標(biāo)題: Titlebook: Carcinogenesis: Fundamental Mechanisms and Environmental Effects; Proceedings of the T Bernard Pullman,Paul O. P. Ts’o,Harry Gelboin Confer [打印本頁] 作者: Aggrief 時(shí)間: 2025-3-21 19:27
書目名稱Carcinogenesis: Fundamental Mechanisms and Environmental Effects影響因子(影響力)
書目名稱Carcinogenesis: Fundamental Mechanisms and Environmental Effects影響因子(影響力)學(xué)科排名
書目名稱Carcinogenesis: Fundamental Mechanisms and Environmental Effects網(wǎng)絡(luò)公開度
書目名稱Carcinogenesis: Fundamental Mechanisms and Environmental Effects網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Carcinogenesis: Fundamental Mechanisms and Environmental Effects被引頻次
書目名稱Carcinogenesis: Fundamental Mechanisms and Environmental Effects被引頻次學(xué)科排名
書目名稱Carcinogenesis: Fundamental Mechanisms and Environmental Effects年度引用
書目名稱Carcinogenesis: Fundamental Mechanisms and Environmental Effects年度引用學(xué)科排名
書目名稱Carcinogenesis: Fundamental Mechanisms and Environmental Effects讀者反饋
書目名稱Carcinogenesis: Fundamental Mechanisms and Environmental Effects讀者反饋學(xué)科排名
作者: Bureaucracy 時(shí)間: 2025-3-21 22:49 作者: choleretic 時(shí)間: 2025-3-22 00:40 作者: Keratectomy 時(shí)間: 2025-3-22 04:42
https://doi.org/10.1007/978-3-642-60775-2possible tautomeric shift with C, the orientation of the substituent plays a major role in determining fidelity. Thus N.-methoxy C acts only as U; N.-hydroxy C, N.-MeC, and N.-MeG act ambiguously; and N.-acetyl C base-pairs only with G. Three different substituents on the N. of A did not affect A·U pairing, indicating an anti conformation.作者: pulmonary-edema 時(shí)間: 2025-3-22 09:30
Business Cycles: Discrete Time, bonds is not understood; it appears, however, that a hydroxyl group can interfere with it. The results of this investigation are of particular importance because of their relevance to the diol epoxides that are implicated as ultimate carcinogenic forms of several polycyclic aromatic hydrocarbons.作者: Annotate 時(shí)間: 2025-3-22 15:12
Business Cycles: Continuous Space, a result of a cytochrome P-450-dependent monooxygenase process. However, a measurable amount of the quinone product contains oxygen incorporated from water suggesting at least two mechanisms of quinone formation.作者: Annotate 時(shí)間: 2025-3-22 19:13
https://doi.org/10.1007/978-3-642-97291-1lorodibenzo-p-dioxin (TCDD) and butylated hydroxy anisole (BHA) were found to promote the formation of both foci and hepatomas. In particular, TCDD is a millionfold more efficient, whereas BHA is significantly less efficient than phenobarbital as promoting agents.作者: 黑豹 時(shí)間: 2025-3-22 22:33 作者: GLARE 時(shí)間: 2025-3-23 01:32 作者: Carbon-Monoxide 時(shí)間: 2025-3-23 06:02 作者: 期滿 時(shí)間: 2025-3-23 11:01 作者: 偽證 時(shí)間: 2025-3-23 14:14
Metabolically Generated Free Radicals from Many Types of Chemical Carcinogens and Binding of the Rapyrene in which no diol-epoxide formation is expected were found to be activated to reactive free radicals. These findings suggest that the metabolically formed free radicals are important in chemical carcinogenesis.作者: admission 時(shí)間: 2025-3-23 18:50
Biological Effects of Specific Hydrocarbon-DNA Reactions,icity of the .- and .-diolepoxides of benzo(a)pyrene revealed differences in absolute efficiency reminiscent of data obtained with methylating agents which gave different DNA alkylation products. The significance of these data to the role of mutation in cancer initiation is discussed作者: gorgeous 時(shí)間: 2025-3-24 01:54
The Effect of Base Modification on Fidelity in Transcription,possible tautomeric shift with C, the orientation of the substituent plays a major role in determining fidelity. Thus N.-methoxy C acts only as U; N.-hydroxy C, N.-MeC, and N.-MeG act ambiguously; and N.-acetyl C base-pairs only with G. Three different substituents on the N. of A did not affect A·U pairing, indicating an anti conformation.作者: 欲望小妹 時(shí)間: 2025-3-24 05:13
On Euler Buckling and Snap-Through,tereochemical factors are also critically important determinants of biological activity. Several hydrocarbons have now been tested, either directly or indirectly, and have been found to meet the predictions of the theory.作者: 關(guān)節(jié)炎 時(shí)間: 2025-3-24 06:35
Business Cycles: Discrete Time,sence of even weak nucleophiles in the incubation. In contrast, products of 7,8-dihydro- 7,8-dihydroxybenzo(a)pyrene seem to be trapped primarily by enzyme- mediated glutathione conjugation. Our results underline the physiological importance of the nuclear envelope in the final activation of benzo(a)- pyrene to DNA-binding products.作者: Bucket 時(shí)間: 2025-3-24 12:41
Carcinogenicity of Polycyclic Aromatic Hydrocarbons: The Bay-Region Theory,tereochemical factors are also critically important determinants of biological activity. Several hydrocarbons have now been tested, either directly or indirectly, and have been found to meet the predictions of the theory.作者: 去世 時(shí)間: 2025-3-24 18:39 作者: hardheaded 時(shí)間: 2025-3-24 22:40 作者: incision 時(shí)間: 2025-3-25 00:35 作者: 他姓手中拿著 時(shí)間: 2025-3-25 07:18 作者: 鋼筆記下懲罰 時(shí)間: 2025-3-25 09:12
0924-4875 Overview: 978-94-009-9106-4978-94-009-9104-0Series ISSN 0924-4875 作者: 消散 時(shí)間: 2025-3-25 14:41
N. Slimani,A. Makhoute,M. Tlidire .: positive ions or uncharged molecules with reactive centers at their electron deficient atoms (see e.g. 1,2). This is true both for carcinogens considered as being active . (a number of relatively simple alkylating agents) and those which necessitate a metabolic activation (aromatic hydrocarbons, aromatic amines, aflatoxin B. etc.) (Fig. 1).作者: 整體 時(shí)間: 2025-3-25 18:44 作者: PRISE 時(shí)間: 2025-3-25 23:30
Nucleophilicity of DNA. Relation to Chemical Carcinogenesis.,re .: positive ions or uncharged molecules with reactive centers at their electron deficient atoms (see e.g. 1,2). This is true both for carcinogens considered as being active . (a number of relatively simple alkylating agents) and those which necessitate a metabolic activation (aromatic hydrocarbons, aromatic amines, aflatoxin B. etc.) (Fig. 1).作者: Angiogenesis 時(shí)間: 2025-3-26 00:36
Structural Modifications and Specific Recognition by Antibodies of Carcinogenic Aromatic Amines Bou-AAF), was studied previously by means of different physical and biochemical techniques. We present here the results obtained by using two other methods:.This latter method appears to be applicable to other types of carcinogens and able, after some improvements, to solve several problems related to the initiation step of carcinogenesis.作者: 擁護(hù)者 時(shí)間: 2025-3-26 06:19
Business Cycles: Discrete Time,Carcinogenic aromatic amines form a group of compounds which can induce tumors in a variety of tissues in various species. In a number of situations certain arylamines may also pose a health hazard to humans. Several properties are responsible for the hazardous nature of this group of compounds, which may be summarized as follows:作者: GNAT 時(shí)間: 2025-3-26 12:15
https://doi.org/10.1007/978-3-642-97291-1A consideration of clinical features as well as cellular, cytogenetic and biochemical studies on patients susceptible to cancer suggests that a simple correlation between exposure to an environmental agent, DNA damage, mutation and cancer may not be an adequate explanation for the observed cancer incidence patterns.作者: originality 時(shí)間: 2025-3-26 14:15 作者: Filibuster 時(shí)間: 2025-3-26 18:38 作者: BIPED 時(shí)間: 2025-3-26 22:12
Jerusalem Symposiahttp://image.papertrans.cn/c/image/221694.jpg作者: 終點(diǎn) 時(shí)間: 2025-3-27 04:01
On Euler Buckling and Snap-Through,part of a bay-region of a carcinogenic polycyclic aromatic hydrocarbon. In general, predicted chemical reactivity for positional isomers of benzo-ring diol epoxides of individual hydrocarbons has been paralleled by their respective mutagenicity and/or tumorigenicity. Although relative reactivity of 作者: Aspirin 時(shí)間: 2025-3-27 05:36 作者: 信任 時(shí)間: 2025-3-27 10:15
J. E. Macías,M. G. Clerc,C. Falcónter embryo cells treated with the hydrocarbon contain adducts arising from the reactions with the nucleic acid of both the ‘bay- region’ .-3,4-diol-1,2-epoxide and the non-‘bay-region’ .-8,9- diol-10,11-epoxide. However, only the 8,9-diol-10,11-epoxide appears to be involved in the reaction of the h作者: 我邪惡 時(shí)間: 2025-3-27 17:25
Z. Liu,F. Leo,S. Coulibaly,M. Takiderivatives, acetylaminofluorene and naphthylamines have been found to be easily converted to free radicals after being activated to the proximate forms. These free radicals were sufficiently reactive to bind covalently with nucleic acid bases. Anthanthrene which lacks bay region and 10-aza-benzo[a)作者: 延期 時(shí)間: 2025-3-27 19:14
N. Slimani,A. Makhoute,M. Tlidire .: positive ions or uncharged molecules with reactive centers at their electron deficient atoms (see e.g. 1,2). This is true both for carcinogens considered as being active . (a number of relatively simple alkylating agents) and those which necessitate a metabolic activation (aromatic hydrocarbon作者: dyspareunia 時(shí)間: 2025-3-28 00:07
Business Cycles: Discrete Time,ar orbital calculations. Of particular interest is the degree to which epoxide ring opening may be facilitated by either or both of two special factors: (1) The proximity, in the molecule, of a double bond, and (2) intramolecular hydrogen bonding between an appropriately oriented hydroxyl group and 作者: BILIO 時(shí)間: 2025-3-28 04:31
https://doi.org/10.1007/978-3-642-60775-2e hamster cells. Within a series of hydrocarbon epoxides, differences in mutagenic effectiveness and efficiency were related to carcinogenic potency. The cell-mediated mutation system was used to compare the mutagenic efficiency of a series of parent hydrocarbons. Quantitative studies of the mutagen作者: 占線 時(shí)間: 2025-3-28 08:35
https://doi.org/10.1007/978-3-642-60775-2ymerase in the presence of Mn.. When normal hydrogen bonding is blocked by a substituent, total ambiguity results with transcription continuing beyond the modified nucleotide. Examples are 3-MeC, 3-MeU, 1-MeA and O.-MeU. In the case of modifications of the exocyclic amino groups, in addition to the 作者: Pulmonary-Veins 時(shí)間: 2025-3-28 13:13 作者: ETHER 時(shí)間: 2025-3-28 17:55 作者: ATRIA 時(shí)間: 2025-3-28 22:48 作者: epinephrine 時(shí)間: 2025-3-28 23:43
Business Cycles: Discrete Time,dihydroxybenzo(a)pyrene and 9-hydroxybenzo(a)pyrene are the major DNA-binding species formed in different experimental systems. Both the extent and pattern of formation of DNA-bound benzo(a)pyrene metabolites varies however between different systems. The formation of DNA-bound metabolites of 9-hydro作者: 火花 時(shí)間: 2025-3-29 06:33 作者: 確定無疑 時(shí)間: 2025-3-29 08:14
Business Cycles: Continuous Space,mum conditions, a binding level of one AFB., residue per 18 DNA nucleotides can be attained. Acid hydrolysis of the modified DNA liberates a mixture of adducts, of which the major one, representing about 90% of bound AFB., is 2,3-dihydro-2-(N.-guanyl) -3-hydroxyAFB. (I). A single i.p. injection of A作者: Goblet-Cells 時(shí)間: 2025-3-29 12:17 作者: GREEN 時(shí)間: 2025-3-29 17:26
https://doi.org/10.1007/978-3-642-97291-1tNU), a highly potent mutagen and pulse-carcinogen (with a developmental stage-dependent, neural tissue-specific tumorigenic effect in rats), about a dozen different DNA ethylation products are known. Of the various sites of ethylation in DNA, the O.-position of deoxyguanosine (dGuo) is of particula作者: 營養(yǎng) 時(shí)間: 2025-3-29 22:20
https://doi.org/10.1007/978-3-642-97291-1 as previously defined in epidermal carcinogenesis in the mouse. Evidence is presented that the immediate clonal progeny of initiated hepatocytes can be distinguished as foci by one of four histochemical techniques. 85% of the total identifiable foci could be scored as .-glutamyl peptidase positive 作者: figure 時(shí)間: 2025-3-30 02:42 作者: 總 時(shí)間: 2025-3-30 05:18 作者: 松雞 時(shí)間: 2025-3-30 11:43
https://doi.org/10.1007/978-3-642-60775-2cation of the adjacent double bond of the dihydrodiols. Quasi-diaxial trans-dihydrodiols with an adjacent double bond at the bay-regions are not or minimally metabolized to the vicinal dihydrodiol-epoxides. A methyl substituent at the hydroxylated carbons or at the adjacent double bonds of the quasi作者: OUTRE 時(shí)間: 2025-3-30 12:43
Business Cycles: Discrete Time,r than to differences in the biological end- points, .., bacterial mutagenicity . mammalian carcinogenicity. Addition and removal of cofactors or pure enzymes showed differential involvement in the control of the mutagenically reactive metabolites of the aromatic carcinogens investigated of monooxyg作者: 翅膀拍動(dòng) 時(shí)間: 2025-3-30 17:50 作者: 正面 時(shí)間: 2025-3-31 00:27 作者: Jejune 時(shí)間: 2025-3-31 02:15
Carcinogenesis: Fundamental Mechanisms and Environmental EffectsProceedings of the T作者: 神圣在玷污 時(shí)間: 2025-3-31 06:14 作者: FEAS 時(shí)間: 2025-3-31 10:10 作者: 移植 時(shí)間: 2025-3-31 15:06 作者: 隱語 時(shí)間: 2025-3-31 19:56
Enzymic Control of Reactive Metabolites from Aromatic Carcinogens,r than to differences in the biological end- points, .., bacterial mutagenicity . mammalian carcinogenicity. Addition and removal of cofactors or pure enzymes showed differential involvement in the control of the mutagenically reactive metabolites of the aromatic carcinogens investigated of monooxyg作者: monopoly 時(shí)間: 2025-3-31 22:15 作者: Debark 時(shí)間: 2025-4-1 01:49
Immunological Detection and Quantification of DNA Components Structurally Modified by Alkylating Cale to eliminate from their DNA the O.-ethyl- dGuo produced by EtNU. To facilitate quantification of alkylation products at low concentrations in the DNA of small amounts of tissues and cells, we have, as a first step, developed high-affinity “conventional” and monoclonal antibodies specifically dire作者: Dappled 時(shí)間: 2025-4-1 07:17 作者: adumbrate 時(shí)間: 2025-4-1 10:52 作者: –吃 時(shí)間: 2025-4-1 16:26
Dihydrodiols and Diol-Epoxides in the Activation and Detoxification of Polycyclic Hydrocarbons,ter embryo cells treated with the hydrocarbon contain adducts arising from the reactions with the nucleic acid of both the ‘bay- region’ .-3,4-diol-1,2-epoxide and the non-‘bay-region’ .-8,9- diol-10,11-epoxide. However, only the 8,9-diol-10,11-epoxide appears to be involved in the reaction of the h作者: 鋸齒狀 時(shí)間: 2025-4-1 22:23
Metabolically Generated Free Radicals from Many Types of Chemical Carcinogens and Binding of the Raderivatives, acetylaminofluorene and naphthylamines have been found to be easily converted to free radicals after being activated to the proximate forms. These free radicals were sufficiently reactive to bind covalently with nucleic acid bases. Anthanthrene which lacks bay region and 10-aza-benzo[a)作者: Gnrh670 時(shí)間: 2025-4-1 22:54
Nucleophilicity of DNA. Relation to Chemical Carcinogenesis.,re .: positive ions or uncharged molecules with reactive centers at their electron deficient atoms (see e.g. 1,2). This is true both for carcinogens considered as being active . (a number of relatively simple alkylating agents) and those which necessitate a metabolic activation (aromatic hydrocarbon
