標(biāo)題: Titlebook: Enzyme-Prodrug Strategies for Cancer Therapy; Roger G. Melton,Richard J. Knox Book 1999 Springer Science+Business Media New York 1999 bioc [打印本頁] 作者: purulent 時間: 2025-3-21 17:34
書目名稱Enzyme-Prodrug Strategies for Cancer Therapy影響因子(影響力)
書目名稱Enzyme-Prodrug Strategies for Cancer Therapy影響因子(影響力)學(xué)科排名
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書目名稱Enzyme-Prodrug Strategies for Cancer Therapy網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Enzyme-Prodrug Strategies for Cancer Therapy被引頻次
書目名稱Enzyme-Prodrug Strategies for Cancer Therapy被引頻次學(xué)科排名
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書目名稱Enzyme-Prodrug Strategies for Cancer Therapy年度引用學(xué)科排名
書目名稱Enzyme-Prodrug Strategies for Cancer Therapy讀者反饋
書目名稱Enzyme-Prodrug Strategies for Cancer Therapy讀者反饋學(xué)科排名
作者: 牽索 時間: 2025-3-21 21:41
Phage Technology for Producing Antibody-Enzyme Fusion Proteins,e of ADEPT systems is that they potentially include an amplification step (each enzyme molecule produces many molecules of the active drug within the tumor) and a bystander effect (destruction of neighboring cells and those binding the antibody fragment) because the final cytotoxic molecule is produ作者: 尖酸一點 時間: 2025-3-22 02:17 作者: 最初 時間: 2025-3-22 07:30
https://doi.org/10.1007/978-1-349-17617-5e of ADEPT systems is that they potentially include an amplification step (each enzyme molecule produces many molecules of the active drug within the tumor) and a bystander effect (destruction of neighboring cells and those binding the antibody fragment) because the final cytotoxic molecule is produ作者: 心神不寧 時間: 2025-3-22 12:01
Introduction,elves and have proved very difficult to overcome. To date, there have been numerous attempts to improve the cytotoxicity of the antibody “missile” by attaching a variety of “warheads” to them, for example, cytotoxic drugs, such as adriamycin or methotrexate, toxins, such as ricin A-chain or . exotoxin, and radioisotopes (.).作者: 多嘴多舌 時間: 2025-3-22 16:39 作者: 多嘴多舌 時間: 2025-3-22 17:51 作者: Schlemms-Canal 時間: 2025-3-23 00:30 作者: VOC 時間: 2025-3-23 02:20
Enzymes and Prodrugs Used for ADEPT,out a hundredfold the equivalent of a normal clinical dose of present day agents. However, this cannot be achieved because of the toxic effect on the normal most rapidly dividing host tissues, such as bone marrow, gut mucosa, and the lymphatic system.作者: 挫敗 時間: 2025-3-23 08:16
The Design and Synthesis of Prodrugs for Antibody-Directed Enzyme Prodrug Therapy (ADEPT),toxic prodrug is administered which releases a therapeutic drug on contact with the enzyme. This two-step approach has the potential to overcome many of the limitations of current chemotherapeutic strategies, allow the generation of high intratumoral concentrations of drug, and minimize damage to normal tissues.作者: 殘廢的火焰 時間: 2025-3-23 13:23
Early Clinical Studies with ADEPT,blems, to obtain guidance on the dose levels of the various components likely to be effective, to test the potential of an immunosuppressive agent to allow more than one cycle of therapy to be given, and if possible, to demonstrate efficacy (.)作者: infantile 時間: 2025-3-23 17:45
,Herbert Marcuse’s Concept of Eros, Milstein (1975). This ability to produce large quantities of monoclonal antibodies (Mabs), reagents of a defined and monospecific nature, greatly facilitated the immunological mapping of the cell plasma membrane and provided a means for targeting cytotoxic drugs specifically at cancer cells.作者: 政府 時間: 2025-3-23 19:41
Factors Influencing Tumor-Selective Localization of Antibody Conjugates, Milstein (1975). This ability to produce large quantities of monoclonal antibodies (Mabs), reagents of a defined and monospecific nature, greatly facilitated the immunological mapping of the cell plasma membrane and provided a means for targeting cytotoxic drugs specifically at cancer cells.作者: Isolate 時間: 2025-3-23 22:20
delivery combined with the amplificationprovided by the enzymatic activation of prodrugs enables selection tobe made between tumour and normal tissue. ADEPT offers a novel fieldof opportunities in the therapy of systemic cancer and may be a majoradvance for the treatment of solid tumours..This book作者: deceive 時間: 2025-3-24 05:11 作者: NAG 時間: 2025-3-24 08:58 作者: orient 時間: 2025-3-24 10:47 作者: NIL 時間: 2025-3-24 17:49
Do Animals Need a ‘Theory of Mind’?], the enzyme itself is not toxic. Thus, in GDEPT, cytotoxicity results only after administering the prodrug. There is also a bystander effect because the active drug can migrate into nontransduced cells.作者: diathermy 時間: 2025-3-24 22:22
Gene-Directed Enzyme Prodrug Therapy (GDEPT) of Cancer,], the enzyme itself is not toxic. Thus, in GDEPT, cytotoxicity results only after administering the prodrug. There is also a bystander effect because the active drug can migrate into nontransduced cells.作者: 吹牛者 時間: 2025-3-25 01:07
Book 1999combined with the amplificationprovided by the enzymatic activation of prodrugs enables selection tobe made between tumour and normal tissue. ADEPT offers a novel fieldof opportunities in the therapy of systemic cancer and may be a majoradvance for the treatment of solid tumours..This book is the fi作者: 善于 時間: 2025-3-25 04:37
Introduction,d by Ehrlich in the early years of this century (.). In practice, however, this goal has remained elusive as a range of obstacles have presented themselves and have proved very difficult to overcome. To date, there have been numerous attempts to improve the cytotoxicity of the antibody “missile” by 作者: 思想 時間: 2025-3-25 09:59
Prodrugs in Cancer Chemotherapy, is the derivatization of this lead chemical to enhance its properties, for example, by reducing side effects and improving selectivity of action. In some instances the derivative has no intrinsic activity but is converted to the active drug, ., at the appropriate time or place. Such analogs are cal作者: outskirts 時間: 2025-3-25 12:13 作者: 賄賂 時間: 2025-3-25 19:07 作者: 木訥 時間: 2025-3-25 23:39 作者: 免除責(zé)任 時間: 2025-3-26 03:47 作者: 挑剔小責(zé) 時間: 2025-3-26 07:56 作者: 跟隨 時間: 2025-3-26 08:42
Early Clinical Studies with ADEPT, many ways a step into the unknown. It seemed possible, even likely, that new and unforeseen problems would emerge. To introduce a series of agents that would interact with each other . was in itself a cause for some apprehension. One of the main objectives of the first study was to identify new pro作者: 大酒杯 時間: 2025-3-26 14:43 作者: 打包 時間: 2025-3-26 20:12 作者: FOIL 時間: 2025-3-26 22:31
Devaluation and the Dangers Ahead,d by Ehrlich in the early years of this century (.). In practice, however, this goal has remained elusive as a range of obstacles have presented themselves and have proved very difficult to overcome. To date, there have been numerous attempts to improve the cytotoxicity of the antibody “missile” by 作者: hematuria 時間: 2025-3-27 01:27 作者: 蹣跚 時間: 2025-3-27 09:17 作者: 馬賽克 時間: 2025-3-27 09:42
Concluding Remarks: The Future of Plagiarismnow used in cancer chemotherapy act by an antiproliferative mechanism. Thus, their action is on cells that are in cycle rather than by specific toxicity directed toward a particular type of cancer cell. Even for the more resistant solid cancers, cures could be achieved if the total dose given was ab作者: pester 時間: 2025-3-27 17:21 作者: 一致性 時間: 2025-3-27 18:06 作者: 調(diào)色板 時間: 2025-3-28 01:59 作者: ORE 時間: 2025-3-28 04:59 作者: conjunctiva 時間: 2025-3-28 09:17 作者: 誘導(dǎo) 時間: 2025-3-28 12:23
978-1-4613-7186-1Springer Science+Business Media New York 1999作者: ATOPY 時間: 2025-3-28 15:54 作者: dragon 時間: 2025-3-28 22:10
