 2025-3-25 07:44
Antisense Oligodeoxynucleotides as a Tool for Studying Cell Regulation: Mechanism of Uptake and Appt, antibodies must be delivered by microinjection to one cell at a time. While possible, such methodology is tedious, requires specialized apparatus and techniques, and does not lend itself to the study of cells growing in suspension culture (i.e. most haematopoietic cells).作者: 摻假 時(shí)間: 2025-3-25 14:04 作者: 射手座 時(shí)間: 2025-3-25 16:24 作者: medieval 時(shí)間: 2025-3-25 20:05
Control of Gene Expression by Oligodeoxynucleotides Covalently Linked to Intercalating Agents and N86) but they might also occur in eukaryotes (Heywood, 1986). The discovery of regulatory RNAs has been the starting point for the design of ‘a(chǎn)ntisense’ RNAs. By inserting a gene fragment close to a strong promoter in the reverse orientation as compared with that of the gene itself, the non-template 作者: 善于騙人 時(shí)間: 2025-3-26 03:44
ical semigroups. The book is a reference for the theory of uniform measures. It includes a self-contained development of the theory with complete proofs, starting with the necessary parts of the theory of uniform spaces. It presents diverse results from many sources organized in a logical whole, and作者: esthetician 時(shí)間: 2025-3-26 05:48
Gerald Zon self-contained development of the theory with complete proofs, starting with the necessary parts of the theory of uniform spaces. It presents diverse results from many sources organized in a logical whole, and978-1-4899-9258-1978-1-4614-5058-0Series ISSN 1069-5273 Series E-ISSN 2194-3079 作者: labile 時(shí)間: 2025-3-26 11:11
Nguyen Thanh Thuong,Ulysse Asseline,Thérèse Montenay-Garestier作者: magnate 時(shí)間: 2025-3-26 13:36 作者: Minikin 時(shí)間: 2025-3-26 18:51 作者: anniversary 時(shí)間: 2025-3-26 22:21
https://doi.org/10.1007/978-1-349-10869-5cancer; cell; DNA; gene; gene expression; genes; nucleic acid; nucleotide作者: 禁止,切斷 時(shí)間: 2025-3-27 03:03
Macmillan Publishers Limited 1989作者: follicular-unit 時(shí)間: 2025-3-27 05:16
Introduction: Strategies and Realities,m has blossomed to such an extent that it has now reached the stage of popularization (Chase, 1988; Kolata, 1988). But the basis for this approach, and the many assumptions and pitfalls involved in it, cannot be dealt with in a limited popular treatment.作者: 一夫一妻制 時(shí)間: 2025-3-27 09:51 作者: 整潔漂亮 時(shí)間: 2025-3-27 15:50
Phosphorothioate Oligodeoxynucleotide Analogues,Phosphorothioates contain a sulphur-for-oxygen substitution at phosphorus (Figure 5.1). In relation to the need for the development of chimeric oligo analogues for the antisense approach, the substitution of one sulphur atom for one oxygen atom is perhaps the most conservative chemical substitution that can be made at the phosphate moiety.作者: 積極詞匯 時(shí)間: 2025-3-27 19:09
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