標(biāo)題: Titlebook: Inhibitors of Protein Kinases and Protein Phosphates; Lorenzo A. Pinna,Patricia T.W. Cohen (Professor of Book 2005 Springer-Verlag Berlin [打印本頁] 作者: Coolidge 時間: 2025-3-21 19:41
書目名稱Inhibitors of Protein Kinases and Protein Phosphates影響因子(影響力)
書目名稱Inhibitors of Protein Kinases and Protein Phosphates影響因子(影響力)學(xué)科排名
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書目名稱Inhibitors of Protein Kinases and Protein Phosphates網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Inhibitors of Protein Kinases and Protein Phosphates被引頻次
書目名稱Inhibitors of Protein Kinases and Protein Phosphates被引頻次學(xué)科排名
書目名稱Inhibitors of Protein Kinases and Protein Phosphates年度引用
書目名稱Inhibitors of Protein Kinases and Protein Phosphates年度引用學(xué)科排名
書目名稱Inhibitors of Protein Kinases and Protein Phosphates讀者反饋
書目名稱Inhibitors of Protein Kinases and Protein Phosphates讀者反饋學(xué)科排名
作者: 避開 時間: 2025-3-21 20:52 作者: BULLY 時間: 2025-3-22 00:27 作者: isotope 時間: 2025-3-22 08:17 作者: 割公牛膨脹 時間: 2025-3-22 10:57
Inhibitors of Protein Kinase CK2: Structural Aspectsver the last 50 years, very little is known about its precise biological function and mode of regulation. The CK2 holoenzyme is composed of two catalytic .- and two regulatory .-subunits and is classified as an acidophilic Ser/Thr kinase. Unique properties of the catalytic α-subunit are its intrinsi作者: 最有利 時間: 2025-3-22 16:49
Aminoglycoside Kinases and Antibiotic Resistanceiotics threatens to render some infections untreatable by existing drugs. As a result, there is considerable interest in understanding the mechanisms of antibiotic resistance and in identifying ways in which antibiotic resistance can be overcome. Aminoglycoside antibiotics are broad-spectrum bacteri作者: athlete’s-foot 時間: 2025-3-22 19:40 作者: 氣候 時間: 2025-3-23 01:14 作者: CARK 時間: 2025-3-23 03:16 作者: 原諒 時間: 2025-3-23 06:56
Serine/Threonine Protein Phosphatase Inhibitors with Antitumor Activityonine protein phosphatases, notably PP2A, PP4, and PP5, may prove useful for the medical management of human cancer. This chapter will review the discovery and development of natural compounds that were originally shown to have marked antitumor activity and subsequently found to act as potent inhibi作者: perjury 時間: 2025-3-23 13:43
Clinical Immunosuppression using the Calcineurin-Inhibitors Ciclosporin and Tacrolimusll activation, ciclosporin, dramatically improved the results of renal transplantation and transformed other types of organ transplantation from experimental to standard therapy. The discovery of a second drug, tacrolimus, that was structurally unrelated to ciclosporin but which had an identical mec作者: anthropologist 時間: 2025-3-23 17:41 作者: carbohydrate 時間: 2025-3-23 21:23
Clinical Aspects of Imatinib Therapyrosine kinase in chronic myeloid leukemia, this was the first disease selected for clinical trials with imatinib. In the clinical trials, patients in all phases of the disease responded to imatinib and experienced minimal toxicity. Responses in patients with chronic phase disease have been durable, 作者: Overthrow 時間: 2025-3-24 01:37 作者: SOBER 時間: 2025-3-24 05:37
Discovery and Development of Iressa: The First in a New Class of Drugs Targeted at the Epidermal Gronesis, and tumour resistance to chemotherapy and radiotherapy. This chapter describes a low-molecular- weight EGFR tyrosine kinase inhibitor (EGFR-TKI), Iressa (gefitinib, ZD1839). Iressa is a potent EGFR-TKI which blocks EGF-stimulated EGFR autophosphorylation in tumour cells and selectively inhibi作者: deviate 時間: 2025-3-24 06:37
S. Kumar,S. M. Blakeu?t bereits der junge Schumann von der historischen Bedeutung der ?romantischen“ Musik seit Beethoven gesprochen hat. 1834, etwa zur Zeit als er aus Wilhelm Christian Müllers ?Aesthetisch-historischen Einleitungen in die Wissenschaft der Tonkunst“ Daten zur Musikgeschichte exzerpierte,. kündigte Sch作者: enhance 時間: 2025-3-24 13:33
M. Ga?el,C. Breitenlechner,S. Herrero,R. Engh,D. Bossemeyernschauung entsprechend, eigentlich mit einer Betrachtung der Schriften Wilhelm Heinrich Wackenroders und Ludwig Tiecks sowie E. T. A. Hoffmanns beginnen. Der Begriff l??t sich aber weder in den ?Herzensergie?ungen eines kunstliebenden Klosterbruders” (1797) noch in den ?Phantasien über die Kunst, fü作者: PANIC 時間: 2025-3-24 18:37 作者: BUST 時間: 2025-3-24 19:56 作者: 我悲傷 時間: 2025-3-25 02:22 作者: 無孔 時間: 2025-3-25 04:07 作者: TSH582 時間: 2025-3-25 08:47 作者: 強(qiáng)所 時間: 2025-3-25 15:44 作者: 小淡水魚 時間: 2025-3-25 17:54 作者: PUT 時間: 2025-3-25 20:13
B. J. Drukere serotonerge Dysfunktion insbesondere bei Patienten mit frühem Krankheitsbeginn beobachtet. Studien zeigten bei dieser Patientengruppe eine erniedrigte Konzentration des Serotoninmetaboliten 5-Hydroxyindolessigs?ure (5-HIAA) im Liquor. Studien mit Primaten ergaben, dass frühe soziale Stresserfahrun作者: Obscure 時間: 2025-3-26 00:33
H. Hidaka,Y. Suzuki,M. Shibuya,Y. Sasakie serotonerge Dysfunktion insbesondere bei Patienten mit frühem Krankheitsbeginn beobachtet. Studien zeigten bei dieser Patientengruppe eine erniedrigte Konzentration des Serotoninmetaboliten 5-Hydroxyindolessigs?ure (5-HIAA) im Liquor. Studien mit Primaten ergaben, dass frühe soziale Stresserfahrun作者: 纖細(xì) 時間: 2025-3-26 07:03
A. E. Wakelinge serotonerge Dysfunktion insbesondere bei Patienten mit frühem Krankheitsbeginn beobachtet. Studien zeigten bei dieser Patientengruppe eine erniedrigte Konzentration des Serotoninmetaboliten 5-Hydroxyindolessigs?ure (5-HIAA) im Liquor. Studien mit Primaten ergaben, dass frühe soziale Stresserfahrun作者: overreach 時間: 2025-3-26 12:20 作者: 物質(zhì) 時間: 2025-3-26 15:42
Isoquinolinesulfonamide: A Specific Inhibitor of Rho-Kinase and the Clinical Aspect of Anti-Rho-Kinaon of various protein kinases and, moreover, toward developing a new type of medicine. This chapter relates to the discovery of new protein kinase inhibitors, their mechanisms of action, and their clinical application in Japan.作者: 斷斷續(xù)續(xù) 時間: 2025-3-26 20:01
Book 2005asic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum of diseases. This goal?is attained by contributions of leader investigators in the field, who?address the issue from different angles. .作者: Kindle 時間: 2025-3-26 22:42
Serine/Threonine Protein Phosphatase Inhibitors with Antitumor Activitytors of certain PPP-family phosphatases. The review will focus on two compounds, cantharidin and fostriecin, addressing discovery, molecular mechanisms of action, affects on cultured cell, clinical use, toxicity, plasma pharmacokinetics, and a brief review of data from a phase I human clinical trial.作者: floodgate 時間: 2025-3-27 02:06
Clinical Aspects of Imatinib Therapythus far. Clinical trials with imatinib were expanded and there are now examples of malignancies driven by each of the targets of imatinib where remarkable results have been seen. The rationale for the use of imatinib in these various diseases and the clinical trial results will be reviewed.作者: 你敢命令 時間: 2025-3-27 06:09
0171-2004 of diseases. This goal?is attained by contributions of leader investigators in the field, who?address the issue from different angles. .978-3-642-42206-5978-3-540-26670-9Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: 系列 時間: 2025-3-27 11:26
Inhibitors of PKA and Related Protein Kinasesm the AGC group and the cocrystallization of these ersatz kinases with small molecules as well as cocrystal structures of other AGC kinases like 3-phosphoinositide-dependent kinase 1 (PDK1) with staurosporine and bisindolylmaleimide derivatives helps in the identification and exploration of factors governing selectivity.作者: conceal 時間: 2025-3-27 15:14
0171-2004 otein phosphatase inhibitors, to provide a thorough overview of the most remarkable achievements in the field and to illustrate how beneficial these studies can be for the advancement of both basic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum 作者: eucalyptus 時間: 2025-3-27 21:11 作者: 極大的痛苦 時間: 2025-3-28 00:46 作者: bacteria 時間: 2025-3-28 03:36 作者: Catheter 時間: 2025-3-28 08:21 作者: Handedness 時間: 2025-3-28 12:41
Inhibitors of Protein Kinase CK2: Structural Aspectsby its ability to use both ATP and GTP as co-substrates and the low susceptiveness to staurosporine inhibition. On the basis of three-dimensional crystal structures, we describe and discuss the effects of the binding to CK2 of inhibitors with a potency in the low micromolar range belonging to differ作者: 錢財 時間: 2025-3-28 15:33 作者: 貪婪地吃 時間: 2025-3-28 20:16
Protein Tyrosine Phosphatases as Therapeutic Targetsown propagation. Taken together, these findings identified specific PTPs as significant targets for the therapeutic intervention in human diseases. For instance, the discovery that PTP1B is a negative regulator of insulin signaling revealed that this molecule is an attractive target for the treatmen作者: Harness 時間: 2025-3-29 00:51
Structure-Based Design of Protein Tyrosine Phosphatase Inhibitors indicating that PTP1B is an important negative regulator of insulin and leptin action and hence a potentially important drug target for the treatment of diabetes and obesity. The development of PTP inhibitors, in particular PTP1B inhibitors, has been greatly facilitated by an impressive number of X作者: 不能逃避 時間: 2025-3-29 06:33
Biological Validation of the CD45 Tyrosine Phosphatase as a Pharmaceutical Targetlls that do exit to the periphery are markedly non-responsive to mitogens. The p56. kinase also has an activating autophosphorylation site that can be dephosphorylated by CD45 under some circumstances. However, the overall regulatory actions of CD45 on p56. function in the context of T cell antigen 作者: Seizure 時間: 2025-3-29 10:12
Clinical Immunosuppression using the Calcineurin-Inhibitors Ciclosporin and Tacrolimuscations outside the field of transplantation. Ciclosporin and tacrolimus are metabolised by cytochrome P450 3A and are substrates for the P-glycoprotein transporter system. This results in complex pharmacokinetics with large variations in bioavailability and metabolism between individuals as well as作者: Epithelium 時間: 2025-3-29 12:36 作者: BIPED 時間: 2025-3-29 18:52
Discovery and Development of Iressa: The First in a New Class of Drugs Targeted at the Epidermal Groressa-resistant tumours appeared during treatment, but some tumours regrew following drug withdrawal. The level of expression of EGFR did not determine xenograft tumour sensitivity to Iressa. These preclinical studies indicated the potential utility of Iressa in the treatment of a wide range of huma作者: 發(fā)源 時間: 2025-3-29 21:28 作者: bromide 時間: 2025-3-30 02:08
M. Ga?el,C. Breitenlechner,S. Herrero,R. Engh,D. Bossemeyeregen scheint E. T. A. Hoffmanns berühmte Rezension zu Beethovens 5. Symphonie (1810) einen nahezu idealen Ausgangspunkt zu bieten. E. T. A. Hoffmann bezeichnet Beethoven nicht nur als einen ?rein romantischen (…) Komponisten, dessen Musik ?die Hebel des Schauers, der Furcht, des Entsetzens, des Schm作者: 嚴(yán)厲批評 時間: 2025-3-30 06:08 作者: membrane 時間: 2025-3-30 09:40 作者: HPA533 時間: 2025-3-30 16:24
N. P. H. M?ller,H. S. Andersen,C. B. Jeppesen,L. F. Iversenne Sache von Be- geisterten, die andere begeistern wollen. Die Vorlesung, auch das gefallt mir an ihr, l??t wenig Raum für multimediale Spielereien, sie mu? auf das Wort setzen, auf die Sprache, auf den Zusammenhang eines im Grunde sehr langen, immer wieder unterbrochenen Textes. Sie kann nicht auf 作者: Somber 時間: 2025-3-30 20:20
D. R. Alexanderne Sache von Be- geisterten, die andere begeistern wollen. Die Vorlesung, auch das gefallt mir an ihr, l??t wenig Raum für multimediale Spielereien, sie mu? auf das Wort setzen, auf die Sprache, auf den Zusammenhang eines im Grunde sehr langen, immer wieder unterbrochenen Textes. Sie kann nicht auf 作者: 有抱負(fù)者 時間: 2025-3-30 23:34 作者: Apoptosis 時間: 2025-3-31 00:58
N. R. Banner,H. Lyster,M. H. Yacoubkonsumierten diese Tiere vermehrt Alkohol, wenn er frei zug?nglich war. Chronischer Alkoholkonsum kann zu einer weitergehenden Sch?digung serotonerger Neurone im Hirnstamm führen, die mit einem Verlust der Serotonintransporter und erh?hter Depressivit?t verbunden ist. Eine stressbedingte Erh?hung de作者: MOT 時間: 2025-3-31 05:38
D. Fabbro,G. Fendrich,V. Guez,T. Meyer,P. Furet,J. Mestan,J. D. Griffin,P. W. Manley,S. W. Cowan-Jackonsumierten diese Tiere vermehrt Alkohol, wenn er frei zug?nglich war. Chronischer Alkoholkonsum kann zu einer weitergehenden Sch?digung serotonerger Neurone im Hirnstamm führen, die mit einem Verlust der Serotonintransporter und erh?hter Depressivit?t verbunden ist. Eine stressbedingte Erh?hung de作者: 曲解 時間: 2025-3-31 10:42
B. J. Drukerkonsumierten diese Tiere vermehrt Alkohol, wenn er frei zug?nglich war. Chronischer Alkoholkonsum kann zu einer weitergehenden Sch?digung serotonerger Neurone im Hirnstamm führen, die mit einem Verlust der Serotonintransporter und erh?hter Depressivit?t verbunden ist. Eine stressbedingte Erh?hung de
