標題: Titlebook: Enzyme- and Transporter-Based Drug-Drug Interactions; Progress and Future K. Sandy‘Pang ,A. David‘Rodrigues,Raimund M. Peter Book 2010 Spr [打印本頁] 作者: frustrate 時間: 2025-3-21 16:32
書目名稱Enzyme- and Transporter-Based Drug-Drug Interactions影響因子(影響力)
書目名稱Enzyme- and Transporter-Based Drug-Drug Interactions影響因子(影響力)學科排名
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書目名稱Enzyme- and Transporter-Based Drug-Drug Interactions網(wǎng)絡(luò)公開度學科排名
書目名稱Enzyme- and Transporter-Based Drug-Drug Interactions被引頻次
書目名稱Enzyme- and Transporter-Based Drug-Drug Interactions被引頻次學科排名
書目名稱Enzyme- and Transporter-Based Drug-Drug Interactions年度引用
書目名稱Enzyme- and Transporter-Based Drug-Drug Interactions年度引用學科排名
書目名稱Enzyme- and Transporter-Based Drug-Drug Interactions讀者反饋
書目名稱Enzyme- and Transporter-Based Drug-Drug Interactions讀者反饋學科排名
作者: 迫擊炮 時間: 2025-3-21 22:40 作者: 階層 時間: 2025-3-22 00:29 作者: 任意 時間: 2025-3-22 04:46
Impact of Nuclear Receptors CAR, PXR, FXR, and VDR, and Their Ligands On Enzymes and Transporterser, PXR, CAR, FXR, and VDR form a core group of nuclear receptors that regulate the expression of a number of important drug-metabolizing enzymes and drug transporters. In this chapter, the molecular determinants of adaptive response to drug exposure are detailed in the context of clinical relevance作者: lesion 時間: 2025-3-22 08:46
Impact of Physiological Determinants: Flow, Binding, Transporters and Enzymes on Organ and Total Bodl as enzymes on the area under the curve and clearances of drugs and metabolites. Whole body PBPK models were then developed, with the kidney and intestine or the kidney and liver as the organs for excretion and metabolism. From these PBPK models, the influence of flow, binding, transporters, and en作者: 一致性 時間: 2025-3-22 13:42
In Silico Approaches to Predict DDIscomputational tools to study DDIs. This chapter outlines the main methodologies currently applied including QSAR modeling, pharmacophore modeling, docking, and the combination of in silico and experimental approaches. There is an emphasis on cytochrome P450 and how in silico models are used in curre作者: 一致性 時間: 2025-3-22 17:21
In Vitro Techniques to Study Drug–Drug Interactions of Drug Metabolism: Cytochrome P450ke predictions of in vivo drug–drug interactions. The in vitro experimental conduct, choice of probe substrates appropriate for individual P450 enzymes and the importance of nonspecific binding within in vitro systems are discussed. In addition to the inhibitor/inducer properties, the importance of 作者: Lasting 時間: 2025-3-22 22:20 作者: BLANC 時間: 2025-3-23 04:57
In Vitro Techniques to Study Transporter-Based DDI drug transporters in, for instance, the liver and kidney. In drug discovery and development, it therefore has become increasingly important to identify the propensity of drug candidates to cause such interactions, either as a victim or perpetrator. In this chapter, we describe the status of in vitr作者: –LOUS 時間: 2025-3-23 09:36
In Vitro Techniques to Study Drug–Drug Interactions Involving Transport: Caco-2 Model for Study of Ptransporter that is constitutively expressed in barrier tissues and excretory organs, and has wide substrate specificity; consequently, it may be responsible for wide-ranging drug–drug interactions (DDIs). This chapter critically evaluates the utility and limitations of Caco-2 cells, a model for hum作者: 饒舌的人 時間: 2025-3-23 11:41 作者: 含糊 時間: 2025-3-23 17:39 作者: 喃喃而言 時間: 2025-3-23 19:50 作者: SCORE 時間: 2025-3-23 23:43
Absorption Models to Examine Bioavailability and Drug–Drug Interactions in Humansions designed to improve bioavailability by enhancing solubility or permeability, the investigation of mechanisms of drug-drug/food interactions in the gastro-intestinal tract, and the determination of intestinal and biliary secretion in humans all require assessment of drug absorption/excretion in 作者: Acetabulum 時間: 2025-3-24 03:05 作者: 憤怒事實 時間: 2025-3-24 08:15
Web-Based Database as a Tool to Examine Drug–Drug Interactions Involving Transporterslico database of drug–drug interaction have been much wanted. In this chapter, examples of, and prediction methods for, transporter-mediated drug–drug interactions are shown, and a Web-based transporter-mediated drug–drug interaction database in TP-search (./) is also described.作者: Overthrow 時間: 2025-3-24 12:52 作者: Ige326 時間: 2025-3-24 16:22
http://image.papertrans.cn/e/image/313099.jpg作者: Felicitous 時間: 2025-3-24 22:49 作者: Mystic 時間: 2025-3-24 23:22
https://doi.org/10.1007/978-1-4419-0840-7Based; Challenges; Drug; Enzyme; Future; Interactions; Pang; Peter; Progress; Rodrigues; Transporter; bioavaila作者: regale 時間: 2025-3-25 05:57
Deutsch-afrikanische Beziehungen 1989entary, and sometimes overlapping, functions, a feature which can set the stage for drug–drug interactions. In this chapter, we provide an overview of the phase I and phase II families of detoxification enzymes, their potential for induction and inhibition, and the role of genetic variants in the oc作者: mendacity 時間: 2025-3-25 11:14 作者: Felicitous 時間: 2025-3-25 12:12 作者: 飛行員 時間: 2025-3-25 17:52 作者: Organization 時間: 2025-3-25 21:54
Institut für Afrika-Kunde,Rolf Hofmeierl as enzymes on the area under the curve and clearances of drugs and metabolites. Whole body PBPK models were then developed, with the kidney and intestine or the kidney and liver as the organs for excretion and metabolism. From these PBPK models, the influence of flow, binding, transporters, and en作者: 闡釋 時間: 2025-3-26 01:22
Deutsch-afrikanische Beziehungen 1997computational tools to study DDIs. This chapter outlines the main methodologies currently applied including QSAR modeling, pharmacophore modeling, docking, and the combination of in silico and experimental approaches. There is an emphasis on cytochrome P450 and how in silico models are used in curre作者: Delirium 時間: 2025-3-26 08:08
Afrika 1998 — Das Jahr im überblickke predictions of in vivo drug–drug interactions. The in vitro experimental conduct, choice of probe substrates appropriate for individual P450 enzymes and the importance of nonspecific binding within in vitro systems are discussed. In addition to the inhibitor/inducer properties, the importance of 作者: Grievance 時間: 2025-3-26 09:16
Afrika 1999 — Das Jahr im überblickveral glucuronides have been shown to reduce the metabolic clearances of cytochrome P4502C8 substrates. Experimental paradigms, based on the use of human liver microsomes (HLM), hepatocytes, and recombinant UGTs as the enzyme sources, are now available for the investigation of drug glucuronidation i作者: Vital-Signs 時間: 2025-3-26 14:01 作者: 進步 時間: 2025-3-26 17:45 作者: 拾落穗 時間: 2025-3-26 21:17 作者: Servile 時間: 2025-3-27 03:57
Deutsch-Afrikanische Beziehungen 2003osed to improve the accuracy of the prediction. Also, a method to predict the alterations caused by drug–drug interactions mediated by intestinal cytochrome P450 3A4 or P-glycoprotein was introduced. In this chapter, these methods and computerized simulation method are shown.作者: 整潔漂亮 時間: 2025-3-27 07:50 作者: 有節(jié)制 時間: 2025-3-27 12:00 作者: sinoatrial-node 時間: 2025-3-27 17:27 作者: fiscal 時間: 2025-3-27 18:11 作者: staging 時間: 2025-3-27 23:24
Deutsch-afrikanische Beziehungen 1989entary, and sometimes overlapping, functions, a feature which can set the stage for drug–drug interactions. In this chapter, we provide an overview of the phase I and phase II families of detoxification enzymes, their potential for induction and inhibition, and the role of genetic variants in the occurrence of drug–drug interactions.作者: 下船 時間: 2025-3-28 03:21
Deutsch-afrikanische Beziehungen 1992er, PXR, CAR, FXR, and VDR form a core group of nuclear receptors that regulate the expression of a number of important drug-metabolizing enzymes and drug transporters. In this chapter, the molecular determinants of adaptive response to drug exposure are detailed in the context of clinical relevance and drug development.作者: dermatomyositis 時間: 2025-3-28 08:46
Deutsch-Afrikanische Beziehungen 2003osed to improve the accuracy of the prediction. Also, a method to predict the alterations caused by drug–drug interactions mediated by intestinal cytochrome P450 3A4 or P-glycoprotein was introduced. In this chapter, these methods and computerized simulation method are shown.作者: 切割 時間: 2025-3-28 10:34
Art and the Ancestor Narrative,lico database of drug–drug interaction have been much wanted. In this chapter, examples of, and prediction methods for, transporter-mediated drug–drug interactions are shown, and a Web-based transporter-mediated drug–drug interaction database in TP-search (./) is also described.作者: 譏笑 時間: 2025-3-28 17:40 作者: FORGO 時間: 2025-3-28 20:52 作者: 痛打 時間: 2025-3-29 00:50
Extrapolation of In Vitro Metabolic and P-Glycoprotein-Mediated Transport Data to In Vivo by Modelinosed to improve the accuracy of the prediction. Also, a method to predict the alterations caused by drug–drug interactions mediated by intestinal cytochrome P450 3A4 or P-glycoprotein was introduced. In this chapter, these methods and computerized simulation method are shown.作者: PATRI 時間: 2025-3-29 05:11 作者: 一起 時間: 2025-3-29 09:23 作者: 老巫婆 時間: 2025-3-29 11:33 作者: inconceivable 時間: 2025-3-29 16:40
The In Vitro Characterization of Inhibitory Drug–Drug Interactions Involving UDP-Glucuronosyltransfeat influence UGT activity in vitro have also led to the development of experimental approaches that accurately predict the magnitude of known DDIs involving glucuronidated drugs, but further work in this area is required to demonstrate the generalizability of these models.作者: 感情脆弱 時間: 2025-3-29 21:29 作者: SEMI 時間: 2025-3-30 00:52
Afrika 1991 — Das Jahr im überblicksupplement this information. Nowadays, metabolic and transport statuses are easily accessible by genotyping and are an important prerequisite to fully judge the potential of a drug for drug interactions.作者: 原諒 時間: 2025-3-30 07:11 作者: Blatant 時間: 2025-3-30 10:00 作者: Cholagogue 時間: 2025-3-30 14:27 作者: 使人入神 時間: 2025-3-30 17:18
Enzyme- and Transporter-Based Drug-Drug InteractionsProgress and Future 作者: 流出 時間: 2025-3-30 21:14
Enzyme- and Transporter-Based Drug-Drug Interactions978-1-4419-0840-7作者: MAZE 時間: 2025-3-31 04:11 作者: CON 時間: 2025-3-31 06:45
