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標(biāo)題: Titlebook: Handbook of Downstream Processing; Elliott Goldberg (Director of Process Engineering) Book 1997 Chapman & Hall 1997 Downstream Processing. [打印本頁]

作者: 浮淺    時(shí)間: 2025-3-21 18:28
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作者: Concerto    時(shí)間: 2025-3-21 21:38
Product recovery and purification via precipitation and crystallization,cts, both crystallization and precipitation are more similar than different. However, some differences exist and will be highlighted during the subsequent discussion. Although many of the examples presented in this chapter will focus on the application to protein molecules, the principles applied may be generalized to any system.
作者: Oration    時(shí)間: 2025-3-22 01:40

作者: Bereavement    時(shí)間: 2025-3-22 07:05

作者: 吸引人的花招    時(shí)間: 2025-3-22 11:07

作者: circumvent    時(shí)間: 2025-3-22 13:42
Richard Willst?tter,Werner Steibeltes exist, the one most often used is distillation. Distillation is simple, has few moving parts, is well understood, can be simulated readily, and often has a low capital cost. On the negative side is the high operating cost associated with high energy requirements to vaporize and condense.
作者: 觀點(diǎn)    時(shí)間: 2025-3-22 18:15

作者: 任命    時(shí)間: 2025-3-23 00:06

作者: PUT    時(shí)間: 2025-3-23 02:26
Controls and automation for biotechnology and pharmaceutical industries,sizes of 9 m (30 ft approx) or longer, a common occurrence, and operators had to move around in order to see all process variables. Additions or change to pneumatic control loops were extremely difficult and expensive.
作者: motivate    時(shí)間: 2025-3-23 07:08

作者: Irritate    時(shí)間: 2025-3-23 12:17
Electrodialysis,pplied across these media. Its ability to remove ionically charged components, electrolytes, from solutions without otherwise affecting the solution composition makes ED useful in the processing of food, pharmaceuticals and numerous products of biotechnology.
作者: Ischemic-Stroke    時(shí)間: 2025-3-23 16:17
Distillation in the pharmaceutical industry,es exist, the one most often used is distillation. Distillation is simple, has few moving parts, is well understood, can be simulated readily, and often has a low capital cost. On the negative side is the high operating cost associated with high energy requirements to vaporize and condense.
作者: recession    時(shí)間: 2025-3-23 20:14
Affinity adsorption,aterial eluted, usually by altering the buffer conditions such that binding is less favorable. The properties of affinity adsorbents make them especially suited for recovery of biomolecules from fermentation broths where the product is often dilute and the broth heterogeneous. Although commonly used
作者: Commentary    時(shí)間: 2025-3-24 00:35

作者: Archipelago    時(shí)間: 2025-3-24 05:56

作者: Hyperalgesia    時(shí)間: 2025-3-24 07:01

作者: 阻礙    時(shí)間: 2025-3-24 14:07
ess be batch or continuous or a combination of batch and continuous? How should the optimum process design be developed? Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk? Should the process be run with ingredi978-94-010-7198-7978-94-009-1563-3
作者: 驚奇    時(shí)間: 2025-3-24 16:26

作者: 處理    時(shí)間: 2025-3-24 23:01
Heinrich Siepmann,Herwig Schenkilized during sublimation drying by the ice crystals. The shape of the dry substance is broadly the same as that of the frozen, wet substance and migration to the surface to form a skin is reduced. Since drying takes place at a low temperature, damage is minimized and volatile components are retaine
作者: 吊胃口    時(shí)間: 2025-3-25 00:54

作者: 斜谷    時(shí)間: 2025-3-25 05:56

作者: 薄荷醇    時(shí)間: 2025-3-25 08:50

作者: 手段    時(shí)間: 2025-3-25 14:43
https://doi.org/10.1007/978-94-009-1563-3Downstream Processing; Fermenter; Lysin; biochemical engineering; biotechnology; chromatography; filtratio
作者: indecipherable    時(shí)間: 2025-3-25 16:50
https://doi.org/10.1007/978-3-663-05011-7In many pharmaceutical processes, separation of solid and liquid is required. Simple decantation is inadequate when the process is slow, when large volumes are involved and when a low liquid content in the solid is required.
作者: 軟弱    時(shí)間: 2025-3-25 23:49

作者: 審問,審訊    時(shí)間: 2025-3-26 04:11

作者: 使閉塞    時(shí)間: 2025-3-26 06:13
Emil Fischer,Hermann O. L. FischerThirty-five years ago the concept of cleaning in place (CIP) was unknown. In all industries manual cleaning of equipment was universally accepted as the best way of achieving acceptable standards of cleanliness. However, there were many disadvantages to manual cleaning:
作者: 典型    時(shí)間: 2025-3-26 09:33
Die Kennzeichnung der untersuchten Betriebe,Agitators have been used in fermenters for many years. The functions of the mixer in fermentation processes requiring dispersion of air or oxygen in a broth are that they:
作者: 先鋒派    時(shí)間: 2025-3-26 14:47

作者: 廣告    時(shí)間: 2025-3-26 18:16

作者: 死亡    時(shí)間: 2025-3-27 00:18

作者: 分開    時(shí)間: 2025-3-27 02:30
Pharmaceutical Packaging Operations,This chapter addresses non-sterile liquid and solid dosage form product packaging lines.
作者: Mingle    時(shí)間: 2025-3-27 06:17

作者: frivolous    時(shí)間: 2025-3-27 11:21

作者: 首創(chuàng)精神    時(shí)間: 2025-3-27 14:23

作者: 政府    時(shí)間: 2025-3-27 19:59

作者: scoliosis    時(shí)間: 2025-3-28 00:26
https://doi.org/10.1007/978-3-663-15782-3 critical unit operation continues to be the main focus of purification development teams as an ever increasing number of biopharmaceuticals are commercialized. Consequently, consideration of column chromatography scale-up and manufacturing issues is a critial element in the successful commercialization of therapeutic proteins.
作者: 引起痛苦    時(shí)間: 2025-3-28 04:46
Bernhard Renfert,Karl Heisig,Josef Thelenods for removal of solvents from dryer exhausts. No discussion is included of typical equipment for the removal of solid particulates such as filters, cyclones, electrostatic precipitators or wet scrubbers from exhaust streams.
作者: 百靈鳥    時(shí)間: 2025-3-28 07:15
https://doi.org/10.1007/978-3-662-24786-0g the space and/or to provide a contaminant-limited or contaminant-free environment, certain specific space plans, finishes, environments, equipment, and services must be provided to support the desired activities.
作者: 排斥    時(shí)間: 2025-3-28 12:35

作者: PSA-velocity    時(shí)間: 2025-3-28 18:03
Membrane separations in downstream processing,g very similar composition and structure to be either passed or excluded. They facilitate active separations with exquisite precision. The facility and ease with which very difficult selection in the passage of components is realized is testimony to the beneficial effects of millennia of natural selection.
作者: GRUEL    時(shí)間: 2025-3-28 20:28

作者: 蛛絲    時(shí)間: 2025-3-29 01:31
Drying in the pharmaceutical and biotechnology fields,ods for removal of solvents from dryer exhausts. No discussion is included of typical equipment for the removal of solid particulates such as filters, cyclones, electrostatic precipitators or wet scrubbers from exhaust streams.
作者: Host142    時(shí)間: 2025-3-29 04:52

作者: 用不完    時(shí)間: 2025-3-29 10:05
Clean room testing and certification,oduce the process to those not familiar with the subject. There are several in-depth papers and articles which can provide more information on the technical nature of the various tests. The standards referenced in this chapter also provide valuable insight to the actual testing equipment, procedures and reporting.
作者: 人類    時(shí)間: 2025-3-29 11:29

作者: 領(lǐng)袖氣質(zhì)    時(shí)間: 2025-3-29 18:45
Synthese der beiden optisch-aktiven Proliner size, charge, or solubility, affinity adsorption relies on highly specific binding interactions. Specificity is the hallmark of affinity-based purifications. It allows the capture of a single molecular component from a complex mixture. The high binding affinity allows high recovery of products in
作者: cringe    時(shí)間: 2025-3-29 19:42
Synthese der α, δ-Diaminovalerians?ureg very similar composition and structure to be either passed or excluded. They facilitate active separations with exquisite precision. The facility and ease with which very difficult selection in the passage of components is realized is testimony to the beneficial effects of millennia of natural sel
作者: 笨拙的你    時(shí)間: 2025-3-30 00:05

作者: Autobiography    時(shí)間: 2025-3-30 07:15

作者: defibrillator    時(shí)間: 2025-3-30 09:45
https://doi.org/10.1007/978-3-662-40061-6on of a molecule results in an amorphous solid that is of low purity relative to a product obtained by crystallization. Precipitation is best utilized as a means of product isolation; whereas, crystallization may be an effective polishing step that provides a product of high purity. As in any unit o
作者: 熄滅    時(shí)間: 2025-3-30 15:42
Heinrich Siepmann,Herwig Schenkdrying. A simple definition of lyophilization is that it is a means of drying, achieved by freezing the wet substance and causing the ice to sublime directly to vapor by exposing it to a low partial pressure of water vapor. In this context, ‘low’ means below about 6 mb (4.6 mmHg) — the triple point
作者: Amendment    時(shí)間: 2025-3-30 17:16

作者: airborne    時(shí)間: 2025-3-30 21:16
Untersuchungen über Bolzenschwei?verfahren this definition, sterility is an absolute concept, in industrial practice sterilization is often referred to as the process through which the probability of survival of undesired organisms is reduced to an arbitrarily low level. Typically this level is so low that the chance that even one organism
作者: 背心    時(shí)間: 2025-3-31 01:34
https://doi.org/10.1007/978-3-663-05032-2 manufacturing process. In the 1940s and early 1950s, control systems were predominantly mechanical and pneumatic, with large case instruments that measured about 36 × 46 cm (14″ × 18″ approx.) in size. These instruments were often mounted directly at the sensing point scattered locally throughout t
作者: Observe    時(shí)間: 2025-3-31 06:30

作者: ONYM    時(shí)間: 2025-3-31 09:20

作者: hardheaded    時(shí)間: 2025-3-31 14:20
https://doi.org/10.1007/978-3-663-05033-9oduce the process to those not familiar with the subject. There are several in-depth papers and articles which can provide more information on the technical nature of the various tests. The standards referenced in this chapter also provide valuable insight to the actual testing equipment, procedures




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