標(biāo)題: Titlebook: Inflammasomes: Clinical and Therapeutic Implications; Mario D. Cordero,Elísabet Alcocer-Gómez Book 2018 Springer International Publishing [打印本頁] 作者: Harding 時(shí)間: 2025-3-21 19:29
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書目名稱Inflammasomes: Clinical and Therapeutic Implications讀者反饋學(xué)科排名
作者: 高談闊論 時(shí)間: 2025-3-21 23:35 作者: Rotator-Cuff 時(shí)間: 2025-3-22 02:35
Lung Diseases,nd small animal disease models that implicate excessive inflammasome responses in the pathogenesis of a number of acute and chronic respiratory inflammatory diseases. Understanding of the role of inflammasomes in lung disease is of great therapeutic interest.作者: LIEN 時(shí)間: 2025-3-22 06:45
Traumatic Injury, trauma is still largely unknown. However, in the following chapter, we provide an overview on the best described inflammasomes in the various settings of trauma, introducing the recent findings on the . best described NLRP inflammasomes and underlying cytokines in the inflammatory response to trauma.作者: 有惡臭 時(shí)間: 2025-3-22 11:02
Role of Inflammasomes in the Development of Gastrointestinal Diseases, NOD-like receptors (NLRs) which are major components of inflammasomes in the development and exacerbation of many diseases of human systems. In this chapter, we discuss the role of inflammasomes in some of the most prevalent diseases of the gastrointestinal tract and highlight potential targets for treatment.作者: Preserve 時(shí)間: 2025-3-22 16:54 作者: 表皮 時(shí)間: 2025-3-22 19:57
Inflammasomes in the Kidney,er inflammasomes in some conditions. While, at least in some disease, the mechanistic details of the involvement of the inflammasome remain to be elucidated, therapies focussed on inflammasomes and their products have potential in treating kidney disease in the future.作者: Humble 時(shí)間: 2025-3-22 21:21
Inflammasomes in Bone Diseases, are characteristics of dysregulated inflammasomes, which are key regulators of innate immunity. In this review, we discuss the role of inflammasomes in bone diseases caused by sterile or non-sterile inflammation.作者: 調(diào)情 時(shí)間: 2025-3-23 03:49
Inflammasomes in Clinical Practice: A Brief Introduction,eases opens a door to developing new therapeutic perspectives. However, the rapid increase in the knowledge about inflammasomes is associated with their involvement in clinical practice. Two topics open the way to future lines of research: a clinical trial with the new specific inhibitors and the development of diagnostic tools.作者: VEN 時(shí)間: 2025-3-23 08:31
Inflammasome in the Pathogenesis of Pulmonary Diseases,ta and IL-18 from their precursors into the active forms is tightly regulated by inflammasomes. In this chapter, we structurally review current evidence of inflammasome-related components in the pathogenesis of acute and chronic lung diseases, focusing on the “inflammasome-caspase-1-IL-1 beta/IL-18” axis.作者: 哄騙 時(shí)間: 2025-3-23 12:59 作者: canvass 時(shí)間: 2025-3-23 14:59
1664-431X usses pharmacological developments in inflammasome inhibitio.The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing作者: Incorruptible 時(shí)間: 2025-3-23 18:27
Gerardus P. J. van Hout,Lena Boschtent the Euro crisis has ‘moved’ party systems to more Eurosceptic positions and whether it has affected the systemic salience of the European integration issue. We argue that worsening economic conditions have directly affected party competition on European integration, but that party systems have 作者: noxious 時(shí)間: 2025-3-24 01:21
Eduardo A. Albornoz,Trent M. Woodruff PhD,Richard Gordon PhD, DABT it addresses and is typically justified as an attempt to discover new facts or to evaluate innovative programs or policies. When, as must often be the case, no new facts are forthcoming or innovative programs turn out not to work, hopes are dashed and time and money are felt to have been wasted. Be作者: 他姓手中拿著 時(shí)間: 2025-3-24 05:25 作者: conifer 時(shí)間: 2025-3-24 06:30
Borna Relja,Johann-Philipp Horstmannght into ontogenetic processes. The spatial geometry of the cusps expressed in the topography of the dentin-enamel junction (DEJ) records the partitioning of cell proliferation and differentiation as well as the timing of these events. The final stage of development is expressed in the topography of作者: Inoperable 時(shí)間: 2025-3-24 13:29
Fengying Xu,Zongmei Wen,Xueying Shi,Jie Fanl consists now of all points (.,…,.) in ?. such that a. < x. ≤ b. for j = 1,…,k. We shall call an interval of this kind a cell. For reasons of convenience, the empty set will also be called a cell. Observe now that the collection . of all cells is not empty and it has the property that if . and . be作者: Magnificent 時(shí)間: 2025-3-24 18:13 作者: Haphazard 時(shí)間: 2025-3-24 19:30
Holly L. Hutton,Maliha A. Alikhan,A. Richard Kitching Its use in infants has made future transplantation a reality. Haemodialysis has been used successfully in children since the late 1960s. but is technically difficult and symptomatically very unpleasant during the treatments, especially in small children with blood volumes under two litres. Very few作者: PTCA635 時(shí)間: 2025-3-25 01:27
Viktória Jeneyon emerged, continuous ambulatory peritoneal dialysis (CAPD) became established as an accepted form of treatment for ESRD patients, taking a place alongside haemodialysis and renal transplantation.. The degree to which ESRD patients are accepted for any form of treatment, and if so, by which modalit作者: 廣大 時(shí)間: 2025-3-25 05:05 作者: 微生物 時(shí)間: 2025-3-25 09:27
Gabriel Mbalaviele,Deborah J. Veis from 499 patients. These data suggest in diabetics with renal insufficiency, the time interval from age at diagnosis of diabetes to initiation of dialysis decreases as the age of diagnosis increases. Mean interval from the time of diabetes diagnosis to CAPD or CCPD initiation was 25 years for patie作者: EXULT 時(shí)間: 2025-3-25 13:09
Zhiyu Wang,Neng Wang,Yifeng Zheng,Shengqi Wang from 499 patients. These data suggest in diabetics with renal insufficiency, the time interval from age at diagnosis of diabetes to initiation of dialysis decreases as the age of diagnosis increases. Mean interval from the time of diabetes diagnosis to CAPD or CCPD initiation was 25 years for patie作者: Magisterial 時(shí)間: 2025-3-25 17:00 作者: 頭腦冷靜 時(shí)間: 2025-3-25 22:03 作者: VOC 時(shí)間: 2025-3-26 00:59 作者: 不如屎殼郎 時(shí)間: 2025-3-26 04:46 作者: colostrum 時(shí)間: 2025-3-26 11:18 作者: 裂隙 時(shí)間: 2025-3-26 14:00
Inflammasomes in CNS Diseases,ivation of the innate immune response in the CNS against a variety of stimuli, including infection, traumatic brain injury, toxic metabolites, aggregated proteins, or autoimmunity. Crucial mediators of this neurinflammatory?process are the?intracellular protein complexes known as inflammasomes which作者: 竊喜 時(shí)間: 2025-3-26 20:00
Lung Diseases,tal and infectious stimuli. Inflammasomes are critical for driving acute innate immune responses that resolve infection and maintain tissue homeostasis. However, dysregulated or excessive inflammasome activation can be detrimental. Here, we discuss the plethora of recent data from clinical studies a作者: Physiatrist 時(shí)間: 2025-3-26 20:58
Traumatic Injury, to the development of post-injury complications. Cytokine-producing capacity of cells is important for the appropriate immune response to trauma and requires not only synthesis and transcription of inflammasome components but also their activation. Unfortunately, the precise role of inflammasome in作者: Irascible 時(shí)間: 2025-3-27 03:11
Inflammasome in the Pathogenesis of Pulmonary Diseases,seases. The important role of IL-1 beta and IL-18 in the inflammatory response of many lung diseases has been elucidated. The cleavage to turn IL-1 beta and IL-18 from their precursors into the active forms is tightly regulated by inflammasomes. In this chapter, we structurally review current eviden作者: 符合國情 時(shí)間: 2025-3-27 09:21
Inflammasome and Oral Diseases,gical structures within an organism and is an essential factor in how to recognize friendly cells that are part of the multicellular organism and which foreign organisms can be harmful. Recognition includes devices such as the major histocompatibility complex (MHC), and the pattern recognition recep作者: Flawless 時(shí)間: 2025-3-27 13:02 作者: 避開 時(shí)間: 2025-3-27 17:38 作者: Indict 時(shí)間: 2025-3-27 18:32
Role of Inflammasomes in the Development of Gastrointestinal Diseases, pathogenesis. Inflammasomes are a group of protein complexes comprising of several intracellular proteins that link the sensing of microbial products and metabolic stress to the proteolytic activation of the proinflammatory cytokines. Recent studies have implicated activation of several families of作者: 消瘦 時(shí)間: 2025-3-27 22:36
Inflammasomes in Bone Diseases,ends on the activity of osteoclasts, which arise from myeloid precursors. Osteoclasts are responsible for bone resorption in normal and disease conditions. Increased osteolysis is a common feature of inflammatory disorders and a risk factor for bone fractures. Thus, bone is impacted negatively not o作者: 喪失 時(shí)間: 2025-3-28 04:42
Inflammasome and Cancer, correlated with elevated levels of IL-1β and IL-18, activation of NF-κB signaling, enhanced mitochondrial oxidative stress, and activation of autophagic process in cancer. Meanwhile, inflammasome component NOD-like receptors (NLRs) are also involved in carcinogenesis and closely correlated to chemo作者: 避開 時(shí)間: 2025-3-28 08:36
Aging and the Inflammasomes, and molecules originating from host proteins, leading to the release of pro-inflammatory cytokines, Il1b and IL18, and a particular inflammatory type of cell death termed pyroptosis. It is broadly considered that chronic inflammation may be a common link in age-related diseases, aging being the gre作者: Confess 時(shí)間: 2025-3-28 11:21 作者: conception 時(shí)間: 2025-3-28 17:07
Inhibiting Inflammasomes with Small Molecules,ts are emerging to protect the intellectual property in valuable compound classes. This chapter focusses specifically on the suite of small-molecule NLRP3 inflammasome inhibitors published, as specific modulation of other inflammasomes is not yet well established. Synthetic molecules, known drugs an作者: Visual-Acuity 時(shí)間: 2025-3-28 21:59
Mario D. Cordero,Elísabet Alcocer-GómezExtensive coverage of the roles played by inflammasomes in various diseases.Examines the inflammasome as a potential therapeutic target.Discusses pharmacological developments in inflammasome inhibitio作者: 環(huán)形 時(shí)間: 2025-3-29 02:23 作者: 盲信者 時(shí)間: 2025-3-29 05:34
https://doi.org/10.1007/978-3-319-89390-7Inflammasome; Inhibitor; Sensor; Cytokine; Metabolic stress作者: nitric-oxide 時(shí)間: 2025-3-29 10:48 作者: Solace 時(shí)間: 2025-3-29 15:19 作者: Communal 時(shí)間: 2025-3-29 16:08 作者: 貪婪性 時(shí)間: 2025-3-29 22:14 作者: 微粒 時(shí)間: 2025-3-30 02:33
Elísabet Alcocer-Gómez,Beatriz Castejón-Vega,Macarena López-Sánchez,Mario D. Cordero作者: 鄙視讀作 時(shí)間: 2025-3-30 05:19 作者: 礦石 時(shí)間: 2025-3-30 09:27
Inflammasomes in CNS Diseases,lia and the infiltrating?macrophages into the CNS. However,?astrocytes and neurons also?express inflammasomes, and the understanding of how they are engaged in the pathogenesis of a variety of neurological diseases is crucial to develop effective therapeutic approaches for CNS pathologies that are p作者: BUCK 時(shí)間: 2025-3-30 14:07 作者: falsehood 時(shí)間: 2025-3-30 19:16
Pro-Inflammatory Actions of Red Blood Cell-Derived DAMPs,mmatory actions independently of their heme releasing capability. Non-Hb-derived DAMPs such as ATP, interleukin-33, heat shock protein 70, as well as RBC membrane-derived microparticles might also contribute to the innate immune response triggered by hemolysis/hemorrhage..In this chapter we will dis作者: 施舍 時(shí)間: 2025-3-30 21:58 作者: 范例 時(shí)間: 2025-3-31 02:53
Gerardus P. J. van Hout,Lena Bosche Eurosceptic—both as a direct reaction to economic hardship and as an indirect response to an increased public dissatisfaction with the regime of the EU. Moreover, an increase in the systemic salience of the European integration issue has occurred mainly in creditor countries, where the public has
