標題: Titlebook: Computer Simulations of Aggregation of Proteins and Peptides; Mai Suan Li,Andrzej Kloczkowski,Maksim Kouza Book 2022 Springer Science+Busi [打印本頁] 作者: 富裕 時間: 2025-3-21 17:48
書目名稱Computer Simulations of Aggregation of Proteins and Peptides影響因子(影響力)
書目名稱Computer Simulations of Aggregation of Proteins and Peptides影響因子(影響力)學科排名
書目名稱Computer Simulations of Aggregation of Proteins and Peptides網(wǎng)絡(luò)公開度
書目名稱Computer Simulations of Aggregation of Proteins and Peptides網(wǎng)絡(luò)公開度學科排名
書目名稱Computer Simulations of Aggregation of Proteins and Peptides被引頻次
書目名稱Computer Simulations of Aggregation of Proteins and Peptides被引頻次學科排名
書目名稱Computer Simulations of Aggregation of Proteins and Peptides年度引用
書目名稱Computer Simulations of Aggregation of Proteins and Peptides年度引用學科排名
書目名稱Computer Simulations of Aggregation of Proteins and Peptides讀者反饋
書目名稱Computer Simulations of Aggregation of Proteins and Peptides讀者反饋學科排名
作者: 微不足道 時間: 2025-3-21 21:11 作者: 平庸的人或物 時間: 2025-3-22 04:00 作者: nepotism 時間: 2025-3-22 07:48
The Role of the National Cancer Instituteses that have no effective treatment. Obtaining the structure of related fibrils and toxic oligomers, as well as describing the pathways and main factors that govern the self-organization process, is of paramount importance, but it is also very difficult. To solve this problem, experimental and comp作者: Gullible 時間: 2025-3-22 10:09 作者: 危機 時間: 2025-3-22 16:16
Complementary and Alternative Medicinetamines and polyalanines at various concentrations of the peptides. We also study associations of two chains of α-synuclein and up to 20 chains of a 12-residue-long segment of protein tau. We demonstrate that the total number of two-chain association events (in an aggregate that comprises at least t作者: 危機 時間: 2025-3-22 18:27
The Cell-Kill Paradigm: Bleak Outcomesproteins’ species, e.g., oligomers and fibrils. The formation of these species occurs via self-assemble of the misfolded proteins in a process which is named “aggregation.” It is known that essential divalent metal ions initiate the aggregation of these misfolded proteins, and that specific concentr作者: agnostic 時間: 2025-3-22 23:17
The Cell-Kill Paradigm: Bleak Outcomess. These structures are neurotoxic and are thought to initiate a cascade of events leading to Alzheimer’s disease. Understanding this pathogenetic process and elucidating targets for drug therapy depends on elucidation of the structural dynamics of Aβ assembly. In this chapter, we describe work pack作者: 廢墟 時間: 2025-3-23 04:22 作者: Coordinate 時間: 2025-3-23 06:01 作者: Favorable 時間: 2025-3-23 10:48 作者: 強所 時間: 2025-3-23 16:44
The Conscience of the Autobiographers diseases. The end products of the aggregation process in these diseases are highly structured amyloid fibrils. Though in most cases, small, soluble oligomers formed during amyloid aggregation are the toxic species. A full understanding of the physicochemical forces that drive protein aggregation i作者: 要控制 時間: 2025-3-23 21:37
The Strange New World of the Quantum,from basic staining techniques, allowing visualization of fibers, to complex methods, e.g., AFM-IR used to their detailed biochemical and structural characterization in nanoscale. Which method is appropriate depends on the goal of an experiment: verification of aggregational properties of a peptide,作者: arsenal 時間: 2025-3-24 00:23
https://doi.org/10.1007/978-1-4684-0360-2macromolecules. We draw some dots along the line that starts from the effect of the ionic atmosphere and ends with the chemical bonds formed by multivalent ions acting as bridges between macromolecules. Many of these dots involve structurally disordered peptides and disordered regions of proteins. A作者: Scintigraphy 時間: 2025-3-24 04:01
Ancient Whispers:The Expanding Universe,or their prominent association with neurodegenerative diseases, including Alzheimer’s, Huntington’s, or Parkinson’s diseases. The assembly of amyloid structures is driven by short sequences called amyloid motifs. In many neurodegenerative diseases, intrinsically disordered proteins (IDPs) self-assem作者: Canary 時間: 2025-3-24 07:44
Ancient Whispers:The Expanding Universe,days feasible, and together with atomic force microscopy experiments has widened our understanding of the forces in the regime of pN-nN and system sizes of about hundreds of nanometers. Several methodologies have been developed to achieve this target, and they range from the atomistic representation作者: 激勵 時間: 2025-3-24 11:28 作者: Bone-Scan 時間: 2025-3-24 18:37 作者: construct 時間: 2025-3-24 22:07 作者: aspect 時間: 2025-3-25 00:48 作者: 媽媽不開心 時間: 2025-3-25 04:29 作者: Anthrp 時間: 2025-3-25 09:32
Computer Simulations of Aggregation of Proteins and Peptides978-1-0716-1546-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: Obsequious 時間: 2025-3-25 13:03 作者: BILL 時間: 2025-3-25 19:20
978-1-0716-1548-5Springer Science+Business Media, LLC, part of Springer Nature 2022作者: WATER 時間: 2025-3-25 20:47
Computer Simulations of Aggregation of Proteins and Peptides作者: 不成比例 時間: 2025-3-26 03:15 作者: absolve 時間: 2025-3-26 04:38 作者: Junction 時間: 2025-3-26 11:18
The Conscience of the Autobiographertting up, running, and analyzing MD simulations of aggregating peptides using GROMACS. For the analysis, we provide the scripts that were developed in our lab, which allow to determine the oligomer size and inter-peptide contacts that drive the aggregation process. Moreover, we explain and provide t作者: 雜色 時間: 2025-3-26 14:52 作者: 種屬關(guān)系 時間: 2025-3-26 20:10
https://doi.org/10.1007/978-3-031-24012-6ly validated and benchmarked computational models, macroscopic aggregation properties can be related to the calculated thermodynamic properties at an atomic level. In this chapter, we describe a useful protocol for designing helical αS multimers, especially tetramers, and scanning the peptide–membra作者: Cupidity 時間: 2025-3-27 00:08 作者: Servile 時間: 2025-3-27 01:37 作者: MARS 時間: 2025-3-27 05:42 作者: 兵團 時間: 2025-3-27 10:27
Molecular Dynamics Simulations of Protein Aggregation: Protocols for Simulation Setup and Analysis tting up, running, and analyzing MD simulations of aggregating peptides using GROMACS. For the analysis, we provide the scripts that were developed in our lab, which allow to determine the oligomer size and inter-peptide contacts that drive the aggregation process. Moreover, we explain and provide t作者: 出生 時間: 2025-3-27 14:48 作者: 防銹 時間: 2025-3-27 19:14 作者: neologism 時間: 2025-3-27 23:29 作者: 顯而易見 時間: 2025-3-28 05:53
1064-3745 oting and avoiding known pitfalls...?..Authoritative and cutting-edge,?.Computer Simulations of Aggregation of Proteins and Peptides .aims to ensure successful results in the further study of this vital field..978-1-0716-1548-5978-1-0716-1546-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: 欲望 時間: 2025-3-28 06:45
Book 2022ship between protein misfolding and protein aggregation, methods of prediction of aggregation propensities of protein, peptides, protein structure, results of computer simulations of aggregation, and computational simulations focused on specific diseases such as Alzheimer’s, Parkinson’s, and preecla作者: GRIEF 時間: 2025-3-28 12:27
Advances in Environmental Microbiology. We present the case studies of the three therapeutic proteins, including antibodies, exploring the practical use of the A3D standalone tool. The case studies demonstrate that protein solubility can be easily improved by the A3D prediction of non-destabilizing amino acid mutations at the protein surfaces.作者: Angioplasty 時間: 2025-3-28 16:22
https://doi.org/10.1007/978-3-031-24012-6he rational manipulation of oligomer formation. Additionally, big data and machine learning methods may provide valuable insights to better understand the nature of proteins involved in PD and their aggregative behavior for the betterment of PD treatment.作者: 蔑視 時間: 2025-3-28 22:38 作者: dictator 時間: 2025-3-29 01:01
https://doi.org/10.1007/978-1-4684-0360-2alent ions acting as bridges between macromolecules. Many of these dots involve structurally disordered peptides and disordered regions of proteins. A broad perspective of the role of multivalent ions in assisting the assembly process, shifting population in polymorphic states, and sealing protein aggregates, is suggested.作者: 抗原 時間: 2025-3-29 06:25 作者: 捕鯨魚叉 時間: 2025-3-29 10:20 作者: 消滅 時間: 2025-3-29 11:44 作者: 尖牙 時間: 2025-3-29 16:08 作者: liposuction 時間: 2025-3-29 22:26
The Cell-Kill Paradigm: Bleak Outcomesdue (UNRES) force field developed in our laboratory to study protein aggregation, in both free simulations and simulations of aggregation propagation from an existing template (seed), and illustrate it with the examples of Aβ-peptide aggregation and Aβ-peptide-assisted aggregation of the peptides derived from the repeat domains of tau (TauRD).作者: Calculus 時間: 2025-3-30 00:02 作者: MENT 時間: 2025-3-30 06:02
The Cell-Kill Paradigm: Bleak Outcomess. These packages include density functional theory, Car–Parrinello molecular dynamics simulations, temperature-dependent replica exchange molecular dynamics simulations, disorder predictors based on bioinformatics, and neural network deep learning.作者: 嬉耍 時間: 2025-3-30 11:26
Complementary and Alternative Medicineomputer simulation methods used for aggregation with some atomistic and coarse-grained results aimed at better characterizing the early formed oligomers and amyloid fibril formation. Then we present the applications of non-equilibrium molecular dynamics simulations to comprehend the dissociation of protein assemblies.作者: indifferent 時間: 2025-3-30 15:02
https://doi.org/10.1007/978-94-017-9165-6ods. These methods can overcome a difficulty, in which simulations tend to get trapped in local-minimum free-energy states. Finally we explain the nonequilibrium MD method. Some simulation results based on these methods are also presented.作者: eulogize 時間: 2025-3-30 18:38
The Strange New World of the Quantum,a limiting factor in studies involving amyloids. Moreover, the results obtained by various experimental methods often differ significantly, which may lead to misclassification of amyloid peptides. Due to ambiguity of experimental results, laborious and time-consuming analysis, bioinformatical methods become more widely used for amyloids.作者: arrhythmic 時間: 2025-3-30 23:58 作者: 許可 時間: 2025-3-31 03:11
Probing Protein Aggregation Using the Coarse-Grained UNRES Force Field,due (UNRES) force field developed in our laboratory to study protein aggregation, in both free simulations and simulations of aggregation propagation from an existing template (seed), and illustrate it with the examples of Aβ-peptide aggregation and Aβ-peptide-assisted aggregation of the peptides derived from the repeat domains of tau (TauRD).作者: delta-waves 時間: 2025-3-31 08:11 作者: ADJ 時間: 2025-3-31 09:39 作者: 太空 時間: 2025-3-31 15:10
Computer Simulations Aimed at Exploring Protein Aggregation and Dissociation,omputer simulation methods used for aggregation with some atomistic and coarse-grained results aimed at better characterizing the early formed oligomers and amyloid fibril formation. Then we present the applications of non-equilibrium molecular dynamics simulations to comprehend the dissociation of protein assemblies.作者: CANDY 時間: 2025-3-31 17:55
All-Atom Molecular Dynamics Simulation Methods for the Aggregation of Protein and Peptides: Replicaods. These methods can overcome a difficulty, in which simulations tend to get trapped in local-minimum free-energy states. Finally we explain the nonequilibrium MD method. Some simulation results based on these methods are also presented.作者: 細微差別 時間: 2025-4-1 01:16
Challenges in Experimental Methods,a limiting factor in studies involving amyloids. Moreover, the results obtained by various experimental methods often differ significantly, which may lead to misclassification of amyloid peptides. Due to ambiguity of experimental results, laborious and time-consuming analysis, bioinformatical methods become more widely used for amyloids.作者: elucidate 時間: 2025-4-1 04:40
Book 2022 of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls...?..Authoritative and cutting-edge,?.Computer Simulations of Aggregation of Proteins and Peptides .aims to ensure successful results in the further study of this vital field..作者: 輕快帶來危險 時間: 2025-4-1 07:04
The Role of the National Cancer Institute OPLS, which have been developed for folded and intrinsically disordered proteins, or both. Continuous and discrete coarse-grained models, which were mainly used to study the kinetics of aggregation, are also summarized.作者: 中古 時間: 2025-4-1 12:09 作者: narcissism 時間: 2025-4-1 16:09
Ancient Whispers:The Expanding Universe,ted together with details about parameterization and current limitations. Then, we discuss some of the applications of such methodologies for the description of bacterial filament and β-amyloid systems. Finally, the latest lines of development are discussed.作者: gimmick 時間: 2025-4-1 20:55 作者: Antigen 時間: 2025-4-2 01:41 作者: Frequency-Range 時間: 2025-4-2 06:21
Assessing the Stability of Biological Fibrils by Molecular-Scale Simulations,ted together with details about parameterization and current limitations. Then, we discuss some of the applications of such methodologies for the description of bacterial filament and β-amyloid systems. Finally, the latest lines of development are discussed.
