作者: 思鄉(xiāng)病 時(shí)間: 2025-3-21 22:48 作者: Hallmark 時(shí)間: 2025-3-22 02:42
Haftung für Gasversorgungsst?rungenors responsible for embryopathies. In pursuing such objectives account is taken not only of the biological effects of potentially embryotoxic agents in isolation but also of the so-called . of the experimental animal used (i.e. the combination of the maternal phenotype with the multiple environmenta作者: Engulf 時(shí)間: 2025-3-22 05:54
Energierechtliche Rahmenbedingungenwhere the mechanism of toxicity is the object of study. There is, of course, much overlap between the two approaches and they are mutually interdependent, but the distinction is useful to define the scope of this chapter. The goal of toxicity testing is to identify hazardous agents, to define the co作者: 狂熱語言 時(shí)間: 2025-3-22 12:41 作者: 杠桿支點(diǎn) 時(shí)間: 2025-3-22 16:01
Schlussfolgerungen für das deutsche Recht impression of the place that biochemical studies occupy in the overall approach to the investigation of human birth defects. Considered out of such context, the unfortunate impression may be given that the biochemical approach is distinctly separate, superior or merely more fashionable than any oth作者: 杠桿支點(diǎn) 時(shí)間: 2025-3-22 20:17
Rechtsvergleichende Betrachtungre likely to cause their adverse effect directly in the fetus — in the tissues which are affected. Evidence for this is that a number of substances accumulate selectively in the critical fetal tissues.作者: 特別容易碎 時(shí)間: 2025-3-23 00:17 作者: interlude 時(shí)間: 2025-3-23 01:55 作者: Impugn 時(shí)間: 2025-3-23 08:58
Insolvenzordnung und Insolvenzverfahrendevelopment are not restricted to the causation of malformations. Exposure to chemical carcinogens may, in addition to cytotoxic effects, lead to the initiation of malignant transformation at very early stages of organogenesis. The first report on transplacental tumour induction in experimental anim作者: 物種起源 時(shí)間: 2025-3-23 11:29 作者: 招募 時(shí)間: 2025-3-23 16:07
Vito Racanelli,Claudia Brunettihom they may be transmitted via the maternal circulation. The most overtly recognisable adverse effect of exposure to a toxicant in this manner is either intrauterine fetal death or birth of the fetus with anatomical malformations (see reviews by Wilson, 1973; Smithells, 1976). Tne identification of作者: 做作 時(shí)間: 2025-3-23 19:15
The Distribution of Drugs and Other Agents in the Fetus,re likely to cause their adverse effect directly in the fetus — in the tissues which are affected. Evidence for this is that a number of substances accumulate selectively in the critical fetal tissues.作者: Synchronism 時(shí)間: 2025-3-24 02:08 作者: 河潭 時(shí)間: 2025-3-24 04:28 作者: erythema 時(shí)間: 2025-3-24 09:16
,Rechtsformübergreifende Entwicklungen,g. polyhalogenated biphenyls, methyl mercury, cigarette smoke, dioxins, etc.) likewise appear to be harmful to human embryos and fetuses. This recognition has also been a major factor in the increased attention to placental toxicology.作者: 尊重 時(shí)間: 2025-3-24 14:40 作者: ABOUT 時(shí)間: 2025-3-24 15:09 作者: malapropism 時(shí)間: 2025-3-24 19:08 作者: TERRA 時(shí)間: 2025-3-25 00:36
Haftung für Gasversorgungsst?rungenpossible embryopathic effects. A quartet of effects are relevant in this context; namely, fetal death (with consequent resorption or abortion), fetal malformation (true teratologies in the morphological sense) abnormalities of function (perhaps associated with faulty histogenesis) and intra-uterine growth retardation.作者: 品牌 時(shí)間: 2025-3-25 06:21 作者: 安裝 時(shí)間: 2025-3-25 11:06 作者: 輕信 時(shí)間: 2025-3-25 14:38 作者: 鳥籠 時(shí)間: 2025-3-25 19:14
Biochemical Mechanisms of Teratogenesis,the problems in this field on an interdisciplinary basis (Bass ., 1970). Also, in a relatively young science like teratology where a large mass of experimental data has now been gathered, but where the theoretical basis of the subject still consists of little more than half a dozen ‘rules of thumb’ 作者: STING 時(shí)間: 2025-3-25 23:49
The Differentiation of Drug Metabolism in Relation to Developmental Toxicology,he mother is the most significant route for the fetus to eliminate foreign chemicals and because this diffusion is thought to be most rapid for unchanged lipid-soluble substances. If, however, the fetus should metabolise foreign substances to more watersoluble metabolites, these metabolites might ac作者: FLAG 時(shí)間: 2025-3-26 02:46 作者: 挑剔為人 時(shí)間: 2025-3-26 07:51 作者: intrude 時(shí)間: 2025-3-26 08:51
Developmental Enzyme Pathology, frank congenital malformations, prenatal toxicity may also manifest itself as functional aberrations, such as behavioural or biochemical abnormalities, which may remain latent before being expressed at later stages of development. It follows from the nature of the defect that such functional abnorm作者: 細(xì)微差別 時(shí)間: 2025-3-26 12:50
Book 1982erapeutic agents could cause damage to the developing organism, but the absence of any known examples of drug-induced birth defects had produced an air of complacency which was reinforced by the lack of any specific regulatory requirements for safety evaluation in this area. The magnitude of the tha作者: stress-response 時(shí)間: 2025-3-26 18:35 作者: induct 時(shí)間: 2025-3-27 01:00
Energierechtliche Rahmenbedingungenediction of toxicity, based upon chemical structure or reactivity, and may also permit preventive, ameliorative or curative measures to be devised. As will be discussed, suitable . test systems cannot be defined without considering the mechanism of toxicity.作者: obstinate 時(shí)間: 2025-3-27 04:25 作者: 失誤 時(shí)間: 2025-3-27 08:06 作者: Carcinogenesis 時(shí)間: 2025-3-27 11:33 作者: Hiatal-Hernia 時(shí)間: 2025-3-27 16:10 作者: PLUMP 時(shí)間: 2025-3-27 19:59 作者: VALID 時(shí)間: 2025-3-28 01:46
Model Systems in Teratology Research,ors responsible for embryopathies. In pursuing such objectives account is taken not only of the biological effects of potentially embryotoxic agents in isolation but also of the so-called . of the experimental animal used (i.e. the combination of the maternal phenotype with the multiple environmenta作者: Expressly 時(shí)間: 2025-3-28 03:59 作者: sigmoid-colon 時(shí)間: 2025-3-28 06:19 作者: Chauvinistic 時(shí)間: 2025-3-28 14:02
Biochemical Mechanisms of Teratogenesis, impression of the place that biochemical studies occupy in the overall approach to the investigation of human birth defects. Considered out of such context, the unfortunate impression may be given that the biochemical approach is distinctly separate, superior or merely more fashionable than any oth作者: Expurgate 時(shí)間: 2025-3-28 16:55
The Distribution of Drugs and Other Agents in the Fetus,re likely to cause their adverse effect directly in the fetus — in the tissues which are affected. Evidence for this is that a number of substances accumulate selectively in the critical fetal tissues.作者: 有機(jī)體 時(shí)間: 2025-3-28 19:09 作者: obeisance 時(shí)間: 2025-3-29 02:38
The Role of the Placenta in Developmental Toxicology,n the developing conceptus. A major reason for this increased interest has been tne recognition that various drugs (e.g. thalidomide, methotrexate, diethylstilboestrol, ethanol, androgens, etc.) are capable of eliciting deleterious effects on the offspring of mothers exposed to doses within the rang作者: LATE 時(shí)間: 2025-3-29 05:50 作者: Engulf 時(shí)間: 2025-3-29 10:50 作者: 背心 時(shí)間: 2025-3-29 13:37
Developmental Enzyme Pathology,hom they may be transmitted via the maternal circulation. The most overtly recognisable adverse effect of exposure to a toxicant in this manner is either intrauterine fetal death or birth of the fetus with anatomical malformations (see reviews by Wilson, 1973; Smithells, 1976). Tne identification of
