作者: 外科醫(yī)生 時間: 2025-3-21 21:00
Macmillan Publishers Limited 1980作者: wangle 時間: 2025-3-22 00:29 作者: foppish 時間: 2025-3-22 06:16
https://doi.org/10.1007/978-0-387-68805-3The development of scientific medicine during the last 30 years has extended to the study of the effects of drugs in man with the development of the speciality of Clinical Pharmacology.作者: 貪婪的人 時間: 2025-3-22 10:31 作者: LURE 時間: 2025-3-22 16:35 作者: LURE 時間: 2025-3-22 19:49
Clinical Pharmacology Methodology: Introduction,The development of scientific medicine during the last 30 years has extended to the study of the effects of drugs in man with the development of the speciality of Clinical Pharmacology.作者: Allowance 時間: 2025-3-22 21:31
Assessment of the Effect of Drugs on the Venous System in Man,Any generalized constriction or dilatation of the systemic venous bed must necessarily result in changes in central venous pressure, and the effect of vasoactive substances on the veins is, in consequence, an important determinant of their action on the circulation as a whole.作者: Osteoarthritis 時間: 2025-3-23 02:14
Methods for the Assessment of the Effects of Drugs on the Arterial System in Man,The arterial system is an anatomical entity which serves a number of circulatory functions. Therefore if we wish to describe the effects of drugs on the system it is first necessary to define the precise functions we are concerned with and devise methods which are appropriate for their measurement. The arterial system has four main functions.作者: 泥土謙卑 時間: 2025-3-23 08:54
Direct Assessment of Cardiac Function,through a period of philosophical revision of our understanding of cardiac function and a new consensus is beginning to appear. The essential part of the heart as far as the systemic circulation is concerned is the left ventricle and most attention is directed to the performance of this chamber and its alteration by disease or drugs.作者: 來就得意 時間: 2025-3-23 12:18
Methods for Assessment of the Effect of Drugs on Cerebral Blood Flow in Man,is. Although the brain represents only 2% of the body mass it has a blood supply of 15% of the resting cardiac output, and utilises nearly a quarter of the body’s total oxygen requirements at rest (Folkow & Neil, 1971). Even small regional changes in flow can result in catastrophic clinical sequelae.作者: gene-therapy 時間: 2025-3-23 15:56 作者: cutlery 時間: 2025-3-23 19:26
https://doi.org/10.1007/978-0-387-68805-3through a period of philosophical revision of our understanding of cardiac function and a new consensus is beginning to appear. The essential part of the heart as far as the systemic circulation is concerned is the left ventricle and most attention is directed to the performance of this chamber and its alteration by disease or drugs.作者: 障礙 時間: 2025-3-24 01:57
https://doi.org/10.1007/978-0-387-68805-3is. Although the brain represents only 2% of the body mass it has a blood supply of 15% of the resting cardiac output, and utilises nearly a quarter of the body’s total oxygen requirements at rest (Folkow & Neil, 1971). Even small regional changes in flow can result in catastrophic clinical sequelae.作者: 進入 時間: 2025-3-24 05:37
https://doi.org/10.1007/978-0-387-68805-3rends in physiology have focused interest on the relationship between RBF and the control of tubular reabsorption. With the introduction of powerful pharmacological agents which affect the resistance to renal blood flow, there has been increasing interest in accurate methods for its measurement.作者: 可觸知 時間: 2025-3-24 07:05 作者: Foreshadow 時間: 2025-3-24 12:11
https://doi.org/10.1007/978-0-387-68805-3diac cycle. It can be performed non-invasively, so has considerable advantages over cardiac catheterization in that normal subjects can be studied, and repeated measurements made, either in the basal state, or after interventions. It is thus attractive for the study of drugs with an action on the ca作者: HOWL 時間: 2025-3-24 15:15
https://doi.org/10.1007/978-0-387-68805-3astolic pressure. While directional changes over each 24 h period can be defined (Millar Craig, Bishop and Raftery, 1978), no two beats generate exactly the same pressures; beat-to-beat pressure variation appears to be a random process influenced by an almost infinite number of variables (Goldberg, 作者: 意見一致 時間: 2025-3-24 22:03 作者: sigmoid-colon 時間: 2025-3-25 00:35 作者: 織布機 時間: 2025-3-25 04:37
https://doi.org/10.1007/978-0-387-68805-3is. Although the brain represents only 2% of the body mass it has a blood supply of 15% of the resting cardiac output, and utilises nearly a quarter of the body’s total oxygen requirements at rest (Folkow & Neil, 1971). Even small regional changes in flow can result in catastrophic clinical sequelae作者: PRE 時間: 2025-3-25 11:25
https://doi.org/10.1007/978-0-387-68805-3rends in physiology have focused interest on the relationship between RBF and the control of tubular reabsorption. With the introduction of powerful pharmacological agents which affect the resistance to renal blood flow, there has been increasing interest in accurate methods for its measurement.作者: 冷漠 時間: 2025-3-25 13:46 作者: 排斥 時間: 2025-3-25 18:40
https://doi.org/10.1007/978-0-387-68805-3nd its use in the study of left ventricular disease has been described in a number of recent monographs and reviews (Feigenbaum, 1976; Roelandt, 1977; Mason and Fortuin, 1978). It allows a number of aspects of left ventricular function to be studied. Of these, the simplest is the measurement of the 作者: Insulin 時間: 2025-3-25 21:08
https://doi.org/10.1007/978-0-387-68805-3ion (Braunwald, 1976; Sobel, Bresnahan, Shell & Yoder, 1972). Experiments, however, indicate that several drugs given early after the occlusion can substantially alter final infarct size. Clinical assessment of the effects of these drugs poses difficulties and an awareness of the limitations of exis作者: Cuisine 時間: 2025-3-26 00:58
https://doi.org/10.1007/978-0-387-68805-3quipment not available in many centres. Two of the most suitable methods for assessing the effects of drugs on coronary flow are coronary sinus thermodilution and isotope washout curves using .xenon or [.I]-iodo-antipyrine. The ideal technique for measuring coronary blood flow has yet to be developed.作者: Intellectual 時間: 2025-3-26 07:12 作者: anchor 時間: 2025-3-26 08:53
https://doi.org/10.1007/978-0-387-68805-3to discuss the electrocardiogram in the assessment of the clinical electrophysiological properties of a drug and secondly, the electrocardiogram in the assessment of the value of the drug in the management of cardiac arrhythmias in man.作者: insipid 時間: 2025-3-26 13:20 作者: 古代 時間: 2025-3-26 20:11
The Methodology of Blood Pressure Recording,y inconceivable that any random measurement of blood pressure should be representative of any patient’s ‘blood pressure’; it cannot represent anything more than the blood pressure generated by the heart of that individual under the prevailing conditions (Figure 1).作者: conquer 時間: 2025-3-27 00:35
The Electrocardiogram in the Assessment of the Effect of Drugs on Cardiac Arrhythmias,to discuss the electrocardiogram in the assessment of the clinical electrophysiological properties of a drug and secondly, the electrocardiogram in the assessment of the value of the drug in the management of cardiac arrhythmias in man.作者: Asperity 時間: 2025-3-27 03:07
https://doi.org/10.1007/978-0-387-68805-3e advantages and disadvantages of the three main methods currently used for assessing acute myocardial infarct size—praecordial electrocardiographic mapping, serial estimates of serum creatine kinase activity, and radionuclide scintigraphy.作者: initiate 時間: 2025-3-27 06:00
Non-Invasive Assessment of the Effects of Drugs on Acute Myocardial Infarct Size in Man,e advantages and disadvantages of the three main methods currently used for assessing acute myocardial infarct size—praecordial electrocardiographic mapping, serial estimates of serum creatine kinase activity, and radionuclide scintigraphy.作者: 擁護者 時間: 2025-3-27 13:26 作者: inhumane 時間: 2025-3-27 13:55
Use of the Systolic Time Intervals in Clinical Pharmacology,diac cycle. It can be performed non-invasively, so has considerable advantages over cardiac catheterization in that normal subjects can be studied, and repeated measurements made, either in the basal state, or after interventions. It is thus attractive for the study of drugs with an action on the ca作者: falsehood 時間: 2025-3-27 18:30 作者: caldron 時間: 2025-3-27 23:50 作者: JIBE 時間: 2025-3-28 02:54 作者: 不可思議 時間: 2025-3-28 07:41
Methods for Assessment of the Effect of Drugs on Cerebral Blood Flow in Man,is. Although the brain represents only 2% of the body mass it has a blood supply of 15% of the resting cardiac output, and utilises nearly a quarter of the body’s total oxygen requirements at rest (Folkow & Neil, 1971). Even small regional changes in flow can result in catastrophic clinical sequelae作者: Kernel 時間: 2025-3-28 10:34 作者: 休息 時間: 2025-3-28 14:47 作者: 遺留之物 時間: 2025-3-28 21:00
Use of M-Mode Echocardiography in Clinical Pharmacology,nd its use in the study of left ventricular disease has been described in a number of recent monographs and reviews (Feigenbaum, 1976; Roelandt, 1977; Mason and Fortuin, 1978). It allows a number of aspects of left ventricular function to be studied. Of these, the simplest is the measurement of the 作者: gruelling 時間: 2025-3-28 23:15
Non-Invasive Assessment of the Effects of Drugs on Acute Myocardial Infarct Size in Man,ion (Braunwald, 1976; Sobel, Bresnahan, Shell & Yoder, 1972). Experiments, however, indicate that several drugs given early after the occlusion can substantially alter final infarct size. Clinical assessment of the effects of these drugs poses difficulties and an awareness of the limitations of exis作者: 單純 時間: 2025-3-29 04:21
https://doi.org/10.1007/978-0-387-68805-3ared, but it must be stressed that this simplicity is only apparent, and may conceal complex underlying changes in circulatory state. Furthermore, although left ventricular disease and drug administration have similar effects on the systolic time intervals, there is much evidence to suggest that the作者: detach 時間: 2025-3-29 09:50
https://doi.org/10.1007/978-0-387-68805-3s in the biological determinants of drug disposition (Wilkinson, 1975; Wilkinson and Shand, 1975). In addition, as surgeons started to treat portal hypertension occurring in liver disease such as cirrhosis by portocaval or similar anastomoses, liver blood flow was assessed with other parameters of l作者: maroon 時間: 2025-3-29 14:00 作者: TOXIN 時間: 2025-3-29 17:44 作者: 殘忍 時間: 2025-3-29 19:44 作者: 言行自由 時間: 2025-3-30 02:33
Use of M-Mode Echocardiography in Clinical Pharmacology,eptal movement to be studied. In addition, it is totally safe, so that it can be used on normal volunteers. Performing echocardiography, however, is difficult, and at least 6 months’ practice is likely to be required before records of adequate technical quality are obtained.
