標題: Titlebook: DNA Repair in Cancer Therapy; Lawrence C. Panasci,Moulay A. Alaoui-Jamali Book 2004 Springer Science+Business Media New York 2004 BRCA.DNA [打印本頁] 作者: calcification 時間: 2025-3-21 19:29
書目名稱DNA Repair in Cancer Therapy影響因子(影響力)
書目名稱DNA Repair in Cancer Therapy影響因子(影響力)學科排名
書目名稱DNA Repair in Cancer Therapy網(wǎng)絡公開度
書目名稱DNA Repair in Cancer Therapy網(wǎng)絡公開度學科排名
書目名稱DNA Repair in Cancer Therapy被引頻次
書目名稱DNA Repair in Cancer Therapy被引頻次學科排名
書目名稱DNA Repair in Cancer Therapy年度引用
書目名稱DNA Repair in Cancer Therapy年度引用學科排名
書目名稱DNA Repair in Cancer Therapy讀者反饋
書目名稱DNA Repair in Cancer Therapy讀者反饋學科排名
作者: 火光在搖曳 時間: 2025-3-22 00:17
Role of Nonhomologous End-Joining and Recombinational DNA Repair in Resistance to Nitrogen Mustard sported by carrier-mediated systems into cells and alkylate DNA, RNA, and proteins .. Alkylation of DNA and, more specifically, the formation of DNA interstrand crosslinks have been considered to be responsible for their cytotoxicity .. Resistance to the nitrogen mustards in murine and human tumor c作者: Palliation 時間: 2025-3-22 00:48
Repair of DNA Interstrand Crosslinks Produced by Cancer Chemotherapeutic Drugs,uch as the nitrogen mustards .. DNA was later identified as a target for these drugs ., and the covalent modification of DNA almost certainly accounts for the antitumor activity of these drugs (1). The fact that a bifunctional covalent reaction with DNA (crosslinking) is essential for the toxicity o作者: 靈敏 時間: 2025-3-22 08:18
Chemosensitization to Platinum-Based Anticancer Drugs,ad, neck, and lung. Cisplatin shows considerable efficacy in the treatment of testicular cancers with cure rates of greater than 90% .. Despite its remarkable success in the treatment of cancer, its efficacy is limited by acquired or intrinsic resistance, and the mechanisms underlying chemoresistanc作者: 舉止粗野的人 時間: 2025-3-22 12:20
Regulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumoregregation. This protective mechanism is essential for maintaining genomic integrity and stability, cell viability, and prevention of mutations. The drugs used in the treatment of human malignancies are invariably genotoxic, and their effectiveness is limited by a variety of factors. The most import作者: 機械 時間: 2025-3-22 14:22
Stress-Activated Signal Transduction Pathways in DNA Damage Response, cells develop an impressive arsenal of constitutive and/or inducible DNA-damage response mechanisms, which can deregulate the cell cycle checkpoints and DNA repair and allow cells to escape from apoptotic cell death.作者: 機械 時間: 2025-3-22 20:40
Overcoming Resistance to Alkylating Agents by Inhibitors of ,,-Alkylguanine-DNA Alkyltransferase,or these agents and the correct repair of DNA damage provides protection from them .. Virtually every DNA repair pathway is able to interact with one or more facets of alkylation damage. Alkylated bases are repaired via base excision repair (BER), nucleotide excision repair (NER), and direct reversa作者: Calibrate 時間: 2025-3-23 00:14 作者: ADJ 時間: 2025-3-23 02:18
Potential Role of PARP Inhibitors in Cancer Treatment and Cell Death,c integrity (reviewed in refs. . and .). DNA damage induces a 10- to 500-fold increase in PARP-1 activity, which causes a drastic lowering of the cellular NAD. content. PARP-1 binds to DNA strand breaks and hydrolyzes NAD. to synthesize poly(ADP-ribose) chains (pADPr) on nuclear protein substrates, 作者: Ballerina 時間: 2025-3-23 08:21
Relationship Among DNA Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normlinically determined tolerance of the normal tissues in the radiation field .. The optimization of XRT treatment plans involves the computation of two factors for a given dose prescription: the tumor control probability (TCP) and the normal tissue complication probability (NTCP). The therapeutic out作者: cutlery 時間: 2025-3-23 12:41
Strand-Break Repair and Radiation Resistance, of the 20th century, new research and technical developments were achieved. A new three-dimensional (3D) treatment optimization technology became available. In addition new biological principles are better understood for application in the area of clinical radiation oncology.作者: 忍耐 時間: 2025-3-23 15:11
V(D)J Recombination and DNA Double-Strand-Break Repair, against infection. Adaptive immune responses also play a crucial role in defense against pathogens and depend on the generation of a vast repertoire of soluble and membrane-bound antigen receptors expressed on B- and T-lymphocytes respectively. The variable regions of the Immunoglobulin (Ig) and th作者: agonist 時間: 2025-3-23 18:33 作者: Diaphragm 時間: 2025-3-23 23:05 作者: 幼稚 時間: 2025-3-24 04:00
Genetic Variations in DNA Repair, types of DNA damage. The six major repair pathways are base excision repair (BER), direct reversal of damage, mismatch excision repair (MMR), nucleotide excision repair (NER), homologous recombination (HR), and nonhomologous end-joining (NHEJ). Over 130 human DNA repair genes have been reported, an作者: Locale 時間: 2025-3-24 10:36
https://doi.org/10.1007/978-1-59259-735-2BRCA; DNA; apoptosis; cancer treatment; cell; cell death; clinical trial; prevention; radiotherapy; tumor; tum作者: insurrection 時間: 2025-3-24 14:12
978-1-61737-480-7Springer Science+Business Media New York 2004作者: constitutional 時間: 2025-3-24 17:41
DNA Repair in Cancer Therapy978-1-59259-735-2Series ISSN 2196-9906 Series E-ISSN 2196-9914 作者: Interlocking 時間: 2025-3-24 21:22
Win–Win and Sharing World of Economics Body cells develop an impressive arsenal of constitutive and/or inducible DNA-damage response mechanisms, which can deregulate the cell cycle checkpoints and DNA repair and allow cells to escape from apoptotic cell death.作者: syring 時間: 2025-3-25 03:09
https://doi.org/10.1007/978-1-4471-1729-2 of the 20th century, new research and technical developments were achieved. A new three-dimensional (3D) treatment optimization technology became available. In addition new biological principles are better understood for application in the area of clinical radiation oncology.作者: Pelago 時間: 2025-3-25 04:32
Producing the Categories of Being: The e first antitumor drug used in clinical practice half a century ago. These compounds can bind to a variety of cellular structures such as membranes, RNA, proteins, and DNA. It is, however, the ability to form DNA interstrand crosslinks that appears to be the most important event with regard to their作者: 平躺 時間: 2025-3-25 09:05 作者: CRUMB 時間: 2025-3-25 12:55 作者: Promotion 時間: 2025-3-25 17:08
DX-Like Ternary/Pair-Map Microcosmad, neck, and lung. Cisplatin shows considerable efficacy in the treatment of testicular cancers with cure rates of greater than 90% .. Despite its remarkable success in the treatment of cancer, its efficacy is limited by acquired or intrinsic resistance, and the mechanisms underlying chemoresistanc作者: 逗它小傻瓜 時間: 2025-3-25 22:25 作者: 遭遇 時間: 2025-3-26 01:54
Win–Win and Sharing World of Economics Body cells develop an impressive arsenal of constitutive and/or inducible DNA-damage response mechanisms, which can deregulate the cell cycle checkpoints and DNA repair and allow cells to escape from apoptotic cell death.作者: 柔軟 時間: 2025-3-26 04:53
Nano × Intangible Body with Relativityor these agents and the correct repair of DNA damage provides protection from them .. Virtually every DNA repair pathway is able to interact with one or more facets of alkylation damage. Alkylated bases are repaired via base excision repair (BER), nucleotide excision repair (NER), and direct reversa作者: 果核 時間: 2025-3-26 12:21
An Anatomy of Wittgenstein’s Picture Theoryisomers differing only in the terminal amine moiety (. Fig. 1), and the most abundant form is bleomycin-A2 .. By the late sixties, substantial evidence had accumulated showing that bleomycin can diminish the growth of experimentally induced tumors in mice and rats and dramatically decrease the size 作者: 嘮叨 時間: 2025-3-26 13:42
Marcin Gabryel,Leszek Rutkowskic integrity (reviewed in refs. . and .). DNA damage induces a 10- to 500-fold increase in PARP-1 activity, which causes a drastic lowering of the cellular NAD. content. PARP-1 binds to DNA strand breaks and hydrolyzes NAD. to synthesize poly(ADP-ribose) chains (pADPr) on nuclear protein substrates, 作者: 仲裁者 時間: 2025-3-26 19:01 作者: originality 時間: 2025-3-27 00:33 作者: ensemble 時間: 2025-3-27 03:46
Tacit Knowledge, Rule-following and Learning against infection. Adaptive immune responses also play a crucial role in defense against pathogens and depend on the generation of a vast repertoire of soluble and membrane-bound antigen receptors expressed on B- and T-lymphocytes respectively. The variable regions of the Immunoglobulin (Ig) and th作者: 商議 時間: 2025-3-27 07:36
https://doi.org/10.1007/978-1-4471-1729-2tudy of relatively obscure genetic diseases, which include cancer predisposition. One hallmark of these diseases is genomic instability. Indeed, it is the characteristic of genomic instability that has given rise to the notion that such instability is a forerunner of cancer and, in fact, is a basic 作者: brassy 時間: 2025-3-27 10:25 作者: GEON 時間: 2025-3-27 14:46
Artificial Animals for Computer Animation types of DNA damage. The six major repair pathways are base excision repair (BER), direct reversal of damage, mismatch excision repair (MMR), nucleotide excision repair (NER), homologous recombination (HR), and nonhomologous end-joining (NHEJ). Over 130 human DNA repair genes have been reported, an作者: CONE 時間: 2025-3-27 18:56 作者: MORT 時間: 2025-3-28 00:14
Strand-Break Repair and Radiation Resistance, of the 20th century, new research and technical developments were achieved. A new three-dimensional (3D) treatment optimization technology became available. In addition new biological principles are better understood for application in the area of clinical radiation oncology.作者: 追逐 時間: 2025-3-28 02:21
Lawrence C. Panasci,Moulay A. Alaoui-JamaliIncludes supplementary material: 作者: coagulate 時間: 2025-3-28 08:27 作者: 消息靈通 時間: 2025-3-28 10:32
2196-9906 linical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Als作者: 大酒杯 時間: 2025-3-28 18:01 作者: 百科全書 時間: 2025-3-28 20:11 作者: 類人猿 時間: 2025-3-29 00:15 作者: 雪上輕舟飛過 時間: 2025-3-29 05:12
Tacit Knowledge, Rule-following and Learningngements, termed V(D)J recombination, the only known form of site-specific DNA rearrangement in vertebrates. This assembly process is highly conserved throughout evolution and present in most of the vertebrates analyzed so far.作者: meditation 時間: 2025-3-29 10:31
https://doi.org/10.1007/978-1-4471-1729-2s that the molecules under normal circumstances in their wild-type state could prove to be targets of modern molecular chemotherapy. Ironically, the very molecular basis of this hypersensitivity can, in the end, be a cause of acquisition of clinical resistance.作者: 沙草紙 時間: 2025-3-29 14:45 作者: Ardent 時間: 2025-3-29 16:45
V(D)J Recombination and DNA Double-Strand-Break Repair,ngements, termed V(D)J recombination, the only known form of site-specific DNA rearrangement in vertebrates. This assembly process is highly conserved throughout evolution and present in most of the vertebrates analyzed so far.作者: 地名表 時間: 2025-3-29 23:02
Inherited Disorders of Genomic Instability and Cancer Susceptibility,s that the molecules under normal circumstances in their wild-type state could prove to be targets of modern molecular chemotherapy. Ironically, the very molecular basis of this hypersensitivity can, in the end, be a cause of acquisition of clinical resistance.作者: Harpoon 時間: 2025-3-30 02:10 作者: insurgent 時間: 2025-3-30 07:22
Book 2004ncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.作者: ARBOR 時間: 2025-3-30 08:24 作者: NORM 時間: 2025-3-30 13:34
DX-Like Ternary/Pair-Map MicrocosmA (interstrand), or between a base on DNA and a reactive group on a protein (DNA—protein). For the bifunctional alkylating drugs, it now seems clear that the interstrand crosslink (ICL) is the critical lesion作者: –scent 時間: 2025-3-30 18:24
