標(biāo)題: Titlebook: Discoidin Domain Receptors in Health and Disease; Rafael Fridman,Paul H. Huang Book 2016 Springer Science+Business Media New York 2016 can [打印本頁] 作者: credit 時(shí)間: 2025-3-21 16:40
書目名稱Discoidin Domain Receptors in Health and Disease影響因子(影響力)
書目名稱Discoidin Domain Receptors in Health and Disease影響因子(影響力)學(xué)科排名
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書目名稱Discoidin Domain Receptors in Health and Disease網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Discoidin Domain Receptors in Health and Disease被引頻次
書目名稱Discoidin Domain Receptors in Health and Disease被引頻次學(xué)科排名
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書目名稱Discoidin Domain Receptors in Health and Disease年度引用學(xué)科排名
書目名稱Discoidin Domain Receptors in Health and Disease讀者反饋
書目名稱Discoidin Domain Receptors in Health and Disease讀者反饋學(xué)科排名
作者: 構(gòu)成 時(shí)間: 2025-3-21 22:39
Staging and Performing Translationnd implantation, as well as wound healing and auditory sensation. In addition, genetically modified mice and DDR mutant mice highlight the role of DDRs in the enhancement or attenuation of diseases, including fibrosis, atherosclerosis, and osteoarthritis in various conditions..Studies on mouse model作者: 合并 時(shí)間: 2025-3-22 03:02 作者: 單調(diào)女 時(shí)間: 2025-3-22 06:05 作者: Nebulizer 時(shí)間: 2025-3-22 09:24
https://doi.org/10.1007/978-3-322-94744-4etastasis. The molecular mechanisms underlying how DDRs contribute to these and other pathologies need to be understood to find new markers and for development of therapeutic agents for treatment of disease. This is particularly the case for EOC in which mechanisms explaining the atypically high lev作者: Demonstrate 時(shí)間: 2025-3-22 13:30
https://doi.org/10.1007/978-3-322-93990-6 we describe the key molecular interactions and signalling pathways elucidated by these studies and where appropriate highlight situations where signalling outcomes appear to be dependent on cellular context. We present an emerging molecular portrait of the DDRs and highlight areas where more intens作者: Demonstrate 時(shí)間: 2025-3-22 20:15
https://doi.org/10.1007/978-3-322-93990-6llagen-independent cell–cell interactions. Collagen-activated DDR1 signals through NF-kB, PI3K/Akt and p38, JNK, and ERK1/2 MAPKs, while inactive DDR1 appears to interact with E-cadherin promoting cell–cell interactions. DDR1 interacts with several other receptors, including Notch1 and Frizzled5, an作者: ostrish 時(shí)間: 2025-3-22 21:38
https://doi.org/10.1007/978-3-663-01602-1n osteoarthritic joint. If, as we suspect, DDR2 is one of the major contributors to progressive joint failure, then drugs that inhibit the kinase activity of DDR2 may be able to ameliorate osteoarthritis conditions.作者: 和平主義者 時(shí)間: 2025-3-23 01:53
https://doi.org/10.1007/978-3-663-01602-1e pathways were not activated which resulted to an impressive preservation of renal function and structure. Further proof of evidence came from experiments with in vivo administration of antisense oligonucleotides against DDR1. The fact that this pharmacogenetic approach protected animals against th作者: 人類 時(shí)間: 2025-3-23 06:46 作者: SPASM 時(shí)間: 2025-3-23 13:08
DDRs and Collagen Fibrillogenesisgen fibrillogenesis. We begin with Sect. ., which summarizes the experimental evidence on the role of DDRs in collagen fibrillogenesis. In the most comprehensive Sect. . we describe the various stages of fibrillogenesis of collagen type I with special attention to the putative role(s) of DDRs at eac作者: 巧辦法 時(shí)間: 2025-3-23 13:57
DDR Mouse Modelsnd implantation, as well as wound healing and auditory sensation. In addition, genetically modified mice and DDR mutant mice highlight the role of DDRs in the enhancement or attenuation of diseases, including fibrosis, atherosclerosis, and osteoarthritis in various conditions..Studies on mouse model作者: prediabetes 時(shí)間: 2025-3-23 21:22 作者: immunity 時(shí)間: 2025-3-24 01:24 作者: sinoatrial-node 時(shí)間: 2025-3-24 03:26 作者: 膽大 時(shí)間: 2025-3-24 08:45 作者: Morsel 時(shí)間: 2025-3-24 12:58 作者: Formidable 時(shí)間: 2025-3-24 18:26
Discoidin Domain Receptor 2 in Development of Osteoarthritisn osteoarthritic joint. If, as we suspect, DDR2 is one of the major contributors to progressive joint failure, then drugs that inhibit the kinase activity of DDR2 may be able to ameliorate osteoarthritis conditions.作者: Lime石灰 時(shí)間: 2025-3-24 22:39
DDR1 in Renal Function and Diseasee pathways were not activated which resulted to an impressive preservation of renal function and structure. Further proof of evidence came from experiments with in vivo administration of antisense oligonucleotides against DDR1. The fact that this pharmacogenetic approach protected animals against th作者: Temporal-Lobe 時(shí)間: 2025-3-25 01:00 作者: 有惡臭 時(shí)間: 2025-3-25 07:09 作者: modish 時(shí)間: 2025-3-25 08:48
http://image.papertrans.cn/e/image/280916.jpg作者: 凝結(jié)劑 時(shí)間: 2025-3-25 14:51 作者: alcohol-abuse 時(shí)間: 2025-3-25 17:14
https://doi.org/10.1007/978-1-4939-6383-6cancer migration; cell signaling; collagen; extracellular matrix; receptor tyrosine kinases作者: chassis 時(shí)間: 2025-3-25 22:28
978-1-4939-8182-3Springer Science+Business Media New York 2016作者: FOLLY 時(shí)間: 2025-3-26 03:49
Margaret Rose,Cristina Marinetti are characterized by the presence of a discoidin homology (DS) domain in their extracellular regions, as well as a domain of similar structure, the DS-like domain. The DDRs function as transmembrane collagen receptors and are thus at the interface of receptor tyrosine kinases and integrins, the mai作者: 有限 時(shí)間: 2025-3-26 05:20 作者: synovitis 時(shí)間: 2025-3-26 09:57
https://doi.org/10.1057/9780230294608family isoforms, are single-pass transmembrane proteins, containing the discoidin (DS) domain and the DS-like domain on the extracellular side, and an extremely long juxtamembrane region and the kinase domain on the intracellular side. This chapter provides an overview of the structural knowledge of作者: 激勵(lì) 時(shí)間: 2025-3-26 13:01 作者: Champion 時(shí)間: 2025-3-26 20:46 作者: 名字 時(shí)間: 2025-3-26 22:21 作者: FAZE 時(shí)間: 2025-3-27 03:28 作者: 陶器 時(shí)間: 2025-3-27 08:42 作者: Benign 時(shí)間: 2025-3-27 11:52 作者: CRAB 時(shí)間: 2025-3-27 13:43
https://doi.org/10.1007/978-3-322-94744-4ntiation, adhesion, and matrix remodeling. Dysregulation of DDRs has been linked to many human diseases, including fibrotic disorders, atherosclerosis, and cancer. Thus, DDRs have been considered as emerging potential molecular targets for new drug discovery. Several classes of DDR small molecular i作者: 才能 時(shí)間: 2025-3-27 18:18 作者: 縱火 時(shí)間: 2025-3-28 01:15
https://doi.org/10.1007/978-3-322-93990-6 activated by collagen. Mounting evidence suggests that DDR1 and DDR2 play crucial roles in the regulation of cellular responses under both normal and pathological conditions and has stimulated intense interest in the development of novel therapies to specifically target DDR function. Recent discove作者: 注視 時(shí)間: 2025-3-28 04:03
,Stahl – Herstellung, Verwendung, Schutz,iting step that determines epithelial cell differentiation. Signals from the microenvironment, including growth factors, cytokines, or the extracellular matrix, all have a significant impact on the assembly of adherens junctions. An increase of collagen deposition is no longer considered to be a con作者: Acetaldehyde 時(shí)間: 2025-3-28 09:51 作者: Insulin 時(shí)間: 2025-3-28 14:29 作者: 高度 時(shí)間: 2025-3-28 18:40
,Stahl – Herstellung, Verwendung, Schutz,llagenous ECM following chronic injury. Fibrosis from persistent injury may progress to cirrhosis, an end-stage lesion, which may lead to liver failure and death. Research is focused on receptor tyrosine kinases (RTKs) as new targets for antifibrotic therapies. Among them, discoidin domain receptors作者: calamity 時(shí)間: 2025-3-28 22:38
https://doi.org/10.1057/9780230294608family isoforms, are single-pass transmembrane proteins, containing the discoidin (DS) domain and the DS-like domain on the extracellular side, and an extremely long juxtamembrane region and the kinase domain on the intracellular side. This chapter provides an overview of the structural knowledge of the DDR receptors.作者: 嘴唇可修剪 時(shí)間: 2025-3-29 01:56
Book 2016tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. ?A failure to establish these normal interactions an作者: Ardent 時(shí)間: 2025-3-29 06:55
Small Molecule Inhibitors of Discoidin Domain Receptors (DDRs)nhibitors have been discovered in recent years. This chapter will provide an updated overview on the chemical structures, mechanism of action (MOA), and potential medical implications of the newly identified DDR small molecule inhibitors.作者: 摻假 時(shí)間: 2025-3-29 08:24 作者: HEPA-filter 時(shí)間: 2025-3-29 14:15 作者: 宣傳 時(shí)間: 2025-3-29 18:01 作者: visceral-fat 時(shí)間: 2025-3-29 21:31 作者: 皮薩 時(shí)間: 2025-3-30 00:29
Discoidin Domain Receptors in Lung Cancer from these studies are inconsistent and sometimes contradictory, which may be explained by differences in the use of analytic methods, the retrospective nature of study reports, and differences in biospecimen procurement, storage, and processing.作者: Albinism 時(shí)間: 2025-3-30 06:53 作者: 朋黨派系 時(shí)間: 2025-3-30 08:50
ignaling networks in cancer cells activated by the extracellThe interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a作者: 提煉 時(shí)間: 2025-3-30 14:14
Staging the Slums, Slumming the Stagees. Accumulated data indicate that the action of DDRs in various cell types have both cell-intrinsic roles as well as affecting the nature of the extracellular matrix produced or present in pathologic conditions.作者: 厭食癥 時(shí)間: 2025-3-30 19:17 作者: choleretic 時(shí)間: 2025-3-30 23:15 作者: Paraplegia 時(shí)間: 2025-3-31 04:08 作者: Mhc-Molecule 時(shí)間: 2025-3-31 05:14
https://doi.org/10.1007/978-3-322-94744-4nhibitors have been discovered in recent years. This chapter will provide an updated overview on the chemical structures, mechanism of action (MOA), and potential medical implications of the newly identified DDR small molecule inhibitors.作者: BORE 時(shí)間: 2025-3-31 09:23
DDRs: Binding Properties, Cell Adhesion and Modulation of Integrin Function are characterized by the presence of a discoidin homology (DS) domain in their extracellular regions, as well as a domain of similar structure, the DS-like domain. The DDRs function as transmembrane collagen receptors and are thus at the interface of receptor tyrosine kinases and integrins, the mai作者: intimate 時(shí)間: 2025-3-31 14:27
