標(biāo)題: Titlebook: Cyclin Dependent Kinase (CDK) Inhibitors; Peter K. Vogt,Steven I. Reed Book 1998 The Editor(s) (if applicable) and The Author(s), under ex [打印本頁(yè)] 作者: expenditure 時(shí)間: 2025-3-21 16:40
書目名稱Cyclin Dependent Kinase (CDK) Inhibitors影響因子(影響力)
作者: cacophony 時(shí)間: 2025-3-21 21:18
Cyclin-Dependent Kinase Inhibitors of , and , ,d other cell cycle components. This article summarizes the current state of the literature on four CKI — Pho85, Sicl, Farl, and Rum1 (Table 1) — with a particular emphasis on placing their activities in the perspective of larger cellular processes.作者: 嬰兒 時(shí)間: 2025-3-22 01:19
Percutaneous Access to the Urinary Tract. 1995; . and . 1996), or by the dominant activation of positive-acting components of the cell cycle machinery, such as the cyclins and cyclin-dependent kinases (CDK) or proto-oncogenes (. 1995a, b; . 1995; . and . 1995).作者: Mendacious 時(shí)間: 2025-3-22 06:13 作者: 原始 時(shí)間: 2025-3-22 08:57
0070-217X e collection of review articles on this topic..The book willMore than 10 years ago, the discovery of cyclin-dependent ki- nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 t作者: PLUMP 時(shí)間: 2025-3-22 14:48 作者: PLUMP 時(shí)間: 2025-3-22 20:02
Samuel C. Kim MD,James E. Lingeman MD, FACSof a mouse gene is now widely used to “knock out” any gene of interest to obtain knowledge of its function. This review focuses on the approaches using knockout mice to understand the physiological function of the cyclin-dependent kinase (CDK) inhibitors.作者: Eeg332 時(shí)間: 2025-3-23 00:59
The INK4 Family of CDK Inhibitors, interfere with differentiation, causing a cell to fail to achieve its fully determined state. Potentially more severe consequences could also ensue from uncontrolled cell division. When this is accompanied by a failure of programmed cell death, a cancerous tumor can result.作者: 薄膜 時(shí)間: 2025-3-23 02:51
Roles of Cyclin-Dependent Kinase Inhibitors: Lessons from Knockout Mice,of a mouse gene is now widely used to “knock out” any gene of interest to obtain knowledge of its function. This review focuses on the approaches using knockout mice to understand the physiological function of the cyclin-dependent kinase (CDK) inhibitors.作者: Incorporate 時(shí)間: 2025-3-23 08:25
Wave Harmonics and Guided Wavesd other cell cycle components. This article summarizes the current state of the literature on four CKI — Pho85, Sicl, Farl, and Rum1 (Table 1) — with a particular emphasis on placing their activities in the perspective of larger cellular processes.作者: arthrodesis 時(shí)間: 2025-3-23 10:59 作者: audiologist 時(shí)間: 2025-3-23 15:45
Access, Stents, and Urinary Drainage1 and they are increasing at a rate of up to 25 per week. The p53 field which dates back to 1979 has had some 6000 references on Medline since 1993. This chapter will highlight some of the recent discoveries emphasizing the role of p21 and p53 in growth control and the maintenance of genomic integrity.作者: 食料 時(shí)間: 2025-3-23 19:30 作者: AWL 時(shí)間: 2025-3-24 01:48 作者: urethritis 時(shí)間: 2025-3-24 06:02
Cyclin-Dependent Kinase Inhibitors of , and , ,derstand about eukaryotic cell division derives from studies in these organisms. Cyclin-dependent protein kinase (CDK) inhibitors (CKI), the focus of this volume, were first described in yeast, and yeast is still the best system for dissecting out the complex in vivo relationships between the CKI an作者: judicial 時(shí)間: 2025-3-24 07:06
Inhibitors of the Cip/Kip Family,zed to date, fundamental mysteries remain concerning their biological roles and their regulation. The family, consisting so far of three members, is characterized by a C-terminal Cdk-inhibitory domain with a shared core homology and unrelated C-terminal domains of varying size (. et al. 1995; . et a作者: Canary 時(shí)間: 2025-3-24 13:27 作者: 合適 時(shí)間: 2025-3-24 15:06
Role of Cyclin-Dependent Kinases and Their Inhibitors in Cellular Differentiation and Development,nated manner (. et al. 1995; . and . 1995; . et al. 1996). Various mitogens, growth factors, cytokines, and a host of other agents can perturb the cell cycle machinery eliciting proliferation, differentiation, or apoptosis (. et al. 1994; . 1994). Any permanent alteration of the cell cycle-regulator作者: 情節(jié)劇 時(shí)間: 2025-3-24 19:47
Roles of Cyclin-Dependent Kinase Inhibitors: Lessons from Knockout Mice,ng to the development of sophisticated vector systems, in combination with the establishment of mouse embryonic stem (ES) cells, targeted mutagenesis of a mouse gene is now widely used to “knock out” any gene of interest to obtain knowledge of its function. This review focuses on the approaches usin作者: neuron 時(shí)間: 2025-3-24 23:58 作者: anthesis 時(shí)間: 2025-3-25 07:12
Cyclin-Dependent Kinase Inhibitors and Human Cancer,ves cells through mitosis and DNA replication. Elimination of CDK inhibitor activity, by mutation for instance, should release CDKs from this form of regulation and remove one of the restraints on cell growth.作者: Ingenuity 時(shí)間: 2025-3-25 09:21
Small-Molecule Inhibitors of Cyclin-Dependent Kinases: Molecular Tools and Potential Therapeutics,61, binding of a cyclin) and inhibitory ones (phosphorylation of T14, Y15, binding of a protein inhibitor, and ubiquitin-mediated proteolysis of the cyclin subunit). All represent potential points of intervention for the design of small-molecule inhibitors. Thus, in theory, it will be possible to id作者: 制造 時(shí)間: 2025-3-25 12:12 作者: Melanocytes 時(shí)間: 2025-3-25 17:32
Book 1998 shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle 作者: 殺蟲劑 時(shí)間: 2025-3-25 21:27 作者: 適宜 時(shí)間: 2025-3-26 02:59
Kazuo Matsuda,Yasuki Kansha,Akira Kishimotoaints, the highest likelihood is that such a small molecule will bind most tightly in small, defined pockets in the target protein, such as the ATP-binding pocket. The potential for disruption of a large protein—protein interface, such as a cyclin—CDK-binding surface, is much lower. It is therefore 作者: 成份 時(shí)間: 2025-3-26 07:02 作者: 橢圓 時(shí)間: 2025-3-26 09:41 作者: Hdl348 時(shí)間: 2025-3-26 15:46
https://doi.org/10.1007/978-3-319-11547-4zed to date, fundamental mysteries remain concerning their biological roles and their regulation. The family, consisting so far of three members, is characterized by a C-terminal Cdk-inhibitory domain with a shared core homology and unrelated C-terminal domains of varying size (. et al. 1995; . et a作者: ETCH 時(shí)間: 2025-3-26 18:07 作者: Magnitude 時(shí)間: 2025-3-26 22:53
Percutaneous Access to the Urinary Tractnated manner (. et al. 1995; . and . 1995; . et al. 1996). Various mitogens, growth factors, cytokines, and a host of other agents can perturb the cell cycle machinery eliciting proliferation, differentiation, or apoptosis (. et al. 1994; . 1994). Any permanent alteration of the cell cycle-regulator作者: Panther 時(shí)間: 2025-3-27 03:22
Samuel C. Kim MD,James E. Lingeman MD, FACSng to the development of sophisticated vector systems, in combination with the establishment of mouse embryonic stem (ES) cells, targeted mutagenesis of a mouse gene is now widely used to “knock out” any gene of interest to obtain knowledge of its function. This review focuses on the approaches usin作者: ventilate 時(shí)間: 2025-3-27 07:34 作者: nascent 時(shí)間: 2025-3-27 11:51 作者: 不發(fā)音 時(shí)間: 2025-3-27 16:03
Kazuo Matsuda,Yasuki Kansha,Akira Kishimoto61, binding of a cyclin) and inhibitory ones (phosphorylation of T14, Y15, binding of a protein inhibitor, and ubiquitin-mediated proteolysis of the cyclin subunit). All represent potential points of intervention for the design of small-molecule inhibitors. Thus, in theory, it will be possible to id作者: V切開 時(shí)間: 2025-3-27 21:49
Cyclin Dependent Kinase (CDK) Inhibitors978-3-642-71941-7Series ISSN 0070-217X Series E-ISSN 2196-9965 作者: 智力高 時(shí)間: 2025-3-27 23:01
Endoscopic Imaging and Instrumentationves cells through mitosis and DNA replication. Elimination of CDK inhibitor activity, by mutation for instance, should release CDKs from this form of regulation and remove one of the restraints on cell growth.作者: 異教徒 時(shí)間: 2025-3-28 04:30 作者: 豎琴 時(shí)間: 2025-3-28 06:55 作者: Keratectomy 時(shí)間: 2025-3-28 11:12
https://doi.org/10.1007/978-3-642-71941-7CDK; CKI; Zellzyklus; biochemistry; biology; cancer; cell; cell cycle; cellular differentiation; cellular gro作者: Nonthreatening 時(shí)間: 2025-3-28 18:11
978-3-642-71943-1The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE作者: 飛來(lái)飛去真休 時(shí)間: 2025-3-28 18:47 作者: Rotator-Cuff 時(shí)間: 2025-3-29 01:01
Die elektrische Gasreinigung,ntladung) und sich auf den einzelnen Staubteilchen festsetzen, diese von der entgegengesetzt geladenen (positiven) Elektrode, der sog. Abscheide- oder Sammelelektrode abgeschieden werden. Ein Teil des Staubes sinkt auch infolge von Wirbelbildungen oder Zusammenballung zu Boden.
