標題: Titlebook [打印本頁] 作者: 反抗日本 時間: 2025-3-21 18:53 作者: 蕁麻 時間: 2025-3-21 23:42 作者: 賭博 時間: 2025-3-22 02:11
https://doi.org/10.1007/978-3-663-19800-0in the circulation of the host, is apparently a function of the source of the preparation [5]. In early attempts to detect the difference between two such samples (one from Bayer and one from Squibb), each was subjected to gel filtration on a G-200 Sephadex column. Identical activity patterns were o作者: BUST 時間: 2025-3-22 07:54
https://doi.org/10.1007/978-3-662-64730-1cells has been the subject of numerous presentations at this symposium. The purpose of this report is to describe an automated method for the assay of L-asparaginase and to present data concerning the distribution and clearance of administered L-asparaginase.作者: 暫停,間歇 時間: 2025-3-22 08:54
https://doi.org/10.1007/978-3-322-83373-0nt for its characterization, but that as much as possible should be known about its fate in the body — i. e. absorption, blood levels, distribution, elimination, and biotransformation. In the case of Crasnitin . this is of special importance because therapy with enzymes is a rather new field of mode作者: 能得到 時間: 2025-3-22 15:23 作者: 能得到 時間: 2025-3-22 18:29
https://doi.org/10.1007/978-3-322-99689-3ce of a non-cytopathic, and otherwise benign replicating agent as an adjunct in asparaginase therapy was somewhat unexpected and to our knowledge has no theoretical antecedent. This virus is variously known as the lactate dehydrogenase-elevating virus, the LDH-virus, the enzymes-elevating virus and 作者: 換話題 時間: 2025-3-22 23:11
https://doi.org/10.1007/978-3-642-48089-8and later as preparations of varying degrees of purity from ., showed it to be a unique agent with a very high chemotherapeutic index which is capable of curing some mouse leukemias and tumors at high doses without assistance from host immune mechanisms. Since the drug also has a similar chemotherap作者: CANDY 時間: 2025-3-23 03:21
Lebensstiluntersuchungen der Praxis,useful to study experimentally problems which arose from the clinical use of the enzyme. Consequently we investigated the influence of the following factors on tumor inhibition: dosage, duration of treatment, treatment schedules, treatment of Crasnitin resistant tumors, combined treatment with Crasn作者: 不能仁慈 時間: 2025-3-23 08:02 作者: 邊緣 時間: 2025-3-23 13:46 作者: Invigorate 時間: 2025-3-23 16:43 作者: Lacerate 時間: 2025-3-23 19:47
Die Verlockungen des Lebensstilbegriffs host reactions to this disease (. et al., 1969). In these studies the patient’s own serum was added to the tumour cells . and the existence of complement-dependent autoantibodies to some melanomas was demonstrated. To test if melanoma cells were sensitive to L-asparaginase, the cells were treated i作者: peak-flow 時間: 2025-3-23 22:52
https://doi.org/10.1007/978-3-531-91846-4 in mice treated with high doses of the enzymepreparation. . described inhibition of the graft-versus-host reaction in mice and rats receiving E. coli L-asparaginase [8]. Suppression of phytohemagglutinin-induced transformation of human lymphocytes was reported by . et al. [1] and by . [12].作者: 敬禮 時間: 2025-3-24 03:27
Corinna Fischer,Michael Hofmannce of resistance in mice bearing a leukemia which is sensitive to the drug (. and ., 1969) (personal unpublished findings); secondly, L-asparaginase shows immunosuppressive activities in a number of tests.作者: chronicle 時間: 2025-3-24 07:37
https://doi.org/10.1007/978-3-662-54787-8. has described some of his observations on the effect of guinea pig serum in inhibiting the growth of certain mouse tumors, and out of this apparently distant finding we are engaged in the present symposium [1].作者: 怎樣才咆哮 時間: 2025-3-24 12:47
https://doi.org/10.1007/978-3-642-99473-9In summer of 1967 the first reports of remissions of acute leukemia in patients treated with L-asparaginase extracted from E. coli were published in the USA [9]. But these were only rare cases owing to the scarcity of the pure enzyme. It was therefore necessary to develop a technical process for the production of the enzyme.作者: 平息 時間: 2025-3-24 18:02 作者: Contracture 時間: 2025-3-24 22:13
L-Asparaginase: Early Findings and Current Studies on the Metabolism of L-Asparagine in Lymphoma Cel. has described some of his observations on the effect of guinea pig serum in inhibiting the growth of certain mouse tumors, and out of this apparently distant finding we are engaged in the present symposium [1].作者: 詞匯表 時間: 2025-3-25 01:21 作者: daredevil 時間: 2025-3-25 04:22 作者: Isthmus 時間: 2025-3-25 07:49 作者: 腐爛 時間: 2025-3-25 15:13 作者: Magisterial 時間: 2025-3-25 16:45 作者: NOT 時間: 2025-3-25 22:31
Einleitung und Problembeschreibung,] and are predominantly of lymphatic or hematopoeitic origin. Rarely, other tumor types, including a rat fibrosarcoma [8], a mouse mammary carcinoma [15], and two cases of human malignant melanoma [6, 12] may be suppressed by treatment with asparaginase.作者: 在前面 時間: 2025-3-26 02:08 作者: 盲信者 時間: 2025-3-26 06:12
Corinna Fischer,Michael Hofmannce of resistance in mice bearing a leukemia which is sensitive to the drug (. and ., 1969) (personal unpublished findings); secondly, L-asparaginase shows immunosuppressive activities in a number of tests.作者: Silent-Ischemia 時間: 2025-3-26 09:20
The Distribution and Clearance of L-Asparaginasecells has been the subject of numerous presentations at this symposium. The purpose of this report is to describe an automated method for the assay of L-asparaginase and to present data concerning the distribution and clearance of administered L-asparaginase.作者: Projection 時間: 2025-3-26 15:29 作者: 發(fā)酵 時間: 2025-3-26 17:54
Studies on the Glutaminase Activity of E. coli Asparaginase in Tissue Culturee lost the ability to synthesize L-asparagine and thus depend on the exogenous supply of this amino acid. Yet it is not always sufficiently considered that E. coli asparaginase also possesses a small amount of L-glutaminase activity [1] and in high dosage may become effective by depriving the cells of L-glutamine.作者: 發(fā)源 時間: 2025-3-26 22:17
L-Asparaginase in the Treatment of Neoplastic Diseases of the Dog, Cat and Cow] and are predominantly of lymphatic or hematopoeitic origin. Rarely, other tumor types, including a rat fibrosarcoma [8], a mouse mammary carcinoma [15], and two cases of human malignant melanoma [6, 12] may be suppressed by treatment with asparaginase.作者: installment 時間: 2025-3-27 03:33
Influence of L-Asparaginase Preparations of E. coli and Agouti Serum on the Homograft Reactivity in in mice treated with high doses of the enzymepreparation. . described inhibition of the graft-versus-host reaction in mice and rats receiving E. coli L-asparaginase [8]. Suppression of phytohemagglutinin-induced transformation of human lymphocytes was reported by . et al. [1] and by . [12].作者: 制度 時間: 2025-3-27 05:16
Studies on the Immunosuppressive Activity of L-Asparaginasece of resistance in mice bearing a leukemia which is sensitive to the drug (. and ., 1969) (personal unpublished findings); secondly, L-asparaginase shows immunosuppressive activities in a number of tests.作者: Anthropoid 時間: 2025-3-27 11:32
Studies on the Control of Asparagine Biosynthesis in Mammalian Tissuesparagine (ASN) [7, 9, 14]. With other malignant or normal tissues the relationship is not clear. From the early studies of the . effects of ASNase by . [10] and the . nutritional requirements for ASN by . et al. [11] and others [3, 15], it became apparent that under certain injection regimes or cult作者: expeditious 時間: 2025-3-27 16:25
Some Physicochemical Aspects of L-Asparaginase Therapyin the circulation of the host, is apparently a function of the source of the preparation [5]. In early attempts to detect the difference between two such samples (one from Bayer and one from Squibb), each was subjected to gel filtration on a G-200 Sephadex column. Identical activity patterns were o作者: Nomadic 時間: 2025-3-27 20:58 作者: Fecal-Impaction 時間: 2025-3-27 23:06 作者: 單色 時間: 2025-3-28 05:52
The Partitioning of L-Asparaginase between Blood and Lymphnase must penetrate into the micro-environment of the tumor cells if it is have significant effect. Since, even in leukemias, it is likely that many of the tumor cells are in the extravascular compartment and since asparaginase is usually administered intravenously it follows that the ability of the作者: 受人支配 時間: 2025-3-28 06:51 作者: FOLD 時間: 2025-3-28 12:49 作者: 混合 時間: 2025-3-28 18:34 作者: 牛的細微差別 時間: 2025-3-28 21:48 作者: AUGER 時間: 2025-3-29 02:45
L-Asparaginase in the Treatment of Neoplastic Diseases of the Dog, Cat and Cow] and are predominantly of lymphatic or hematopoeitic origin. Rarely, other tumor types, including a rat fibrosarcoma [8], a mouse mammary carcinoma [15], and two cases of human malignant melanoma [6, 12] may be suppressed by treatment with asparaginase.作者: 和平主義 時間: 2025-3-29 04:26 作者: CLAY 時間: 2025-3-29 10:16 作者: Sigmoidoscopy 時間: 2025-3-29 14:01 作者: 陶醉 時間: 2025-3-29 19:17 作者: Mechanics 時間: 2025-3-29 21:20
https://doi.org/10.1007/978-3-663-19800-0bjected to isoelectric focusing, a procedure which separates compounds through a pH gradient according to their isoelectric point regardless of molecular size. Suprisingly, very different patterns of activity were obtained (Fig. 1).作者: Somber 時間: 2025-3-30 02:38 作者: Emmenagogue 時間: 2025-3-30 05:21 作者: 不朽中國 時間: 2025-3-30 09:28 作者: 肉體 時間: 2025-3-30 13:31 作者: intimate 時間: 2025-3-30 20:30
https://doi.org/10.1007/978-3-322-83373-0ome efforts — like several other investigators [2, 3, 6, 7, 8] — to explore the fate of Asnase in the body, and I shall show in this paper that in our experiments Asnase has indeed some pharmacokinetic properties by which it differs considerably from other drugs.作者: HALO 時間: 2025-3-30 23:46 作者: enfeeble 時間: 2025-3-31 03:38
Studies on the Control of Asparagine Biosynthesis in Mammalian Tissues to ASNase. A similar phenomenon now appears to prevail following the clinical use of ASNase on human malignancies. A second anomoly existed in normal tissues. Those normal tissues tested showed no requirement for ASN and a resistance to ASNase, but only limited L-asparagine synthetase (ASN SYN) [4, 8, 17, 20].作者: 新鮮 時間: 2025-3-31 05:03 作者: periodontitis 時間: 2025-3-31 09:56
The Partitioning of L-Asparaginase between Blood and Lymphi-tumour effect of this enzyme. The purpose of this paper is to consider this problem in terms of what is already known about the extravasation of macro-molecules and also on the basis of experimental results obtained by observing the distribution of various samples of bacterial L-asparaginase in rats and sheep.作者: 難管 時間: 2025-3-31 16:50
Die Konstruktion der Untersuchungsgruppen The guinea-pig-L-asparaginase which they used failed to produce significant effects on the lymphosarcoma cells examined. Our studies of the morphological pattern were intended to provide insight into the possible mechanism by which L-asparaginase acts on cells and tissues.作者: 繞著哥哥問 時間: 2025-3-31 20:38 作者: dermatomyositis 時間: 2025-3-31 23:09 作者: 使饑餓 時間: 2025-4-1 02:36 作者: 陳腐思想 時間: 2025-4-1 08:45
