標題: Titlebook: Experimental Models of Parkinson’s Disease; Yuzuru Imai Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license [打印本頁] 作者: Disclose 時間: 2025-3-21 18:21
書目名稱Experimental Models of Parkinson’s Disease影響因子(影響力)
書目名稱Experimental Models of Parkinson’s Disease影響因子(影響力)學科排名
書目名稱Experimental Models of Parkinson’s Disease網(wǎng)絡公開度
書目名稱Experimental Models of Parkinson’s Disease網(wǎng)絡公開度學科排名
書目名稱Experimental Models of Parkinson’s Disease被引頻次
書目名稱Experimental Models of Parkinson’s Disease被引頻次學科排名
書目名稱Experimental Models of Parkinson’s Disease年度引用
書目名稱Experimental Models of Parkinson’s Disease年度引用學科排名
書目名稱Experimental Models of Parkinson’s Disease讀者反饋
書目名稱Experimental Models of Parkinson’s Disease讀者反饋學科排名
作者: CHOKE 時間: 2025-3-21 22:05 作者: Conspiracy 時間: 2025-3-22 02:06 作者: reptile 時間: 2025-3-22 08:30
Grundlegende Begriffe und S?tzend α-syn fibrils extracted from the brains of patients with MSA at the atomic level. In this chapter, we describe negative staining and immunoelectron microscopy protocols for ultrastructural characterization of synthetic α-syn fibrils and pathological α-syn fibrils.作者: 舊病復發(fā) 時間: 2025-3-22 11:04
https://doi.org/10.1007/978-3-658-28590-6red α-Syn in exosomes and revealed that exosomes may regulate intracellular α-Syn levels by transporting outside the cells. In this chapter, we describe a protocol to measure α-Syn levels in exosomes.作者: 使糾纏 時間: 2025-3-22 15:01 作者: 使糾纏 時間: 2025-3-22 20:52
Electron Microscopic Analysis of α-Synuclein Fibrilsnd α-syn fibrils extracted from the brains of patients with MSA at the atomic level. In this chapter, we describe negative staining and immunoelectron microscopy protocols for ultrastructural characterization of synthetic α-syn fibrils and pathological α-syn fibrils.作者: 羊齒 時間: 2025-3-23 01:06
Analysis of α-Synuclein in Exosomesred α-Syn in exosomes and revealed that exosomes may regulate intracellular α-Syn levels by transporting outside the cells. In this chapter, we describe a protocol to measure α-Syn levels in exosomes.作者: Chromatic 時間: 2025-3-23 04:43 作者: 錢財 時間: 2025-3-23 09:13 作者: 費解 時間: 2025-3-23 12:30
Surfaces of Negative Curvature,hosphorylation, which functioned in the suppression of lysosomal enlargement as well as the promotion of the exocytic release of lysosomal cathepsins. In this chapter, we introduce two methods to analyze cellular functions of LRRK2 upon exposure to lysosomal overload stress in RAW264.7 cells.作者: 嫌惡 時間: 2025-3-23 15:56
https://doi.org/10.1007/978-3-642-61779-9ne (MPTP), and rotenone, which inhibit the mitochondrial complex I, are widely used. Animal models of PD using these neurotoxins are also known as mitochondrial toxin models. Here this chapter describes the preparation of these mitochondrial toxin models.作者: gregarious 時間: 2025-3-23 18:42 作者: 歡樂中國 時間: 2025-3-24 01:12
Geometry -Intuition and Conceptsdies. Recent studies on PD genes associated with lysosomal function suggest that GCase activity is decreased in cell models of PD and in neurons derived from PD patients. In this chapter, we describe a protocol to measure GCase activity in cultured cells.作者: CLAIM 時間: 2025-3-24 06:24 作者: blister 時間: 2025-3-24 06:30 作者: custody 時間: 2025-3-24 10:40 作者: Supplement 時間: 2025-3-24 14:53 作者: 遷移 時間: 2025-3-24 19:18
Differentiation of Midbrain Dopaminergic Neurons from Human iPS Cells induction of dopaminergic neurons from human iPS cells. Here, we describe an efficient method for differentiating human iPS cells into midbrain dopaminergic neurons. This protocol holds merit for obtaining a deeper understanding of the disease and for developing novel treatments.作者: Fraudulent 時間: 2025-3-25 03:01
Monitoring PINK1-Parkin Signaling Using Dopaminergic Neurons from iPS Cells. Moreover, dopaminergic neurons could provide new findings not obtained in other cells. In this chapter, we will describe our method for monitoring PINK1-Parkin signaling using iPS cell-derived dopaminergic neurons.作者: Budget 時間: 2025-3-25 03:48 作者: 美麗的寫 時間: 2025-3-25 11:28
Josef Hoschek,Franz-Josef Schneideruclein and the evaluation of its modifying factors are required to understand the pathogenesis of Parkinson’s disease and to develop new therapies. In this chapter, we describe a cell-based assay for detecting α-synuclein propagation.作者: 不愛防注射 時間: 2025-3-25 15:34 作者: Hyperplasia 時間: 2025-3-25 16:01
Mathematics and its Applicationsice tissues with Sca.eS technique. These include brain slice preparation, tissue clarification, chemical and immunohistochemical labeling (ChemSca.e and AbSca.e), and observation of labeled tissues using a confocal laser scanning microscope (CLSM).作者: 意外的成功 時間: 2025-3-25 20:43
α-Synuclein Seeding Assay Using Cultured Cellsuclein and the evaluation of its modifying factors are required to understand the pathogenesis of Parkinson’s disease and to develop new therapies. In this chapter, we describe a cell-based assay for detecting α-synuclein propagation.作者: 廣口瓶 時間: 2025-3-26 01:36
Midbrain Slice Culture as an Ex Vivo Analysis Platform for Parkinson’s Diseaseowever, some discrepancy is observed in these results. In order to analyze progressive neurodegenerative disease, experimental platform amenable to continuous observation and experimental manipulation is required. In this chapter, we provide a practical method to slice and cultivate the midbrain tissue as an ex vivo experimental model.作者: 相同 時間: 2025-3-26 08:19 作者: deriver 時間: 2025-3-26 08:46 作者: 佛刊 時間: 2025-3-26 14:02 作者: 征稅 時間: 2025-3-26 20:33 作者: Communicate 時間: 2025-3-26 23:03 作者: Coordinate 時間: 2025-3-27 03:30
Grundlegende Begriffe und S?tze disease, dementia with Lewy bodies, and multiple system atrophy (MSA). The synaptic protein α-syn is water-soluble under normal physiological conditions, but in these patients’ brains, we see accumulation of insoluble amyloid-like α-syn fibrils with prion-like properties. Intracerebral accumulation作者: 猛擊 時間: 2025-3-27 08:18 作者: ablate 時間: 2025-3-27 12:07 作者: Anticoagulant 時間: 2025-3-27 14:23
Geometry -Intuition and Conceptsase lead to the accumulation of glucosylceramide, which causes the development of the lysosomal storage disease known as Gaucher’s disease. Loss-of-function mutations in the . gene are the most important genetic risk factor for synucleinopathies, such as Parkinson’s disease and dementia with Lewy bo作者: 抵押貸款 時間: 2025-3-27 17:45
Surfaces of Negative Curvature,mal regulation. We have previously shown that endogenous LRRK2 recruited its substrates Rab8a and Rab10 onto overloaded lysosomes depending on their phosphorylation, which functioned in the suppression of lysosomal enlargement as well as the promotion of the exocytic release of lysosomal cathepsins.作者: 抱怨 時間: 2025-3-27 23:51
V. N. Berestovskij,I. G. Nikolaeviseases, considering the difficulty to obtain live pathological tissue. The midbrain dopaminergic neurons of the substantia nigra are mainly affected in Parkinson’s disease, but it is impossible to obtain and analyze viable dopaminergic neurons from live patients. This problem can be overcome by the作者: 狗窩 時間: 2025-3-28 04:54
Lattices, packings and tilings in the plane,INK1 and Parkin, regulate mitochondrial autophagy, called mitophagy, and motility. Dopaminergic neurons derived from human-induced pluripotent stem (iPS) cells are a useful tool for analyzing the pathogenesis caused by defects in mitochondrial quality control and for screening candidate drugs for PD作者: 松馳 時間: 2025-3-28 07:59 作者: 美食家 時間: 2025-3-28 13:13 作者: Projection 時間: 2025-3-28 18:33 作者: opprobrious 時間: 2025-3-28 18:47
Geometry and Analysis on Manifoldsmentia with Lewy bodies, and multiple system atrophy..Here we describe a nonhuman primate model of αS propagation using common marmosets (.) with an intracerebral injection of synthetic preformed αS fibrils. This protocol enables observation of the formation of phosphorylated αS pathology and its pr作者: MANIA 時間: 2025-3-29 01:46 作者: 大洪水 時間: 2025-3-29 06:20 作者: Morsel 時間: 2025-3-29 10:58 作者: CRUDE 時間: 2025-3-29 11:51
Geometry and Analysis on Manifoldsmentia with Lewy bodies, and multiple system atrophy..Here we describe a nonhuman primate model of αS propagation using common marmosets (.) with an intracerebral injection of synthetic preformed αS fibrils. This protocol enables observation of the formation of phosphorylated αS pathology and its propagation three months after the injection.作者: 剛毅 時間: 2025-3-29 16:53 作者: 難管 時間: 2025-3-29 21:20
978-1-0716-1497-6The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: ostrish 時間: 2025-3-30 03:58 作者: COLON 時間: 2025-3-30 05:40
https://doi.org/10.1007/978-1-0716-1495-2PD development; α-Synuclein; Cellular models; Mammalian models; Invertebrate models; Neurodegenerative di作者: 時代 時間: 2025-3-30 10:35 作者: 在駕駛 時間: 2025-3-30 15:15 作者: certain 時間: 2025-3-30 18:08 作者: ALLAY 時間: 2025-3-30 23:07
α-Synuclein Seeding Assay Using RT-QuICrted that αSyn RT-QuIC exhibits specificity between 82% and 100%, while its sensitivity varies between 70% and 100%, on the basis of a study in which this assay was performed at multiple different laboratories. Furthermore, it has been suggested that the αSyn RT-QuIC method can be applied to study t作者: 倔強一點 時間: 2025-3-31 03:45
1064-3745 own pitfalls.?.Authoritative and practical, .Experimental Models of Parkinson‘s Disease. is an ideal guide for researchers continuing to work toward making PD risk predictable and surmountable..978-1-0716-1497-6978-1-0716-1495-2Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: 傳授知識 時間: 2025-3-31 08:03
α-Synuclein Seeding Assay Using RT-QuIC’s disease, dementia with Lewy bodies, and multiple system atrophy. In each disease, it has been proposed that aggregates of αSyn represent different conformational strains of αSyn, leading to self-propagation and spreading from cell to cell. It has been considered that αSyn aggregates grow by seede作者: 可轉(zhuǎn)變 時間: 2025-3-31 10:51
Electron Microscopic Analysis of α-Synuclein Fibrils disease, dementia with Lewy bodies, and multiple system atrophy (MSA). The synaptic protein α-syn is water-soluble under normal physiological conditions, but in these patients’ brains, we see accumulation of insoluble amyloid-like α-syn fibrils with prion-like properties. Intracerebral accumulation作者: 巧思 時間: 2025-3-31 15:28 作者: AWE 時間: 2025-3-31 19:15
