標(biāo)題: Titlebook: Conjugation and Deconjugation of Ubiquitin Family Modifiers; Marcus Groettrup Book 2010 Landes Bioscience and Springer Science+Business Me [打印本頁] 作者: 無限 時間: 2025-3-21 18:56
書目名稱Conjugation and Deconjugation of Ubiquitin Family Modifiers影響因子(影響力)
書目名稱Conjugation and Deconjugation of Ubiquitin Family Modifiers影響因子(影響力)學(xué)科排名
書目名稱Conjugation and Deconjugation of Ubiquitin Family Modifiers網(wǎng)絡(luò)公開度
書目名稱Conjugation and Deconjugation of Ubiquitin Family Modifiers網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Conjugation and Deconjugation of Ubiquitin Family Modifiers被引頻次
書目名稱Conjugation and Deconjugation of Ubiquitin Family Modifiers被引頻次學(xué)科排名
書目名稱Conjugation and Deconjugation of Ubiquitin Family Modifiers年度引用
書目名稱Conjugation and Deconjugation of Ubiquitin Family Modifiers年度引用學(xué)科排名
書目名稱Conjugation and Deconjugation of Ubiquitin Family Modifiers讀者反饋
書目名稱Conjugation and Deconjugation of Ubiquitin Family Modifiers讀者反饋學(xué)科排名
作者: isotope 時間: 2025-3-21 22:38
Control of Deneddylation by the COP9 Signalosome,es an intrinsic metalloprotease with a Jab1/Pad1/MPN+ (JAMM) motif responsible for deneddylation..In the present chapter we focus on the CSN-mediated deneddylation and its biological significance. We summarize latest developments on the mechanism of the CSN and its association with supercomplexes. I作者: 紋章 時間: 2025-3-22 01:13 作者: 信條 時間: 2025-3-22 06:08
,Ubiquitin Conjugation and Deconjugation in NF-κB Signaling,itin deconjugation acts as a negative regulatory feedback mechanism that is critically involved in balancing the strength and the duration of the NF-κB response. Moreover, inactivation of deconjugating enzymes can cause sustained NF-κB activity under pathological conditions like chronic inflammation作者: 陰郁 時間: 2025-3-22 09:33
,Functions of Linear Ubiquitin Chains in the NF-κB Pathway,y studied. In this chapter, we will discuss the distinct roles of linear and K63-linked ubiquitin chains in TNF-α mediated NF-κB activation and the future directions for linear ubiquitin chain research.作者: hereditary 時間: 2025-3-22 16:13
Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53,lved in the regulation of p53 ubiquitination but will focus on the enzymes and components of the respective conjugation systems that have been implicated in p53 modification and how the respective modifications (ubiquitin, SUMO-1, NED 8) may impinge on p53 activity.作者: hereditary 時間: 2025-3-22 19:52
Ubiquitylation in the ERAD Pathway,rotein of the endoplasmic reticulum membrane and polyubiquitylation in the cytosol by the ubiquitin-activating, ubiquitin-conjugating and ubiquitin-ligating enzyme machinery..Ubiquitylation is required for different steps of the ER-associated degradation process (ERAD). It facilitates efficient extr作者: 空中 時間: 2025-3-22 23:20 作者: inflame 時間: 2025-3-23 03:39
0306-0225 REGULATION OF CRLs 34 41 34 edd 47 48 S. pombe 49 51 p27 and I by SCF and SCF 57 58 59 60 CTD CTD CTD CTD in Cul5 CTD CTD CTD 60 18978-1-4939-4110-0978-1-4419-6676-6Series ISSN 0306-0225 Series E-ISSN 2542-8810 作者: 殘忍 時間: 2025-3-23 07:19 作者: 凹槽 時間: 2025-3-23 11:54 作者: 豐富 時間: 2025-3-23 16:32
Reorientation and Controversy (1895–1899)biquitination and the different layers of deubiquitinase specificity. The individual deubiquitinase families are discussed with a focus on structure, regulation and specificity features for selected enzymes.作者: Expostulate 時間: 2025-3-23 21:09 作者: 同位素 時間: 2025-3-23 22:13 作者: staging 時間: 2025-3-24 02:28
Reorientation and Controversy (1895–1899)lved in the regulation of p53 ubiquitination but will focus on the enzymes and components of the respective conjugation systems that have been implicated in p53 modification and how the respective modifications (ubiquitin, SUMO-1, NED 8) may impinge on p53 activity.作者: 女歌星 時間: 2025-3-24 09:28 作者: maudtin 時間: 2025-3-24 14:22
https://doi.org/10.1007/978-0-387-75688-2gases that specifically recognize SUMO-modified proteins have been discovered in species ranging from yeasts to humans. This chapter summarizes what is known about these ligases and their role in controlling sumoylated proteins.作者: deface 時間: 2025-3-24 16:46
Conjugation and Deconjugation of Ubiquitin Family Modifiers作者: 天真 時間: 2025-3-24 20:52 作者: Essential 時間: 2025-3-24 23:54
https://doi.org/10.1007/978-0-387-75688-2ty of specific proteases to mediate these cellular events is presented. In addition, we examine cases in which aberrant SUMO protease expression affects normal embryonic development, carcinogenesis and the onset of additional pathophysiological conditions.作者: Blood-Clot 時間: 2025-3-25 03:40
Reorientation and Controversy (1895–1899)stinct ubiquitin ligases and isopeptidases can also mediate ISG15 linkage and deconjugation, respectively. The system is strongly induced by Type I interferons or microbial infections and studies based on gene targeted mice have shown that it plays an important role in antiviral defence.作者: 引起痛苦 時間: 2025-3-25 08:56 作者: Recessive 時間: 2025-3-25 12:57 作者: Abrupt 時間: 2025-3-25 16:47
The In Vivo Functions of Desumoylating Enzymes,ty of specific proteases to mediate these cellular events is presented. In addition, we examine cases in which aberrant SUMO protease expression affects normal embryonic development, carcinogenesis and the onset of additional pathophysiological conditions.作者: Nomadic 時間: 2025-3-25 21:34
In Vivo Functions of Isgylation,stinct ubiquitin ligases and isopeptidases can also mediate ISG15 linkage and deconjugation, respectively. The system is strongly induced by Type I interferons or microbial infections and studies based on gene targeted mice have shown that it plays an important role in antiviral defence.作者: 元音 時間: 2025-3-26 04:01
FAT10,characterized. It turned out that the novel E1 activating enzyme UBA6, which serves as a second E1 for ubiquitin in higher eukaryotes, additionally has the ability to activate FAT10. In this chapter the activation of FAT10 and ubiquitin by UBA6 as well as the role of FAT10 in protein degradation will be discussed.作者: esculent 時間: 2025-3-26 05:01 作者: paradigm 時間: 2025-3-26 11:14
Related Sediments and Industrial Deposits,fic cellular responses. The activity of Ub-receptors is controlled by “coupled monoubiquitination” which provides an efficient switch from an active to an inactive conformation. In this chapter we discuss the molecular basis of the underlying processes of coupled monoubiquitination and their physiological significance.作者: 圍裙 時間: 2025-3-26 13:07 作者: Acquired 時間: 2025-3-26 18:14 作者: 表示向前 時間: 2025-3-26 23:02
Sumo Control,em is controlled. Sumoylation is a highly dynamic regulatory mechanism, involving an energy dependent enzyme cascade for conjugation and another set of enzymes for deconjugation. In this chapter we will highlight the different mechanisms controlling the SUMO system.作者: HAIRY 時間: 2025-3-27 03:50
Organisms Associated with Travertine,hat enable them to modulate the ubiquitylation state of substrates. This chapter introduces the major groups of Cdc48 cofactors and discusses the versatile options of substrate-processing cofactors to control the fate of Cdc48 substrates.作者: 粗語 時間: 2025-3-27 05:49 作者: CORE 時間: 2025-3-27 11:16 作者: peritonitis 時間: 2025-3-27 14:59
Mineralogy and Elemental Composition,charging the cognate carrier protein supporting downstream ligation steps. Therefore, the family of activating enzymes are critical components of cell regulation that have only recently been recognized as important pharmacological targets.作者: 高射炮 時間: 2025-3-27 20:57
https://doi.org/10.1007/978-0-387-75688-2”) to target proteins. In addition, because it is unclear whether or not Pup, like ubiquitin, is recycled or degraded during substrate targeting to the proteasome, we propose methods that may identify Pup deconjugation enzymes (“depupylases”). Finally, we outline future directions for Pup research and anti-tuberculosis drug discovery.作者: acrobat 時間: 2025-3-28 00:28
Activation of Ubiquitin and Ubiquitin-Like Proteins,charging the cognate carrier protein supporting downstream ligation steps. Therefore, the family of activating enzymes are critical components of cell regulation that have only recently been recognized as important pharmacological targets.作者: Minutes 時間: 2025-3-28 03:45 作者: 濕潤 時間: 2025-3-28 07:12
Book 2010 M and k 18 22 23 K M 24 25 K M 26 edd 45 18 27 K M K D 18 25 . 8 10 M 21 28 MECHANISM AND REGULATION OF CRLs 34 41 34 edd 47 48 S. pombe 49 51 p27 and I by SCF and SCF 57 58 59 60 CTD CTD CTD CTD in Cul5 CTD CTD CTD 60 18作者: 冷峻 時間: 2025-3-28 10:48 作者: 愛花花兒憤怒 時間: 2025-3-28 16:43
Regulatory Functions of Ubiquitin and SUMO in DNA Repair Pathways,n and SUMO are particularly important in the control of the DNA damage response network, which coordinates a set of DNA repair pathways and allows cells to cope with different types of genotoxic stress. In this chapter we will illustrate some key functions of ubiquitin and SUMO in the control of selected DNA repair pathways.作者: MURKY 時間: 2025-3-28 22:04
Identification and Validation of ISG15 Target Proteins,mately 15 interferon-induced proteins. This chapter provides an overview of the target identification process and the validation of these targets. We also discuss the limited number of examples where the biochemical effect of ISG15 conjugation on target proteins has been characterized.作者: 不足的東西 時間: 2025-3-29 01:22
Book 2010UFD 4 10 of Cdc48. 18 30 of Ufd2. COFACTORS 47 23 13 47 47 47 72 15 15 and of Spt23 p90. Ufd2 and Cdc48. In C. elegans 74 16 75 75 76 76 Ufd2 25 54 54 7 56 p47 7 7 80 30 30 81 82 82 but and CD3 26 DUB COFACTORS 30 UFD3 OTU1 4 Cdc48 30 4 OLE1. 15 27 87 REFERENCES 30 REGULATION OF UBIQUITIN MONOUBIQUI作者: insular 時間: 2025-3-29 05:26 作者: 糾纏 時間: 2025-3-29 08:22
Control of Ubiquitin Conjugation by Cdc48 and Its Cofactors,olytic pathways. The diverse cellular tasks of Cdc48 are controlled by a large number of cofactors. Substrate-recruiting cofactors mediate the specific recognition of ubiquitylated target proteins, whereas substrate-processing cofactors often exhibit ubiquitin ligase or deubiquitylating activities t作者: insert 時間: 2025-3-29 14:52
Regulation of Ubiquitin Receptors by Coupled Monoubiquitination,eins with Ubiquitin (Ub). Ub-receptors, i.e., effector proteins carrying Ub-binding domains (UBDs), recognize ubiquitinated proteins and trigger specific cellular responses. The activity of Ub-receptors is controlled by “coupled monoubiquitination” which provides an efficient switch from an active t作者: 凈禮 時間: 2025-3-29 16:15
Control of Cullin-Ring Ubiquitin Ligase Activity by Nedd8,nzymes regulate cell biology by conjugating ubiquitin onto target proteins that are involved in a multitude of processes. In most cases this leads to degradation of the target, but in some cases CRL-dependent ubiquitination acts as a switch to activate or repress target function. The ubiquitin ligas作者: UTTER 時間: 2025-3-29 21:48
Control of Deneddylation by the COP9 Signalosome,entiation. One of the best studied crosstalks between Ub family modifiers is the stimulation of ubiquitination by Nedd8 (neural precursor cell expressed developmentally down regulated 8) modification. The neddylation-deneddylation pathway controls the selective ubiquitination of important cellular r作者: Allure 時間: 2025-3-30 00:01 作者: 背叛者 時間: 2025-3-30 05:41
,Ubiquitin Conjugation and Deconjugation in NF-κB Signaling,impact of the covalent protein modifier ubiquitin on signal transduction. The discovery in the early 1990s that degradation of cytosolic NF-κB inhibitors (IκBs) is mediated by the ubiquitin proteasome system (UPS) was the first example for a direct involvement of ubiquitination in cellular signaling作者: 鉆孔 時間: 2025-3-30 09:32 作者: pessimism 時間: 2025-3-30 15:56
Assembly of K11-Linked Ubiquitin Chains by the Anaphase-Promoting Complex,ttached to a substrate. K48-linked ubiquitin chains target proteins for degradation by the 26S proteasome, while those chains connected through K63 regulate intracellular signaling cascades independently of protein degradation. Although all other linkages are detected in cells, their function is not作者: VOC 時間: 2025-3-30 16:37 作者: daredevil 時間: 2025-3-30 23:57 作者: misanthrope 時間: 2025-3-31 01:49
Pupylation,et them for destruction by a bacterial proteasome in a manner akin to ubiquitin in eukaryotes. Despite using a proteasome as the end point for proteolysis, Pup and ubiquitin differ in sequence, structure and method of activation and conjugation to protein substrates. Pup is so far the only known pos作者: maculated 時間: 2025-3-31 06:38 作者: 肉體 時間: 2025-3-31 12:15
The In Vivo Functions of Desumoylating Enzymes,mily. All members of this cysteine protease family express isopeptidase activity to deSUMOylate conjugated cellular protein targets. Here, we discuss how SUMO proteases discriminate amongst the SUMOylated targets based on subcellular localization and conjugated SUMO isoform. Several signal transduct作者: bourgeois 時間: 2025-3-31 16:11
Regulatory Functions of Ubiquitin and SUMO in DNA Repair Pathways,raditionally known as a signal for proteasomal degradation, its nondegradative actions are equally important in the control of cellular key processes. Similarly, the SUMO system primarily acts in a nondegradative manner. Accumulating evidence indicates that these nonproteolytic functions of ubiquiti作者: 弄污 時間: 2025-3-31 18:55 作者: Bouquet 時間: 2025-3-31 22:58
In Vivo Functions of Isgylation, on physiological aspects and the biological relevance of ISG15 conjugation and deconjugation. ISG15 contains two domains with structural similarity to ubiquitin and was the first ubiquitin like modifier (UBL) described. It can be conjugated to protein substrates in a process similar to ubiquitin mo作者: 苦澀 時間: 2025-4-1 01:59 作者: 幻影 時間: 2025-4-1 07:45
FAT10,ts proteins to proteasomal degradation. The covalent linkage of ubiquitin or other ubiquitin-like modifiers (ULM) to specific substrates is achieved by adjoining them to target proteins with an enzyme cascade using three enzymes: E1, E2 and E3. The first enzyme activates the ULM, the second enzyme s作者: Constrain 時間: 2025-4-1 12:44
https://doi.org/10.1007/978-1-4419-6676-6Conjugation; Deconjugation; Groettrup; Modifiers; Ubiquitin; enzymes; regulation作者: hemophilia 時間: 2025-4-1 16:17 作者: 聰明 時間: 2025-4-1 21:04
Mineralogy and Elemental Composition,markably pleiotropic effects on cell function. These posttranslational modifications share a common mechanism comprised of three steps: an activating enzyme to couple ATP hydrolysis to formation of a high-energy intermediate at the carboxyl terminus of ubiquitin or the ubiquitin-like protein, a liga作者: altruism 時間: 2025-4-2 02:41 作者: 跳脫衣舞的人 時間: 2025-4-2 03:54 作者: Carcinogenesis 時間: 2025-4-2 09:39
Chemical Composition of Source Waters,nzymes regulate cell biology by conjugating ubiquitin onto target proteins that are involved in a multitude of processes. In most cases this leads to degradation of the target, but in some cases CRL-dependent ubiquitination acts as a switch to activate or repress target function. The ubiquitin ligas
