標題: Titlebook: Data Mining in Structural Biology; Signal Transduction I. Schlichting,U. Egner Conference proceedings 2001 Springer-Verlag Berlin Heidelbe [打印本頁] 作者: Asphyxia 時間: 2025-3-21 19:08
書目名稱Data Mining in Structural Biology影響因子(影響力)
書目名稱Data Mining in Structural Biology影響因子(影響力)學科排名
書目名稱Data Mining in Structural Biology網絡公開度
書目名稱Data Mining in Structural Biology網絡公開度學科排名
書目名稱Data Mining in Structural Biology被引頻次
書目名稱Data Mining in Structural Biology被引頻次學科排名
書目名稱Data Mining in Structural Biology年度引用
書目名稱Data Mining in Structural Biology年度引用學科排名
書目名稱Data Mining in Structural Biology讀者反饋
書目名稱Data Mining in Structural Biology讀者反饋學科排名
作者: 偽造 時間: 2025-3-21 21:52
Common Eye Diseases and their Management thyroid hormone receptor. A growing subgroup of NRs, for which no ligand has yet been characterized, is called the orphan receptors (Gronemeyer and Laudet 1995). Steroid hormone receptors regulate complex gene networks involved in growth, cellular differentiation, homeostasis, and morphogenesis and organ genesis.作者: tenuous 時間: 2025-3-22 02:20
N. R. Galloway BA, MB, ChB, DO, FRCS, MDdevoid of kinase activity but which interact with cytoplasmic tyrosine kinases. Another important family of cytokines is the transforming growth factor-β (TGF-β) family; these factors have important roles in pattern formation during embryonal development and often inhibit cell growth via binding to protein serine/threonine kinase receptors.作者: Digitalis 時間: 2025-3-22 05:05 作者: contrast-medium 時間: 2025-3-22 09:19
N. R. Galloway BA, MB, ChB, DO, FRCS, MDes and pharmaceutical and biotechnology companies. Recent crystallographic data on complexes of PTKs with selective and non-selective inhibitors (see below) has opened the door, in principle, to the improvement of rational drug design.作者: 錯事 時間: 2025-3-22 14:45
Common Eye Diseases and their Managementny new technologies, in particular high-throughput methods in screening and chemistry, has greatly changed the way in which drug discovery research is carried out. In parallel, structure-based methods have been further developed, resulting in successful de novo design and new applications such as virtual screening and library design.作者: 錯事 時間: 2025-3-22 19:09 作者: Offstage 時間: 2025-3-23 00:10
Structural Basis for Substrate Recognition and Control in Protein Kinases,ains no genuine eukaryotic protein kinase among its 4,288 genes, although it does contain several histidine kinases as part of the prokaryotic dual response mechanism to environmental factors. The genome of ., a bacterium that exhibits a more complex life style than ., contains 11 protein kinase genes.作者: Ascendancy 時間: 2025-3-23 04:14
The Selectivity of Small Molecules Towards Protein Tyrosine Kinases,es and pharmaceutical and biotechnology companies. Recent crystallographic data on complexes of PTKs with selective and non-selective inhibitors (see below) has opened the door, in principle, to the improvement of rational drug design.作者: Oligarchy 時間: 2025-3-23 07:34 作者: 肥料 時間: 2025-3-23 09:41 作者: Foolproof 時間: 2025-3-23 17:47 作者: 觀點 時間: 2025-3-23 20:18
N. R. Galloway BA, MB, ChB, DO, FRCS, MDimulation. The orderly progression through the cell cycle is critical for the correct transmission of genetic information to subsequent cell generations, and hence for the life and development of all organisms.作者: Inculcate 時間: 2025-3-23 22:41
N. R. Galloway BA, MB, ChB, DO, FRCS, MDying the regulation of normal growth and dysregulation of malignant growth. Major scientific breakthroughs — the discovery of oncogenes, tumour suppressor genes, mechanisms of angiogenesis, and apoptosis — have occurred during the last two to three decades, but these have not led to any major progress in cancer treatment.作者: Schlemms-Canal 時間: 2025-3-24 04:26 作者: 發(fā)源 時間: 2025-3-24 09:21
Elements of Signal Transduction in Drug Discovery with Special Reference to Inhibitors of Protein Kying the regulation of normal growth and dysregulation of malignant growth. Major scientific breakthroughs — the discovery of oncogenes, tumour suppressor genes, mechanisms of angiogenesis, and apoptosis — have occurred during the last two to three decades, but these have not led to any major progress in cancer treatment.作者: avarice 時間: 2025-3-24 13:43 作者: 樣式 時間: 2025-3-24 17:09
,The Berlin “Protein Structure Factory” Initiative: A Technology-Oriented Approach to Structural Gen0; Oliver 2000; Pandey and Mann 2000; Roberts et al. 2000; Uetz et al. 2000) need to be developed and are, indeed, being developed in order to complement the vast amount of genomic information with the corresponding data pertaining to the gene products and their interactions.作者: 針葉樹 時間: 2025-3-24 19:35 作者: 滔滔不絕的人 時間: 2025-3-24 23:17
0947-6075 dimensional protein structures. This structural information is being ex- plored in various ways in the drug discovery process. It is not only used in structure978-3-662-04647-0978-3-662-04645-6Series ISSN 0947-6075 作者: SPECT 時間: 2025-3-25 05:22 作者: 蛤肉 時間: 2025-3-25 07:49 作者: 聯想記憶 時間: 2025-3-25 15:17 作者: 哀悼 時間: 2025-3-25 16:07 作者: 字形刻痕 時間: 2025-3-25 23:54
Structural Basis for Substrate Recognition and Control in Protein Kinases,yrosine residues results in a number of different responses that include activation of enzyme activity, inhibition of enzyme activity, protein/protein recognition and association, protein/protein dissociation, and sub-cellular targeting. Consistent with their key roles in cellular signalling process作者: INCUR 時間: 2025-3-26 00:35
The Selectivity of Small Molecules Towards Protein Tyrosine Kinases,oteins inolved in human cancers. Enhanced PTK activity is also implicated in nonmalignant proliferative diseases, such as psoriasis, papilloma, re-stenosis, and pulmonary fibrosis. These findings have led to an enormous surge over the past decade in studies aimed at targeting PTKs for drug developme作者: 同步信息 時間: 2025-3-26 08:02
Elements of Signal Transduction in Drug Discovery with Special Reference to Inhibitors of Protein Kmortality as a whole has remained almost unchanged during the last two decades despite enormous worldwide efforts. This is particularly surprising in view of the tremendous progress that has been achieved during the last 20–25 years with regard to our understanding of the molecular mechanisms underl作者: 廢墟 時間: 2025-3-26 09:24
,The Berlin “Protein Structure Factory” Initiative: A Technology-Oriented Approach to Structural Genement of a “working draft” of the human genome sequence (Macilwaine 2000). This major publicity event followed closely completion of the DNA sequencing of the two smallest human chromosomes (Dunham et al. 1999; Hattori et al. 2000). In addition, a rapidly growing number of DNA sequences representing作者: shrill 時間: 2025-3-26 16:24 作者: linear 時間: 2025-3-26 17:37 作者: caldron 時間: 2025-3-26 21:25 作者: BARGE 時間: 2025-3-27 04:56 作者: 摻假 時間: 2025-3-27 07:04 作者: 乳白光 時間: 2025-3-27 10:03 作者: Graphite 時間: 2025-3-27 16:58 作者: Mortal 時間: 2025-3-27 19:44
N. R. Galloway BA, MB, ChB, DO, FRCS, MDives from its environment. Such signals come from direct interactions between receptors in the plasma membrane and components in the extracellular matrix or on other cells, as well as from interactions between cellular receptors and soluble growth regulatory factors. Several growth stimulatory facto作者: 小爭吵 時間: 2025-3-27 23:26
N. R. Galloway BA, MB, ChB, DO, FRCS, MDgated to the two daughter cells. S and M phases are separated by two so-called “gap” phases, G1 (prior to S) and G2 (prior to M), respectively. Non-proliferating cells are considered to be in a separate state, referred to as Go, from where they can be prompted to enter the cell cycle by mitogenic st作者: 鉤針織物 時間: 2025-3-28 03:35
N. R. Galloway BA, MB, ChB, DO, FRCS, MDyrosine residues results in a number of different responses that include activation of enzyme activity, inhibition of enzyme activity, protein/protein recognition and association, protein/protein dissociation, and sub-cellular targeting. Consistent with their key roles in cellular signalling process作者: resilience 時間: 2025-3-28 06:39 作者: 使出神 時間: 2025-3-28 12:11 作者: hankering 時間: 2025-3-28 16:25
Basic Anatomy and Physiology of the Eyeement of a “working draft” of the human genome sequence (Macilwaine 2000). This major publicity event followed closely completion of the DNA sequencing of the two smallest human chromosomes (Dunham et al. 1999; Hattori et al. 2000). In addition, a rapidly growing number of DNA sequences representing作者: 急性 時間: 2025-3-28 19:59
Common Eye Diseases and their Management was accompanied by generally high expectations. It was soon realised, however, that de novo drug design was very difficult, and the focus changed to assisting lead optimisation through highly interactive modelling activities. The value of experimental determination of binding modes was recognised a作者: 喃喃訴苦 時間: 2025-3-28 23:39
https://doi.org/10.1007/978-3-319-32869-0 and developmental and apoptotic signals. External and internal cellular signals lead to the activation of transcription factors, which bind to sequence-specific DNA-response elements and stimulate transcription using their .-activating regions to recruit RNA polymerase to the start site of transcri作者: 一個姐姐 時間: 2025-3-29 06:29 作者: 楓樹 時間: 2025-3-29 07:27 作者: Daily-Value 時間: 2025-3-29 12:36 作者: 罵人有污點 時間: 2025-3-29 15:48
