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標題: Titlebook: Interpretation and Extrapolation of Reproductive Data to Establish Human Safety Standards; K. S. Khera,H. C. Grice,D. J. Clegg Book 1989 S [打印本頁]

作者: FORAY    時間: 2025-3-21 16:31
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作者: Density    時間: 2025-3-21 21:25

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作者: CRUDE    時間: 2025-3-22 05:42
Behavioral-Functional Teratology,ure. Because this interest is concerned with protecting society from potential harm, it reflects an advancement in safety assessment (Christian, 1983a; Riley and Vorhees, 1986). Published reports that maternal exposure to lead (Palmisano et al., 1969) and methyl mercury (Matsumoto et al., 1965; Hara
作者: breadth    時間: 2025-3-22 09:23
In Vitro Developmental Toxicity Assays,een, in large part, limited to the field of genetic toxicology. Recent advances in molecular and cellular differentiation have provided new insights into the mechanisms of embryonic development and new opportunities to analyze the causes and effects of teratogenic insult. For example, observations o
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作者: Trigger-Point    時間: 2025-3-23 08:26
1431-2468 ittle attention being given to specific problems or issues. A failure to resolve these problems has frequently resulted in increased testing costs and complicat978-0-387-96962-6978-1-4684-6379-8Series ISSN 1431-2468
作者: ASSAY    時間: 2025-3-23 12:30
Book 1989ved in a rapid and largely unplanned fashion. Attempts to improve the system have mainly been directed toward broad general concerns, with little attention being given to specific problems or issues. A failure to resolve these problems has frequently resulted in increased testing costs and complicat
作者: aerial    時間: 2025-3-23 17:40
In Vitro Developmental Toxicity Assays, system morphogenesis. Investigations such as those using the nematode . (Sulston and Horvitz, 1977) have developed and extended the concept of cell lineages in the process of postembryonic growth. Mechanistic and morphologically based investigations of the types just described proceed apace. Their
作者: Intact    時間: 2025-3-23 18:20

作者: 不安    時間: 2025-3-24 02:13
Teratogenicity (Embryotoxicity) Studies: Design, Conduct, and Evaluation,o provide assurance that the data used in risk estimation are sound. In this chapter only basic principles related to these elements are discussed. References cited in the text should be consulted for details regarding the design and conduct of such studies.
作者: figure    時間: 2025-3-24 02:24

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作者: 鴿子    時間: 2025-3-24 12:29
Epidemiology,from work for two or more weeks during the year because of pregnancy. Although this number is only an approximation of the total number of women in the labor force who were pregnant during that year, it is an indication of the large number of pregnancies potentially at risk from the occupational environment.
作者: A簡潔的    時間: 2025-3-24 16:22
Guidelines for Reproductive Toxicity Tests in Different Countries With a Proposal for International (Segment 3) for safety assessment of pharmaceutical drugs. Embryo-toxicity or teratogenicity studies (Segment 2) and multigeneration reproduction studies are required for agricultural and environmental chemicals and food additives.
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作者: 白楊    時間: 2025-3-25 04:06

作者: ITCH    時間: 2025-3-25 08:09

作者: Transfusion    時間: 2025-3-25 14:27
https://doi.org/10.1007/978-1-4684-6379-8CNS; cell; cell culture; drug; environment; health effects; human health; human health effects; reproduction
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作者: STANT    時間: 2025-3-26 01:24

作者: 宣稱    時間: 2025-3-26 08:12
Introduction,This monograph focuses on extrapolating data from animal reproduction studies to permit the assessment of exposure levels acceptable for human reproduction that are consistent with the maintenance of public health.
作者: 正論    時間: 2025-3-26 11:58
Multigeneration Studies,tential to cause adverse effects in a particular species of animal. In attempting to predict such adverse effects in humans, the toxicologist is obliged to extrapolate data from experimental animal studies, thus further complicating the process.
作者: byline    時間: 2025-3-26 13:56
Gunilla-Friederike Buddet nicht notwendig, da? er diese Eigenschaft auch bei der Begründung der relativistischen Quantenmechanik beh?lt. In der Relativit?tstheorie bildet ja die Zeit mit den drei Raumkoordinaten zusammen einen Vierervektor . (., ., .,..) und ebenso der Impuls eines Massenpunktes mit dessen Energie zusammen
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作者: 指派    時間: 2025-3-27 03:17

作者: 思想靈活    時間: 2025-3-27 07:11
Myopathies with Myofibrillar Pathology,leading to accumulation of myofibrillar degradation products and multiple ectopic sarcoplasmic proteins aggregates. Myopathies with myofibrillar pathology (myofibrillar myopathies, MFM) are clinically and genetically heterogeneous. They can manifest with proximal, distal, axial or scapuloperoneal ph
作者: 輕信    時間: 2025-3-27 09:59
,The European Examination — its present status and potential development,d differences in priorities of teaching in the different countries. The explosion of medical knowledge poses an additional challenge to all those responsible in setting priorities for what is thought to be the core knowledge in a given training programme. With the concept of developing European stan
作者: 令人悲傷    時間: 2025-3-27 15:49
1866-8348 lated evolutions of state and shape works throughout more coSoil is matter in its own right. Its nature can be captured by means of monotonous, cyclic and strange attractors. Thus material properties are defined by the asymptotic response of sand- and clay-like samples to imposed deformations and st
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作者: AMPLE    時間: 2025-3-27 23:34

作者: 少量    時間: 2025-3-28 05:10
https://doi.org/10.1007/978-3-642-91745-5 different but at the same time complementary concepts (e.g. image and signal processing, machine learning, computer vision). This conjugation applied to the endoscopic domain provides a set of features capable of improving the gastroenterologist’s activities during and after the procedure.
作者: amenity    時間: 2025-3-28 08:18
Sonia Moussa,Zied Hajaiej,Ali Garsallahs a more rigorous understanding of the affective, and aesthetic repercussions of?indifference—itself?a nod to modernist impersonality—as it appears in both texts. Drawing on Affect Theory and Modernist Studies, this paper contributes to contemporary conceptions of horror?and early modernism, bringin
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作者: Harass    時間: 2025-3-28 17:41
0302-9743 d- ciplines that share interests in modelling and analysis of timed systems. In this volume, there are articles on: – Foundations and Semantics: contributions 978-3-540-45026-9978-3-540-45031-3Series ISSN 0302-9743 Series E-ISSN 1611-3349
作者: Hyperalgesia    時間: 2025-3-28 19:07
g and development). We bring these new concepts to life using a cultural-historical approach to analysis of play, supported in each chapter by the use of case studies with visual narratives used as a research method for re-theorising play as being pedagogical.
作者: Watemelon    時間: 2025-3-29 01:42
Strukturelle Konflikte in Unternehmen erkennen,itarbeitern Verhaltensweisen hervorgerufen, die nicht im Sinne des Unternehmenserfolgs sein k?nnen. Im zweiten Beispiel geht es um das Thema Macht beim Start eines Projekts. Das dritte Beispiel betrifft die ?Gemütslage“ eines ganzen Unternehmens. Diese idealtypische Form eines strukturellen Konflikt
作者: 迫擊炮    時間: 2025-3-29 06:20
2297-2951 relations between the two countries in the light of a chang.The contributions in this proceedings volume offer a new perspective on the mathematical ties between France and Italy, and reveal how mathematical developments in these two countries affected one another. The focus is above all on the Pen




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