標題: Titlebook: Cell Culture Engineering and Technology; In appreciation to P Ralf P?rtner Book 2021 The Editor(s) (if applicable) and The Author(s), under [打印本頁] 作者: Autopsy 時間: 2025-3-21 17:46
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作者: Suggestions 時間: 2025-3-21 21:54
Remote Control of Mammalian Therapeutic Designer Cellsar of medicine. Controlling and fine-tuning the behaviour of engineered cells is therefore becoming increasingly important. In the quest for the best-in-class genetic control modalities, traceless physical cues such as light, temperature, mechanical force, magnetic fields, and electrical pulses have作者: 自然環(huán)境 時間: 2025-3-22 00:24 作者: PAGAN 時間: 2025-3-22 08:25 作者: 疲勞 時間: 2025-3-22 09:35 作者: 手段 時間: 2025-3-22 13:31
Monoclonal Antibody Glycoengineering for Biopharmaceutical Quality Assurancecribed for the treatment of several types of cancer and autoimmune disorders. Glycosylation is considered a critical quality attribute of mAbs because it is essential to the safety, pharmacokinetics, and pharmacodynamics of these life-saving biopharmaceuticals. High degrees of glycosylation variabil作者: 手段 時間: 2025-3-22 18:35 作者: 大吃大喝 時間: 2025-3-23 00:58
Manufacturing Human Pluripotent Stem Cells and Differentiated Progenitorsdies have thus far demonstrated the maintenance of cells in static culture plates, which are difficult to scale-up to industrial manufacturing due to the vast quantities of cells required for therapy. Bioreactors have become the most promising alternative for large-scale production and studies have 作者: Fillet,Filet 時間: 2025-3-23 04:25
Biomanufacturing of Mesenchymal Stromal Cells for Therapeutic Applicationsed by degenerative diseases, or indirectly through secretion of trophic or immunomodulatory factors. However, it is estimated that 10.–10. MSCs are needed for a single dose. This, combined with the fact that MSC populations are heterogenous, presents a number of manufacturing challenges. Selection o作者: nepotism 時間: 2025-3-23 05:58 作者: 控制 時間: 2025-3-23 11:31 作者: 有惡意 時間: 2025-3-23 14:36
Practical Considerations for the Scale-Up of Chinese Hamster Ovary (CHO) Cell Cultures the fastest-growing segment of the global biopharmaceutical market. During process development, scale-up is done stepwise from micro-bioreactors or shake flasks, to benchtop bioreactors, passing by pilot-scale platforms before finally being implemented in industrial-scale vessels. However, achievin作者: terazosin 時間: 2025-3-23 21:19
Intensified and Continuous mAb Production with Single-Use Systemsic and autoimmune diseases. Their commercial production processes are mainly based on Chinese hamster ovary (CHO) suspension cells, which are currently cultivated in fed-batch mode at cubic meter scale. The annually growing market for therapeutic mAbs and the pressure on producers to reduce their ma作者: 詼諧 時間: 2025-3-24 00:22
Mathematical Modelling of Cell Culture Processesdels can be used to simulate mammalian cells. Modelling of bioprocesses largely benefit from including kinetics, which reflects the influence of metabolites or other factors on the process variables. Due to the complexity of the kinetic models, with the challenges of determining the kinetic equation作者: ingestion 時間: 2025-3-24 04:13 作者: Antigen 時間: 2025-3-24 09:55
Filtering of spatio-temporal fields, these challenges. This chapter describes the current and future cell engineering strategies to achieve high therapeutic protein productivity with desired product quality in biotechnologically important mammalian cell lines.作者: Costume 時間: 2025-3-24 13:30 作者: acheon 時間: 2025-3-24 18:40
Next-Generation Cell Engineering Platform for Improving Recombinant Protein Production in Mammalian these challenges. This chapter describes the current and future cell engineering strategies to achieve high therapeutic protein productivity with desired product quality in biotechnologically important mammalian cell lines.作者: 喪失 時間: 2025-3-24 21:54 作者: Affluence 時間: 2025-3-25 02:09 作者: POLYP 時間: 2025-3-25 03:24 作者: 大炮 時間: 2025-3-25 09:12 作者: 連系 時間: 2025-3-25 11:50 作者: 鋼盔 時間: 2025-3-25 19:36
Book 2021comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assiste作者: 脫毛 時間: 2025-3-25 20:20 作者: CLAM 時間: 2025-3-26 00:31 作者: CANE 時間: 2025-3-26 06:18
Book 2021d strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences...?.This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.作者: 調(diào)味品 時間: 2025-3-26 10:00
1389-6946 ether the knowledge and experience of experts in the field o.This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for作者: 膝蓋 時間: 2025-3-26 13:12
On the Compatibility of Flexible Instruments emerged as advanced strategies to remote-control cellular behavior in a safe, precise and efficient manner. Here, we describe recent advances in developing remotely-controllable designer cells for the on-demand expression of therapeutic proteins and discuss their applications in translational medicine.作者: ANA 時間: 2025-3-26 17:20
https://doi.org/10.1007/978-94-011-4844-3accelerated bioprocess design and optimization. Second, the computational evaluation of process strategies during scale-up from cultures in microbioreactors to pilot scale is reviewed. In the end, further challenges towards the Digital Twin concept are discussed.作者: Leaven 時間: 2025-3-26 22:35
Next Generation Cell Engineering Using microRNAsed miRNAs, and the control and fine-tuning of target gene expression. Resulting novel miRNA based strategies for cell line engineering emphasize the great potential of these non-coding RNAs for the development of new CHO expression cell lines.作者: 暴露他抗議 時間: 2025-3-27 04:00
An Omic’s Data-Driven Approach Towards Engineering Mammalian Cell Factories and Bioprocesses for Biourrent tools for engineering mammalian systems, the key lessons learnt from omics data on the limitations or ‘bottlenecks’ of mammalian cells, and the potential for rational design of engineering strategies that combine the use of omics data with molecular and computational tools for enhanced biopha作者: FOLLY 時間: 2025-3-27 05:22 作者: 偏狂癥 時間: 2025-3-27 13:22 作者: Mosaic 時間: 2025-3-27 13:37 作者: strain 時間: 2025-3-27 18:16
Biomanufacturing of Mesenchymal Stromal Cells for Therapeutic Applicationsr scale-out strategies. As MSCs are anchorage-dependent, the choice of microcarrier will be important regardless of the bioreactor type and mode of operation. Finally, the clinical success of MSCs is subject to the identification and ability to measure Critical Quality Attributes (CQAs) as a means o作者: 魯莽 時間: 2025-3-28 01:16 作者: 先兆 時間: 2025-3-28 06:07
Practical Considerations for the Scale-Up of Chinese Hamster Ovary (CHO) Cell Culturest volumetric power input (P/V), constant oxygen mass transfer coefficient (k.a), constant gas flow rate per unit volume (vvm) and constant impeller tip speed are among the most frequently used criteria when performing culture scale-up, but they all have implications and inherent limitations that mus作者: 背心 時間: 2025-3-28 08:05 作者: 馬具 時間: 2025-3-28 10:27
1389-6946 nes like cell biology, engineering, biotechnology and biomedical sciences...?.This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.978-3-030-79873-4978-3-030-79871-0Series ISSN 1389-6946 Series E-ISSN 2542-9515 作者: atrophy 時間: 2025-3-28 17:18 作者: 情感脆弱 時間: 2025-3-28 22:12 作者: 保全 時間: 2025-3-29 00:33 作者: fender 時間: 2025-3-29 03:06
Catrinus J. Jepma,Wytze Van Der Gaastapitulates the progress made towards controlling mAb glycosylation within the context of biopharmaceutical quality assurance. The chapter presents a critical review of the vast number of (.) cellular, (.) metabolic, and (.) . glycoengineering strategies that have been developed to enhance the qualit作者: 我正派 時間: 2025-3-29 10:05
Multifrequency Monitoring of Blazars,mount, with new developments in media and extracellular matrix (ECM) substrates allowing fully defined xeno-free cultivation. Here we present an overview of the hPSC scale-up methods currently being explored. We highlight the strengths and weaknesses of both aggregate and microcarrier cultures, and 作者: Melanoma 時間: 2025-3-29 13:12 作者: 寡頭政治 時間: 2025-3-29 17:55
David Wilczynski,David K. Wallaceon would enable the treatment of a wide variety of genetic diseases. Optimization strategies have focused on the genetic components needed for AAV assembly, the production cell lines, as well as omics-based approaches.作者: helper-T-cells 時間: 2025-3-29 22:57 作者: 喚起 時間: 2025-3-30 03:44
OOPS in real-time control applicationss context, the terms “process intensification” and “continuous process” are defined, while the preferential application of single-use systems is described using literature, and further by own studies. Based on the findings, the main challenges for the implementation of intensified and continuous mAb作者: 瑣碎 時間: 2025-3-30 04:19 作者: 傳授知識 時間: 2025-3-30 10:06 作者: grudging 時間: 2025-3-30 13:57
