標題: Titlebook: Chronic Myeloid Leukemia; Methods and Protocol Shaoguang Li,Haojian Zhang Book 2016 Springer Science+Business Media New York 2016 Cancer st [打印本頁] 作者: 添加劑 時間: 2025-3-21 19:22
書目名稱Chronic Myeloid Leukemia影響因子(影響力)
書目名稱Chronic Myeloid Leukemia影響因子(影響力)學科排名
書目名稱Chronic Myeloid Leukemia網(wǎng)絡(luò)公開度
書目名稱Chronic Myeloid Leukemia網(wǎng)絡(luò)公開度學科排名
書目名稱Chronic Myeloid Leukemia被引頻次
書目名稱Chronic Myeloid Leukemia被引頻次學科排名
書目名稱Chronic Myeloid Leukemia年度引用
書目名稱Chronic Myeloid Leukemia年度引用學科排名
書目名稱Chronic Myeloid Leukemia讀者反饋
書目名稱Chronic Myeloid Leukemia讀者反饋學科排名
作者: unstable-angina 時間: 2025-3-21 22:52 作者: 要塞 時間: 2025-3-22 04:27 作者: aspersion 時間: 2025-3-22 05:22 作者: 審問,審訊 時間: 2025-3-22 09:33
An Integrative Analysis of microRNA and mRNA Profiling in CML Stem Cells,involvement of miRNA and their targets in CML stem cells self-renewal, maintenance, and therapeutic resistance. Here, we describe a simplified integrative analysis using Ingenuity Pathway Analysis software after performing proper RNA extraction, miRNA and mRNA microarray and data analysis.作者: HATCH 時間: 2025-3-22 13:10 作者: HATCH 時間: 2025-3-22 20:03
Methods in Molecular Biologyhttp://image.papertrans.cn/c/image/226398.jpg作者: PUT 時間: 2025-3-23 00:33
Ein Zeitalter radikaler Ungewissheittic event in CML. Tyrosine kinase inhibitors (TKIs), such as imatinib, are synthesized small molecules that primarily target BCR-ABL tyrosine kinases and have become a first-line treatment for CML. Detection of BCR-ABL transcript level by real-time quantitative polymerase chain reaction (RQ-PCR) is 作者: crutch 時間: 2025-3-23 01:31
https://doi.org/10.1007/978-3-658-12932-3romosome). Formation of the Ph chromosome is caused by a reciprocal translocation between the chromosomes 9 and 22 t(9;22)(q34;q11), resulting in a fusion protein known as BCR-ABL which has constitutive tyrosine kinase activity and promotes the proliferation of leukemia cells via multiple mechanisms作者: GROG 時間: 2025-3-23 07:10 作者: 博愛家 時間: 2025-3-23 10:42 作者: Cardiac-Output 時間: 2025-3-23 17:43
https://doi.org/10.1007/978-3-531-91124-3 be long-term effective because of CML stem cells’ insensitivity to tyrosine kinase inhibitors. Therefore, studying more about CML stem cells is essential to understand the pathways of CML stem cell development and proliferation and finally lead to effective treatments to eliminate CML stem cells an作者: Optimum 時間: 2025-3-23 21:48 作者: botany 時間: 2025-3-23 23:15
https://doi.org/10.1007/978-3-531-91124-3-phase CML patients are treated with impressive efficacy with TK inhibitors (TKi) such as imatinib mesylate (IM). However, rather than definitively curing CML, TKi induces a state of minimal residual disease, due to the persistence of leukemia stem cells (LSC) which are insensitive to this class of 作者: Gum-Disease 時間: 2025-3-24 04:45 作者: Biomarker 時間: 2025-3-24 06:56 作者: 情感脆弱 時間: 2025-3-24 11:55
https://doi.org/10.1007/978-3-531-91124-3s the genome. The method creates specific signatures at unmethylated and methylated CpG sites by sequential digests of genomic DNA with restriction endonucleases .I and .I, respectively. Both enzymes have the same CCCGGG recognition site; however, they differ in their sensitivity to CpG methylation 作者: Popcorn 時間: 2025-3-24 18:41
https://doi.org/10.1007/978-3-531-91124-3ng Chronic Myeloid Leukemia (CML). This leads to deregulation of transcription that is often causally linked to the tumorigenic state. Chromatin-immunoprecipitation coupled with massively parallel DNA sequencing (ChIP-.) is the key technology to study transcription as it allows in vivo whole-genome 作者: 不利 時間: 2025-3-24 22:06 作者: chalice 時間: 2025-3-25 02:58
https://doi.org/10.1007/978-1-4612-3878-2patient relapse remains a challenge. Acquisition of BCR-ABL mutations is crucial in the resistance but the underlying molecular mechanisms are poorly understood. Here we describe a cell culture model for CML acquired resistance in which blast crisis CML cells undergo initial apoptosis upon treatment作者: POLYP 時間: 2025-3-25 05:39 作者: 情感脆弱 時間: 2025-3-25 10:09 作者: Veneer 時間: 2025-3-25 12:17 作者: 遺傳學 時間: 2025-3-25 17:22
Panja Schweder,Phil C. Langer,Angela Kühnerluable in detecting and characterizing genome-wide miRNAs of either too high or too low abundance. Besides, it can also be used in detecting novel miRNAs. Here, we describe an ab initio analysis of an example chronic myeloid leukemia miRNA sequencing data set to quantify the global expression of miR作者: 熱心 時間: 2025-3-25 21:50
https://doi.org/10.1007/978-3-658-03112-1involvement of miRNA and their targets in CML stem cells self-renewal, maintenance, and therapeutic resistance. Here, we describe a simplified integrative analysis using Ingenuity Pathway Analysis software after performing proper RNA extraction, miRNA and mRNA microarray and data analysis.作者: Geyser 時間: 2025-3-26 03:30 作者: antipsychotic 時間: 2025-3-26 05:53 作者: Palliation 時間: 2025-3-26 12:20
https://doi.org/10.1007/978-3-658-12932-3ogenesis and evaluate therapeutic drugs in the past three decades. Here, we describe the procedures to generate a CML mouse model by introducing . into Lin.Sca1. cKit. population cells purified from mouse bone marrow. In CML retroviral transduction/transplantation mouse models, this modified model can mimic CML pathogenesis on high fidelity.作者: ascetic 時間: 2025-3-26 15:24 作者: 陰謀 時間: 2025-3-26 20:00 作者: CROAK 時間: 2025-3-26 21:58
Book 2016 in the highly successful .Methods in Molecular Biology .series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls...Authori作者: ASSET 時間: 2025-3-27 03:18 作者: 地殼 時間: 2025-3-27 05:26
https://doi.org/10.1007/978-1-4612-3878-2ious models systems, e.g., in cell culture models. In this chapter, we describe in detail immunoprecipitations and quantitative proteomics analysis using stable isotope labeling by amino acids in cell culture (SILAC) of components of the Bcr-Abl signaling pathway in the human CML cell line K562.作者: overrule 時間: 2025-3-27 12:07
https://doi.org/10.1007/978-3-663-12340-8mised mice. Using models such as these will allow researchers to gain valuable insight into the primitive leukemic subtypes that evade current therapy regimes and are critical to understand, in order to eradicate malignancy.作者: 泥沼 時間: 2025-3-27 15:48 作者: 6Applepolish 時間: 2025-3-27 17:56
Quantitative Proteomics Analysis of Leukemia Cells,ious models systems, e.g., in cell culture models. In this chapter, we describe in detail immunoprecipitations and quantitative proteomics analysis using stable isotope labeling by amino acids in cell culture (SILAC) of components of the Bcr-Abl signaling pathway in the human CML cell line K562.作者: 用不完 時間: 2025-3-27 22:31
Biological Analysis of Human CML Stem Cells; Xenograft Model of Chronic Phase Human Chronic Myeloidmised mice. Using models such as these will allow researchers to gain valuable insight into the primitive leukemic subtypes that evade current therapy regimes and are critical to understand, in order to eradicate malignancy.作者: 倔強一點 時間: 2025-3-28 03:15
Single-Cell Cytokine Profiling to Investigate Cellular Functional Diversity in Hematopoietic Malign contribute to lineage reprogramming. Here, we describe of a platform combining subnanoliter microchambers and a high-density antibody barcode array for the study of single-cell cytokine secretions in hematopoietic cancer cell populations.作者: innovation 時間: 2025-3-28 09:35 作者: iodides 時間: 2025-3-28 12:59 作者: 從屬 時間: 2025-3-28 17:48
https://doi.org/10.1007/978-3-531-91124-3igh-quality protein-genome binding maps that have proven especially useful for studying difficult to ‘ChIP’ transcription regulatory factors in Chronic Myeloid Leukemia (CML) and related malignancies.作者: 歌曲 時間: 2025-3-28 21:22 作者: 新鮮 時間: 2025-3-28 23:06 作者: 者變 時間: 2025-3-29 04:42
Book 2016ary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls...Authoritative and cutting-edge, .Chronic Myeloid Leukemia: Methods and Protocols. aims to ensure successful results in the further study of this vital field..作者: Expediency 時間: 2025-3-29 08:06
https://doi.org/10.1007/978-3-531-91124-3 antibody-based probes, has already increased our understanding of the biology of the rare CML LSC population. In the future, the use of this approach may contribute to the development of novel therapeutics aimed at eradicating CML LSCs in CML patients.作者: 乳汁 時間: 2025-3-29 14:01 作者: sebaceous-gland 時間: 2025-3-29 16:14 作者: semiskilled 時間: 2025-3-29 22:14 作者: LANCE 時間: 2025-3-30 03:29
https://doi.org/10.1007/978-3-663-12340-8etailed procedure for performing a high-throughput RNAi screen using a genome-wide human short hairpin RNA (shRNA) library for identifying tyrosine kinase inhibitor (TKI)-resistance genes in a human CML cell line model.作者: INCH 時間: 2025-3-30 04:18 作者: GUEER 時間: 2025-3-30 12:08 作者: 動物 時間: 2025-3-30 13:16
Histological and In Vivo Microscopic Analysis of the Bone Marrow Microenvironment in a Murine Modelcombination with various stainings that can help to understand the complex interaction between leukemic cells, their normal hematopoietic counterparts, and the bone marrow microenvironment. We conclude with describing how to image the bone marrow niche using in vivo microscopy.作者: 觀察 時間: 2025-3-30 18:59 作者: 不適當 時間: 2025-3-30 22:11
A Convenient Cell Culture Model for CML Acquired Resistance Through BCR-ABL Mutations, with therapeutically effective doses of TKIs, but the cells regrow quickly with development of resistance through BCR-ABL mutations. This model mimics the clinical process of acquisition of BCR-ABL mutations and will be an important tool to dissect molecular mechanisms of CML drug resistance and to explore strategies to overcome resistance.作者: 鴕鳥 時間: 2025-3-31 02:18 作者: Employee 時間: 2025-3-31 06:48 作者: 本能 時間: 2025-3-31 12:29
Molecular Detection of BCR-ABL in Chronic Myeloid Leukemia,tic event in CML. Tyrosine kinase inhibitors (TKIs), such as imatinib, are synthesized small molecules that primarily target BCR-ABL tyrosine kinases and have become a first-line treatment for CML. Detection of BCR-ABL transcript level by real-time quantitative polymerase chain reaction (RQ-PCR) is 作者: 偏離 時間: 2025-3-31 15:01 作者: 繁榮中國 時間: 2025-3-31 19:18 作者: TERRA 時間: 2025-3-31 22:54 作者: 推延 時間: 2025-4-1 01:49
