標(biāo)題: Titlebook: Deoxynucleoside Analogs in Cancer Therapy; Godefridus J. Peters (Professor of Medical Oncolog Book 2006 Humana Press 2006 HIV.cancer.cance [打印本頁] 作者: TIBIA 時間: 2025-3-21 17:34
書目名稱Deoxynucleoside Analogs in Cancer Therapy影響因子(影響力)
書目名稱Deoxynucleoside Analogs in Cancer Therapy影響因子(影響力)學(xué)科排名
書目名稱Deoxynucleoside Analogs in Cancer Therapy網(wǎng)絡(luò)公開度
書目名稱Deoxynucleoside Analogs in Cancer Therapy網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Deoxynucleoside Analogs in Cancer Therapy被引頻次
書目名稱Deoxynucleoside Analogs in Cancer Therapy被引頻次學(xué)科排名
書目名稱Deoxynucleoside Analogs in Cancer Therapy年度引用
書目名稱Deoxynucleoside Analogs in Cancer Therapy年度引用學(xué)科排名
書目名稱Deoxynucleoside Analogs in Cancer Therapy讀者反饋
書目名稱Deoxynucleoside Analogs in Cancer Therapy讀者反饋學(xué)科排名
作者: 窗簾等 時間: 2025-3-21 22:07
Wolfgang Beitz,Karl-Heinz KüttnerGX Pharmaceuticals, Inc.) is the first nucleoside analog with anticancer activity that has an unnatural stereochemical configuration. Its broad preclinical antineoplastic spectrum led to its clinical development. Summaries of the preclinical data and of the initial phase I and II clinical trials are presented.作者: 打擊 時間: 2025-3-22 01:27
Hydrostatik (Statik der Flüssigkeiten)ionales to be evaluated with minimal likelihood of untoward toxicity. Exploration of additional schedules and combinations along with availability of an oral formulation strongly indicate promising possibilities with this agent.作者: 考得 時間: 2025-3-22 05:17
Clofarabine,ionales to be evaluated with minimal likelihood of untoward toxicity. Exploration of additional schedules and combinations along with availability of an oral formulation strongly indicate promising possibilities with this agent.作者: 金絲雀 時間: 2025-3-22 11:18 作者: fodlder 時間: 2025-3-22 16:28
Kurven und Fl?chen, Vektoranalysisand FLT. Consequently, FLT labeled with .F is a PET tracer of TK1 activity, and as such an indirect marker of DNA synthesizing activity and cell proliferation. Potential applications of FLT are in detecting and staging tumors.作者: fodlder 時間: 2025-3-22 18:58 作者: Horizon 時間: 2025-3-22 23:40 作者: Magnificent 時間: 2025-3-23 05:23 作者: 勉勵 時間: 2025-3-23 08:24
Erg?nzungen zur Mathematik für Ingenieurenation chemotherapy based on its multiple mechanisms of action and relatively mild toxicity profile. This chapter summarizes the current preclinical and clinical knowledge of gemcitabine as a single agent and in combinations in non-small cell lung cancer, and pancreatic, bladder, breast, ovarian, gastric, and esophageal cancer.作者: Narcissist 時間: 2025-3-23 10:36
Hydrostatik (Statik der Flüssigkeiten)NT; SLC29 gene family) nucleoside transporters, which differ in their substrate selectivity and their energy requirements. Both nucleoside transporter families have also been involved in the transmembrane transport of nucleoside-derived compounds, many of them currently used in antiviral and antitum作者: 柱廊 時間: 2025-3-23 14:04 作者: GROSS 時間: 2025-3-23 18:09 作者: Antagonism 時間: 2025-3-23 22:56
Hydrostatik (Statik der Flüssigkeiten)de analogs need to be phosphorylated to attain full clinical potency; thus, knowledge of the metabolism of this class of drugs is required to improve their clinical use. The 5′-nucleotidases are a family of enzymes that catalyze the final dephosphorylation step of nucleotides in the cell and, by opp作者: 行乞 時間: 2025-3-24 04:28 作者: Generic-Drug 時間: 2025-3-24 07:19
Karl-Heinrich Grote,J?rg Feldhusenoietic malignancies. The activity of ara-C depends on the conversion to its cytotoxic triphosphate derivative, ara-CTP. This process is influenced by multiple factors, including transport, phosphorylation, deamination, and levels of competing metabolites, deoxycytidine triphosphate in particular. Fu作者: 俗艷 時間: 2025-3-24 11:15
Hydrostatik (Statik der Flüssigkeiten)the drug in acute leukemias is favorable relative to fludarabine or cladribine and may have prognostic value for its clinical activity. The toxicity profile of this agent is different from other nucleoside analogs in that it clearly has clinical activity when used as a single agent against adult acu作者: 宏偉 時間: 2025-3-24 18:45
Beanspruchung stabf?rmiger Bauteiledes and nucleoside analogs are available. Among nucleoside analogs, nonnatural L-enantiomers have been particularly interesting. The most notable example is lamivudine, which has been playing an important role in the treatment of human immunodeficiency virus and hepatitis B virus infections. The rea作者: 相容 時間: 2025-3-24 21:04
Wolfgang Beitz,Karl-Heinz Küttnerg DNA synthesis and inducing apoptosis following their incorporation into DNA. Troxacitabine (Troxatyl? Shire Biochem, Inc., exclusively licensed to SGX Pharmaceuticals, Inc.) is the first nucleoside analog with anticancer activity that has an unnatural stereochemical configuration. Its broad precli作者: PLAYS 時間: 2025-3-24 23:51
Mechanische Konstruktionselemente,1995 before a prodrug of ara-G, nelarabine, entered clinical trials. Ara-G is a deoxyguanosine analog that needs to be phosphorylated inside the cell for pharmacological activity. In the first and rate-limiting phosphorylation step, ara-G is a substrate of both the mitochondrial deoxyguanosine kinas作者: OPINE 時間: 2025-3-25 06:54
https://doi.org/10.1007/3-540-26620-8h as non-small cell lung carcinoma and pancreatic and bladder cancer. In this chapter, we summarize the role of the key enzymes in its metabolic activation and deactivation pathways, the role of the various targets, the associated mechanisms of acquired and inherent resistance, and the changes in DN作者: 葡萄糖 時間: 2025-3-25 10:34 作者: 有權(quán)威 時間: 2025-3-25 15:27
Komponenten des thermischen Apparatebaus,e, fluoromethylenedeoxycytidine) can synergistically enhance ionizing radiation-induced cell killing. These analogs are able to radiosensitize a wide variety of tumor cell types in vitro and several have proven clinical efficacy as well. They share a requirement for intracellular metabolism to phosp作者: DRILL 時間: 2025-3-25 17:37
https://doi.org/10.1007/978-3-662-10219-0ravenously administered nucleoside analogs cytosine arabinoside (ara-C) and fludarabine phosphate (F-ara-A) in pediatric patients with leukemias. A description of the major NONMEM tasks as well as the statistical models has been given for these drugs. Two pharmacokineticpharmacodynamic (PK-PD) model作者: 不能平靜 時間: 2025-3-25 20:27 作者: 善變 時間: 2025-3-26 02:37 作者: Cocker 時間: 2025-3-26 08:11
Godefridus J. Peters (Professor of Medical OncologIncludes supplementary material: 作者: Hallmark 時間: 2025-3-26 12:20
Cancer Drug Discovery and Developmenthttp://image.papertrans.cn/d/image/265686.jpg作者: Custodian 時間: 2025-3-26 13:39 作者: 放肆的你 時間: 2025-3-26 20:20 作者: duplicate 時間: 2025-3-26 23:57
Nucleoside Transport Into Cells,NT; SLC29 gene family) nucleoside transporters, which differ in their substrate selectivity and their energy requirements. Both nucleoside transporter families have also been involved in the transmembrane transport of nucleoside-derived compounds, many of them currently used in antiviral and antitum作者: 退出可食用 時間: 2025-3-27 03:32
The Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog Activation,nly enzyme that can supply cells with all four precursors of DNA; is capable of 5′-phosphorylation of the natural substrates deoxycytidine (dCyt), deoxyadenosine, and deoxyguanosine; and can be interconverted into thymine nucleotides. The deoxycytidine triphosphate (dCTP), in addition to DNA, can be作者: deficiency 時間: 2025-3-27 09:00 作者: 思考才皺眉 時間: 2025-3-27 11:34 作者: 檔案 時間: 2025-3-27 16:54 作者: debble 時間: 2025-3-27 20:42 作者: 不規(guī)則 時間: 2025-3-28 00:40
Clofarabine,the drug in acute leukemias is favorable relative to fludarabine or cladribine and may have prognostic value for its clinical activity. The toxicity profile of this agent is different from other nucleoside analogs in that it clearly has clinical activity when used as a single agent against adult acu作者: 充滿裝飾 時間: 2025-3-28 02:19
,-Nucleosides as Chemotherapeutic Agents,des and nucleoside analogs are available. Among nucleoside analogs, nonnatural L-enantiomers have been particularly interesting. The most notable example is lamivudine, which has been playing an important role in the treatment of human immunodeficiency virus and hepatitis B virus infections. The rea作者: 細(xì)菌等 時間: 2025-3-28 07:44 作者: Talkative 時間: 2025-3-28 13:13
,9-β-,-Arabinofuranosylguanine,1995 before a prodrug of ara-G, nelarabine, entered clinical trials. Ara-G is a deoxyguanosine analog that needs to be phosphorylated inside the cell for pharmacological activity. In the first and rate-limiting phosphorylation step, ara-G is a substrate of both the mitochondrial deoxyguanosine kinas作者: Manifest 時間: 2025-3-28 16:32
Gemcitabine,h as non-small cell lung carcinoma and pancreatic and bladder cancer. In this chapter, we summarize the role of the key enzymes in its metabolic activation and deactivation pathways, the role of the various targets, the associated mechanisms of acquired and inherent resistance, and the changes in DN作者: 很像弓] 時間: 2025-3-28 21:14 作者: NIP 時間: 2025-3-29 00:41 作者: obnoxious 時間: 2025-3-29 05:27 作者: Aphorism 時間: 2025-3-29 08:46 作者: Concrete 時間: 2025-3-29 15:16 作者: 變化 時間: 2025-3-29 18:15
Hydrostatik (Statik der Flüssigkeiten)n of the substrates by their transporters. This will be a key point in the development of rationally designed new drugs. Other aspects of nucleoside transporters are also relevant to their function as drug transporters. On the one hand, several polymorphisms have been described in CNT and ENT protei作者: linguistics 時間: 2025-3-29 23:12 作者: Calculus 時間: 2025-3-30 00:05
J. Lackmann,H. Mertens,R. Liebichl drug zidovudine (AZT) and, to a lesser degree, d4T (stavudine). Until recently, the two mitochondrial deoxynucleoside kinases, thymidine kinase 2 (TK2) and dGK (deoxyguanosine kinase), have not been in focus as drug-targeting enzymes, but the accumulating knowledge of the role these kinases play f作者: 低三下四之人 時間: 2025-3-30 06:18
Hydrostatik (Statik der Flüssigkeiten)vation and thereby contribute to drug resistance. Because cloned 5′_nucleotidases have been described in human tissues, it is not always possible to assess which particular 5′-nucleotidase is important in nucleoside drug catabolism. In this chapter, we review the properties of all cloned 5′-nucleoti作者: Electrolysis 時間: 2025-3-30 11:29
Beanspruchung stabf?rmiger Bauteile 5-fluorodeoxyuridine, possibly because MRP8 can efflux the monophosphate derivative of these analogs. However, the affinity of these transporters for the nucleotide analogs studied thus far is relatively low (millimolar rather than micromolar), and this limits their potential impact on resistance. 作者: Vaginismus 時間: 2025-3-30 16:17
Karl-Heinrich Grote,J?rg Feldhusenent injection or by continuous infusion over 5–10 d. The presence of drug refractoriness and relapsing leukemia together with insights into the mechanisms of ara-C resistance led to the development of high-dose (1–3 g/m.) ara-C treatment. A number of different strategies have been developed to incre作者: 江湖騙子 時間: 2025-3-30 16:34
Beanspruchung stabf?rmiger Bauteilevirus infections, and several other analogs, such as clevudine and troxacitabine, are in advanced clinical trial development stages. Among these, troxacitabine, a true chain terminator, is the first L-nucleoside endowed with promising antitumor activity against leukemia as well as solid tumors. This作者: N斯巴達(dá)人 時間: 2025-3-30 22:25
