標(biāo)題: Titlebook: Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism; Aparajita Dey Book 2013 Springer Science+Business Media Dordrecht 2013 Cytoc [打印本頁(yè)] 作者: 相似 時(shí)間: 2025-3-21 16:21
書(shū)目名稱Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism影響因子(影響力)
書(shū)目名稱Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism影響因子(影響力)學(xué)科排名
書(shū)目名稱Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism被引頻次
書(shū)目名稱Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism被引頻次學(xué)科排名
書(shū)目名稱Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism年度引用
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書(shū)目名稱Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism讀者反饋
書(shū)目名稱Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism讀者反饋學(xué)科排名
作者: 謊言 時(shí)間: 2025-3-21 23:01
S. A. M. Dhaese,V. Stove,J. J. De Waeletral pathways by which ethanol generates oxidative stress. CYP2E1 can be induced by ethanol and several low molecular weight chemicals such as pyrazole. The chapter discusses biochemical and toxicological effects of CYP2E1 and the effects of Nrf2 in modulating these actions of CYP2E1.Besides ethanol作者: 火光在搖曳 時(shí)間: 2025-3-22 01:09 作者: fabricate 時(shí)間: 2025-3-22 07:57
B. M. Tang,V. Herwanto,A. S. McLeanenerates hydroxyethyl radicals which promote ethanol hepatotoxicity. Greater induction of CYP2E1 and hence greater liver injury occurs with co-administration of ethanol and drugs. Induction of CYP2E1 leads to prominent epigenetic effects and CYP2E1 polymorphism may be associated with alcoholic liver作者: ETCH 時(shí)間: 2025-3-22 11:41 作者: CARE 時(shí)間: 2025-3-22 14:48 作者: CARE 時(shí)間: 2025-3-22 17:17 作者: 身體萌芽 時(shí)間: 2025-3-22 23:38 作者: 隱士 時(shí)間: 2025-3-23 04:35 作者: Aerophagia 時(shí)間: 2025-3-23 07:49
Subcellular Biochemistryhttp://image.papertrans.cn/d/image/242614.jpg作者: 切掉 時(shí)間: 2025-3-23 10:24 作者: AER 時(shí)間: 2025-3-23 16:51 作者: Resection 時(shí)間: 2025-3-23 19:44
Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism978-94-007-5881-0Series ISSN 0306-0225 Series E-ISSN 2542-8810 作者: 戲服 時(shí)間: 2025-3-24 01:41
0306-0225 pplementary material: The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associate作者: 冷淡一切 時(shí)間: 2025-3-24 03:05
B. M. Tang,V. Herwanto,A. S. McLeantration of ethanol and drugs. Induction of CYP2E1 leads to prominent epigenetic effects and CYP2E1 polymorphism may be associated with alcoholic liver disease. These are some aspects of CYP2E1, amongst many others which account for its importance in the context of drug metabolism and disease development and have been reviewed in the chapter.作者: 秘密會(huì)議 時(shí)間: 2025-3-24 08:41
A. De Jong,D. Verzilli,S. Jaber presentation, and macromolecular degradation, all of which are crucial to liver cell function and viability. Here, we describe our own and other published work relevant to the importance of CYP2E1-catalyzed ethanol oxidation and how this catalysis affects the aforementioned cellular processes to produce liver injury.作者: gangrene 時(shí)間: 2025-3-24 11:25
P. Formenti,M. Brioni,D. ChiumelloYP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions. This chapter focuses on the discussion of CYP2E1 in ethanol metabolism in the CNS, covering topics including how it is regulated, where it is expressed and how it influences sensitivity to ethanol in the brain.作者: 注意力集中 時(shí)間: 2025-3-24 17:27 作者: linguistics 時(shí)間: 2025-3-24 20:44
The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous System,YP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions. This chapter focuses on the discussion of CYP2E1 in ethanol metabolism in the CNS, covering topics including how it is regulated, where it is expressed and how it influences sensitivity to ethanol in the brain.作者: 系列 時(shí)間: 2025-3-25 02:18
Book 2013al for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty l作者: periodontitis 時(shí)間: 2025-3-25 05:18
Cytochrome P450 2E1: Its Clinical Aspects and a Brief Perspective on the Current Research Scenario, modulation of drug efficacy. Studies involving these interesting facets of CYP2E1 have been discussed in the chapter focusing on the recent observations or ongoing studies illustrating the crucial role of CYP2E1 in disease development and drug metabolism.作者: mendacity 時(shí)間: 2025-3-25 09:35
The Importance of CYP2E1 in the Pathogenesis of Alcoholic Liver Disease and Drug Toxicity and the Rtration of ethanol and drugs. Induction of CYP2E1 leads to prominent epigenetic effects and CYP2E1 polymorphism may be associated with alcoholic liver disease. These are some aspects of CYP2E1, amongst many others which account for its importance in the context of drug metabolism and disease development and have been reviewed in the chapter.作者: Nomadic 時(shí)間: 2025-3-25 12:15
A. Hall,L. W. Busse,M. Ostermann modulation of drug efficacy. Studies involving these interesting facets of CYP2E1 have been discussed in the chapter focusing on the recent observations or ongoing studies illustrating the crucial role of CYP2E1 in disease development and drug metabolism.作者: Arresting 時(shí)間: 2025-3-25 16:24
Book 2013bolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.作者: debase 時(shí)間: 2025-3-25 20:04
S. A. M. Dhaese,V. Stove,J. J. De Waeled could be prevented by antioxidants and potentiated if glutathione (GSH) was removed. The E47 cells had higher GSH levels and a Twofold increase in catalase, cytosolic and microsomal glutathione transferase, and heme oxygenase-1 (HO-1) than control HepG2 cells due to activation of their respective 作者: 使迷醉 時(shí)間: 2025-3-26 01:36
B. Hamilton,L. B. Ware,M. A. Matthayin diets and in tobacco smoke to their carcinogenic metabolites. Among these, nitrosamines seem to be the most important carcinogens. CYP2E1 also degrades retinoic acid and retinol to polar metabolites. Metabolism of retinoic acid not only results in the loss of retinoic acid promoting carcinogenesi作者: 王得到 時(shí)間: 2025-3-26 05:00
P. Formenti,M. Brioni,D. Chiumelloignificance was not achieved because of small sample sizes. Some more indirect data also suggests a relationship between high CYP2E1 activity and progression to NASH. However, three recent genome-wide association studies on NAFLD have failed to find any evidence that single nucleotide polymorphisms 作者: modest 時(shí)間: 2025-3-26 09:16 作者: corpuscle 時(shí)間: 2025-3-26 15:05 作者: CHAR 時(shí)間: 2025-3-26 20:37
Nrf2 and Antioxidant Defense Against CYP2E1 Toxicity,d could be prevented by antioxidants and potentiated if glutathione (GSH) was removed. The E47 cells had higher GSH levels and a Twofold increase in catalase, cytosolic and microsomal glutathione transferase, and heme oxygenase-1 (HO-1) than control HepG2 cells due to activation of their respective 作者: 調(diào)味品 時(shí)間: 2025-3-27 00:41 作者: engagement 時(shí)間: 2025-3-27 03:46
Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease,ignificance was not achieved because of small sample sizes. Some more indirect data also suggests a relationship between high CYP2E1 activity and progression to NASH. However, three recent genome-wide association studies on NAFLD have failed to find any evidence that single nucleotide polymorphisms 作者: Fulminate 時(shí)間: 2025-3-27 08:15 作者: deface 時(shí)間: 2025-3-27 10:50 作者: 嚴(yán)厲批評(píng) 時(shí)間: 2025-3-27 16:16 作者: 辮子帶來(lái)幫助 時(shí)間: 2025-3-27 19:27 作者: 下級(jí) 時(shí)間: 2025-3-27 23:51
The Role of Cytochrome P450 2E1 in Ethanol-Mediated Carcinogenesis,ch an induction in the mucosa of the small intestine and the colon. The overall induction of CYP2E1 shows interindividual variations and occurs already following a daily ingestion of 40 g of ethanol after 1 week. CYP2E1 induction is associated with an increased metabolism of ethanol resulting in the作者: 語(yǔ)源學(xué) 時(shí)間: 2025-3-28 05:27 作者: 內(nèi)部 時(shí)間: 2025-3-28 09:40
Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease,. Increased hepatic expression of CYP2E1, which carries out omega hydroxylation of fatty acids, was first shown in a mouse model of NASH and this was later also reported for human NASH, though not all studies agree with this finding and further larger studies are still needed. In view of its role in作者: 大范圍流行 時(shí)間: 2025-3-28 11:48 作者: nettle 時(shí)間: 2025-3-28 17:11
CYP2E1, Oxidative Stress, Post-translational Modifications and Lipid Metabolism,apo J, resulting in defective VLDL assembly and intracellular lipid and lipoprotein transport, which in turn is responsible for alcoholic hepatosteatosis and ALD. The mechanism of ethanol action involves thedepletion of a unique RNA binding protein that specifically interacts with its 3′-UTR region 作者: Indebted 時(shí)間: 2025-3-28 21:37
The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous System,, and the reinforcement or aversion of alcohol consumption. Acetaldehyde (the direct metabolite of ethanol oxidation) contributes to many aspects of the behavioral effects of ethanol. Given acetaldehyde cannot pass through the blood brain barrier, its concentration in the CNS is primarily determined作者: 喚起 時(shí)間: 2025-3-29 01:50
The Use of Nude Mice to Ascertain the Malignant Capacity of Human Colon Cancerathymic, nude mice. Many of these lines produced lung metastases after intravenous injection (experimental metastasis) and subcutaneous injection (spontaneous metastasis) into nude mice; however, the most dramatic expression of metastatic behavior was obtained after the injection of tumor cells into作者: anus928 時(shí)間: 2025-3-29 04:24 作者: 闖入 時(shí)間: 2025-3-29 08:03
Die Heiz- und Lüftungsanlagen in den verschiedenen Geb?udearteneinschlie?lich Warmw
