作者: LOPE 時間: 2025-3-21 21:38 作者: 法律的瑕疵 時間: 2025-3-22 01:50
Ahmed M. Ali,Bedatri Moulik,Dirk S?ffkerand α.2.3, respectively; also known as α.,α. and α.). The use of selective peptide toxins has allowed the association of Ca.2.1, 2.2 and 2.3 with P- or Q-, N-, and B-type calcium currents, respectively (Catterall, 2000; Ertel et al., 2000; Jarvis and Zamponi, 2001). These currents are found almost e作者: AVOW 時間: 2025-3-22 06:45 作者: 控制 時間: 2025-3-22 11:20
Neue Dynamiken in der Süd-Süd-Kooperationpotent and highly selective blockers or modulators of calcium channel function, and as such are valuable pharmacological tools and potentially valuable leads in human therapeutic development. Cone shells and spiders are rich sources of such toxins, although they are also found in scorpions and insec作者: 辯論的終結(jié) 時間: 2025-3-22 13:18 作者: 辯論的終結(jié) 時間: 2025-3-22 18:34 作者: 大笑 時間: 2025-3-23 00:28
https://doi.org/10.1007/978-3-322-89441-0elease, control of neuronal excitability, and gene expression (Catterall, 1998 Hofmann et al., 1999). To date, several kinds of VDCCs have been identified by electrophysiological and pharmacological means, and molecular biological studies have identified ten mammalian genes coding for the pore-formi作者: 問到了燒瓶 時間: 2025-3-23 04:35 作者: 愉快嗎 時間: 2025-3-23 05:32
https://doi.org/10.1007/978-3-663-15858-5lead to calcium channel modulation. Agonist activation of the GPCR superfamily releases a G protein heterotrimer and promotes dissociation of a G protein α subunit from a G protein βγ heterodimer. Each of these components (Gα and Gβγ) regulates calcium channel activity. Gα mediates voltage-independe作者: 強(qiáng)化 時間: 2025-3-23 11:37
https://doi.org/10.1007/978-3-531-19795-1age-gated calcium channel family. All major calcium channel subunits, Ca.α., Ca.β, and Ca.α.γ, are subject to alternative splicing. The structural changes generated by this form of RNA processing are often quite subtle but clearly critical for highly effective coupling to specific signaling pathways作者: 盲信者 時間: 2025-3-23 14:08
http://image.papertrans.cn/c/image/220770.jpg作者: Merited 時間: 2025-3-23 19:38 作者: 試驗 時間: 2025-3-23 22:56 作者: 做事過頭 時間: 2025-3-24 05:38 作者: bibliophile 時間: 2025-3-24 10:12
Heinrich Ostendarp,Manfred Weck models of state-dependent inhibition, including use-dependent block, modulated and guarded receptors, and drug-inactivation synergism, and shows how these models can explain the molecular mechanisms of block by several commonly used calcium channel antagonists.作者: Autobiography 時間: 2025-3-24 12:36
Xiaoyi Ma,Xiaowei Hu,Dieter Schrammth processes. Thus, in a very real sense we are conceived in a moment of calcium-mediated enthusiasm, we die from an excess of calcium and we are laid to rest under a tombstone of calcium carbonate. Voltage-gated calcium channels are important contributors to both the life and death of the cell.作者: Grievance 時間: 2025-3-24 18:04 作者: floodgate 時間: 2025-3-24 19:38 作者: 硬化 時間: 2025-3-24 23:16
Book 2004r a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant作者: 緯線 時間: 2025-3-25 04:22
https://doi.org/10.1007/978-3-322-89441-0e the skeletal L-type calcium channel α., which is the only calcium channel that coordinates muscle contraction in skeletal muscle, and the L-type channel subtype α., whose expression seems to be restricted to retinaltissue.作者: Bother 時間: 2025-3-25 11:05 作者: 細(xì)絲 時間: 2025-3-25 15:07 作者: canonical 時間: 2025-3-25 18:52
Modulation of High Voltage-Activated Calcium Channels by G Protein-Coupled Receptors,ling cascades are presented briefly. We examine the molecular determinants of Gβγ binding to presynaptic calcium channels and the modulation of Gβγ effects by other converging signaling pathways. Mechanisms for desensitization of GPCR activity and new evidence of receptor dimerization will be discussed.作者: Focus-Words 時間: 2025-3-25 21:26 作者: 異常 時間: 2025-3-26 02:20
https://doi.org/10.1007/978-3-531-19795-1development. In certain instances, structural and functional differences generated by alternative splicing translate into unique pharmacological phenotypes. Pharmacologically distinct splice isoforms preferentially expressed in specific tissues or cell types offer exciting new targets for the design of highly specific drugs.作者: Initiative 時間: 2025-3-26 04:46 作者: 夾死提手勢 時間: 2025-3-26 11:31 作者: Fierce 時間: 2025-3-26 16:09 作者: 串通 時間: 2025-3-26 17:52
Pharmacology of Cav1 (L-Type) Channels,lcium is a key physiological requirement for both sperm motility and the fertilization response, and calcium is a pathological contributor to cell death processes. Thus, in a very real sense we are conceived in a moment of calcium-mediated enthusiasm, we die from an excess of calcium and we are laid作者: fiction 時間: 2025-3-26 21:30
The Therapeutic Utility of Targeting Cav2 Channels,and α.2.3, respectively; also known as α.,α. and α.). The use of selective peptide toxins has allowed the association of Ca.2.1, 2.2 and 2.3 with P- or Q-, N-, and B-type calcium currents, respectively (Catterall, 2000; Ertel et al., 2000; Jarvis and Zamponi, 2001). These currents are found almost e作者: 漂白 時間: 2025-3-27 01:54 作者: HAUNT 時間: 2025-3-27 08:21 作者: 使困惑 時間: 2025-3-27 10:12
Pharmacology of Cav3 (T-Type) Channels,e 1984). Ca. entry through these channels serves to regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression, in response to action potentials and other membrane potential changes. Although all voltage-operated Ca. channels are activated by a conformati作者: jocular 時間: 2025-3-27 16:46
Cellular Functions of Calcium Channel Subtypes,ase and cell migration. Voltage-activated calcium channels play a crucial role in severalof these processes (see Figure 1). Although the functional diversity of calcium channels can be explained by the rich molecular variety of this channel superfamily, a common denominator of calcium channel functi作者: countenance 時間: 2025-3-27 19:02 作者: sacrum 時間: 2025-3-28 00:19 作者: Enervate 時間: 2025-3-28 05:10
Modulation of High Voltage-Activated Calcium Channels by G Protein-Coupled Receptors,lead to calcium channel modulation. Agonist activation of the GPCR superfamily releases a G protein heterotrimer and promotes dissociation of a G protein α subunit from a G protein βγ heterodimer. Each of these components (Gα and Gβγ) regulates calcium channel activity. Gα mediates voltage-independe作者: corporate 時間: 2025-3-28 09:23
Alternative Splicing in Voltage Gated Calcium Channels,age-gated calcium channel family. All major calcium channel subunits, Ca.α., Ca.β, and Ca.α.γ, are subject to alternative splicing. The structural changes generated by this form of RNA processing are often quite subtle but clearly critical for highly effective coupling to specific signaling pathways作者: Mendacious 時間: 2025-3-28 11:50
Book 2004vioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.作者: Stress-Fracture 時間: 2025-3-28 16:32 作者: 邪惡的你 時間: 2025-3-28 18:48 作者: 生氣的邊緣 時間: 2025-3-29 00:34
Calcium Channel Blocking Polypeptides,eatment of chronic pain. We then consider how these naturally occurring toxins might be mimicked in non-peptide (peptidomimetic) compounds that could be useful therapeutically for the treatment of pain and in other indications.作者: Between 時間: 2025-3-29 06:46 作者: cyanosis 時間: 2025-3-29 10:14
Genetic Approaches to the Elucidation of Calcium Channel Functions in Vivo,since it can be used to eliminate completely a specific VDCC in all the cells of an animal. An increasing number of knockout animals carrying mutations in VOCC genes have been reported, to study the . functions of different VDCCs. This chapter reviews the abnormalities found in VDCC knockout mice an作者: 不怕任性 時間: 2025-3-29 14:18 作者: perimenopause 時間: 2025-3-29 16:47 作者: murmur 時間: 2025-3-29 23:08
Neue Dynamiken in der Süd-Süd-Kooperationeatment of chronic pain. We then consider how these naturally occurring toxins might be mimicked in non-peptide (peptidomimetic) compounds that could be useful therapeutically for the treatment of pain and in other indications.作者: 威脅你 時間: 2025-3-30 01:40
Einleitung, Fragestellung und These,hysiological and pharmacological characterization of voltage-operated Ca. channel . and the biochemical and molecular characterization of voltage-operated Ca. channel .. This has led to the emergence of two separate nomenclatures. The correspondence between these two nomenclatures has been difficult
