標(biāo)題: Titlebook: Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models; Aslak Tveito,Glenn T. Lines Book‘‘‘‘‘‘‘‘ 2016 The [打印本頁] 作者: Neogamist 時(shí)間: 2025-3-21 17:45
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書目名稱Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models被引頻次
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書目名稱Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models年度引用學(xué)科排名
書目名稱Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models讀者反饋
書目名稱Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models讀者反饋學(xué)科排名
作者: Invigorate 時(shí)間: 2025-3-21 23:10
Models of Open and Closed State Blockers,rtial differential equations giving the probability density functions of the open and the closed states. Furthermore, we found analytical solutions of the stationary solutions of the probability density system.作者: 出沒 時(shí)間: 2025-3-22 00:56 作者: 臨時(shí)抱佛腳 時(shí)間: 2025-3-22 08:12 作者: 低三下四之人 時(shí)間: 2025-3-22 10:38 作者: 逗留 時(shí)間: 2025-3-22 14:22 作者: 逗留 時(shí)間: 2025-3-22 19:24 作者: 空氣 時(shí)間: 2025-3-22 22:59 作者: Prostaglandins 時(shí)間: 2025-3-23 04:35 作者: Sigmoidoscopy 時(shí)間: 2025-3-23 09:10
Foundations and Methods of Didactique,nodine receptors (RyRs) and the L-type calcium channels (LCCs). The purpose of the present chapter is to introduce theoretical drugs aimed at repairing the effect of mutations of both the LCCs and RyR channels. Model parameters used throughout this chapter are given in Table?9.1.作者: maintenance 時(shí)間: 2025-3-23 13:22 作者: 真 時(shí)間: 2025-3-23 15:27 作者: 不發(fā)音 時(shí)間: 2025-3-23 20:39
One-Dimensional Calcium Release, control the flow of calcium from the internal stores referred to as the sarcoplasmic reticulum (SR). This process is referred to as the calcium-induced calcium release (CICR) and is of vital importance in the functioning of the heart. A schematic description of the process is given in Fig.?2.1.作者: inflate 時(shí)間: 2025-3-24 01:44
Action Potentials: Summing Up the Effect of Loads of Ion Channels,gle ion channel. The size of a single channel is about 1 nm. Now we address what is going on in a whole cell and it is important to realize that, compared to the single dyad and the single ion channel, the whole cell is huge; a normal ventricular cell is about 30,000?μm. [3], or on the order of 30 million times larger than the single dyad.作者: diathermy 時(shí)間: 2025-3-24 04:26 作者: 填滿 時(shí)間: 2025-3-24 10:16 作者: conifer 時(shí)間: 2025-3-24 13:50
Generalized Systems Governing Probability Density Functions,Huertas and Smith [35]. We will introduce the more compact notation simply by providing a couple of examples. These will, hopefully, clarify how to formulate rather complex models in an expedient manner.作者: Hyaluronic-Acid 時(shí)間: 2025-3-24 15:38
A Prototypical Model of an Ion Channel, the effect of allowing the concentration of the junctional sarcoplasmic reticulum to change and we studied how the overall processes were affected by introducing the transmembrane potential and allowing the L-type calcium channel (LCC) to open and close.作者: 徹底明白 時(shí)間: 2025-3-24 20:22
Book‘‘‘‘‘‘‘‘ 2016ell known Markov models are studied anda systematic approach toincluding the effect of mutations is presented. Lastly, the book shows how to derive the optimal propertiesof a theoretical model of a drug for a given mutation defined in termsof a Markov model..作者: 因無茶而冷淡 時(shí)間: 2025-3-24 23:30
https://doi.org/10.1007/0-306-47211-2Certain mutations impair the ability of the channel to deactivate, which may lead to arrhythmias. We will return to this topic below. Here, it suffices to state that we need to introduce an inactivated state in the prototype model discussed above.作者: 飛鏢 時(shí)間: 2025-3-25 04:24 作者: Countermand 時(shí)間: 2025-3-25 10:35 作者: nascent 時(shí)間: 2025-3-25 13:40
One-Dimensional Calcium Release, channels (LCCs). When these channels are open, calcium flows into a rather small space called the dyadic cleft (often simply referred to as the dyad), leading to a locally increased concentration of Ca. ions. This increased concentration leads to the opening of the ryanodine receptors (RyRs), which作者: Ceremony 時(shí)間: 2025-3-25 16:35
Models of Open and Closed State Blockers,ng release from internal storage to the dyad. We found that this model could be analyzed using Monte Carlo simulations or a system of deterministic partial differential equations giving the probability density functions of the open and the closed states. Furthermore, we found analytical solutions of作者: 打包 時(shí)間: 2025-3-25 22:09 作者: 不自然 時(shí)間: 2025-3-26 00:09
Generalized Systems Governing Probability Density Functions,hat the associated probability density functions are governed by 2 × 2 systems of partial differential equations. When a drug is added to the Markov model, an extra state is introduced associated with either the open or the closed state and we obtain a model for the probability density functions phr作者: sacrum 時(shí)間: 2025-3-26 06:28 作者: 要控制 時(shí)間: 2025-3-26 08:33
A Prototypical Model of an Ion Channel,he development of the concentration of calcium ions in the dyad and kept everything else constant. The interesting part was then to see how the release mechanism of the ryanodine receptor RyR changes the dynamics of the dyad concentration. In particular, we were interested in RyR mutations and their作者: Forage飼料 時(shí)間: 2025-3-26 13:02
Inactivated Ion Channels: Extending the Prototype Model,that the channel is non-conducting, but when the channel is inactivated, it is harder to open again than when the channel is in the closed state. This feature is useful in modeling an action potential. In the action potential of a cardiac cell, the upstroke is driven mainly by the sodium current. Wh作者: 開始發(fā)作 時(shí)間: 2025-3-26 19:43
A Simple Model of the Sodium Channel,hanism that could be either open or closed. A Markov model governed the gating and we derived a system giving the probability density functions of the states involved in the Markov model. We used the probability density approach to compute optimal theoretical drugs and noted that a mutation leading 作者: insightful 時(shí)間: 2025-3-26 22:42
Action Potentials: Summing Up the Effect of Loads of Ion Channels,all parts of a cell. We started by studying the dynamics going on in a single dyad; see Fig.?2.1 The size of one dyad is less than 1/1,000?μm.[3] and we have been concerned with the concentration of calcium ions in this small volume. We have also studied the voltage dynamics in the vicinity of a sin作者: 果仁 時(shí)間: 2025-3-27 04:13
Properties of Probability Density Functions,n be used to gain an understanding of calcium release. We will also show how the characteristics relate to the concepts already introduced and we will discuss how the characteristics vary as functions of the mutation severity index. Finally, we will show how the statistical characterizations can be 作者: spinal-stenosis 時(shí)間: 2025-3-27 06:53
1439-7358 ations is presented. Lastly, the book shows how to derive the optimal propertiesof a theoretical model of a drug for a given mutation defined in termsof a Markov model..978-3-319-80708-9978-3-319-30030-6Series ISSN 1439-7358 Series E-ISSN 2197-7100 作者: 方便 時(shí)間: 2025-3-27 11:08 作者: 盡責(zé) 時(shí)間: 2025-3-27 14:24 作者: Brocas-Area 時(shí)間: 2025-3-27 20:38
Didactical Problems with Decimals,l models often phrased in terms of differential equations. Our aim in these notes is to study such models and show how the effect of drugs can be optimized. More precisely, drugs are represented in terms of a set of parameters and we show how optimal drugs can be characterized by tuning the paramete作者: liposuction 時(shí)間: 2025-3-28 01:24
Problems with Teaching Decimal Numbers, channels (LCCs). When these channels are open, calcium flows into a rather small space called the dyadic cleft (often simply referred to as the dyad), leading to a locally increased concentration of Ca. ions. This increased concentration leads to the opening of the ryanodine receptors (RyRs), which作者: ACRID 時(shí)間: 2025-3-28 04:15
Didactical Problems with Decimals,ng release from internal storage to the dyad. We found that this model could be analyzed using Monte Carlo simulations or a system of deterministic partial differential equations giving the probability density functions of the open and the closed states. Furthermore, we found analytical solutions of作者: Ascribe 時(shí)間: 2025-3-28 08:24
Problems with Teaching Decimal Numbers,c models give results that are hard to interpret and it is therefore common to run many simulations and compute the average, and we have also seen that we can derive models governing the probability density functions. These are powerful tools that provide insight in the processes. In this chapter we作者: 巧思 時(shí)間: 2025-3-28 14:02
https://doi.org/10.1007/0-306-47211-2hat the associated probability density functions are governed by 2 × 2 systems of partial differential equations. When a drug is added to the Markov model, an extra state is introduced associated with either the open or the closed state and we obtain a model for the probability density functions phr作者: 前面 時(shí)間: 2025-3-28 14:37 作者: 阻礙 時(shí)間: 2025-3-28 20:02 作者: cochlea 時(shí)間: 2025-3-28 23:51
https://doi.org/10.1007/0-306-47211-2that the channel is non-conducting, but when the channel is inactivated, it is harder to open again than when the channel is in the closed state. This feature is useful in modeling an action potential. In the action potential of a cardiac cell, the upstroke is driven mainly by the sodium current. Wh作者: Ganglion-Cyst 時(shí)間: 2025-3-29 05:16 作者: 通知 時(shí)間: 2025-3-29 08:06
Atoms and Pointwise Multipliers,all parts of a cell. We started by studying the dynamics going on in a single dyad; see Fig.?2.1 The size of one dyad is less than 1/1,000?μm.[3] and we have been concerned with the concentration of calcium ions in this small volume. We have also studied the voltage dynamics in the vicinity of a sin作者: 出血 時(shí)間: 2025-3-29 12:24
Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models978-3-319-30030-6Series ISSN 1439-7358 Series E-ISSN 2197-7100 作者: 可忽略 時(shí)間: 2025-3-29 18:18 作者: 流浪 時(shí)間: 2025-3-29 20:44
: What Use is it to a Teacher?,Let us briefly recall the difficulty we want to overcome with the theoretical drug. The difficulty is that in the prototypical reaction defined by the Markov model. the rates may change under various mutations. One case that we have focused on in these notes is CO-mutations where the reaction rate from C to O is increased.作者: essential-fats 時(shí)間: 2025-3-30 02:55 作者: entreat 時(shí)間: 2025-3-30 07:25 作者: 性別 時(shí)間: 2025-3-30 09:27 作者: 拱墻 時(shí)間: 2025-3-30 16:17
Two-Dimensional Calcium Release,The essence of calcium-induced calcium release is once more illustrated in Fig.?5.1. This figure is very similar to Fig.?2.1 on page?24 except that the box surrounded by a thin red line is now slightly extended.作者: 寬敞 時(shí)間: 2025-3-30 18:07
Computing Theoretical Drugs in the Two-Dimensional Case,Let us briefly recall the difficulty we want to overcome with the theoretical drug. The difficulty is that in the prototypical reaction defined by the Markov model. the rates may change under various mutations. One case that we have focused on in these notes is CO-mutations where the reaction rate from C to O is increased.
