標題: Titlebook: Catalytic RNA; Fritz Eckstein,David M. J. Lilley Book 1997 Springer-Verlag Berlin Heidelberg 1997 AIDS.HIV.Nucleotide.RNA.biology.catalysi [打印本頁] 作者: Withdrawal 時間: 2025-3-21 17:26
書目名稱Catalytic RNA影響因子(影響力)
書目名稱Catalytic RNA影響因子(影響力)學科排名
書目名稱Catalytic RNA網(wǎng)絡公開度
書目名稱Catalytic RNA網(wǎng)絡公開度學科排名
書目名稱Catalytic RNA被引頻次
書目名稱Catalytic RNA被引頻次學科排名
書目名稱Catalytic RNA年度引用
書目名稱Catalytic RNA年度引用學科排名
書目名稱Catalytic RNA讀者反饋
書目名稱Catalytic RNA讀者反饋學科排名
作者: 鴕鳥 時間: 2025-3-21 22:42 作者: 硬化 時間: 2025-3-22 02:40 作者: 友好關系 時間: 2025-3-22 05:05 作者: Indelible 時間: 2025-3-22 10:07
https://doi.org/10.1007/978-3-031-22039-5Vol. This application has been successfully extended to the study of transgenic animals containing a hammerhead ribozyme gene targeted against the gene of interest (Heinrich et al. 1993; Zhao and Pick 1993; Efrat et al. 1994; Larsson et al. 1994; see also L’Huillier, this Vol.).作者: 音的強弱 時間: 2025-3-22 15:42 作者: 音的強弱 時間: 2025-3-22 17:19
Terminal Control of?Multi-agent Systeme in the use of ribozymes with long-chain flanking sequences that have been expressed endogenously or transcribed enzymatically in vitro before being introduced into cells. Only rarely have short-chain and chemically synthesized ribozymes been used succesfully in living cells. Conversely, their stru作者: reaching 時間: 2025-3-22 21:48
Lecture Notes in Computer Scienceith protein enzymes has redefined the role that RNA may have played in early evolution (Cech 1993). Furthermore, these novel activities of RNA now permit us to contemplate the development of enzymatic RNA molecules as therapeutic entities for the treatment of human disease (Marschall et al. 1994; Ch作者: Agnosia 時間: 2025-3-23 03:55 作者: Misnomer 時間: 2025-3-23 05:51
Maria Stefanova,Stanislav Baklanovn enzymatic reaction in which a target substrate is cleaved and the ribozyme itself is not altered during the reaction. Ribozyme-mediated cleavage in vitro was first demonstrated by Uhlenbeck (1987) and subsequently by Haseloff and Gerlach (1988).作者: syncope 時間: 2025-3-23 12:34
Concepts in Computational Cognition,hocytes being most apparent. There is a high mortality rate (90–100% over 10 years) associated with the progression to AIDS, the pathogenesis being a very complex process encompassing initial infection, acute syndrome, clinical latency, and finally, clinical disease (Fig. 1; Ho et al. 1989; Pantaleo作者: Intellectual 時間: 2025-3-23 15:46
Dynamics of a Group I Ribozyme Detected by Spectroscopic Methods,unction. The RNA motion most intensively studied thus far in this system is docking of substrate into the catalytic core of the ribozyme (Bevilacqua et al. 1992, 1993, 1994; Li et al. 1995; Li, Profenno and Turner, unpubl. results). This chapter reviews the methods and results of these studies, and 作者: expeditious 時間: 2025-3-23 21:21
Interaction of Aminoglycoside Antibiotics with RNA, weight products encompassing a wide range of different chemical classes from the secondary metabolism of microorganisms, able to inhibit growth of other microorganisms. Most of the effects on RNA function that were found are caused by aminoglycoside antibiotics — more specifically, by the disubstit作者: AWE 時間: 2025-3-23 23:06
Structural Analysis of the Bacterial Ribonuclease P RNA,erstanding of the structure of the RNase P RNA. An important key to understanding the function and specificity of this interesting enzyme is to gain perspective on its structure. A detailed secondary structure model of the bacterial RNA has been derived through phylogenetic comparative analysis, and作者: cortex 時間: 2025-3-24 05:29
Structural Analysis and Modifications of the Hairpin Ribozyme,ocessing site; it contains the sequences that are recognized by the ribozyme. Interestingly, the analogous RNA processing reactions that occur during replication of the plus strand utilize the hammerhead motif (Long and Uhlenbeck 1993). In contrast to phylogenetically abundant RNA catalysts such as 作者: conscience 時間: 2025-3-24 07:14 作者: intuition 時間: 2025-3-24 11:40
Probing the Cleavage Activity of the Hammerhead Ribozyme Using Analog Complexes,metal cofactor in order to stabilize the transition state resulting along the cleavage pathway. Cleavage of the RNA occurs by an internal transesterification reaction involving the 2′-hydroxyl adjacent to the scissile phosphodiester, generating a terminal 5′-hydroxyl fragment and a terminal 2′,3′-cy作者: contrast-medium 時間: 2025-3-24 17:02 作者: Affiliation 時間: 2025-3-24 21:55
Design, Synthesis, and Function of Therapeutic Hammerhead Ribozymes,ith protein enzymes has redefined the role that RNA may have played in early evolution (Cech 1993). Furthermore, these novel activities of RNA now permit us to contemplate the development of enzymatic RNA molecules as therapeutic entities for the treatment of human disease (Marschall et al. 1994; Ch作者: Thyroxine 時間: 2025-3-25 02:19 作者: Outspoken 時間: 2025-3-25 07:11
Efficacy of Hammerhead Ribozymes Targeting ,-Lactalbumin Transcripts: Experiments in Cells and Trann enzymatic reaction in which a target substrate is cleaved and the ribozyme itself is not altered during the reaction. Ribozyme-mediated cleavage in vitro was first demonstrated by Uhlenbeck (1987) and subsequently by Haseloff and Gerlach (1988).作者: conservative 時間: 2025-3-25 11:30 作者: 有花 時間: 2025-3-25 13:55
Nucleic Acids and Molecular Biologyhttp://image.papertrans.cn/c/image/222482.jpg作者: bourgeois 時間: 2025-3-25 16:09
Organized Crime in the 21st Centuryg and catalysis over the past 10 years. By 1985 the sequential steps in RNA self-splicing had been described (Zaug and Cech 1982) and the secondary structure common to group I introns had been determined (Davies et al. 1982; Michel et al. 1982; Waring and Davies 1984). Furthermore, several fungal mi作者: cluster 時間: 2025-3-25 21:58 作者: cancer 時間: 2025-3-26 03:08
Susan Watkinson,Swapna Naskar Williamsonions (Cech 1993). In vitro, these ribozymes carry out self-splicing via two consecutive transesterification reactions, leading to their own excision from a pre-messenger RNA and the ligation of the flanking exon sequences, generally, in the absence of protein (Cech 1990). This relatively complex pro作者: BRAND 時間: 2025-3-26 06:23
Springer Series in Reliability Engineeringl RNA, led to a new aspect in studying RNA structure and function. Simple amino sugars were added to the list of components influencing catalytic RNAs. Although several experiments pointed to a direct interaction of antibiotics with the ribosomal RNA, the presence of ribosomal proteins excluded a sa作者: mosque 時間: 2025-3-26 10:58 作者: enchant 時間: 2025-3-26 15:48 作者: 閃光東本 時間: 2025-3-26 19:49 作者: Inordinate 時間: 2025-3-26 21:53 作者: FLACK 時間: 2025-3-27 04:27
N. Aslimani,E.-G. Talbi,R. Ellaia (Buzayan et al. 1986; Hutchins et al. 1986; Prody et al. 1986). The consensus sequence required for bond cleavage consists of a “core” of nucleotides at the juncture of three base-paired stems (Fig. la; Forster and Symons 1987; Ruffner et al. 1990). Although the hammerhead ribozyme was originally c作者: 不整齊 時間: 2025-3-27 05:56 作者: 侵略 時間: 2025-3-27 12:38
Lecture Notes in Computer Sciencelogical systems (Symons 1991; Pyle 1993). The hammerhead ribozyme is a relatively small RNA catalyst that is derived from a structural motif present in the RNA genomes of several plant pathogens, where it is believed that RNA-mediated cleavage events are an essential step in the viroid’s replication作者: itinerary 時間: 2025-3-27 14:48
Aleksandr Beznosikov,Alexander Gasnikov (Altman 1989; Cech 1989; Michel et al. 1989; Noller et al. 1992; Symons 1992; Bratty et al. 1993; Gesteland and Atkins 1993). Of all these catalytic RNAs, the hammerhead ribozyme is the smallest. Naturally occurring hammerhead ribozymes were identified initially within RNA viruses and they act in .作者: 解決 時間: 2025-3-27 19:23 作者: 一加就噴出 時間: 2025-3-27 22:19 作者: entail 時間: 2025-3-28 03:49
Maria Stefanova,Stanislav Baklanovhas led to the design of short oligoribonucleotides that are able to function in . as specific endoribonucleases (Uhlenbeck 1987; Haseloff and Gerlach 1988). The naturally occurring self-cleavage reaction plays a central role in the rolling circle replication of these pathogenic RNAs (Symons 1989). 作者: 北極人 時間: 2025-3-28 09:32
Maria Stefanova,Stanislav Baklanovt motifs, and catalyze RNA cleavage and RNA splicing reactions (Symons 1989). For the hammerhead and hairpin ribozyme motifs identified in the (+) and (?) strands of the satellite RNA of tobacco ringspot virus, the cleavage reactions are intramolecular. However, dissection of the catalytic motifs ha作者: 嚴峻考驗 時間: 2025-3-28 11:38 作者: Delirium 時間: 2025-3-28 14:49
Stine Helene Falsig Pedersen,Diane L. Barberreplication of its causative agent, human immunodeficiency virus (HIV). Since the efforts of prophylactic vaccines have repeatedly failed, anti-viral strategies are now being aimed at direct inhibition of the virus or its replication. Infection by HIV leads to a progressive depletion of CD4. cells o作者: Debility 時間: 2025-3-28 21:30 作者: flutter 時間: 2025-3-29 02:15
https://doi.org/10.1007/978-3-642-61202-2AIDS; HIV; Nucleotide; RNA; biology; catalysis; chemistry; fungi; genetics; molecular biology; molecular genet作者: 小鹿 時間: 2025-3-29 07:04
978-3-540-62679-4Springer-Verlag Berlin Heidelberg 1997作者: 未開化 時間: 2025-3-29 08:05
Catalytic RNA978-3-642-61202-2Series ISSN 0933-1891 Series E-ISSN 1869-2486 作者: 玩笑 時間: 2025-3-29 15:15 作者: mastopexy 時間: 2025-3-29 18:40
Dynamics of a Group I Ribozyme Detected by Spectroscopic Methods,ed from the group I intron of . (Zaug et al. 1988; Kay and Inoue 1987) provides an excellent system for studying dynamics, since its secondary structure is known (Michel and Dujon 1983; Burke et al. 1987; Cech et al. 1994) and a good model is available for its three-dimensional structure (Michel and作者: gonioscopy 時間: 2025-3-29 20:03
The Structure of Group I Ribozymes,ions (Cech 1993). In vitro, these ribozymes carry out self-splicing via two consecutive transesterification reactions, leading to their own excision from a pre-messenger RNA and the ligation of the flanking exon sequences, generally, in the absence of protein (Cech 1990). This relatively complex pro作者: bleach 時間: 2025-3-30 02:50 作者: Perceive 時間: 2025-3-30 07:59 作者: bleach 時間: 2025-3-30 09:47
Structural Analysis of the Bacterial Ribonuclease P RNA,e tRNAs. The enzyme is present and essential in all cells and organelles that produce tRNA. RNase P is remarkable because of its composition: it is composed of RNA and protein subunits. The RNA moiety forms the catalytic center, so RNase P is intrinsically a ribozyme. The enzyme from a broad diversi作者: 思考才皺眉 時間: 2025-3-30 15:56 作者: 大約冬季 時間: 2025-3-30 19:34 作者: 時代錯誤 時間: 2025-3-30 23:59 作者: expeditious 時間: 2025-3-31 03:12
The Hammerhead Ribozyme,mons 1992 and Bratty et al. 1993). Its two-dimensional representation (Fig. 1) has now been transformed into a three-dimensional model by the application of X-ray crystallography (Pley et al. 1994; Scott et al. 1995) (see also chapter by McKay), fluorescence resonance energy transfer (FRET) measurem作者: embolus 時間: 2025-3-31 08:29 作者: biosphere 時間: 2025-3-31 11:25
Mechanistic Studies on Hammerhead Ribozymes, (Altman 1989; Cech 1989; Michel et al. 1989; Noller et al. 1992; Symons 1992; Bratty et al. 1993; Gesteland and Atkins 1993). Of all these catalytic RNAs, the hammerhead ribozyme is the smallest. Naturally occurring hammerhead ribozymes were identified initially within RNA viruses and they act in .作者: 原諒 時間: 2025-3-31 16:57
Hammerhead Ribozymes with Long Flanking Sequences: a Structural and Kinetic View, et al. 1982; Guerrier-Takada et al. 1983) in an intramolecular (in .) as well as an intermolecular (in .) reaction. All classes of ribozymes (for review, see Symons 1992; Cech 1993) recognize their target by duplex formation via complementary sequences and hydrolyze the cleavable motif after format作者: Cryptic 時間: 2025-3-31 19:29
Design, Synthesis, and Function of Therapeutic Hammerhead Ribozymes, the function of RNA in chemistry, biology, and medicine. RNA traditionally was viewed as a passive molecule that only carries information or provides structure. It is now clear that RNA can act as an enzyme, capable of catalyzing not only RNA splicing and cleavage, but a diverse number of reactions作者: sterilization 時間: 2025-3-31 23:56 作者: figurine 時間: 2025-4-1 04:46
Efficacy of Hammerhead Ribozymes Targeting ,-Lactalbumin Transcripts: Experiments in Cells and Trant motifs, and catalyze RNA cleavage and RNA splicing reactions (Symons 1989). For the hammerhead and hairpin ribozyme motifs identified in the (+) and (?) strands of the satellite RNA of tobacco ringspot virus, the cleavage reactions are intramolecular. However, dissection of the catalytic motifs ha作者: 凝結(jié)劑 時間: 2025-4-1 07:32 作者: 極力證明 時間: 2025-4-1 10:14
Inhibition of HIV Replication by the Hairpin Ribozyme,replication of its causative agent, human immunodeficiency virus (HIV). Since the efforts of prophylactic vaccines have repeatedly failed, anti-viral strategies are now being aimed at direct inhibition of the virus or its replication. Infection by HIV leads to a progressive depletion of CD4. cells o作者: 芳香一點 時間: 2025-4-1 14:54 作者: osteocytes 時間: 2025-4-1 20:41
Book 1997ndergone a kind of explosion, with a huge interest in RNA-mediated catalysis. At the same time, our structural understanding of DNA-protein interactions has increased enormously, and the related area of RNA-protein interactions is beginning to gather pace. This softcover edition from the successful 作者: 頌揚國家 時間: 2025-4-2 02:22
0933-1891 stry has undergone a kind of explosion, with a huge interest in RNA-mediated catalysis. At the same time, our structural understanding of DNA-protein interactions has increased enormously, and the related area of RNA-protein interactions is beginning to gather pace. This softcover edition from the s
