作者: CRASS 時(shí)間: 2025-3-22 00:06
978-1-4419-4177-0Springer-Verlag US 2006作者: CYT 時(shí)間: 2025-3-22 03:19
https://doi.org/10.1007/978-3-8349-4359-0us progress in life sciences compared with the sophistication of experimental approaches themselves. The genesis of recent spectacular breakthroughs in molecular biology that led to the discovery of the enzymatic function of several nonmetabolic enzymes illustrates that this relationship is beginnin作者: Melodrama 時(shí)間: 2025-3-22 05:20
https://doi.org/10.1007/978-3-8349-4359-0ased function prediction provides information about a proteins’ molecular function (what does the protein do at a molecular scale?), the analysis of the sequence in the context of its genome or in other types of genomics data provides information about its functional context (what are the proteins’ 作者: ESPY 時(shí)間: 2025-3-22 11:45
https://doi.org/10.1007/978-3-8349-9276-5by cytochrome P450. It is an attractive drug target, e.g., cytochrome P450s of . are promising targets in the fight against tuberculosis. The structure provides new insights for investigation of structure/mechanism of cytochrome P450, and for rational design of inhibitor molecules. We will illustrat作者: 發(fā)起 時(shí)間: 2025-3-22 16:52 作者: 發(fā)起 時(shí)間: 2025-3-22 20:59 作者: HUMP 時(shí)間: 2025-3-22 23:34
Strategy and Politics in the Blair Eratarts with locating the mutations in a chromosomal band, as narrow as possible, and follows with the manual analysis of all the genes mapping in this region. Usually this is not an easy task, but it can be facilitated by complementary computational approaches that evaluate all genes in a region of i作者: 細(xì)胞膜 時(shí)間: 2025-3-23 04:41
Strategy and Politics in the Blair Eravariety of cellular conditions. In addition, microarray-based genomewide measurements of promoter occupancy (the occupome) are now available for an increasing number of transcription factors. With this data and the complete genome sequence of many important organisms, it is becoming possible to quan作者: 幸福愉悅感 時(shí)間: 2025-3-23 07:47
Rationalit?tsgrenzen politischer Strategie, is an ever-increasing field of research. The results of most modelling studies in this field are in good qualitative or even quantitative agreement with experimental results. However, a widely held view among many experimentalists is that modelling and simulation only reproduce what has been known作者: 悠然 時(shí)間: 2025-3-23 12:26 作者: 和平 時(shí)間: 2025-3-23 16:16 作者: 有機(jī)體 時(shí)間: 2025-3-23 18:11
Diversifikation durch strategische Allianzending regions, contributes to phenotypic variation. However, much of the variation in coding regions may not produce any functional effects. There are two broad strategies for classifying polymorphism as functional or neutral: sequence-based methods predict functional significance based on conservati作者: 思鄉(xiāng)病 時(shí)間: 2025-3-24 00:55
Diversifikation durch Unternehmenskaufotein-protein interactions, and others, are rapidly accumulating. Numerous attempts were made by many groups to examine connections between these properties and quantitative measures of gene evolution. The questions addressed pertain to the most fundamental aspects of biology: what determines the ef作者: Systemic 時(shí)間: 2025-3-24 06:21
Frank EisenhaberContributors examine how sequence analysis becomes even more powerful if it is combined with automated scientific text mining (for the prediction of gene function and gene-disease association), with t作者: fallible 時(shí)間: 2025-3-24 07:51
Molecular Biology Intelligence Unithttp://image.papertrans.cn/e/image/281013.jpg作者: Glower 時(shí)間: 2025-3-24 10:40 作者: Benign 時(shí)間: 2025-3-24 16:33
Introductionortant questions. Currendy, theoretical methods have best chances to contribute to new biological insight independently of experiments in the area of genome text interpretation and especially for gene function prediction. Experimental studies can help progress in the development of theoretical metho作者: resistant 時(shí)間: 2025-3-24 23:04
Reliable and Specific Protein Function Prediction by Combining Homology with Genomic(s) Contextt-based function prediction provide complementary information about a protein’s function and can becombined to make predictions that are specific enough for experimental testing. Here we discuss the genomic coverage and reliability of combining genomics data for protein function prediction and surve作者: Flounder 時(shí)間: 2025-3-25 01:10 作者: pulmonary 時(shí)間: 2025-3-25 05:14 作者: 尖叫 時(shí)間: 2025-3-25 10:37
Literature and Genome Data Mining for Prioritizing Disease-Associated Genesromosomal region to identify potential candidates that are scored using the precomputed associations. The scoring of associations between biological concepts using links across databases can be extended to other databases in Molecular Biology and to nondisease phenotypes.作者: BARGE 時(shí)間: 2025-3-25 11:45 作者: Ruptured-Disk 時(shí)間: 2025-3-25 16:02
The Predictive Power of Molecular Network Modellingl predictions on features of intracellular biological systems later. The three cases concern the optimal time course of gene expression in metabolic pathways, the operation of a metabolic route involving part of the tricarboxylic acid cycle and glyoxylate shunt, and the decoding of calcium oscillati作者: 吹牛大王 時(shí)間: 2025-3-25 21:32 作者: 尖 時(shí)間: 2025-3-26 04:08 作者: 沐浴 時(shí)間: 2025-3-26 05:39 作者: 嘮叨 時(shí)間: 2025-3-26 08:44
1431-0414 ce researchers and higher-level students that work on biomolecular mechanisms and wish to understand the impact of computational biology for their success. .978-1-4419-4177-0978-0-387-36747-7Series ISSN 1431-0414 作者: Pde5-Inhibitors 時(shí)間: 2025-3-26 15:13
https://doi.org/10.1007/978-3-8349-4359-0ortant questions. Currendy, theoretical methods have best chances to contribute to new biological insight independently of experiments in the area of genome text interpretation and especially for gene function prediction. Experimental studies can help progress in the development of theoretical metho作者: MORT 時(shí)間: 2025-3-26 17:13
https://doi.org/10.1007/978-3-8349-4359-0t-based function prediction provide complementary information about a protein’s function and can becombined to make predictions that are specific enough for experimental testing. Here we discuss the genomic coverage and reliability of combining genomics data for protein function prediction and surve作者: 孵卵器 時(shí)間: 2025-3-26 22:53 作者: 極力證明 時(shí)間: 2025-3-27 03:24 作者: Irremediable 時(shí)間: 2025-3-27 07:04
Strategy and Politics in the Blair Eraromosomal region to identify potential candidates that are scored using the precomputed associations. The scoring of associations between biological concepts using links across databases can be extended to other databases in Molecular Biology and to nondisease phenotypes.作者: 委托 時(shí)間: 2025-3-27 12:49 作者: intolerance 時(shí)間: 2025-3-27 17:27 作者: Microgram 時(shí)間: 2025-3-27 19:08
https://doi.org/10.1007/978-3-322-84753-9 earlier established processivity rule. The derived genealogy of all 64 codons suggests several important predictions that are confirmed: Gradual decay of glycine content in protein evolution; traces of the most ancient 6-residue long gly-rich and ala-rich minigenes in extant sequences; and manifest作者: ineptitude 時(shí)間: 2025-3-27 22:29 作者: Bone-Scan 時(shí)間: 2025-3-28 03:10
Introductionus progress in life sciences compared with the sophistication of experimental approaches themselves. The genesis of recent spectacular breakthroughs in molecular biology that led to the discovery of the enzymatic function of several nonmetabolic enzymes illustrates that this relationship is beginnin作者: NORM 時(shí)間: 2025-3-28 06:36 作者: 清晰 時(shí)間: 2025-3-28 11:51
Clues from Three-Dimensional Structure Analysis and Molecular Modellingby cytochrome P450. It is an attractive drug target, e.g., cytochrome P450s of . are promising targets in the fight against tuberculosis. The structure provides new insights for investigation of structure/mechanism of cytochrome P450, and for rational design of inhibitor molecules. We will illustrat作者: 不能約 時(shí)間: 2025-3-28 17:06
Prediction of Protein Function a life science research environment. The understanding of protein function is typically the main difficulty. This chapter intends to give practical advise to students and researchers that have only introductory knowledge in the field of protein sequence analysis..Applicable theoretical approaches r作者: 最有利 時(shí)間: 2025-3-28 19:19 作者: instructive 時(shí)間: 2025-3-28 23:45
Literature and Genome Data Mining for Prioritizing Disease-Associated Genestarts with locating the mutations in a chromosomal band, as narrow as possible, and follows with the manual analysis of all the genes mapping in this region. Usually this is not an easy task, but it can be facilitated by complementary computational approaches that evaluate all genes in a region of i作者: 不能根除 時(shí)間: 2025-3-29 03:46 作者: 群居男女 時(shí)間: 2025-3-29 10:11 作者: subacute 時(shí)間: 2025-3-29 12:59
Theory of Early Molecular Evolutionssical cycle is then repeated generating the earliest picture of evolving Life. First, a consensus temporal order (“chronology”) of appearance of amino acids and their respective codons on evolutionary scene is reconstructed on the basis of 60 different criteria, resulting in the order: G, A, D, V, 作者: Root494 時(shí)間: 2025-3-29 17:33
Hitchhiking Mappingand could be applied in an ecological context. This review focuses on the use of microsatellite markers in genome scans for the identification of beneficial mutations. The pitfalls and potential of the lnR6 test statistic are discussed as well as different approaches for the identification of the mo作者: 規(guī)范就好 時(shí)間: 2025-3-29 21:30
Understanding the Functional Importance of Human Single Nucleotide Polymorphismsding regions, contributes to phenotypic variation. However, much of the variation in coding regions may not produce any functional effects. There are two broad strategies for classifying polymorphism as functional or neutral: sequence-based methods predict functional significance based on conservati作者: 并置 時(shí)間: 2025-3-30 02:37 作者: 管理員 時(shí)間: 2025-3-30 04:51
1431-0414 ction of gene function and gene-disease association), with t.In this anthology, leading researchers present critical reviews of methods and high-impact applications in computational biology that lead to results that also non-bioinformaticians must know to design efficient experimental research plans作者: ARC 時(shí)間: 2025-3-30 10:44
