標(biāo)題: Titlebook: Discovery DMPK Quick Guide; Guide to Data Interp S. Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop Book 2022 Springer Nature Switzerland A [打印本頁] 作者: Iridescent 時間: 2025-3-21 17:23
書目名稱Discovery DMPK Quick Guide影響因子(影響力)
作者: 橡子 時間: 2025-3-21 20:57
ADME Assays,on). The combination of fast optimization of key DMPK properties based on a target profile together with efficient bioanalytical methods has allowed for robust screening of drug candidates. For example, determining the metabolism rate . using liver microsomes or hepatocytes has allowed for the calcu作者: 青少年 時間: 2025-3-22 02:15
Book 2022 is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies?that can facilitate drug discovery.? The case studies are intended to be short and relevant to the topic discussed?and present?another dimension to the discussions..作者: FLAT 時間: 2025-3-22 05:13 作者: 大暴雨 時間: 2025-3-22 10:25 作者: Manifest 時間: 2025-3-22 13:39 作者: Manifest 時間: 2025-3-22 20:09 作者: 吵鬧 時間: 2025-3-22 22:05
978-3-031-10693-4Springer Nature Switzerland AG 2022作者: AUGUR 時間: 2025-3-23 03:40
Cross-border-UnternehmensakquisitionenThis section addresses some typical DMPK questions that an ADME scientist encounters during drug discovery support. These questions are addressed by means of general concepts, experimental approaches, and examples. They are also linked to other sections for the ease of search and understanding.作者: ALB 時間: 2025-3-23 08:56
Visionen, Missionen und LeitbilderThis chapter is used as a reference for provided various resources as it comes to regulatory authorities. This includes the counties, codes of US federal regulations, IND sections plus various modules and notable guidance for industry by FDA.作者: consent 時間: 2025-3-23 09:59
Q&A of DMPK Issues and Tools for Drug Discovery,This section addresses some typical DMPK questions that an ADME scientist encounters during drug discovery support. These questions are addressed by means of general concepts, experimental approaches, and examples. They are also linked to other sections for the ease of search and understanding.作者: ALOFT 時間: 2025-3-23 14:10
Regulatory Documents for IND to Support FIH,This chapter is used as a reference for provided various resources as it comes to regulatory authorities. This includes the counties, codes of US federal regulations, IND sections plus various modules and notable guidance for industry by FDA.作者: avarice 時間: 2025-3-23 18:14 作者: CYN 時間: 2025-3-24 01:53 作者: STENT 時間: 2025-3-24 04:36
Cross-border-Unternehmensakquisitionen optimization of molecules based on key ADME attributes. This has had a huge impact on the molecular design cycles: design, synthesis, assessment and re-design..In this chapter, we discuss the strategies for optimization of small molecules during drug discovery and address various ADME liabilities t作者: 自由職業(yè)者 時間: 2025-3-24 08:00 作者: 四指套 時間: 2025-3-24 13:25 作者: Anthem 時間: 2025-3-24 15:32
Book 2022dicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology.? It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion作者: Haphazard 時間: 2025-3-24 19:39 作者: chlorosis 時間: 2025-3-25 01:37 作者: Banquet 時間: 2025-3-25 04:15 作者: 使無效 時間: 2025-3-25 08:46
l for day-to-day interpretation of ADME studies.Multi discip.This book is intended for a broad readership,?in particular,?those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinic作者: Aids209 時間: 2025-3-25 13:48 作者: 本土 時間: 2025-3-25 18:57 作者: JOT 時間: 2025-3-25 23:19 作者: 拋媚眼 時間: 2025-3-26 01:47 作者: BADGE 時間: 2025-3-26 05:36 作者: barium-study 時間: 2025-3-26 11:43
Goals for DMPK During Drug Optimizations,f a molecule’s interaction/modulation of a therapeutic target. What allows conversion of a potent chemical starting point to a final drug/drug candidate during the optimization process is the incorporation of appropriate ADME properties that balance efficacy and toxicity. Here we capture the high-le作者: 財主 時間: 2025-3-26 14:29
Drug Properties, (1) an inability to demonstrate that the target can modulate the disease in a preclinical model, (2) the lack of a therapeutic index to modulate the target safely or (3) the inability to find molecules with the right balance of properties such as potency, selectivity, ADME properties, safety endpoi作者: ALTER 時間: 2025-3-26 17:42
DMPK Lead Optimization, optimization of molecules based on key ADME attributes. This has had a huge impact on the molecular design cycles: design, synthesis, assessment and re-design..In this chapter, we discuss the strategies for optimization of small molecules during drug discovery and address various ADME liabilities t作者: 睨視 時間: 2025-3-26 21:22 作者: craven 時間: 2025-3-27 01:53
ADME Assays, A survey in 1991 indicated that about 40% of all drugs in development failed because of poor ADME properties. It is very satisfying to see that the attrition in the clinic due to poor pharmacokinetic properties has decreased markedly. This can be ascribed to (1) high quality . reagents and models, 作者: obeisance 時間: 2025-3-27 07:40
9樓作者: 搖晃 時間: 2025-3-27 10:52
9樓作者: 荒唐 時間: 2025-3-27 15:58
10樓作者: Tinea-Capitis 時間: 2025-3-27 19:16
10樓作者: 干涉 時間: 2025-3-28 00:20
10樓作者: V切開 時間: 2025-3-28 05:38
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