標(biāo)題: Titlebook: Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis; Otto R. Hommes,Giancarlo Comi Book 2004 Springer-Verlag Italia 20 [打印本頁(yè)] 作者: GOLF 時(shí)間: 2025-3-21 19:04
書目名稱Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis影響因子(影響力)
書目名稱Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis影響因子(影響力)學(xué)科排名
書目名稱Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis網(wǎng)絡(luò)公開度
書目名稱Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis被引頻次
書目名稱Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis被引頻次學(xué)科排名
書目名稱Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis年度引用
書目名稱Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis年度引用學(xué)科排名
書目名稱Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis讀者反饋
書目名稱Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis讀者反饋學(xué)科排名
作者: Entreaty 時(shí)間: 2025-3-21 20:56
Genetic Regulation of Nerve Cell Death/Glial Activation and Protective Effects of Myelin Basic Proten 5% and 60% [7, 10, 11]. Notably, no single HLA type seems to exclude MS. It is therefore clear that as yet unidentified genes residing outside the HLA must also be of importance for disease susceptibility in MS.作者: 遣返回國(guó) 時(shí)間: 2025-3-22 00:48 作者: 長(zhǎng)處 時(shí)間: 2025-3-22 07:10
Monounsaturated Fatty Acids and Neuroprotection. The Results of a Study of Cognitive Decline in Oldmore-detailed procedure for the assessment of cognitive decline than those listed in the AAMI criteria. A high incidence (45%) of dementia was found in individuals aged >75 years who were diagnosed as having “minimal dementia” by the CAMDEX interview [7]. Furthermore, in another study 48% of patient作者: nepotism 時(shí)間: 2025-3-22 09:45
Early Treatment in Multiple Sclerosis with Intravenous Immunoglobulin: Rationale and Study Design,ctive of this study was to investigate the efficacy of IVIg treatment, administered at 0.4 g/kg per day for 5 consecutive days, as a loading dose, and 0.4 g/kg per day every 6 weeks thereafter as a booster dose, for a 1-year period, on the risk of patients with clinically probable MS and positive br作者: 斜坡 時(shí)間: 2025-3-22 14:30 作者: 斜坡 時(shí)間: 2025-3-22 18:56 作者: 藥物 時(shí)間: 2025-3-22 23:59
The Yin and Yang of Inflammation in Multiple Sclerosis,neity occurs is currently unknown. Are RR and PPMS different diseases or are they part of the same clinical spectrum? Why do some patients develop progressive disease whilst others do not? Answers to these questions will not only improve our understanding of MS, but will also have major implications作者: radiograph 時(shí)間: 2025-3-23 04:14
Book 2004fect. Pathological studies in multiple sclerosis have now clearly demonstrated that destructive processes may be followed by recovery phases in such a way that myelin may be morphologically and functionally reconstituted. These findings provide the rationale for early treatment and emphasize the imp作者: 通便 時(shí)間: 2025-3-23 09:36 作者: FUME 時(shí)間: 2025-3-23 18:21 作者: 松軟 時(shí)間: 2025-3-23 23:47
https://doi.org/10.1007/978-3-7091-4484-8en 5% and 60% [7, 10, 11]. Notably, no single HLA type seems to exclude MS. It is therefore clear that as yet unidentified genes residing outside the HLA must also be of importance for disease susceptibility in MS.作者: 代替 時(shí)間: 2025-3-24 02:47
Einleitung und rechtliche Bestimmungen,phological analysis of brain sections [4, 9]. Immunohistochemical studies have recently emphasized the correlation between inflammation and axonal damage during the early stages of MS [4, 9]. In addition, long-term axonal pathology has been described in a number of myelin protein gene knockout and t作者: Encoding 時(shí)間: 2025-3-24 09:14 作者: 旁觀者 時(shí)間: 2025-3-24 13:36
ctive of this study was to investigate the efficacy of IVIg treatment, administered at 0.4 g/kg per day for 5 consecutive days, as a loading dose, and 0.4 g/kg per day every 6 weeks thereafter as a booster dose, for a 1-year period, on the risk of patients with clinically probable MS and positive br作者: 裂縫 時(shí)間: 2025-3-24 18:42
ential independent markers of the MS disease process compared with the conventional MR measures of subclinical disease — the T2-lesions, and markers of inflammation, the enhancing lesions [7, 8]. Here we summarize the analyses of T1-black holes from the MS Collaborative Research Group Trial of inter作者: 我沒(méi)有強(qiáng)迫 時(shí)間: 2025-3-24 21:44
cells are even found in the CSF in the absence of anti-myelin Abs, suggesting that antibodies rapidly bind to target structures, such as the corresponding auto-antigens or to Fcreceptors, and therefore become undetectable [8, 9]. In organotypic, myelinated cultures of CNS tissue, sera of MS patients作者: Bronchial-Tubes 時(shí)間: 2025-3-25 00:05
Welfare Economics in English Utopiasneity occurs is currently unknown. Are RR and PPMS different diseases or are they part of the same clinical spectrum? Why do some patients develop progressive disease whilst others do not? Answers to these questions will not only improve our understanding of MS, but will also have major implications作者: surmount 時(shí)間: 2025-3-25 07:22
Anti-MOG Antibodies as Early Predictors for Conversion to Relapsing-Remitting Disease Course in Patgen for autoreactive antibodies might be the central nervous system (CNS) specific myelin oligodendrocyte glycoprotein (MOG), which is exclusively localized on the surface of myelin sheaths and oligodendrocytes.作者: 陶器 時(shí)間: 2025-3-25 11:34
Sunlight, Vitamin D, and Multiple Sclerosis,pairs are discordant for MS, indicating that inheriting MS susceptibility genes is not sufficient for disease development [3]. Thus, MS development requires exposure to one or more environmental risk factors. This suggests that MS may be preventable if these risk factors can be identified and avoided.作者: 期滿 時(shí)間: 2025-3-25 15:37
brain damage accumulates very early in the course of multiple sclerosis. This book reviews the main neurobiological, magnetic resonance imaging, and clinical aspects of the early phases of the dis- ease. Mechanisms ofirreversible axonal damage and the role played by the inter- action of glia and the作者: Foreknowledge 時(shí)間: 2025-3-25 17:17
https://doi.org/10.1007/978-3-540-37639-2is might be explained by observations, especially from magnetic resonance imaging (MRI) studies, that the correlation of inflammation with disease progression and development of disability is poor [1].作者: Instantaneous 時(shí)間: 2025-3-25 22:36
at axonal damage occurs early during RRMS. Disease progression thus develops well in advance of clinical progression and remains subclinical because, due to compensatory mechanisms, impairment does not interfere with daily living activities at that stage.作者: Harrowing 時(shí)間: 2025-3-26 02:02 作者: Gobble 時(shí)間: 2025-3-26 04:33
these three MR techniques to the understanding of the evolution of WMD, with a special focus on multiple sclerosis (MS). The application of MR techniques to the study of MS has indeed dramatically changed our understanding of how MS causes irreversible deficits and can serve as a useful model to be applied to other WMD.作者: left-ventricle 時(shí)間: 2025-3-26 08:44
nflammation. Some forms of cell death in the ischemic penumbra also involve apoptosis [1, 2]. Studies in patients using positron emission tomography, combined perfusion and diffusion magnetic resonance imaging (MRI), and MR spectroscopy indicate that the penumbra in humans may remain viable for several (up to 48) hours after stroke onset [3-6].作者: 發(fā)源 時(shí)間: 2025-3-26 15:17
Imaging for Tissue Characterization in Multiple Sclerosis and Other White Matter Diseases,these three MR techniques to the understanding of the evolution of WMD, with a special focus on multiple sclerosis (MS). The application of MR techniques to the study of MS has indeed dramatically changed our understanding of how MS causes irreversible deficits and can serve as a useful model to be applied to other WMD.作者: FILTH 時(shí)間: 2025-3-26 16:56
Neuroprotection in Acute Ischemic Stroke: Lessons for Early Treatment in Multiple Sclerosis,nflammation. Some forms of cell death in the ischemic penumbra also involve apoptosis [1, 2]. Studies in patients using positron emission tomography, combined perfusion and diffusion magnetic resonance imaging (MRI), and MR spectroscopy indicate that the penumbra in humans may remain viable for several (up to 48) hours after stroke onset [3-6].作者: Surgeon 時(shí)間: 2025-3-27 00:04
Neuroprotective Treatment in Primary Progressive Multiple Sclerosis: a Phase I/II Study with Riluzois might be explained by observations, especially from magnetic resonance imaging (MRI) studies, that the correlation of inflammation with disease progression and development of disability is poor [1].作者: 水獺 時(shí)間: 2025-3-27 05:00
Early Treatment of Progression in Multiple Sclerosis,at axonal damage occurs early during RRMS. Disease progression thus develops well in advance of clinical progression and remains subclinical because, due to compensatory mechanisms, impairment does not interfere with daily living activities at that stage.作者: Clinch 時(shí)間: 2025-3-27 05:33
Soluble VCAM-1 Release Indicates Inflammatory Blood-Brain Barrier Pathology and Further Modulates Ain barrier (BBB) during inflammatory central nervous system (CNS) diseases [1]. Adhesion molecules can be induced by proinflammatory cytokines, like tumor necrosis factor-a (TNF-α), on various cell types, e.g., endothelial cells, macrophages, and lymphocytes [2].作者: Aspiration 時(shí)間: 2025-3-27 11:06
gen for autoreactive antibodies might be the central nervous system (CNS) specific myelin oligodendrocyte glycoprotein (MOG), which is exclusively localized on the surface of myelin sheaths and oligodendrocytes.作者: 貪婪地吃 時(shí)間: 2025-3-27 17:20 作者: 滋養(yǎng) 時(shí)間: 2025-3-27 19:24 作者: 過(guò)分自信 時(shí)間: 2025-3-27 22:30 作者: 巧思 時(shí)間: 2025-3-28 03:30
Inflammation, Demyelination, and Axonal Degeneration: Three Aspects of the Pathogenesis of Multiple relapse, for instance, or the transition from relapsing-remitting disease to progressive accumulation of disability. Here, we report observation from the close study of a small number of patients treated with an experimental agent, Campath-1H, that cast some light on these issues.作者: Fortuitous 時(shí)間: 2025-3-28 07:28
Genetic Regulation of Nerve Cell Death/Glial Activation and Protective Effects of Myelin Basic Prot to ten genes theoretically having a major impact on disease susceptibility [1-3]. This is supported by epidemiological data demonstrating a considerable lowering of concordance rates from monozygotic to dizygotic twins [4]. It has been known for approximately 30 years that certain haplotypes of the作者: 改良 時(shí)間: 2025-3-28 14:30
Neuroprotective Treatment in Primary Progressive Multiple Sclerosis: a Phase I/II Study with Riluzoomponent of the disease. Their main clinical impact is on relapses whereas an effect on permanent disability so far has been less well established. This might be explained by observations, especially from magnetic resonance imaging (MRI) studies, that the correlation of inflammation with disease pro作者: 槍支 時(shí)間: 2025-3-28 17:56 作者: Blasphemy 時(shí)間: 2025-3-28 19:19
Autoimmune Inflammation and Multiple Sclerosis,edness was the natural result of blood vessel physiology. Now we know that the blood vessels are only one of the many factors involved in inflammation, a process in which immune cells of various types and their molecular products interact with signal molecules produced by the injured tissue.作者: 浪費(fèi)物質(zhì) 時(shí)間: 2025-3-29 01:30
Early Treatment of Progression in Multiple Sclerosis,tting (RR) to the progressive stages. It is becoming increasingly clear that progressive multiple sclerosis (MS) is associated with axonal loss and that axonal damage occurs early during RRMS. Disease progression thus develops well in advance of clinical progression and remains subclinical because, 作者: 鴿子 時(shí)間: 2025-3-29 06:43
Imaging for Tissue Characterization in Multiple Sclerosis and Other White Matter Diseases,time. However, conventional MRI is not able to characterize and quantify the tissue damage within and outside these lesions. Other quantitative MR techniques have the potential to overcome such limitation. Among these techniques, MR spectroscopy (MRS), magnetization transfer imaging (MTI), and diffu作者: 蚊帳 時(shí)間: 2025-3-29 11:02 作者: Substitution 時(shí)間: 2025-3-29 12:29 作者: 山羊 時(shí)間: 2025-3-29 19:17 作者: BIDE 時(shí)間: 2025-3-29 21:13
Early Treatment in Multiple Sclerosis with Intravenous Immunoglobulin: Rationale and Study Design,udies of the natural course of the disease showed that disability will accumulate in more that 90% of patients and additional relapses may result in significant handicap [2]. Assessment of patients with a diagnosis of probable MS with positive brain magnetic resonance imaging (MRI) demonstrated that作者: ADORN 時(shí)間: 2025-3-30 00:48
T1-Hypointense Lesions (T1 Black Holes) in Mild-to-Moderate Disability Relapsing Multiple Sclerosishe more non-specific T2-hyperintense lesions, which show greater signal intensity than normal brain on T2-weighted magnetic resonance imaging (MRI). The T1-hypointense lesions are areas of axonal loss, as well as matrix disruption [1, 2]. T1-hypointense lesions are moderately correlated with focal r作者: galley 時(shí)間: 2025-3-30 06:54 作者: 道學(xué)氣 時(shí)間: 2025-3-30 09:57
Antibody Mediated Demyelination, laboratory marker supporting the diagnosis of this disease. The intrathecal IgG fractions contain Abs with many different specificities, including myelin-specific Abs. Reports on anti-myelin Abs in cerebrospinal (CSF) and sera are controversial [1-7]. Several reports describe the presence of anti-m作者: Duodenitis 時(shí)間: 2025-3-30 15:29 作者: GIBE 時(shí)間: 2025-3-30 17:58
Sunlight, Vitamin D, and Multiple Sclerosis, progression of the disease [1]. Compared with unrelated individuals, biological first-degree relatives of MS patients show a 20- to 40-fold increased risk of disease, and this increased risk is attributable to genetic factors, rather than a transmissible agent [2]. However, 70% of monozygotic twin 作者: 癡呆 時(shí)間: 2025-3-30 23:41
The Yin and Yang of Inflammation in Multiple Sclerosis,by attacks of neurological dysfunction due to focal central nervous system (CNS) inflammation, followed by recovery and a period of remission, and on the other side is primary progressive (PP) disease, which is progressive from the outset with no clinical relapses. Between these two extremes are pat作者: Hiatal-Hernia 時(shí)間: 2025-3-31 01:25 作者: 火海 時(shí)間: 2025-3-31 06:27
https://doi.org/10.1007/978-3-8274-2676-5 relapse, for instance, or the transition from relapsing-remitting disease to progressive accumulation of disability. Here, we report observation from the close study of a small number of patients treated with an experimental agent, Campath-1H, that cast some light on these issues.作者: 吝嗇性 時(shí)間: 2025-3-31 12:07
https://doi.org/10.1007/978-3-7091-4484-8 to ten genes theoretically having a major impact on disease susceptibility [1-3]. This is supported by epidemiological data demonstrating a considerable lowering of concordance rates from monozygotic to dizygotic twins [4]. It has been known for approximately 30 years that certain haplotypes of the作者: genuine 時(shí)間: 2025-3-31 14:34 作者: MIRE 時(shí)間: 2025-3-31 20:06 作者: 閃光東本 時(shí)間: 2025-3-31 22:32
Weiterempfehlungen mit Service-Recoveryedness was the natural result of blood vessel physiology. Now we know that the blood vessels are only one of the many factors involved in inflammation, a process in which immune cells of various types and their molecular products interact with signal molecules produced by the injured tissue.作者: GRILL 時(shí)間: 2025-4-1 02:09
tting (RR) to the progressive stages. It is becoming increasingly clear that progressive multiple sclerosis (MS) is associated with axonal loss and that axonal damage occurs early during RRMS. Disease progression thus develops well in advance of clinical progression and remains subclinical because, 作者: Anonymous 時(shí)間: 2025-4-1 07:34
time. However, conventional MRI is not able to characterize and quantify the tissue damage within and outside these lesions. Other quantitative MR techniques have the potential to overcome such limitation. Among these techniques, MR spectroscopy (MRS), magnetization transfer imaging (MTI), and diffu作者: 植物群 時(shí)間: 2025-4-1 12:31
https://doi.org/10.1007/978-981-97-7827-0lished of these classifications is age-associated memory impairment (AAMI) [1], but it is generally non-progressive and is thus more likely to be a phenomenon of normal aging [2, 3]. The terms “age-related cognitive decline” (ARCD) and “aging-associated cognitive decline” have been proposed recently作者: drusen 時(shí)間: 2025-4-1 18:05 作者: 苦惱 時(shí)間: 2025-4-1 18:52 作者: Conflagration 時(shí)間: 2025-4-2 00:03 作者: Obstruction 時(shí)間: 2025-4-2 03:36
he more non-specific T2-hyperintense lesions, which show greater signal intensity than normal brain on T2-weighted magnetic resonance imaging (MRI). The T1-hypointense lesions are areas of axonal loss, as well as matrix disruption [1, 2]. T1-hypointense lesions are moderately correlated with focal r作者: DRAFT 時(shí)間: 2025-4-2 08:06
uantified by a number of common, easily available, neuro-ophthalmological techniques. Detection of an early, subtle, optic neuropathy is relatively easy compared with many of the difficult-to-document sensory or even motor complaints in early multiple sclerosis (MS).
