作者: 模范 時間: 2025-3-21 22:47
Fazit, Thesen und Forschungsdesiderate, and allosteric sites for specific modulation of these receptors offers an opportunity to gain more knowledge of the role of receptor subtypes and the potential to develop novel therapeutic agents that should impact a number of psychiatric and neurological disorders where these receptors are implica作者: bifurcate 時間: 2025-3-22 01:22
https://doi.org/10.57088/978-3-7329-9007-8though at present these GPCRs-eGABA.Rs cross-talks have been investigated in a limited number of brain areas (i.e., thalamus, cerebellum, hippocampus, striatum), it is already evident that eGABA.Rs show a nucleus- and neuronal type-selective regulation by GPCRs that differs from that of sGABA.Rs. Th作者: 排出 時間: 2025-3-22 07:59
https://doi.org/10.1007/978-3-658-43582-0h motor control, chronic pain and anesthesia. This chapter highlights past and present developments in the field of extrasynaptic GABA. receptors and emphasizes their subunit composition, distribution, and physiological role in the spinal cord.作者: dearth 時間: 2025-3-22 10:36
https://doi.org/10.1007/978-3-322-96412-0process in these events is alteration in neuronal response to incoming inputs—manipulations that increase neuronal firing to a given input are likely to induce changes in neuronal structure and alterations in cortical maps. It has been assumed that changes in neuronal excitability underlie processes作者: 忍受 時間: 2025-3-22 15:00
Bj?rn Hermstein,Markus N. Sauerweinence for such a change in GABA. receptor-mediated inhibition during epileptogenesis and speculate on the possible functional impact that such a shift in inhibition will have. In particular, we argue that shifts from phasic to tonic inhibition in the hippocampus will lead to a maintenance of “inhibit作者: 忍受 時間: 2025-3-22 20:46
https://doi.org/10.1007/978-3-658-29892-0, and are supported by the evidence that drugs that increase GABAergic signalling elicit or aggravate absence seizures in animal model and humans. Furthermore, by highlighting a vital role for astrocytes and eGABA.Rs in the pathophysiology of typical absence epilepsy, these new findings offer novel 作者: BRIBE 時間: 2025-3-22 23:30
https://doi.org/10.1007/978-3-658-25025-6GABA.Rs, respectively. The GABAergic control of the HPA axis is highly plastic and is altered by both acute and chronic stress. Here, I review the role of extrasynaptic GABA.Rs in the regulation of the HPA axis and the physiological response to stress.作者: FIS 時間: 2025-3-23 03:01 作者: 自愛 時間: 2025-3-23 09:29
1048-6909 rs in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.978-1-4939-5321-9978-1-4939-1426-5Series ISSN 1048-6909 Series E-ISSN 2524-6488 作者: narcissism 時間: 2025-3-23 12:39
Book 2014evant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.作者: freight 時間: 2025-3-23 15:24 作者: anticipate 時間: 2025-3-23 20:51 作者: Encapsulate 時間: 2025-3-23 22:43 作者: Popcorn 時間: 2025-3-24 05:34
Extrasynaptic GABAA Receptors and Tonic Inhibition in Spinal Cord,h motor control, chronic pain and anesthesia. This chapter highlights past and present developments in the field of extrasynaptic GABA. receptors and emphasizes their subunit composition, distribution, and physiological role in the spinal cord.作者: affluent 時間: 2025-3-24 07:29
The Role of Peri-synaptic GABA Receptors After Stroke,process in these events is alteration in neuronal response to incoming inputs—manipulations that increase neuronal firing to a given input are likely to induce changes in neuronal structure and alterations in cortical maps. It has been assumed that changes in neuronal excitability underlie processes作者: 外表讀作 時間: 2025-3-24 10:55
The Role of Extrasynaptic GABAA Receptors in Focal Epilepsy,ence for such a change in GABA. receptor-mediated inhibition during epileptogenesis and speculate on the possible functional impact that such a shift in inhibition will have. In particular, we argue that shifts from phasic to tonic inhibition in the hippocampus will lead to a maintenance of “inhibit作者: MOTIF 時間: 2025-3-24 17:29 作者: 百靈鳥 時間: 2025-3-24 22:16
,GABAergic Control of the Hypothalamic–Pituitary–Adrenal (HPA) Axis: Role of Extrasynaptic GABAA RecGABA.Rs, respectively. The GABAergic control of the HPA axis is highly plastic and is altered by both acute and chronic stress. Here, I review the role of extrasynaptic GABA.Rs in the regulation of the HPA axis and the physiological response to stress.作者: 任意 時間: 2025-3-25 03:07 作者: reserve 時間: 2025-3-25 03:34 作者: 手段 時間: 2025-3-25 10:06
The Receptorshttp://image.papertrans.cn/e/image/319996.jpg作者: installment 時間: 2025-3-25 12:05
978-1-4939-5321-9Springer Science+Business Media, LLC 2014作者: 蛙鳴聲 時間: 2025-3-25 15:49 作者: CARK 時間: 2025-3-25 23:37
https://doi.org/10.1007/978-3-658-25544-2smitter receptors, the ionotropic receptors, known as GABA. receptors, and metabotropic receptors that are classified as GABA. receptors. The classical phasic inhibitory postsynaptic potential (IPSP) is mediated by GABA. receptors that are located in the postsynaptic membrane. However, GABA also pro作者: Jejune 時間: 2025-3-26 02:18
Grundlegendes zum Inklusionsbegriffthose containing the subunits α4, α5, α6, and δ are preferentially located outside of the postsynaptic density and are activated tonically by GABA. Owing to their subunit composition, these extrasynaptic GABA.R have specific functional properties and pharmacological profiles that distinguish them fr作者: ALIBI 時間: 2025-3-26 06:54 作者: Tractable 時間: 2025-3-26 12:15 作者: intellect 時間: 2025-3-26 15:13 作者: 鳥籠 時間: 2025-3-26 18:57
https://doi.org/10.1007/978-3-658-26602-8 the generation of a tonic conductance that has been shown to influence neuronal excitability (see other chapters). In the current chapter, we explore the many factors that can influence the ambient GABA concentration paying particular attention to how GABA synthesis, release, diffusion and uptake b作者: harpsichord 時間: 2025-3-26 23:13
https://doi.org/10.57088/978-3-7329-9007-8ely tuned by other neurotransmitters and endogenous ligands. The regulation of synaptic GABA.Rs (sGABA.Rs) by G protein-coupled receptors (GPCRs) has been well characterized and is known to occur either through the conventional activation of second-messenger signalling cascades by G proteins or dire作者: 會犯錯誤 時間: 2025-3-27 01:06
https://doi.org/10.1007/978-3-658-43582-0 on ligand-gated chloride-permeable channels termed GABA. receptors (GABA.R). The activation of these receptors produces two different types of inhibition: fast and tonic, mediated by synaptic and extrasynaptic GABA.Rs, respectively. The molecular conformation of the extrasynaptic GABA. receptors an作者: 錯 時間: 2025-3-27 05:31 作者: REP 時間: 2025-3-27 12:42
Bj?rn Hermstein,Markus N. Sauerwein, head injury or prolonged seizures (status epilepticus). The time from the insult to the development of seizures is termed the epileptogenic period during which there are changes in connectivity, neurotransmission and neuronal excitability..Epileptogenesis has conventionally been viewed as being as作者: albuminuria 時間: 2025-3-27 13:44 作者: ANTE 時間: 2025-3-27 18:24
https://doi.org/10.1007/978-3-658-25025-6y GABAergic inhibition. Parvocellular neurosecretory neurons located in the paraventricular nucleus (PVN) of the hypothalamus which release corticotropin-releasing hormone (CRH) govern the output of the HPA axis. CRH neurons are innervated by a high density of GABAergic terminals and are regulated b作者: Flatter 時間: 2025-3-28 01:52
Diversit?t in der Entwicklung des Lesensse effects of reduced inhibitory function of this receptor system range from mood disorders and anxiety to epilepsy. Converging lines of evidence support the hypothesis that alterations in cellular excitability are a common mechanism underlying neurodevelopmental disorders including those in the aut作者: COM 時間: 2025-3-28 04:21
https://doi.org/10.1007/978-1-4939-1426-5GABAA tonic inhibition; Parkinson‘s disease; alcohol addiction; epilepsy作者: ECG769 時間: 2025-3-28 07:28 作者: Anticonvulsants 時間: 2025-3-28 11:30 作者: observatory 時間: 2025-3-28 15:03
,Biophysical Properties of Recombinant γ2- and δ-subunit Containing GABAA Receptors, GABA. receptors mediate two modes of inhibitory neurotransmission, phasic synaptic inhibition and tonic extra- or perisynaptic inhibition. Phasic inhibition is mediated primarily by activation of subsynaptic αβγ2 receptors, whereas tonic inhibition is mediated primarily by extrasynaptic or perisyna作者: 類型 時間: 2025-3-28 21:26 作者: emission 時間: 2025-3-29 02:40 作者: Dorsal 時間: 2025-3-29 06:25 作者: Platelet 時間: 2025-3-29 10:46
GPCR Modulation of Extrasynapitic GABAA Receptors,ely tuned by other neurotransmitters and endogenous ligands. The regulation of synaptic GABA.Rs (sGABA.Rs) by G protein-coupled receptors (GPCRs) has been well characterized and is known to occur either through the conventional activation of second-messenger signalling cascades by G proteins or dire作者: 他日關(guān)稅重重 時間: 2025-3-29 14:49
Extrasynaptic GABAA Receptors and Tonic Inhibition in Spinal Cord, on ligand-gated chloride-permeable channels termed GABA. receptors (GABA.R). The activation of these receptors produces two different types of inhibition: fast and tonic, mediated by synaptic and extrasynaptic GABA.Rs, respectively. The molecular conformation of the extrasynaptic GABA. receptors an作者: 憤憤不平 時間: 2025-3-29 16:01
The Role of Peri-synaptic GABA Receptors After Stroke, trials. As a result, stroke/cerebral ischemia remains the second leading cause of death and is the leading cause of lasting adult disability worldwide. Stroke-induced cell death occurs due to an excess release of glutamate. As a consequence to this, a compensatory increased release of γ-aminobutyri作者: dithiolethione 時間: 2025-3-29 21:05
The Role of Extrasynaptic GABAA Receptors in Focal Epilepsy,, head injury or prolonged seizures (status epilepticus). The time from the insult to the development of seizures is termed the epileptogenic period during which there are changes in connectivity, neurotransmission and neuronal excitability..Epileptogenesis has conventionally been viewed as being as作者: PALMY 時間: 2025-3-30 02:18 作者: Chromatic 時間: 2025-3-30 04:41 作者: 新字 時間: 2025-3-30 11:48
Tonic GABAA-Receptor-Mediated Inhibition in Fragile-X Syndrome: A Cause of Dysfunction or a Pathwayse effects of reduced inhibitory function of this receptor system range from mood disorders and anxiety to epilepsy. Converging lines of evidence support the hypothesis that alterations in cellular excitability are a common mechanism underlying neurodevelopmental disorders including those in the aut作者: LURE 時間: 2025-3-30 14:28
https://doi.org/10.1007/978-3-658-25544-2current knowledge of extrasynaptic GABA. receptor structure, function, cellular distribution and pharmacology and the roles of tonic inhibition in neuronal excitability, physiology and pathophysiology.作者: ensemble 時間: 2025-3-30 16:51
