作者: 同時發(fā)生 時間: 2025-3-21 23:58 作者: 狂熱文化 時間: 2025-3-22 03:51
Thomas F. Fletcher,Shelle A. Malkmusrol, electrical engineering, mechanical engineering, machine learning, reliability, and preference models. This large coverage of practical optimization problems makes this text very useful to those working on and researching systems design. The intended audience includes industrial engineers, postg作者: 毗鄰 時間: 2025-3-22 04:37 作者: somnambulism 時間: 2025-3-22 09:01
Sarah D. Cramer,Mark T. Buttems, tables and figures are numbered con- secutively in each section and indicate, in addition, the section number. In cross references to other chapters the (latin) chapter number is put first. References to the bibliography are again by "author" plus "year" in parentheses. The bibliography again c作者: 肉體 時間: 2025-3-22 15:42 作者: declamation 時間: 2025-3-22 17:24
The History of Spinal Drug Delivery: The Evolution of Lumbar Puncture and Spinal Narcosis,prompting the search for more ideal drugs, equipment, and injection techniques, which continues to this day. This chapter will focus on the first 50?years of the evolution of the neuraxial delivery of therapeutics.作者: agitate 時間: 2025-3-22 22:27
The History and Evolution of Intrathecal Drug Delivery: From the 1950s to the Present,ocus on managing chronic conditions. The growth in understanding spinal sensory/motor biology along with the development of novel delivery platforms have led us to the current advancing state of neuraxial therapeutic interventions for managing not just pain or spasticity but also neurodegenerative d作者: 入會 時間: 2025-3-23 01:49
CSF Flow Dynamics in Relation to Intrathecal Drug Transport,complex picture and conflicting information. Animal models, consistent with the behavioral effects of IT drugs, emphasize a highly restricted biodistribution when delivered as a small volume at low rates of infusion. Bench-top models mimicking the physical IT space and its pressure dynamics serve to作者: 沙草紙 時間: 2025-3-23 06:57
Intrathecal Delivery of Viral Vector-Mediated Gene Therapy, off-target expression or effects of the therapeutic payload. Since covering all types of viral vectors is beyond the scope of this chapter, the use of recombinant adeno-associated virus for gene therapy was selected as the exemplar to highlight the different therapeutic liabilities in-depth.作者: 有權(quán) 時間: 2025-3-23 13:04 作者: thrombus 時間: 2025-3-23 14:57
Spinal Cellular Implants in Treatment of Neurodegenerative Disorders,nic stem cells-derived neural precursors (NPCs) for in vivo grafting, while more recently a technology of inducible pluripotent stem cells from adult somatic cells is more frequently beeing used for generation of transplantable NPCs. As will be reviewd in this chapter several preclinical studies wer作者: Cpap155 時間: 2025-3-23 18:50
Book 2023nd device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy.?..Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find .Neuraxial Therapeutics.,? to be an invaluable guide to th作者: 周年紀(jì)念日 時間: 2025-3-24 02:11
Tony L. Yakshen for our numerical examples. Each chapter is divided into sections. Numbers of formulas, theorems, tables and figures are consecutive in each section and indi978-3-662-12607-3Series ISSN 0179-3632 Series E-ISSN 2198-3712 作者: 凹槽 時間: 2025-3-24 02:54 作者: Cosmopolitan 時間: 2025-3-24 09:03 作者: 免費 時間: 2025-3-24 11:16
Mariana Bravo-Hernández,Oleksandr Platoshyn,Joseph D. Ciacci,Martin Marsalas for error control and automatic time step selection, and all the solvers are implemented as a class hierarchy in Python..978-3-031-46767-7978-3-031-46768-4Series ISSN 2512-1677 Series E-ISSN 2512-1685 作者: 陳列 時間: 2025-3-24 15:54
veloped in collaboration with scientists of different fields (biology, medicine, etc.) and industry. We wanted this book to be useful both to readers more interested in the theoretical aspects and those more co978-88-470-2411-3978-88-470-2412-0Series ISSN 2038-5714 Series E-ISSN 2532-3318 作者: NADIR 時間: 2025-3-24 21:22 作者: hidebound 時間: 2025-3-25 02:55
Juraj ?evc,Anna Alexovi? Matia?ová,Zuzana Daxnerováveloped in collaboration with scientists of different fields (biology, medicine, etc.) and industry. We wanted this book to be useful both to readers more interested in the theoretical aspects and those more co978-88-470-2411-3978-88-470-2412-0Series ISSN 2038-5714 Series E-ISSN 2532-3318 作者: 占線 時間: 2025-3-25 06:34
Jaroslav Pavel,Erika Kellerova,Jana Snopkovaeference models. This large coverage of practical optimization problems makes this text very useful to those working on and researching systems design. The intended audience includes industrial engineers, postg978-3-031-52461-5978-3-031-52459-2Series ISSN 1931-6828 Series E-ISSN 1931-6836 作者: 桉樹 時間: 2025-3-25 08:58
Shelle A. Malkmus,Robert B. Boyd,Linda S. Sorkin,Tony L. Yakshtion, the section number. In cross references to other chapters the (latin) chapter number is put first. References to the bibliography are again by "author" plus "year" in parentheses. The bibliography again c978-3-642-05220-0978-3-642-05221-7Series ISSN 0179-3632 Series E-ISSN 2198-3712 作者: degradation 時間: 2025-3-25 14:25
Tony L. Yaksh,Robert B. Boyd,Orion Paul Keifer Jr.tion, the section number. In cross references to other chapters the (latin) chapter number is put first. References to the bibliography are again by "author" plus "year" in parentheses. The bibliography again c978-3-642-05220-0978-3-642-05221-7Series ISSN 0179-3632 Series E-ISSN 2198-3712 作者: Dislocation 時間: 2025-3-25 17:13 作者: 敵意 時間: 2025-3-25 21:07 作者: Trypsin 時間: 2025-3-26 02:33 作者: CARE 時間: 2025-3-26 06:06
Emerging Insights into the Interstitial Distribution of Neuraxial Therapeutics via the Cerebrospinaggesting that CSF–interstitial exchange is anatomically organized, rapid, physiologically regulated, and impaired in the setting of CNS pathology. We then discuss the implications that these recent findings may have on the delivery of small molecules, biologics, viral-, and cell-based therapeutics to the CNS.作者: Gratuitous 時間: 2025-3-26 10:35
Cerebrospinal Fluid, the Meninges, and the Subarachnoid Space,n in the CSF are reviewed in chapters “Emerging Insights into the Interstitial Distribution of Neuraxial Therapeutics via the Cerebrospinal Fluid Compartment” and “CSF Flow Dynamics in Relation to Intrathecal Drug Transport.”作者: 譏諷 時間: 2025-3-26 16:42
Formulation of Therapeutics for Neuraxial Infusion,r parenteral routes of administration. In this chapter, we review the specific anatomical and physiological features of the central nervous system that drive formulation principles for neuraxial delivery and detail excipient properties that are considered appropriate for solutions intended for spinal drug delivery.作者: output 時間: 2025-3-26 16:51
,‘resource to intrathecal therapies.Authored by worldwide le.This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics.? It reviews the historical evolution of this approach from its inception in the later 1800‘s to present day. ? This amply referenced text cover作者: 制定法律 時間: 2025-3-26 21:52
Animal Models of Neuraxial Drug Delivery,d safety. The present chapter reviews and considers the issue related to the use of preclinical models for neuraxial delivery in small and large animals considering the spinal (epidural, intraganglionic, intracisternal, and intrathecal) and supraspinal (intraventricular, intraparenchymal, and intranasal) routes of access.作者: oxidize 時間: 2025-3-27 02:04
Book 2023 from its inception in the later 1800‘s to present day. ? This amply referenced text covers basic discussions of spinal anatomy, embryogenesis,? neuraxial vascularity,? cerebrospinal fluid flow dynamics and parenchymal molecule movement.?The pharmacokinetic and pharmacodynamic properties of? differe作者: Psa617 時間: 2025-3-27 08:09 作者: 我們的面粉 時間: 2025-3-27 13:27 作者: FIN 時間: 2025-3-27 15:14
Compounding for Intrathecal Targeted Drug Delivery: A Comprehensive Guide,akes place, environmental monitoring of that space, personnel training, and regular testing to ensure adherence to proper procedure is followed at every step of the compounding process. This chapter presents the current considerations of these critical aspects of compounding intrathecal pharmaceuticals for continuous infusion.作者: 沒血色 時間: 2025-3-27 21:36
Spinal Subpial Viral Vector Delivery in Treatment of Neurodegenerative Disorders, viral particulate movement after intrathecal and subpial delivery. This approach has scientific relevance as it described the regulatory properties of this pial barrier and suggests the clinical relevance of transpial delivery.作者: Unsaturated-Fat 時間: 2025-3-28 01:26
Development of the Spinal Cord,kages with specific neuraxial substrates. This chapter reviews these linkages, the biology associated with the trophic targeting of these linkages, and the time course of the development process of these coordinated events.作者: 角斗士 時間: 2025-3-28 04:19 作者: CRAB 時間: 2025-3-28 06:29
Cerebrospinal and Interstitial Fluids: Production, Outflow, and Circulation,at the blood–brain barrier, contributing to ISF formation. Exchanges of solutes between ISF and CSF are considered along with fluid circulation within the brain. The implications of these fluid movements for effective intrathecal drug delivery are discussed.作者: attenuate 時間: 2025-3-28 11:14 作者: Mets552 時間: 2025-3-28 14:40
lications Examples from different fields (biology, medicine)This book stems from the long standing teaching experience of the authors in the courses on Numerical Methods in Engineering and Numerical Methods for Partial Differential Equations given to undergraduate and graduate students of Politecnic作者: 壯麗的去 時間: 2025-3-28 20:30
David C. Mackey Partial Differential Equations given to undergraduate and graduate students of Politecnico di Milano (Italy), EPFL Lausanne (Switzerland), University of Bergamo (Italy) and Emory University (Atlanta, USA). It aims at introducing students to the numerical approximation of Partial Differential Equati作者: 不如樂死去 時間: 2025-3-28 23:52 作者: JAMB 時間: 2025-3-29 03:23 作者: 保守 時間: 2025-3-29 08:34 作者: 樂章 時間: 2025-3-29 15:06 作者: 生存環(huán)境 時間: 2025-3-29 16:07
Jaroslav Pavel,Erika Kellerova,Jana Snopkovaand undergraduates in systems design will find useful.Large This text focuses on simple and easy-to-use design strategies for solving complex engineering problems that arise in several fields of engineering design, namely non-convex optimization problems.?.The main optimization tool used in this boo作者: dialect 時間: 2025-3-29 21:50
Andreas A. Linninger,Kevin Tangen,Ayankola O. Ayansiji,Daniel S. Gehrke,Indu Venugopal,Tony L. YakshMark Twain) "Gauss‘ dictum, "when a building is completed no one should be able to see any trace of the scaffolding," is often used by mathematicians as an excuse for neglecting the motivation behind their own work and the history of their field. For- tunately, the opposite sentiment is gaining stre作者: GRAVE 時間: 2025-3-30 01:15
Tony L. Yaksh Book. " (Mark Twain) "Gauss‘ dictum, "when a building is completed no one should be able to see any trace of the scaffolding," is often used by mathematicians as an excuse for neglecting the motivation behind their own work and the history of their field. For- tunately, the opposite sentiment is ga作者: NIP 時間: 2025-3-30 05:15
Shelle A. Malkmus,Robert B. Boyd,Linda S. Sorkin,Tony L. Yakshd and enlarged edition contains, in particular, such new mat"Whatever regrets may be, we have done our best." (Sir Ernest Shack- 0 leton, turning back on 9 January 1909 at 88 23‘ South.) Brahms struggled for 20 years to write his first symphony. Compared to this, the 10 years we have been working on作者: 變量 時間: 2025-3-30 10:31
Tony L. Yaksh,Robert B. Boyd,Orion Paul Keifer Jr.d and enlarged edition contains, in particular, such new mat"Whatever regrets may be, we have done our best." (Sir Ernest Shack- 0 leton, turning back on 9 January 1909 at 88 23‘ South.) Brahms struggled for 20 years to write his first symphony. Compared to this, the 10 years we have been working on作者: 多山 時間: 2025-3-30 12:54 作者: podiatrist 時間: 2025-3-30 18:07
Carolyn A. Fairbanks,Cristina D. Peterson,Benjamin Michael Clements,Virginia L. Ghafoor,Tony L. Yaksrs to write his first symphony. Compared to this, the 10 years we have been working on these two volumes may even appear short. This second volume treats stiff differential equations and differential alge- braic equations. It contains three chapters: Chapter IV on one-step (Runge- Kutta) methods for作者: 離開真充足 時間: 2025-3-31 00:43 作者: 讓你明白 時間: 2025-3-31 04:00
Orion Paul Keifer Jr.and important and fundamental concepts.The book provides a d.This open access volume explains the foundations of modern solvers for ordinary differential equations (ODEs). Formulating and solving ODEs is an essential part of mathematical modeling and computational science, and numerous solvers are a作者: 獨裁政府 時間: 2025-3-31 08:33 作者: 半圓鑿 時間: 2025-3-31 10:45
The History of Spinal Drug Delivery: The Evolution of Lumbar Puncture and Spinal Narcosis,ic substances, along with the invention and evolution of equipment such as the syringe, hypodermic needle, and epidural catheter—all in the setting of an increasingly accurate understanding of spinal anatomic structures. An appreciation of the local anesthetic effects of cocaine when utilized as a t作者: CULP 時間: 2025-3-31 13:52
The History and Evolution of Intrathecal Drug Delivery: From the 1950s to the Present,years following the descriptions by Corning and then by Bier and Hildebrand of the epidural and intrathecal delivery of cocaine, respectively, to produce a medullary narcosis, there was a truly impressive implementation of spinal delivery to induce regional anesthesia, to perform a variety of surgic作者: Mri485 時間: 2025-3-31 20:52 作者: 蓋他為秘密 時間: 2025-3-31 23:06
Human Spinal Microanatomy, medical treatments and procedures presented in this book. This chapter also describes the barriers protecting axons that shape the nervous system at the spinal level..A detailed description is made of the neural structures of the spinal cord such as the nerve rootlets, the dorsal and ventral nerve 作者: LAITY 時間: 2025-4-1 05:33
Spinal Anatomy of Experimental Animals,odent species (rats). These species were chosen because of their extensive use as preclinical models for spinal drug delivery. Specific comments about the salient features of other animal species, including porcine, ovine, bovine, and primate, are also considered.作者: 使殘廢 時間: 2025-4-1 07:32
Spinal Cord Vasculature: General Anatomy and Physiology,nd venules penetrate the parenchyma through the perivascular Virchow-Robin spaces, and the venous outflow exits through the intradural and extradural vessels and plexi. Species differences in this perfusion structure are compared and contrasted. Specific discussions of rostrocaudal flow patterns, sp作者: 寒冷 時間: 2025-4-1 10:51
Cerebrospinal and Interstitial Fluids: Production, Outflow, and Circulation, and interstitial fluid (ISF), which surrounds cells within the brain and spinal cord parenchyma. Although these fluids fulfill different primary roles in the CNS, their formation, exit from the CNS, and circulation are intimately linked. This chapter describes CSF production at the choroid plexuses作者: 合唱隊 時間: 2025-4-1 14:51
Emerging Insights into the Interstitial Distribution of Neuraxial Therapeutics via the Cerebrospinasearch has brought to light physiological and pathological processes that regulate the movement of fluids and solutes between the cerebrospinal fluid (CSF) compartment and the CNS interstitium and may have important implications for neuraxial therapeutic delivery. Here, we review recent findings, su作者: PHONE 時間: 2025-4-1 20:35 作者: Hot-Flash 時間: 2025-4-2 00:46
