標(biāo)題: Titlebook: Cell Cycle Inhibitors in Cancer Therapy; Current Strategies Antonio Giordano,Kenneth J. Soprano Book 2003 Springer Science+Business Media N [打印本頁] 作者: negation 時(shí)間: 2025-3-21 16:39
書目名稱Cell Cycle Inhibitors in Cancer Therapy影響因子(影響力)
書目名稱Cell Cycle Inhibitors in Cancer Therapy影響因子(影響力)學(xué)科排名
書目名稱Cell Cycle Inhibitors in Cancer Therapy網(wǎng)絡(luò)公開度
書目名稱Cell Cycle Inhibitors in Cancer Therapy網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Cell Cycle Inhibitors in Cancer Therapy被引頻次
書目名稱Cell Cycle Inhibitors in Cancer Therapy被引頻次學(xué)科排名
書目名稱Cell Cycle Inhibitors in Cancer Therapy年度引用
書目名稱Cell Cycle Inhibitors in Cancer Therapy年度引用學(xué)科排名
書目名稱Cell Cycle Inhibitors in Cancer Therapy讀者反饋
書目名稱Cell Cycle Inhibitors in Cancer Therapy讀者反饋學(xué)科排名
作者: Congruous 時(shí)間: 2025-3-21 22:03
CDK Inhibitors as Targets of Chemoprevention Agents,many chemopreventive agents spans a diverse range of cellular functions such as, inhibition of ras oncogene, epidermal growth factor receptor (EGFR), angiogenesis, and many more .for the purposes of this chapter, we are going to focus on agents that target components involved in cell proliferation a作者: Pander 時(shí)間: 2025-3-22 03:19
Cell Cycle Regulatory Genes as Targets of Retinoids,g cell proliferation, abnormal differentiation, and inflammation. 11-cis-retinal is the chromophore in the visual protein, rhodopsin. With the exception of vision and reproduction, all of the action of vitamin A can be accomplished by retinoic acid. 9-cis and 13-cis RA are natural isomers of all-. R作者: 褻瀆 時(shí)間: 2025-3-22 08:23 作者: 粗魯?shù)娜?nbsp; 時(shí)間: 2025-3-22 12:08 作者: 災(zāi)禍 時(shí)間: 2025-3-22 14:18 作者: 災(zāi)禍 時(shí)間: 2025-3-22 19:40
Book 2003 cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produ作者: 相互影響 時(shí)間: 2025-3-22 23:43 作者: 預(yù)示 時(shí)間: 2025-3-23 04:35
Modulators of Cyclin-Dependent Kinases, DNA duplication, preventing the propagation of these errors to daughter cells. In contrast, the G. phase represents the period of commitment to cell cycle progression that separates M and S phases as cells prepare for DNA duplication upon mitogenic signals ..作者: 進(jìn)取心 時(shí)間: 2025-3-23 07:26
Book 2003ced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.作者: 歪曲道理 時(shí)間: 2025-3-23 11:07 作者: 兒童 時(shí)間: 2025-3-23 17:53
https://doi.org/10.1007/978-94-024-2115-6ical progression from normal cells to premalignant stages to invasive tumors. The multistep process in tumorigenesis is responsible for the age-dependent appearance of tumors in humans; four to seven major genetic alterations that accumulate over time are responsible for the development of the ultimate tumor cell.作者: Oligarchy 時(shí)間: 2025-3-23 18:32 作者: MUT 時(shí)間: 2025-3-24 01:02
Cell Cycle Regulators,ical progression from normal cells to premalignant stages to invasive tumors. The multistep process in tumorigenesis is responsible for the age-dependent appearance of tumors in humans; four to seven major genetic alterations that accumulate over time are responsible for the development of the ultimate tumor cell.作者: Preserve 時(shí)間: 2025-3-24 05:23
Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer, oscillate, being regulated mainly at the transcriptional level but also by protein degradation via the ubiquitin proteasome pathway (.). The activity of cyclin/CDK complexes is further regulated by both positive and negative phosphorylation events (.), as well as their association with specific inhibitory proteins (.).作者: Cholesterol 時(shí)間: 2025-3-24 08:57
2196-9906 rmation about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show ho作者: semiskilled 時(shí)間: 2025-3-24 14:39
Maria Teresa Riviello,Anna Espositoordinated to occur in an ordered fashion at precisely the right time (for a review . refs. .). This regulation and coordination results from a combination of several signals from different regulatory pathways that are activated in response to the presence of specific stimuli (for a review . ref. .).作者: 驚惶 時(shí)間: 2025-3-24 15:11 作者: 袋鼠 時(shí)間: 2025-3-24 22:03 作者: 琺瑯 時(shí)間: 2025-3-25 02:27
Cell Cycle Regulators as Targets of Anticancer Therapy,nd mitosis: from growth factors to cyclin-dependent kinases. Given the increasing number of experimental therapeutic compounds, I will limit the discussion to those therapeutic agents that are undergoing at least Phase I clinical evaluation.作者: Ventricle 時(shí)間: 2025-3-25 05:04
Lucinda Backwell,Francesco d’Erricouppressor genes may result in an unregulated cell cycle and eventual neoplastic transformation (Table 1). As such, one might define cancer as a genetic disease of the cell cycle. An understanding of the regulatory control of the cell cycle will be needed to understand some of the most common genetic abnormalities of tumors.作者: 神刊 時(shí)間: 2025-3-25 11:17
Tumor-Suppressor Genes as Diagnostic Tools,uppressor genes may result in an unregulated cell cycle and eventual neoplastic transformation (Table 1). As such, one might define cancer as a genetic disease of the cell cycle. An understanding of the regulatory control of the cell cycle will be needed to understand some of the most common genetic abnormalities of tumors.作者: 分開如此和諧 時(shí)間: 2025-3-25 11:49
Lucinda Backwell,Francesco d’Erricoignals that operate within distinct biological contexts. Equally important from a clinical perspective, fidelity of cell cycle regulatory mechanisms is compromised in transformed and tumor cells and in nonmalignant disorders, and reflects deregulation of cell growth or abrogation of cell death.作者: 鑲嵌細(xì)工 時(shí)間: 2025-3-25 16:59
Science in Transition Reduced to Practice, DNA duplication, preventing the propagation of these errors to daughter cells. In contrast, the G. phase represents the period of commitment to cell cycle progression that separates M and S phases as cells prepare for DNA duplication upon mitogenic signals ..作者: LEERY 時(shí)間: 2025-3-25 23:02 作者: insurgent 時(shí)間: 2025-3-26 00:35 作者: mydriatic 時(shí)間: 2025-3-26 05:54
Maria Teresa Riviello,Anna Espositoplicates its genome, and M phase, in which the cell splits into two daughter cells. It is necessary that these two crucial events are regulated and coordinated to occur in an ordered fashion at precisely the right time (for a review . refs. .). This regulation and coordination results from a combina作者: 動(dòng)機(jī) 時(shí)間: 2025-3-26 10:02
Maria Teresa Riviello,Anna Esposito survival of patients with tumors of the colon, breast, prostate, lung, pituitary, and many other tissues. Tumors arising in these organs that were not expressing p27 protein tended to be more aggressive and patients had a poorer clinical outcome. However, it is not clear why p27 was such a strong p作者: anaphylaxis 時(shí)間: 2025-3-26 13:04 作者: 一致性 時(shí)間: 2025-3-26 20:21 作者: 百科全書 時(shí)間: 2025-3-26 23:38 作者: nautical 時(shí)間: 2025-3-27 04:14
Lucinda Backwell,Francesco d’Erricoastic period. The goal of chemopreventive drug development is to identify safe and effective chemopreventive agents for clinical use .. Agents with chemopreventive potential are tested in preclinical toxicity and pharmacokinetic studies and then moved forward to Phase I, II, and III clinical trials 作者: Confess 時(shí)間: 2025-3-27 06:39 作者: largesse 時(shí)間: 2025-3-27 11:27 作者: 公式 時(shí)間: 2025-3-27 14:23
https://doi.org/10.1007/978-94-024-2115-6atic cells. The genetic defects associated with the process of tumor progression affect control of proliferation, programmed cell death (or apoptosis), cell-aging, angiogenesis, escape from immune response, and invasion and metastasis (.). These characteristics of tumor cells are to be considered as作者: Spangle 時(shí)間: 2025-3-27 17:58
https://doi.org/10.1007/978-94-6091-385-3lopment of mechanism-based therapeutics. Compounds are becoming available that target almost every key regulator that governs the entry into S phase and mitosis: from growth factors to cyclin-dependent kinases. Given the increasing number of experimental therapeutic compounds, I will limit the discu作者: 使痛苦 時(shí)間: 2025-3-27 22:24 作者: CROW 時(shí)間: 2025-3-28 03:13 作者: chronology 時(shí)間: 2025-3-28 07:20
Antonio Giordano,Kenneth J. SopranoIncludes supplementary material: 作者: 神經(jīng) 時(shí)間: 2025-3-28 13:38 作者: somnambulism 時(shí)間: 2025-3-28 17:50 作者: 組裝 時(shí)間: 2025-3-28 18:45
Synthetic Oligopeptides as Cancer Cell Cycle Modulators,In higher eukaryotes, many important biological processes, such as cellular differentiation, apoptosis, embryonic development, and finally cancer onset and progression, are closely related to the modulation of the cell cycle.作者: 呼吸 時(shí)間: 2025-3-29 00:14 作者: Lice692 時(shí)間: 2025-3-29 06:22 作者: 捐助 時(shí)間: 2025-3-29 07:17
Cdk Inhibitors,plicates its genome, and M phase, in which the cell splits into two daughter cells. It is necessary that these two crucial events are regulated and coordinated to occur in an ordered fashion at precisely the right time (for a review . refs. .). This regulation and coordination results from a combina作者: 過剩 時(shí)間: 2025-3-29 14:30 作者: conflate 時(shí)間: 2025-3-29 18:34
Cell Cycle Control of Transcription at the G1/S Phase Transition,n cycle in response to the multi-directional signals of cell type specific signaling cascades. The parameters that mediate growth control are complex and interdependent, and whether cells grow or cease division reflects the integration of a broad spectrum of positive and negative growth regulatory s作者: organic-matrix 時(shí)間: 2025-3-29 20:49 作者: Melatonin 時(shí)間: 2025-3-30 01:13 作者: 使人煩燥 時(shí)間: 2025-3-30 07:24
CDK Inhibitors as Targets of Chemoprevention Agents,astic period. The goal of chemopreventive drug development is to identify safe and effective chemopreventive agents for clinical use .. Agents with chemopreventive potential are tested in preclinical toxicity and pharmacokinetic studies and then moved forward to Phase I, II, and III clinical trials 作者: instulate 時(shí)間: 2025-3-30 10:55
Cell Cycle Regulatory Genes as Targets of Retinoids,nd its derivatives play an essential role in vision, immuno-modulation, reproduction, maintaining epithelial tissue, cell growth, and differentiation. Retinol, retinal, and retinoic acid (RA) are among the most important natural retinoids. Retinol is the alcohol form, and is the major transport form作者: 織物 時(shí)間: 2025-3-30 16:23
Modulators of Cyclin-Dependent Kinases, cell cycle. First, synthesis of DNA (genome duplication), also known as S phase, occurs followed by separation of two daughter cells (chromatid separation) or M phase. The time between the S and M phases is known as G. phase (. Fig. 1). This period is where cells can repair errors that occur during
