作者: conflate 時間: 2025-3-21 22:50
Textbook 2023spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related discip作者: Multiple 時間: 2025-3-22 03:50
Neurotrophins and Cell Deathvity and function, making them essential for proper nervous system development. Dysregulation of neurotrophins or their receptors at critical stages during development results in neurodevelopmental disorders that arise from perturbations in neuronal survival, proliferation, differentiation, synaptic function, connectivity, and plasticity.作者: 我吃花盤旋 時間: 2025-3-22 07:14
Axonal Guidanceard or away from these cues, respectively. To date, several neurological diseases, including neurodevelopmental disorders, have been attributed to mutations or dysregulation of specific genes encoding growth cone receptors, ligands, or extracellular cues required for axonal guidance.作者: 配置 時間: 2025-3-22 12:35 作者: 天文臺 時間: 2025-3-22 14:47 作者: Antecedent 時間: 2025-3-22 17:19 作者: 直覺好 時間: 2025-3-22 22:02 作者: NAIVE 時間: 2025-3-23 03:54 作者: opportune 時間: 2025-3-23 05:54
Neural Induction and Regionalization specified into neuroectoderm and subsequently fuses in the midline to become the neural tube. The early hypothesis that neural induction is a default pathway has not prevailed due to different experimental outcomes using various vertebrate model systems, including the chick and .. There is an overa作者: 脫水 時間: 2025-3-23 11:05 作者: blight 時間: 2025-3-23 16:23
Neurotrophins and Cell Deathonnections between them refined via tightly controlled cell death. Cell death is regulated by a family of secreted proteins known as the neurotrophins. The four members of this family, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-作者: 罐里有戒指 時間: 2025-3-23 21:50
Synaptogenesis appropriate partners, but they also must acquire the appropriate properties to serve their particular functions in the circuit. The establishment of mature neuronal connectivity depends on coordinated activity of many individual molecules, any of which could potentially be altered by genetic variat作者: Mucosa 時間: 2025-3-23 22:14 作者: monochromatic 時間: 2025-3-24 06:23
Myelinationhe central nervous system, myelin sheaths are produced by oligodendrocytes subsequent to the activation of several genes, including the . and . transcription factors and . and . encoding proteins that make up the myelin sheath and which also play roles in oligodendrocyte development from oligodendro作者: 脫落 時間: 2025-3-24 06:45 作者: Gobble 時間: 2025-3-24 10:46
The Impact of an Adverse Intrauterine Environment on Neurodevelopmentammation. Notably, chorioamnionitis, hypoxia-ischemia, placental insufficiency, and certain toxins, such as opioids and alcohol, can catalyze a pro-inflammatory intrauterine microenvironment and facilitate inflammatory signal transduction through the maternal–placental–fetal brain axis. Both molecul作者: 柳樹；枯黃 時間: 2025-3-24 16:46
Stress as a Determinant of Neurodevelopmental Outcomes8% of all pregnancies, can shift the neurodevelopmental trajectory resulting in altered behaviour and neuroendocrine function in offspring after birth. Notably, affected infants and children exhibit modified HPA axis function, most often showing elevated cortisol levels in both basal and stimulated 作者: 仔細(xì)閱讀 時間: 2025-3-24 22:04 作者: 逃避現(xiàn)實 時間: 2025-3-25 01:00
The History of Autism Spectrum Disordereatures of ASD are found within historical texts, as well as oral histories across regions and cultures. These core features have persisted throughout the evolution of our understanding of the condition. In a medical model, autism was first conceptualized in the early twentieth century within the fi作者: Amenable 時間: 2025-3-25 04:52 作者: LATE 時間: 2025-3-25 10:35 作者: 帶子 時間: 2025-3-25 15:29 作者: 下邊深陷 時間: 2025-3-25 19:23 作者: Orgasm 時間: 2025-3-25 22:43
Neuropathology of Autismissue for morphologic analysis dependent on post-mortem donation, resulting in small samples in most of the studies..Nonetheless, progress has been made into elucidating some of the morphological changes and their genetic background in many situations. Almost all the morphological and immunohistoche作者: 直覺好 時間: 2025-3-26 03:30
s influences a wide range of events during growth and development (.). For example, cytokinins inhibit leaf senescence, root elongation and lateral root initiation. They are involved in promoting leaf and cotyledon expansion, auxiliary meristem growth, nutrient mobilisation, root hair growth and sto作者: Heart-Rate 時間: 2025-3-26 08:20 作者: Alpha-Cells 時間: 2025-3-26 09:26
Richard E. Brownlopment soon after penetration. As plants lack a circulatory system and antibodies, they have evolved defense mechanisms that are distinct from the vertebrate immune system. In contrast to animal cells, each plant cell is capable of defending itself by means of a combination of constitutive mechanis作者: 雪上輕舟飛過 時間: 2025-3-26 13:38 作者: 泛濫 時間: 2025-3-26 17:26 作者: 套索 時間: 2025-3-26 22:46
Arman Shekari,Crystal Mahadeo,Nisha Sanwalka,Margaret Fahnestock Cardiac fibrosis is recognized as a major disease modifier and as such is important in the pathogenesis of heart failure of most etiologies. This review is focused on R-Smad signaling in cardiac myofibroblasts and their role in remodeling the extracellular matrix of the failing myocardium after myo作者: 有危險 時間: 2025-3-27 04:45
Margaret H. Hastings,James Gilbert,Yuda Huo,Heng-Ye Mancell responses are temperature-dependent. Especially in applications using fluorescent probes, adequate control of the temperature is critical, since dissociation constants of fluorescent probes such as Fura-2 are also highly dependent on temperature. (Lattanzio 1990, for review see Moore 1990). Vid作者: Highbrow 時間: 2025-3-27 08:55
Mikaela Nevin,Janine Gallego,David D. Eisenstatcell responses are temperature-dependent. Especially in applications using fluorescent probes, adequate control of the temperature is critical, since dissociation constants of fluorescent probes such as Fura-2 are also highly dependent on temperature. (Lattanzio 1990, for review see Moore 1990). Vid作者: 紀(jì)念 時間: 2025-3-27 11:48
Janine Gallego,Mikaela Nevin,David D. Eisenstatcell responses are temperature-dependent. Especially in applications using fluorescent probes, adequate control of the temperature is critical, since dissociation constants of fluorescent probes such as Fura-2 are also highly dependent on temperature. (Lattanzio 1990, for review see Moore 1990). Vid作者: visceral-fat 時間: 2025-3-27 16:40
Helena Biasibetti-Brendler,Michael Steffen Koborn areas with direct clinical significance.The authors are ex.This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topi作者: DEFT 時間: 2025-3-27 20:08
Sindhu Ramachandra,Michelle Low,Nethra Madurai,Maide Ozen,Yuma Kitase,Shenandoah Robinson,Lauren L. n areas with direct clinical significance.The authors are ex.This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topi作者: 女歌星 時間: 2025-3-27 22:27
Bona Kim,Stephen G. Matthewsn areas with direct clinical significance.The authors are ex.This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topi作者: incisive 時間: 2025-3-28 04:41 作者: 無效 時間: 2025-3-28 08:18
n areas with direct clinical significance.The authors are ex.This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topi作者: Morose 時間: 2025-3-28 13:57
Alexandra Jackman,Lonnie Zwaigenbaumn areas with direct clinical significance.The authors are ex.This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topi作者: Oversee 時間: 2025-3-28 14:55 作者: 諷刺 時間: 2025-3-28 21:48
Cecilia Lee,Melanie Pennern areas with direct clinical significance.The authors are ex.This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topi作者: 抓住他投降 時間: 2025-3-29 02:52 作者: 羊欄 時間: 2025-3-29 06:49
Hsiang-Yuan Lin,Meng-Chuan Lain areas with direct clinical significance.The authors are ex.This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topi作者: Maximizer 時間: 2025-3-29 11:03 作者: 相一致 時間: 2025-3-29 13:21
Overview of CNS Organization and Developmenty of neural development is the importance of synapse formation and modulation for the creation of functional excitatory and inhibitory neural circuits that underlie cognitive functions. The goal of this chapter is, therefore, to provide a background in the CNS development and organization underlying作者: Neuralgia 時間: 2025-3-29 17:27
Neural Induction and Regionalizationrogenitors. These findings may be more readily applied to the treatment of disorders of the developing nervous system as well as neurodegenerative diseases. Examples of disorders of neural induction, early regionalization, and patterning are discussed, including holoprosencephaly, neural tube defect作者: Ligament 時間: 2025-3-29 21:33
Neural Stem Cells, Differentiation, and Migrationonal heterogeneity of NSCs and the niche factors that regulate their behaviour including age, injury, and disease. Exploiting NSPCs for neuroplasticity and neural repair has been at the forefront of regenerative medicine strategies. With both exogenous and endogenous cell-based approaches, a number 作者: 山羊 時間: 2025-3-30 00:12
Epigeneticssses, such as synaptic plasticity and responses to stimuli. With a combination of validated models and new technologies, further studies will be able to go beyond correlation and assess causation, and thus provide insights into the roles of epigenetics in neurodevelopment. Taken together, this chapt作者: GEON 時間: 2025-3-30 06:45
The Impact of an Adverse Intrauterine Environment on Neurodevelopmentd responses to subsequent inflammatory stimuli later in life. Indeed, this sustained immune hyperreactivity leaves both the immature brain and immune system vulnerable over extended developmental periods. Primary sequelae of severe and persistent intrauterine inflammation can manifest as a broad spe作者: 脾氣暴躁的人 時間: 2025-3-30 11:35 作者: 間諜活動 時間: 2025-3-30 14:58 作者: 陶醉 時間: 2025-3-30 19:30
The History of Autism Spectrum Disorder and social and family history. In the 1960s–70s, researchers classified children by clusters of quantifiable and observable behaviours, establishing an evidence-informed understanding of ASD. Since the 1980s, clinicians and researchers have explored biologic associations, such as seizure disorders 作者: 易發(fā)怒 時間: 2025-3-30 23:23
Epidemiologye underlying genetic, biological, or environmental risk factors. Although multiple hypotheses have linked variation in autism prevalence to factors, such as geography, race/ethnicity, nativity, and SES, there is currently no direct evidence to support these hypotheses. Indeed, testing such hypothese作者: Grandstand 時間: 2025-3-31 01:43
The Neuroradiology of Autism: Framing Neuroimaging Investigations of the Autistic Brain Based on the cognitive presentations, and imaging methodological caveats. The development of new imaging sequences, computational methods, conceptual frameworks, integration with genetics and animal model studies, and moving beyond a case–control design are key opportunities to elucidate the heterogeneous neuro作者: 迅速飛過 時間: 2025-3-31 07:04
Neuropathology of Autismibed. Immunologic-driven alterations have also been described, including a consistent increase in CD8+ T-cell lymphocytes in ASD subjects, and alterations involving the blood–brain barrier..Given that ASD is well established as a heritable psychiatric disorder in up to 50% of the cases, animal model作者: novelty 時間: 2025-3-31 10:38
Textbook 2023hree disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. 作者: FLUSH 時間: 2025-3-31 16:21 作者: pacifist 時間: 2025-3-31 17:54 作者: bourgeois 時間: 2025-3-31 23:52 作者: 惡臭 時間: 2025-4-1 05:55 作者: defendant 時間: 2025-4-1 09:12
