作者: 該得 時(shí)間: 2025-3-21 22:16
The Same But Different,electron density maps. Frontier applications such as determining single-site ligand-binding affinities crystallographically, high-throughput screening of combinatorial compound libraries, . competition assays, and inferring protein function via exogenous ligand-binding screens are discussed.作者: euphoria 時(shí)間: 2025-3-22 00:34
Cryocrystallography of Macromolecules,col can give substantial improvements to both the resolution and quality of the data, often resulting in more straightforward structure solution and subsequent model refinement. Attention to seemingly insignificant details can have a real impact on the usefulness of the final dataset, and are thus worth addressing.作者: urethritis 時(shí)間: 2025-3-22 07:53 作者: Calculus 時(shí)間: 2025-3-22 09:59 作者: 莎草 時(shí)間: 2025-3-22 16:45 作者: nephritis 時(shí)間: 2025-3-22 17:29 作者: Recessive 時(shí)間: 2025-3-22 22:39 作者: Palatial 時(shí)間: 2025-3-23 05:22
Book 2007nd Crystallization of Macromolecules is dedicated to the crystallization and ways to increase the odds of obtaining crystals in macromolecules, while Volume 2, Structure Determination, covers both computational methods for characterizing crystals and solving structures.作者: CANDY 時(shí)間: 2025-3-23 07:45 作者: LAVA 時(shí)間: 2025-3-23 09:41 作者: 創(chuàng)作 時(shí)間: 2025-3-23 14:44
Phase Determination Using Halide Ions,-wavelength anomalous diffraction (SAD) techniques and iodides through SAD or multiple isomorphous replacement (MIRAS) phasing. The halide cryosoaking approach involves very little preparative effort and offers a rapid and simple way of solving novel protein crystal structures.作者: 一再煩擾 時(shí)間: 2025-3-23 19:40
Quality Control and Validation,sible, prior to analysis and publication of the model. Validation is the process of assessing the reliability of the final model (or certain aspects of it, e.g., the active site residues) that is about to be analyzed, published, deposited, and possibly used in follow-up studies.作者: 緩和 時(shí)間: 2025-3-24 01:09
Crystallographic Software,ucational sites on crystallography. For each program/site included at CRYSTAL, a detailed description will include: the most current version, the authors, and appropriate operating systems to host the program. Links to download the programs, available tutorials, and references to cite when using the program/site are also provided.作者: indifferent 時(shí)間: 2025-3-24 03:52 作者: Omnipotent 時(shí)間: 2025-3-24 09:16
ircumstances it is appropriate for certain types of persons to commit suicide. They also provide a script that the actor should follow if he intends for his death to communicate an appropriate message to his survivors. This script establishes what steps precede the deed and what method the suicide s作者: 拖債 時(shí)間: 2025-3-24 13:56
Elspeth Garman,Robin L. Owenresent its various typologies. The chapter concludes by extending on the existing scholarship to highlight what life strategy means from the perspective of contemporary regime transition/crisis in Ukraine and how it is intimately bound up with the social change and migration.作者: 傀儡 時(shí)間: 2025-3-24 15:02
Kelvin Chuhe 16 data points. The chapter then necessarily moves to extend the discussion around the limitations of the life strategy conceptual framework and future research. The chapter concludes with the discussion around the main trends and ideas that follow from this book.作者: analogous 時(shí)間: 2025-3-24 20:14 作者: 郊外 時(shí)間: 2025-3-25 00:04
David Jeruzalmial unrest in Ukraine. The second section of this chapter looks into the migration patterns of ‘a(chǎn)chievement migrants’. It discusses the two most popular modes of entry to Australia—the skilled migration stream and the family migration stream—and examines the gender-specific migrations. The chapter co作者: violate 時(shí)間: 2025-3-25 06:34 作者: 脫水 時(shí)間: 2025-3-25 10:44
Michael R. Sawaya mean by migration and regime crisis in order to adequately respond to the global challenges confronting numerous democracies today. As such, it will appeal to scholars of sociology and politics with interests in migration, political theory and democracy..978-3-030-39841-5978-3-030-39839-2作者: 惡名聲 時(shí)間: 2025-3-25 12:23 作者: 浮雕 時(shí)間: 2025-3-25 19:20 作者: tooth-decay 時(shí)間: 2025-3-25 23:28
Gerard J. Kleywegte support systems are examined, including nuclear submarines and our natural life support system here on Earth! Overall, this book serves as an approachable primer for any student seeking to understand the intricacies of spacecraft life support systems..作者: 手工藝品 時(shí)間: 2025-3-26 00:10 作者: oxidant 時(shí)間: 2025-3-26 07:11 作者: consolidate 時(shí)間: 2025-3-26 12:30
Molecular Replacement,tion. As crystallographers aim to solve larger macromolecular complexes that more faithfully depict the actors in cellular events, having existing phase information for parts of those biological machines will reinforce the technological advancements in data collection and structure solution that hav作者: separate 時(shí)間: 2025-3-26 15:04 作者: Mundane 時(shí)間: 2025-3-26 18:44
Clemens Vonrhein,Eric Blanc,Pietro Roversi,Gérard Bricogne作者: 非秘密 時(shí)間: 2025-3-26 23:07 作者: ineffectual 時(shí)間: 2025-3-27 03:29
Cryocrystallography of Macromolecules,that cryocrystallography is now standard practice. The main advantage of these methods is the vastly reduced rate of radiation damage to protein crystals in the X-ray beam at cryogenic temperatures over room temperature, extending their lifetimes so that complete datasets can be collected from a sin作者: 冷漠 時(shí)間: 2025-3-27 06:33
Determination of Reaction Intermediate Structures in Heme Proteins,gh atomic-resolution structures of proteins are becoming more common, a growing number of structural studies have focused on the role played by dynamics and have sought to determine the structure of intermediates in protein reactions. These experiments have revealed the first atomic-level pictures o作者: 切掉 時(shí)間: 2025-3-27 09:32 作者: 試驗(yàn) 時(shí)間: 2025-3-27 17:13
First Analysis of Macromolecular Crystals,esis on dissolved crystals informs on the content of the crystal. Detailed protocols are given for mounting crystals in capillaries or fiber loops in preparation for analysis of their X-ray diffractive properties.作者: progestin 時(shí)間: 2025-3-27 18:11 作者: Redundant 時(shí)間: 2025-3-27 23:45 作者: 輪流 時(shí)間: 2025-3-28 03:55 作者: Diaphragm 時(shí)間: 2025-3-28 07:19 作者: 憲法沒有 時(shí)間: 2025-3-28 10:41
The Same But Different,on or the binding of ligands. Practical aspects of isomorphous methods and differential crystallography are presented, particularly in their application to the phasing of new structures by multiple isomorphous replacement and the detection and characterization of ligand binding. Techniques for maint作者: Confidential 時(shí)間: 2025-3-28 17:18 作者: 廣大 時(shí)間: 2025-3-28 19:32 作者: bleach 時(shí)間: 2025-3-29 00:55 作者: 王得到 時(shí)間: 2025-3-29 06:32
Introduction to Macromolecular Refinement,y fi X-ray diffraction data. Each of the refinement packages currently under development reduces the difficulty of this problem by utilizing a unique combination of targets, assumptions, and optimization methods. This chapter summarizes the basic methods and underlying assumptions in the commonly us作者: Immunoglobulin 時(shí)間: 2025-3-29 09:07
Quality Control and Validation,raphic model under investigation. Quality control is defined as the analysis of an intermediate model to identify aspects of it that are unusual in some sense and that could, therefore, be a result of errors in the model building or refinement process. Any such errors need to be fixed, if at all pos作者: 天然熱噴泉 時(shí)間: 2025-3-29 12:33 作者: Asymptomatic 時(shí)間: 2025-3-29 16:49
at anthropology offers an analytical perspective that is concerned with understanding the cultural context in which suicides occur. Anthropology seeks to explain suicide as being a culturally constructed act that is performed in the context of a system of meaning. The system of meaning communicates,作者: 反叛者 時(shí)間: 2025-3-29 23:46 作者: 強(qiáng)有力 時(shí)間: 2025-3-30 01:45
Kelvin Chuted ‘a(chǎn)chievement life strategy’ and conservative, risk-minimising and survival-oriented ‘survival life strategy’. The chapter summarises how the innovative conceptual life strategy model, presented in this book, has enabled the research into lives of people experiencing crisis, their migration exper作者: Paleontology 時(shí)間: 2025-3-30 07:18
B. Leif Hanson,Gerard J. Bunickescape the regime in crisis. Referring to the example of post-independence Ukrainian migrants to Australia, this chapter investigates how these two cohorts get a visa to Australia, come and stay in Australia permanently. The first section looks into the migration patterns of ‘survival migrants’—from作者: 樂意 時(shí)間: 2025-3-30 11:08
David Jeruzalmiescape the regime in crisis. Referring to the example of post-independence Ukrainian migrants to Australia, this chapter investigates how these two cohorts get a visa to Australia, come and stay in Australia permanently. The first section looks into the migration patterns of ‘survival migrants’—from作者: curriculum 時(shí)間: 2025-3-30 14:46 作者: 神刊 時(shí)間: 2025-3-30 17:09
Michael R. Sawayaresearch.Focuses on life strategies of migrants in the time .This book offers a profoundly new examination of life strategies of migrants from regimes in crisis. By focusing on the unique paired comparison of two opposing life strategies—the dynamic, risk-taking and future-oriented ‘a(chǎn)chievement life作者: Airtight 時(shí)間: 2025-3-30 21:43
Eric A. Tothlimates, adapting to a life in which they depended entirely on the meat of large mammals for food, for increasingly longer periods of the year, and then penetrating along the river valleys into the productive periglacial zones. While Neanderthal man evolved in the north, there is evidence to indicat作者: 詢問 時(shí)間: 2025-3-31 03:31
Miroslawa Dauter,Zbigniew Dautereast that of the temperate regions, began to decline as well as to oscillate. The oscillations increased in frequency and amplitude to culminate ultimately in the major glaciations. Each major glaciation was characterized by several stadials during which the ice front advanced, and several interstad
