作者: Glucose 時(shí)間: 2025-3-21 23:22
Methods in Molecular Biologyhttp://image.papertrans.cn/d/image/241990.jpg作者: myelography 時(shí)間: 2025-3-22 01:14
Studies in Systems, Decision and Controlbeyond the traditional “Rule-of-5” chemistry space (Lipinski et al., Adv Drug Deliv Rev. 23(1): 3–25, 1997). An important component of meeting this challenge is to design cyclic peptides with good intestinal permeability. Here we discuss the design principles for intestinal permeability that have be作者: Altitude 時(shí)間: 2025-3-22 05:30
https://doi.org/10.1007/978-3-030-21927-7leading to the defined 3-D orientation of the constituent amino acids (pharmacophore). Although they are attractive candidates for lead discovery owing to the unique conformational features, their peptidic backbone is susceptible to proteolytic cleavage in various biological fluids that compromise t作者: 阻擋 時(shí)間: 2025-3-22 10:18 作者: Offensive 時(shí)間: 2025-3-22 15:43 作者: Offensive 時(shí)間: 2025-3-22 20:32
AC Microgrid Seamless Transitionorated into cyclic peptides (CPs), many primary peptide structures and functions are markedly altered by cyclization. Accordingly, to mimic linear peptide interfaces with cyclic peptides, it can be beneficial to screen combinatorial cyclic peptide libraries. Computational methods have been developed作者: 角斗士 時(shí)間: 2025-3-22 21:19 作者: Hay-Fever 時(shí)間: 2025-3-23 01:41 作者: 浪費(fèi)物質(zhì) 時(shí)間: 2025-3-23 07:27
https://doi.org/10.1007/978-3-319-45735-2se of copper-catalyzed [3?+?2] azide–alkyne cycloaddition (CuAAC), better known as “click reaction” in the design and synthesis of cyclic peptide and cyclic peptidomimetic compounds. The usage of “click chemistry” reactions includes various topics: (a) mimicking peptide bonds; (b) synthesis of order作者: HAUNT 時(shí)間: 2025-3-23 11:26
https://doi.org/10.1007/978-3-319-45735-2tructural features that potentially modulate cellular permeability. Examples range from exclusively peptidic structures like cyclosporin A or phepropeptins to compounds with mostly non-peptidic character, such as telomestatin or largazole. Furthermore, semisynthetic approaches and synthesis platform作者: 熔巖 時(shí)間: 2025-3-23 15:49
https://doi.org/10.1007/978-3-319-21623-2 a result, the majority of existing drugs address only a narrow range of biological targets. In the era of post-genomics, transcriptomics, and proteomics, there is an increasing interest on larger modulators of proteins that can span larger surfaces, access new therapeutic mechanisms of action, and 作者: pulmonary 時(shí)間: 2025-3-23 19:01 作者: 象形文字 時(shí)間: 2025-3-23 22:32 作者: aristocracy 時(shí)間: 2025-3-24 03:54 作者: stress-response 時(shí)間: 2025-3-24 07:17 作者: 財(cái)主 時(shí)間: 2025-3-24 14:01 作者: 顛簸下上 時(shí)間: 2025-3-24 18:35 作者: 逃避系列單詞 時(shí)間: 2025-3-24 20:34
DNA-Encoded Macrocyclic Peptide Library,a macrocyclic DNA-encoded library; how to perform selection, sequencing, and data analysis to identify potential active peptides; and how to synthesize off-DNA peptides to confirm activity. This approach provides an effective tool for pharmaceutical research based on peptides.作者: 慢慢啃 時(shí)間: 2025-3-25 01:56
https://doi.org/10.1007/978-1-4939-9504-2Drug design; Small molecules; Natural product chemistry; Helical peptides; Cell permeability; Protein-pro作者: nutrition 時(shí)間: 2025-3-25 04:03
978-1-4939-9506-6Springer Science+Business Media, LLC, part of Springer Nature 2019作者: 暴發(fā)戶 時(shí)間: 2025-3-25 10:02
Cyclic Peptide Design978-1-4939-9504-2Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: 惡意 時(shí)間: 2025-3-25 15:06 作者: 圍巾 時(shí)間: 2025-3-25 19:35
Digital Sliding-Mode Prediction Controla macrocyclic DNA-encoded library; how to perform selection, sequencing, and data analysis to identify potential active peptides; and how to synthesize off-DNA peptides to confirm activity. This approach provides an effective tool for pharmaceutical research based on peptides.作者: 灰姑娘 時(shí)間: 2025-3-25 23:18 作者: 構(gòu)想 時(shí)間: 2025-3-26 03:47 作者: 終止 時(shí)間: 2025-3-26 04:47
https://doi.org/10.1007/978-3-319-21623-2 scaffolds associated with natural products. Here we describe recent efforts toward identification of novel natural cyclopeptides and macrocycles as well as selected medicinal chemistry strategies to increase drug-like properties or further exploration of their activity.作者: extrovert 時(shí)間: 2025-3-26 09:08
Digital Sliding-Mode Prediction Control the market for the treatment of postpartum hemorrhage. Many other OT analogs with improved pharmacological properties (e.g., barusiban, Antag III) have been identified. These peptides have been tested in clinical trials and/or used as pharmacological tools. In this chapter, the modifications of the作者: 愉快嗎 時(shí)間: 2025-3-26 16:15 作者: abreast 時(shí)間: 2025-3-26 17:14 作者: 撫育 時(shí)間: 2025-3-26 22:27
,Building upon Nature’s Framework: Overview of Key Strategies Toward Increasing Drug-Like Properties scaffolds associated with natural products. Here we describe recent efforts toward identification of novel natural cyclopeptides and macrocycles as well as selected medicinal chemistry strategies to increase drug-like properties or further exploration of their activity.作者: GUILT 時(shí)間: 2025-3-27 04:55
Design of Oxytocin Analogs, the market for the treatment of postpartum hemorrhage. Many other OT analogs with improved pharmacological properties (e.g., barusiban, Antag III) have been identified. These peptides have been tested in clinical trials and/or used as pharmacological tools. In this chapter, the modifications of the作者: granite 時(shí)間: 2025-3-27 08:55
Discovery of Functional Macrocyclic Peptides by Means of the RaPID System,the random non-standard peptide integrated discovery (RaPID) system, has in turn allowed for the simultaneous screening of trillions of macrocyclic peptides against challenging biological targets. The macrocyclization methodologies are chosen depending on the structural and functional characteristic作者: 易碎 時(shí)間: 2025-3-27 10:22 作者: Tonometry 時(shí)間: 2025-3-27 14:49 作者: 上下連貫 時(shí)間: 2025-3-27 20:48 作者: 枯萎將要 時(shí)間: 2025-3-27 23:44 作者: 停止償付 時(shí)間: 2025-3-28 04:47 作者: NEG 時(shí)間: 2025-3-28 10:06 作者: 控制 時(shí)間: 2025-3-28 10:54 作者: Folklore 時(shí)間: 2025-3-28 17:39
Design and Synthetic Strategies for Helical Peptides,” for traditional small molecules. Peptides, emerging as a new therapeutic modality, can efficiently mimic PPIs with their large scaffolds. Natural peptides are flexible and usually have poor serum stability and cell permeability, features that limit their further biological applications. To satisfy作者: 小蟲(chóng) 時(shí)間: 2025-3-28 22:09 作者: GRIPE 時(shí)間: 2025-3-29 00:54
Frontier Between Cyclic Peptides and Macrocycles,tructural features that potentially modulate cellular permeability. Examples range from exclusively peptidic structures like cyclosporin A or phepropeptins to compounds with mostly non-peptidic character, such as telomestatin or largazole. Furthermore, semisynthetic approaches and synthesis platform作者: Promotion 時(shí)間: 2025-3-29 03:49 作者: Ablation 時(shí)間: 2025-3-29 09:33
Design of Oxytocin Analogs,y seven decades. Despite having rather poor drug-like properties, OT is used as a treatment for labor induction, postpartum hemorrhage, and lactation support. The potential use of OT in the treatment of central nervous system (CNS)-related diseases has recently renewed interest in the pharmacology o作者: cogitate 時(shí)間: 2025-3-29 13:25
DNA-Encoded Macrocyclic Peptide Library,a macrocyclic DNA-encoded library; how to perform selection, sequencing, and data analysis to identify potential active peptides; and how to synthesize off-DNA peptides to confirm activity. This approach provides an effective tool for pharmaceutical research based on peptides.作者: Indurate 時(shí)間: 2025-3-29 16:43 作者: 價(jià)值在貶值 時(shí)間: 2025-3-29 22:03 作者: 痛得哭了 時(shí)間: 2025-3-30 00:27 作者: 手工藝品 時(shí)間: 2025-3-30 04:25 作者: DENT 時(shí)間: 2025-3-30 09:33 作者: consolidate 時(shí)間: 2025-3-30 14:17 作者: 磨碎 時(shí)間: 2025-3-30 17:09 作者: 被詛咒的人 時(shí)間: 2025-3-30 23:06
Click Chemistry for Cyclic Peptide Drug Design,cyclic peptidomimetic compounds. The usage of “click chemistry” reactions includes various topics: (a) mimicking peptide bonds; (b) synthesis of ordered structures; (c) ligation of peptidomimetic scaffolds; and most importantly in this chapter (d) cyclization of peptidomimetic scaffolds using the triazole ring as constraint of conformation.作者: 展覽 時(shí)間: 2025-3-31 03:15 作者: Arresting 時(shí)間: 2025-3-31 06:14
Jinghang Lu,Baoze Wei,Xiaochao Hou,Yao Sunon and macrocyclization in order to limit a peptide’s conformational possibilities, to increase its chemical and enzymatic stability, to prolong the time of action, and to increase activity and selectivity toward the receptor.
