標(biāo)題: Titlebook: Computational Methods in Systems Biology; 11th International C Ashutosh Gupta,Thomas A. Henzinger Conference proceedings 2013 Springer-Verl [打印本頁(yè)] 作者: Consonant 時(shí)間: 2025-3-21 17:46
書目名稱Computational Methods in Systems Biology影響因子(影響力)
書目名稱Computational Methods in Systems Biology影響因子(影響力)學(xué)科排名
書目名稱Computational Methods in Systems Biology網(wǎng)絡(luò)公開度
書目名稱Computational Methods in Systems Biology網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Computational Methods in Systems Biology被引頻次
書目名稱Computational Methods in Systems Biology被引頻次學(xué)科排名
書目名稱Computational Methods in Systems Biology年度引用
書目名稱Computational Methods in Systems Biology年度引用學(xué)科排名
書目名稱Computational Methods in Systems Biology讀者反饋
書目名稱Computational Methods in Systems Biology讀者反饋學(xué)科排名
作者: choleretic 時(shí)間: 2025-3-21 22:45 作者: 成績(jī)上升 時(shí)間: 2025-3-22 01:12
An Approximate Execution of Rule-Based Multi-level ModelsML-Rules, that allow a compact and concise description of these models. However, the more complex models become the more important is an efficient execution of these models. .-leaping algorithms can speed up the execution of biochemical reaction models significantly by introducing acceptable inaccur作者: 使成核 時(shí)間: 2025-3-22 05:33
Computing Cumulative Rewards Using Fast Adaptive Uniformisation adaptive uniformisation method introduced by Mateescu approximates the probability by neglecting insignificant states, and has proven to be effective for quantitative analysis of stochastic models arising in chemical and biological applications. However, this method has only been formulated for the作者: Lipoma 時(shí)間: 2025-3-22 11:52
Linking Discrete and Stochastic Models: The Chemical Master Equation as a Bridge between Process Hitsometimes to an inhibitive extent. By building bridges in existing models, we can exploit the advantages of each, widening the range of analysis possible for larger, more detailed models of gene regulatory networks. In this paper, we create just such a link between Process Hitting [6,7,8], a recentl作者: canonical 時(shí)間: 2025-3-22 16:40 作者: canonical 時(shí)間: 2025-3-22 20:22
Modelling and Analysis of Phase Variation in Bacterial Colony Growthorming circular colonies on a flat medium. We explore the application of two different geometries, rectangular and circular, for modelling and analysing the colony growth in 2.5 dimensions. Our modelling paradigm is that of coloured stochastic Petri nets and we employ stochastic simulation in order 作者: 對(duì)待 時(shí)間: 2025-3-22 22:21
Using Probabilistic Strategies to Formalize and Compare ,-Synuclein Aggregation and Propagation unden’s disease (PD). To the best of our knowledge, this is the first executable formal model of the propagation of .-syn aggregates through a neural network that is dynamically changing as a consequence of neuronal death. We then define different probabilistic strategies on top of our model to formaliz作者: 破裂 時(shí)間: 2025-3-23 03:18 作者: 類似思想 時(shí)間: 2025-3-23 05:55
Statistical Model Checking Based Calibration and Analysis of Bio-pathway Modelsl-to-cell variability explicitly by using probability distributions to model initial concentrations and kinetic rate values. This implicitly defines a distribution over a set of ODE trajectories, the properties of which are to be characterized. The core component of our framework is an SMC procedure作者: 幻想 時(shí)間: 2025-3-23 10:29
Constraint Programming in Community-Based Gene Regulatory Network Inferenceve posed many challenges to the inference problem. . integrate predictions from individual methods in a “meta predictor”, in order to compose the advantages of different methods and soften individual limitations. This paper proposes a novel methodology to integrate prediction ensembles using Constra作者: In-Situ 時(shí)間: 2025-3-23 15:26
ABC–Fun: A Probabilistic Programming Language for Biologyables the use of elegant analysis tools such as model checking, but usually relies on a complete specification of the model of interest and cannot easily accommodate uncertain data. In contrast, data-driven modelling, based on machine learning techniques, can fit models to available data but their r作者: ferment 時(shí)間: 2025-3-23 18:07
A Temporal Logic Approach to Modular Design of Synthetic Biological Circuitsae. We first show how to characterise with STL formulae the input/output behaviour of biological modules miming the classical logical gates (AND, NOT, OR). Hence, we provide the regions of the parameter space for which these specifications are satisfied. Given a STL specification of the target circu作者: FLING 時(shí)間: 2025-3-23 23:01 作者: WAIL 時(shí)間: 2025-3-24 03:05
On the Hybrid Composition and Simulation of Heterogeneous Biochemical Modelsher deterministic Ordinary Differential Equations, stochastic continuous-time Markov Chains, Petri nets or Boolean transition systems. While the formal composition of reaction models can be syntactically defined as the (multiset) union of the reactions, the hybrid composition of models in different 作者: 真實(shí)的人 時(shí)間: 2025-3-24 07:36
On the Verification and Correction of Large-Scale Kinetic Models in Systems Biologycal kinetics to ensure the plausibility of a model and the positivity of its solution. These criteria include the positivity of the rate functions, their kinetic type dependence on the reactant species concentrations, and the absence of the negative cross-effects that together guarantee the nonnegat作者: Physiatrist 時(shí)間: 2025-3-24 13:01
Context-Sensitive Flow Analyses: A Hierarchy of Model Reductionsone attempts to describe formally the behaviour of the networks, which motivates the use of abstractions to make these models more coarse-grained..Context-insensitive abstractions of the intrinsic flow of information among the sites of chemical complexes through the rules have been proposed to infer作者: 異端邪說2 時(shí)間: 2025-3-24 17:36
Irene Roda,Marco Macchi,Luca Fumagallistructures cause specific challenges. We present a .-leaping algorithm for ML-Rules which tackles these specific challenges and evaluate the efficiency and accuracy of this adapted .-leaping based on a recently developed visual analysis technique.作者: Ambulatory 時(shí)間: 2025-3-24 20:13 作者: 健壯 時(shí)間: 2025-3-24 23:09
Shota Suginouchi,Hajime Mizuyama the subset of the parameter space in which those constraints are satisfied, providing also a measure of the robustness for the target circuit design. This approach, which leverages recent results on the quantitative semantics of Signal Temporal Logic, is illustrated by synthesising a biological implementation of an half-adder.作者: 脆弱帶來 時(shí)間: 2025-3-25 06:50
An Approximate Execution of Rule-Based Multi-level Modelsstructures cause specific challenges. We present a .-leaping algorithm for ML-Rules which tackles these specific challenges and evaluate the efficiency and accuracy of this adapted .-leaping based on a recently developed visual analysis technique.作者: 不規(guī)則 時(shí)間: 2025-3-25 10:35
Constraint Programming in Community-Based Gene Regulatory Network Inferenceon of diverse forms of knowledge. The paper experimentally shows the potential of this method: the addition of biological constraints can offer improvements in the prediction accuracy, and the method shows promising results in assessing biological hypothesis using constraints.作者: Inexorable 時(shí)間: 2025-3-25 11:55
A Temporal Logic Approach to Modular Design of Synthetic Biological Circuits the subset of the parameter space in which those constraints are satisfied, providing also a measure of the robustness for the target circuit design. This approach, which leverages recent results on the quantitative semantics of Signal Temporal Logic, is illustrated by synthesising a biological implementation of an half-adder.作者: 負(fù)擔(dān) 時(shí)間: 2025-3-25 18:37 作者: Accomplish 時(shí)間: 2025-3-25 21:33
Modelling and Analysis of Phase Variation in Bacterial Colony Growthto generate output which is then analysed for sector patterning. The analysis results are used to compare the two geometries, and our multidimensional approach is a precursor to more work on detailed multiscale modelling.作者: Adulate 時(shí)間: 2025-3-26 01:14
Using Probabilistic Strategies to Formalize and Compare ,-Synuclein Aggregation and Propagation undee the aggregation and propagation of .-syn in three different scenarios: (i) in a healthy person, (ii) in a person predisposed to PD, and (iii) in a predisposed person that is given some treatment with rapamycin. We use PSMaude to simulate our model in these different scenarios.作者: 好開玩笑 時(shí)間: 2025-3-26 04:28
Context-Sensitive Flow Analyses: A Hierarchy of Model Reductions sound coarse-graining, providing an efficient way to find macro-variables and the corresponding reduced models. In this paper, we propose a framework to allow the tuning of the context-sensitivity of the information flow analyses and show how these finer analyses can be used to find fewer macro-variables and smaller reduced differential models.作者: 萬靈丹 時(shí)間: 2025-3-26 12:04
Chen-Fu Chien,Yun-Siang Lin,Yu-Shin Taniased model is conducted only on the remaining significant part of the state space. The efficiency and the accuracy of our method are studied through a benchmark model that recently received considerable attention in the literature.作者: POWER 時(shí)間: 2025-3-26 16:01 作者: 脾氣暴躁的人 時(shí)間: 2025-3-26 18:04
Vittal Prabhu,Marco Taisch,Dimitris Kiritsiscrete models without sacrificing the ability to obtain a full space state solution, widening the scope of analysis and interpretation possible. As a demonstration of the utility of this methodology, we have applied it here to the p53-mdm2 network [4,5], a widely studied biological regulatory network.作者: Hypomania 時(shí)間: 2025-3-27 00:19 作者: cardiovascular 時(shí)間: 2025-3-27 04:47
Computing Cumulative Rewards Using Fast Adaptive Uniformisationty of the approach, we integrate the method into the probabilistic model checker PRISM and apply it to a range of biological models, demonstrating superior performance compared to existing techniques.作者: PANG 時(shí)間: 2025-3-27 05:36
Linking Discrete and Stochastic Models: The Chemical Master Equation as a Bridge between Process Hitcrete models without sacrificing the ability to obtain a full space state solution, widening the scope of analysis and interpretation possible. As a demonstration of the utility of this methodology, we have applied it here to the p53-mdm2 network [4,5], a widely studied biological regulatory network.作者: 瑪瑙 時(shí)間: 2025-3-27 10:38 作者: 土坯 時(shí)間: 2025-3-27 15:29
0302-9743 gular papers included in this volume were carefully reviewed and selected from 27 submissions. They deal with computational models for all levels, from molecular and cellular, to organs and entire organisms.978-3-642-40707-9978-3-642-40708-6Series ISSN 0302-9743 Series E-ISSN 1611-3349 作者: Inflamed 時(shí)間: 2025-3-27 19:00
Alessandro Bertoni,Raj Jiten Machchharpopulation as a whole. We discuss how stochastic models of biochemical reaction networks which enable one to study heterogeneous cell populations can be identified from data and how experiments which make this identification as easy as possible can be designed.作者: 手術(shù)刀 時(shí)間: 2025-3-27 22:11
Bojan Lalic,Vidosav Majstorovic,David Romeroto generate output which is then analysed for sector patterning. The analysis results are used to compare the two geometries, and our multidimensional approach is a precursor to more work on detailed multiscale modelling.作者: Neuralgia 時(shí)間: 2025-3-28 03:02
I. Roda,M. Macchi,C. Parmigiani,A. A. Aratae the aggregation and propagation of .-syn in three different scenarios: (i) in a healthy person, (ii) in a person predisposed to PD, and (iii) in a predisposed person that is given some treatment with rapamycin. We use PSMaude to simulate our model in these different scenarios.作者: 大暴雨 時(shí)間: 2025-3-28 08:52 作者: 山羊 時(shí)間: 2025-3-28 14:13
0302-9743 he 11th International Conference on Computational Methods in Systems Biology, CMSB 2013, held in Klosterneuburg, Austria, in September 2013. The 15 regular papers included in this volume were carefully reviewed and selected from 27 submissions. They deal with computational models for all levels, fro作者: 割讓 時(shí)間: 2025-3-28 16:19 作者: 漫不經(jīng)心 時(shí)間: 2025-3-28 20:42 作者: 絕食 時(shí)間: 2025-3-29 01:48 作者: gnarled 時(shí)間: 2025-3-29 04:48 作者: 慢跑鞋 時(shí)間: 2025-3-29 09:28 作者: averse 時(shí)間: 2025-3-29 13:30 作者: 畸形 時(shí)間: 2025-3-29 19:31
On the Verification and Correction of Large-Scale Kinetic Models in Systems Biologyted on biochemical models taken from the Biomodels database. In particular, a set of 11 kinetic models related with . are checked, finding two with deficiencies. Correcting actions for these models are proposed.作者: 樂器演奏者 時(shí)間: 2025-3-29 20:27
Bojan Lalic,Vidosav Majstorovic,David Romeroade of yeast pheromone response signaling. Results demonstrate that the molecules of the MAPK cascade co-localize along scaffold molecules, while the scaffold binds to a plasma membrane bound upstream component, localizing the whole signaling complex to the plasma membrane. Especially we show, how r作者: 混雜人 時(shí)間: 2025-3-30 01:53
Production Internet - Functional Perspectivector (GDNF), which is expressed in the mesenchyme and induces outgrowth of ureteric branches. Considering that the Turing model represents the interaction between the GDNF and its receptor RET very well and that the model reproduces the relevant expression patterns in developing wildtype and mutant 作者: DEFT 時(shí)間: 2025-3-30 08:02
https://doi.org/10.1007/978-3-319-66923-6ocedures. We have evaluated our method on two large pathway models, namely, the segmentation clock network and the thrombin-dependent MLC phosphorylation pathway. The results show that our method scales well and yields good parameter estimates that are robust. Our sensitivity analysis framework lead作者: 異端邪說2 時(shí)間: 2025-3-30 12:08
Geir Ringen,Kjersti ?verb? Schultenguage. We extend the expressivity of an existing probabilistic programming language, Infer.NET Fun, in order to enable inference and simulation of CTMCs. We demonstrate our method on simple test cases, including a more complex model of gene expression. Our results suggest that this is a promising a作者: 不可思議 時(shí)間: 2025-3-30 16:17 作者: antiandrogen 時(shí)間: 2025-3-30 19:06
Retrofit Concept for Textile Productionpiled and simulated in this framework, through the specification of a high-level interface for composing heterogeneous models. This is illustrated by a hybrid stochastic-differential model of bacteriophage T7 infection, and by a reconstruction of the hybrid model of the mammalian cell cycle regulati作者: 諄諄教誨 時(shí)間: 2025-3-31 00:40 作者: Notify 時(shí)間: 2025-3-31 04:17
Alessandro Bertoni,Raj Jiten Machchharical reactions inside the cells. On a higher level, the molecular noise and other stochastic effects can lead to fundamentally different behavior of the cells in a population. As a consequence, average dynamics of a cell population are often not adequate to understand or control the dynamics of the 作者: 離開可分裂 時(shí)間: 2025-3-31 07:12 作者: lanugo 時(shí)間: 2025-3-31 09:23
Irene Roda,Marco Macchi,Luca FumagalliML-Rules, that allow a compact and concise description of these models. However, the more complex models become the more important is an efficient execution of these models. .-leaping algorithms can speed up the execution of biochemical reaction models significantly by introducing acceptable inaccur作者: allude 時(shí)間: 2025-3-31 15:36
Hyun Woo Jeon,Vittaldas V. Prabhu adaptive uniformisation method introduced by Mateescu approximates the probability by neglecting insignificant states, and has proven to be effective for quantitative analysis of stochastic models arising in chemical and biological applications. However, this method has only been formulated for the作者: Narrative 時(shí)間: 2025-3-31 19:04
Vittal Prabhu,Marco Taisch,Dimitris Kiritsissometimes to an inhibitive extent. By building bridges in existing models, we can exploit the advantages of each, widening the range of analysis possible for larger, more detailed models of gene regulatory networks. In this paper, we create just such a link between Process Hitting [6,7,8], a recentl作者: 音樂戲劇 時(shí)間: 2025-4-1 01:07 作者: 魅力 時(shí)間: 2025-4-1 02:45
Bojan Lalic,Vidosav Majstorovic,David Romeroorming circular colonies on a flat medium. We explore the application of two different geometries, rectangular and circular, for modelling and analysing the colony growth in 2.5 dimensions. Our modelling paradigm is that of coloured stochastic Petri nets and we employ stochastic simulation in order 作者: ingenue 時(shí)間: 2025-4-1 07:15
