作者: 懶惰民族 時(shí)間: 2025-3-21 23:22
Critical steps in cellular fatty acid uptake and utilization,an organs are still incompletely understood. In non-fenestratred organs such as heart and skeletal muscle, membrane barriers for blood-borne FA are the luminal and abluminal membranes of endothelial cells, the sarcolemma and the mitochondrial membranes. Transport of FA through the phospholipid bilay作者: Femine 時(shí)間: 2025-3-22 03:46 作者: Glossy 時(shí)間: 2025-3-22 07:45 作者: 錯(cuò)事 時(shí)間: 2025-3-22 10:29 作者: Crater 時(shí)間: 2025-3-22 15:57
Insights into binding of fatty acids by fatty acid binding proteins,eal distinct binding preferences with regard to ligand structure and conformation, when binding is assessed by the Lipidex method (removal of unbound ligand by hydrophobic polymer) or by isothermal titration calorimetry, a true equilibrium method. Subfamily proteins bind retinoids, subfamily II prot作者: Crater 時(shí)間: 2025-3-22 19:14
,The effect of charge reversal mutations in the α-helical region of liver fatty acid binding proteins. LFABP is able to bind long chain fatty acids with a 2:1 stoichiometry and the crystal structure has identified two fatty acid binding sites in the binding cavity. The presumed primary site (site 1 ) involves the fatty acid binding with the carboxylate group buried in the cavity whereas the fatty 作者: acetylcholine 時(shí)間: 2025-3-22 23:26 作者: MANIA 時(shí)間: 2025-3-23 02:15
Evolution of the family of intracellular lipid binding proteins in vertebrates,g-chain fatty acids and retinoids. iLBPs are low molecular mass proteins (14–16 kDa) sharing a common structural fold. The iLBP family likely arose through duplication and diversification of an ancestral iLBP gene. Phylogenetic analysis undertaken in the present study indicates that the ancestral iL作者: 鞏固 時(shí)間: 2025-3-23 06:22 作者: 不能約 時(shí)間: 2025-3-23 13:33
Analysis on the phenotype of E-FABP-gene knockout mice,eu of the cornified cell layer in the epidermis. In view of this importance in the skin, we examined the phenotype of epidermal fatty acid binding protein (E-FABP)-deficient mice. In spite of total lack of E-FABP expression in the various tissues of E-FABP deficient mice, these animals appeared norm作者: 提名 時(shí)間: 2025-3-23 17:14
Sterol carrier protein-2: Not just for cholesterol any more,hese cells, a potential role for SCP-2 in fatty acid uptake and trafficking has not been appreciated. Certainly, recent experiments have shown that SCP-2 binds fatty acids . with an affinity similar to that observed for fatty acid binding proteins. Because of the ubiquitous tissue distribution of SC作者: 墻壁 時(shí)間: 2025-3-23 19:51 作者: 向外 時(shí)間: 2025-3-24 01:37 作者: 賞錢(qián) 時(shí)間: 2025-3-24 04:04
Alternative lipid mobilization: The insect shuttle system, to energy generation for sustained locomotion in mammals, the work accomplished by non-stop flight activity is powered by oxidation of free fatty acids (FFA) derived from endogenous reserves of triacylglycerol. The transport form of the lipid, however, is diacylglycerol (DAG), which is delivered to作者: 顛簸地移動(dòng) 時(shí)間: 2025-3-24 10:07
Giant membrane vesicles as a model to study cellular substrate uptake dissected from metabolism,iver, skeletal muscle and adipose tissue. We investigated which cell types and which plasma membrane regions are involved in giant vesicle formation and we examined the presence of transporters for metabolic substrates. Analysis of giant vesicles with markers specific for distinct cell types and dis作者: Ancillary 時(shí)間: 2025-3-24 12:06
Peroxisome proliferator-activated receptors: Lipid binding proteins controling gene expression,g of the nineties the three isoforms (PPARα, β/δ and γ, encoded by different genes) have been implicated in the regulation of almost every single aspect of lipid metabolism and, consequently, in diseases that involve disturbances in lipid metabolism (obesity, diabetes, atherosclerosis, cardiac failu作者: 戲法 時(shí)間: 2025-3-24 17:27
New insights into the fatty acid-binding protein (FABP) family in the small intestine, acids (LCFAs), bile acids (BAs) or retinoids. In the small intestine, three different FABP isoforms exhibiting a high affinity for LCFAs and/or BAs are expressed: the intestinal and the liver-type (I-FABP and L-FABP) and the ileal bile acid-binding protein (I-BABP). Despite of extensive investigati作者: 厚顏 時(shí)間: 2025-3-24 22:09 作者: 歌劇等 時(shí)間: 2025-3-25 01:32 作者: Lumbar-Stenosis 時(shí)間: 2025-3-25 05:38 作者: Ccu106 時(shí)間: 2025-3-25 08:08
Similar mechanisms of fatty acid transfer from human anal rodent fatty acid-binding proteins to memase of human IFABP, both the Ala.and Thr. forms were examined. The results show clearly that for all FABPs examined, the mechanisms of ligand transfer observed for rodent proteins hold true for their human counterparts. Moreover, it appears that the Ala to Thr substitution at residue 54 of the human作者: insomnia 時(shí)間: 2025-3-25 12:47
Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of the’ membrane. Membrane-active FABPs catalyze dissociation of the fatty acid from the donor membrane and binding to the acceptor membrane, while membrane-inactive FABPs catalyze diffusion of fatty acids across the aqueous cytosol. Thus, FABPs catalyze all three steps in intracellular transport. A simpl作者: FOVEA 時(shí)間: 2025-3-25 16:41
Insights into binding of fatty acids by fatty acid binding proteins,ty acids. The ADIFAB-method is a fluorescent test for fatty acid in equilibrium with iLBP and reveals some correlation of binding affinity to fatty acid solubility in the aqueous phase; these data are often at variance with those obtained by the other methods. Thus, in this review published binding 作者: Peak-Bone-Mass 時(shí)間: 2025-3-25 23:33 作者: 健壯 時(shí)間: 2025-3-26 00:55
Solution structure of fatty acid-binding protein from human brain,d with docosahexaenoic acid [12] reveals only minor differences in both secondary structure and overall topology. Moreover, the NMR data indicate a close structural relationship between human B-FABP and heart-type FABP with respect to fatty acid binding inside the protein cavity. (Mol Cell Biochem .作者: Motilin 時(shí)間: 2025-3-26 04:55
Evolution of the family of intracellular lipid binding proteins in vertebrates,plasmic trafficking of distinct ligands. It is speculated that recruitment of an iLBP during evolution of animals enabled the mitochondrial oxidation of long-chain fatty acids. (Mol Cell Biochem .: 69–77, 2002)作者: 輕率的你 時(shí)間: 2025-3-26 10:57 作者: Overstate 時(shí)間: 2025-3-26 14:26 作者: debris 時(shí)間: 2025-3-26 17:11 作者: CANT 時(shí)間: 2025-3-27 00:36 作者: 實(shí)施生效 時(shí)間: 2025-3-27 01:50
Alternative lipid mobilization: The insect shuttle system,rgy generation. The depletion of DAG from LDLp results in the recovery of both HDLp and apoLp-III, which are reutilized for another cycle of DAG transport. Areceptor for HDLp, identified as a novel member of the vertebrate low-density lipoprotein (LDL) receptor family, does not seem to be involved i作者: ESPY 時(shí)間: 2025-3-27 08:21
Giant membrane vesicles as a model to study cellular substrate uptake dissected from metabolism,ain vesicular lumen consisting of the soluble constituents of the cytoplasm including, fatty-acid binding proteins. Furthermore, giant vesicles isolated from heart, liver, skeletal muscle and adipose tissue are similar in size (10–15 μm) and shape and do not contain subcellular organelles, providing作者: aerobic 時(shí)間: 2025-3-27 10:37
Peroxisome proliferator-activated receptors: Lipid binding proteins controling gene expression,urally occurring lipid-like substances acting as low-affinity ligands. More recently this concept has been confirmed by crystallographic studies on the ligand-binding pocket. In addition to ligand availability, the trans-activating capacity likely depends on phosphorylation status of the PPARs and o作者: MINT 時(shí)間: 2025-3-27 14:54
New insights into the fatty acid-binding protein (FABP) family in the small intestine, the small intestine supporting a specialization, it is likely that L-FABP and I-BABP genes exert the same type of basic function(s) in the enterocyte, in contrast to I-FABP. (Mol Cell Biochem .: 139–147, 2002)作者: 內(nèi)部 時(shí)間: 2025-3-27 18:58
Book 2002lecular and Cellular Biochemistry. comprises selected papers based on the lectures and posters presented during the 4th conference, and provides insight into the significance of these proteins for the functioning of the cell.作者: Daily-Value 時(shí)間: 2025-3-28 01:57
sue of .Molecular and Cellular Biochemistry. comprises selected papers based on the lectures and posters presented during the 4th conference, and provides insight into the significance of these proteins for the functioning of the cell.978-1-4613-4868-9978-1-4419-9270-3作者: GNAW 時(shí)間: 2025-3-28 05:55
Alexandra Sturm,Ilga Opterbeck,Jochen Gurt (L-FABP.) functions in long-term, ligand-induced regulation of gene expression by directly interacting with nuclear receptors. Therefore, the properties of the lipid-protein complex, rather than those of the lipid ligand itself, determine the fate of the ligand in the cell. Finally, there are an in作者: 投射 時(shí)間: 2025-3-28 06:17 作者: Hallowed 時(shí)間: 2025-3-28 12:18
Entwickeln eines Führungssystemsase of human IFABP, both the Ala.and Thr. forms were examined. The results show clearly that for all FABPs examined, the mechanisms of ligand transfer observed for rodent proteins hold true for their human counterparts. Moreover, it appears that the Ala to Thr substitution at residue 54 of the human作者: 刺耳 時(shí)間: 2025-3-28 16:50
Organisationsentwicklung konkret’ membrane. Membrane-active FABPs catalyze dissociation of the fatty acid from the donor membrane and binding to the acceptor membrane, while membrane-inactive FABPs catalyze diffusion of fatty acids across the aqueous cytosol. Thus, FABPs catalyze all three steps in intracellular transport. A simpl作者: 排他 時(shí)間: 2025-3-28 22:37 作者: EVEN 時(shí)間: 2025-3-29 01:31 作者: 項(xiàng)目 時(shí)間: 2025-3-29 04:57
Organisationstheoretische Modelle,d with docosahexaenoic acid [12] reveals only minor differences in both secondary structure and overall topology. Moreover, the NMR data indicate a close structural relationship between human B-FABP and heart-type FABP with respect to fatty acid binding inside the protein cavity. (Mol Cell Biochem .作者: 花爭(zhēng)吵 時(shí)間: 2025-3-29 08:12
Entwicklung der Organisationstheorie,plasmic trafficking of distinct ligands. It is speculated that recruitment of an iLBP during evolution of animals enabled the mitochondrial oxidation of long-chain fatty acids. (Mol Cell Biochem .: 69–77, 2002)作者: Fortify 時(shí)間: 2025-3-29 13:46 作者: Functional 時(shí)間: 2025-3-29 16:18 作者: Anticoagulants 時(shí)間: 2025-3-29 22:08 作者: AER 時(shí)間: 2025-3-30 00:30 作者: Talkative 時(shí)間: 2025-3-30 05:00 作者: Estrogen 時(shí)間: 2025-3-30 10:30 作者: arthroscopy 時(shí)間: 2025-3-30 12:49
https://doi.org/10.1007/978-3-531-93298-9urally occurring lipid-like substances acting as low-affinity ligands. More recently this concept has been confirmed by crystallographic studies on the ligand-binding pocket. In addition to ligand availability, the trans-activating capacity likely depends on phosphorylation status of the PPARs and o作者: 寄生蟲(chóng) 時(shí)間: 2025-3-30 18:56
https://doi.org/10.1007/978-3-531-93298-9 the small intestine supporting a specialization, it is likely that L-FABP and I-BABP genes exert the same type of basic function(s) in the enterocyte, in contrast to I-FABP. (Mol Cell Biochem .: 139–147, 2002)作者: LARK 時(shí)間: 2025-3-30 23:41
Alexandra Sturm,Ilga Opterbeck,Jochen Gurtatty acid-binding proteins putatively function in protein-mediated transmembrane transport of fatty acids, likely coexisting with passive diffusional uptake. The intracellular trafficking of fatty acids, bile acids, and other lipid ligands, may involve their interaction with specific membrane or pro作者: 閃光東本 時(shí)間: 2025-3-31 01:27 作者: 多山 時(shí)間: 2025-3-31 05:10
Entwickeln eines Führungssystems can be controlled at the plasma membrane of a typical cell. Is there a protein that acts as gatekeeper, regulating the amount, and possibly the type, of fatty acid that can enter the cell for metabolism? Is the lipid bilayer of the membrane highly permeable to fatty acids, and is the rate of simple作者: 排名真古怪 時(shí)間: 2025-3-31 12:48 作者: Expurgate 時(shí)間: 2025-3-31 15:11
Organisationsentwicklung konkretcific functions remain unclear. Two classes have been described. Membrane-active FABPs interact directly with membranes during exchange of fatty acids between the protein binding site and the membrane, while membrane-inactive FABPs bind only to fatty acids that are already in aqueous solution. Despi作者: 流出 時(shí)間: 2025-3-31 18:56 作者: 曲解 時(shí)間: 2025-4-1 01:25 作者: 寒冷 時(shí)間: 2025-4-1 02:36
Organisationstheoretische Modelle, in solution using high-resolution NMR spectroscopy. The sequential assignments of the .H and .N resonances were achieved by applying multidimensional homo- and heteronuclear NMR experiments. The ensemble of the 20 final energy-minimized structures, representing human B-FABP in solution, have been c作者: Metastasis 時(shí)間: 2025-4-1 08:13 作者: 花束 時(shí)間: 2025-4-1 13:23 作者: Hirsutism 時(shí)間: 2025-4-1 14:23 作者: gratify 時(shí)間: 2025-4-1 20:50
