標(biāo)題: Titlebook: Checkpoint Controls and Cancer; Volume 1: Reviews an Axel H. Sch?nthal Book 2004 Humana Press 2004 [打印本頁(yè)] 作者: 選民 時(shí)間: 2025-3-21 18:28
書(shū)目名稱(chēng)Checkpoint Controls and Cancer影響因子(影響力)
書(shū)目名稱(chēng)Checkpoint Controls and Cancer影響因子(影響力)學(xué)科排名
書(shū)目名稱(chēng)Checkpoint Controls and Cancer網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱(chēng)Checkpoint Controls and Cancer網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱(chēng)Checkpoint Controls and Cancer被引頻次
書(shū)目名稱(chēng)Checkpoint Controls and Cancer被引頻次學(xué)科排名
書(shū)目名稱(chēng)Checkpoint Controls and Cancer年度引用
書(shū)目名稱(chēng)Checkpoint Controls and Cancer年度引用學(xué)科排名
書(shū)目名稱(chēng)Checkpoint Controls and Cancer讀者反饋
書(shū)目名稱(chēng)Checkpoint Controls and Cancer讀者反饋學(xué)科排名
作者: maladorit 時(shí)間: 2025-3-21 22:45 作者: 廣告 時(shí)間: 2025-3-22 03:54
Analyzing the Spindle Checkpoint in Yeast and Frogs kinetochore plays an integral role in spindle checkpoint signaling by integrating chromosome attachment to the spindle with cell cycle progression. A single kinetochore can inhibit cell cycle progression in the absence of proper spindle attachment or tension from bipolar orientation. Recent advance作者: 輕觸 時(shí)間: 2025-3-22 08:16 作者: Multiple 時(shí)間: 2025-3-22 09:42 作者: 疏忽 時(shí)間: 2025-3-22 13:06
Analyzing Checkpoint Controls in Human Skinowing exposure to ultraviolet radiation (UVR). This model affords the opportunity to manipulate the growth and nutrient conditions, and to perform detailed biochemical and immunohistochemical analysis of skin cells in their normal epidermal layer microenvironment. The use of this model is described 作者: 疏忽 時(shí)間: 2025-3-22 19:21 作者: 絕種 時(shí)間: 2025-3-22 22:32 作者: 大氣層 時(shí)間: 2025-3-23 04:58 作者: 暗指 時(shí)間: 2025-3-23 09:18
A , Cell-Free System for Functional Analysis of the Chfr Ubiquitin Ligase Involved in Control of Mitee system. We showed that Chfr is a ubiquitin ligase that targets polo-like kinase (Plk1) for degradation, leading to delayed activation of the Cdc25C phosphatase and prolonged inhibitory phosphorylation of Cdc2 at the G2/M transition. In this chapter, we will describe biochemical methods we develop作者: 美色花錢(qián) 時(shí)間: 2025-3-23 09:41
Control of Mitotic Entry After DNA Damage in ,lticellular model organism, ., are described here. These include the collection of embryos and larvae, irradiation with x-rays to damage DNA, and fixing and staining of tissues with an antibody to phosphorylated histone H3 to measure the mitotic index. These methods should be useful in identifying p作者: 文藝 時(shí)間: 2025-3-23 15:03
Methods for Analyzing Checkpoint Responses in ,or elicit programmed cell death (apoptosis) of affected cells. The . germ line was recently established as a model system to study these processes in a genetically tractable, multicellular organism. The utility of this system was revealed by the finding that upon treatment with genotoxic agents, pre作者: Infirm 時(shí)間: 2025-3-23 18:21 作者: Flat-Feet 時(shí)間: 2025-3-24 00:53 作者: Pulmonary-Veins 時(shí)間: 2025-3-24 04:00
Axel H. Sch?nthalIncludes supplementary material: 作者: 刺耳的聲音 時(shí)間: 2025-3-24 06:43
Methods in Molecular Biologyhttp://image.papertrans.cn/c/image/224210.jpg作者: 潔凈 時(shí)間: 2025-3-24 12:02
Analyzing Checkpoint Controls in Human Skinowing exposure to ultraviolet radiation (UVR). This model affords the opportunity to manipulate the growth and nutrient conditions, and to perform detailed biochemical and immunohistochemical analysis of skin cells in their normal epidermal layer microenvironment. The use of this model is described in this chapter.作者: mediocrity 時(shí)間: 2025-3-24 17:51
Checkpoint Controls and Cancer978-1-59259-788-8Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: Nibble 時(shí)間: 2025-3-24 20:05
Cost of Product Development Model,owing exposure to ultraviolet radiation (UVR). This model affords the opportunity to manipulate the growth and nutrient conditions, and to perform detailed biochemical and immunohistochemical analysis of skin cells in their normal epidermal layer microenvironment. The use of this model is described in this chapter.作者: Oratory 時(shí)間: 2025-3-25 00:08
https://doi.org/10.1007/978-1-4302-0580-7n is coordinated with cell growth, while the initiation of DNA synthesis (S phase) is precisely ordered to prevent inappropriate amplification of the DNA that may cause genome instability. To ensure that these fundamental requirements of cell division are met, cells have developed a surveillance mec作者: Bone-Scan 時(shí)間: 2025-3-25 05:38 作者: 小木槌 時(shí)間: 2025-3-25 11:08 作者: 切碎 時(shí)間: 2025-3-25 11:42
The Macro Recorder and Code Modules,important cellular processes required for cell division and the maintenance of cellular homeostasis; they are governed by many extra- and intra-cellular stimuli. Progression of normal cell division depends on cyclin interaction with cyclin-dependent kinases (Cdk) and the degradation of cyclins befor作者: 上腭 時(shí)間: 2025-3-25 16:24 作者: 勤勞 時(shí)間: 2025-3-25 19:58
Cost of Product Development Model,owing exposure to ultraviolet radiation (UVR). This model affords the opportunity to manipulate the growth and nutrient conditions, and to perform detailed biochemical and immunohistochemical analysis of skin cells in their normal epidermal layer microenvironment. The use of this model is described 作者: Neolithic 時(shí)間: 2025-3-26 01:38
Cost of Sales and Marketing Model,. results in recessive embryonic lethality, which obscures the functions of . in breast cancer formation. Cre-loxP-mediated tissue-specific knockout was employed to overcome this obstacle. We found that the presence of a ploxP-.-loxP cassette in intron 10 of . resulted in severe interference with ge作者: exorbitant 時(shí)間: 2025-3-26 06:53
Cost of Goods Sold and Inventory Model,lopment. For example, conventional deletion of . (.), . (.), . (.), . (.), . (.), . (.), . (.), or . (.) leads to developmental arrest prior to gastrulation. While prior to arrest the number of cells extant in these embryos is low, procedures allowing rudimentary analysis of cell cycle checkpoints a作者: 符合你規(guī)定 時(shí)間: 2025-3-26 10:51 作者: Implicit 時(shí)間: 2025-3-26 12:42
Cost of Goods Sold and Inventory Model,ee system. We showed that Chfr is a ubiquitin ligase that targets polo-like kinase (Plk1) for degradation, leading to delayed activation of the Cdc25C phosphatase and prolonged inhibitory phosphorylation of Cdc2 at the G2/M transition. In this chapter, we will describe biochemical methods we develop作者: GILD 時(shí)間: 2025-3-26 19:42
Cost of Goods Sold and Inventory Model,lticellular model organism, ., are described here. These include the collection of embryos and larvae, irradiation with x-rays to damage DNA, and fixing and staining of tissues with an antibody to phosphorylated histone H3 to measure the mitotic index. These methods should be useful in identifying p作者: 障礙 時(shí)間: 2025-3-26 22:42
Statements of Profit and Loss and Cash Flow,or elicit programmed cell death (apoptosis) of affected cells. The . germ line was recently established as a model system to study these processes in a genetically tractable, multicellular organism. The utility of this system was revealed by the finding that upon treatment with genotoxic agents, pre作者: optional 時(shí)間: 2025-3-27 02:20 作者: 大方一點(diǎn) 時(shí)間: 2025-3-27 08:51 作者: AGGER 時(shí)間: 2025-3-27 12:15
1064-3745 , or to monitor mitotic spindle assembly, and to prevent exit from mitosis until chromosome segregation has been completed. Thus, well functioning checkpoint mechanisms are central to the maint978-1-61737-426-5978-1-59259-788-8Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: 等待 時(shí)間: 2025-3-27 15:32
Book 2004 enforced—for example, to ensure that DNA replication is c- plete and occurs only once before cell division, or to monitor mitotic spindle assembly, and to prevent exit from mitosis until chromosome segregation has been completed. Thus, well functioning checkpoint mechanisms are central to the maint作者: Little 時(shí)間: 2025-3-27 20:41
The Macro Recorder and Code Modules, mammalian cells contain damaged DNA, the p53 tumor suppressor and the Rb family of transcriptional repressors work together to downregulate a large number of genes that encode proteins required for G2 and M. Elimination of these essential cell cycle proteins helps to keep the cells arrested in G2.作者: gimmick 時(shí)間: 2025-3-28 01:42
The Macro Recorder and Code Modules,somes to daughter cells. Understanding the checkpoint pathways and genes involved in the cellular response to DNA damage and cell division events in normal and cancer cells, provides information about cancer predisposition, and suggests design of small molecules and other strategies for cancer thera作者: 大量 時(shí)間: 2025-3-28 04:06
Cost of Goods Sold and Inventory Model,g to note that recently developed methods to introduce single-copy transgenes into one-cell zygotes via lentiviruses (.) may provide a means to generate Cre/lox-conditional cell lines from these conventional knockouts.作者: adipose-tissue 時(shí)間: 2025-3-28 06:58
Statements of Profit and Loss and Cash Flow,tosis responses depend on conserved DNA damage checkpoint proteins. Genetics- and genomics-based approaches that have demonstrated roles for conserved checkpoint proteins have also begun to uncover novel components of these response pathways. In this chapter, we will briefly review the . DNA damage 作者: 盤(pán)旋 時(shí)間: 2025-3-28 11:07
Cost of Goods Sold and Inventory Model,s and subsequent purification of any soluble protein from organisms amenable to genetic manipulation, such as yeast, as long as the function of that protein is not perturbed by the addition of an epitope tag.作者: 秘傳 時(shí)間: 2025-3-28 18:24 作者: 收養(yǎng) 時(shí)間: 2025-3-28 22:50
Cell Cycle Checkpoint Control Mechanisms That Can Be Disrupted in Cancersomes to daughter cells. Understanding the checkpoint pathways and genes involved in the cellular response to DNA damage and cell division events in normal and cancer cells, provides information about cancer predisposition, and suggests design of small molecules and other strategies for cancer thera作者: 褲子 時(shí)間: 2025-3-29 00:58
Analysis of Cell Cycle Progression and Genomic Integrity in Early Lethal Knockoutsg to note that recently developed methods to introduce single-copy transgenes into one-cell zygotes via lentiviruses (.) may provide a means to generate Cre/lox-conditional cell lines from these conventional knockouts.作者: PIZZA 時(shí)間: 2025-3-29 03:59
Methods for Analyzing Checkpoint Responses in ,tosis responses depend on conserved DNA damage checkpoint proteins. Genetics- and genomics-based approaches that have demonstrated roles for conserved checkpoint proteins have also begun to uncover novel components of these response pathways. In this chapter, we will briefly review the . DNA damage 作者: 收藏品 時(shí)間: 2025-3-29 08:58 作者: 新字 時(shí)間: 2025-3-29 13:26 作者: Congregate 時(shí)間: 2025-3-29 19:08 作者: Synapse 時(shí)間: 2025-3-29 22:46 作者: cognizant 時(shí)間: 2025-3-30 03:19
Statements of Profit and Loss and Cash Flow,ein kinases and several DNA damage checkpoint signaling pathways that inhibit initiation of DNA replication. We provide protocols to prepare cell-free extracts, DNA templates, protein kinase substrates, and to perform checkpoint assays. In addition, we describe related methods that provide useful readouts of the DNA damage response.作者: 割讓 時(shí)間: 2025-3-30 06:11 作者: Goblet-Cells 時(shí)間: 2025-3-30 10:28
Cost of Goods Sold and Inventory Model,ng and staining of tissues with an antibody to phosphorylated histone H3 to measure the mitotic index. These methods should be useful in identifying potential mutants that are unable to regulate mitosis following DNA damage.作者: d-limonene 時(shí)間: 2025-3-30 15:17
Analyzing the Spindle Checkpoint in Yeast and Frogs single kinetochore can inhibit cell cycle progression in the absence of proper spindle attachment or tension from bipolar orientation. Recent advances have shed light on how the kinetochore measures these situations, transduces a signal, and inhibits the entry into anaphase.作者: Circumscribe 時(shí)間: 2025-3-30 18:45
Establishment of a Cell-Free System to Study the Activation of Chk2eat germ extract in vitro transcription/translation system is inactive and can be activated by incubating with a rabbit reticulocyte lysate. This method will be useful for identification of cofactors required for activation of Chk2.
