標(biāo)題: Titlebook: Calcium Antagonists; Mechanism of Action Nicholas Sperelakis,James B. Caulfield Book 1984 Martinus Nijhoff Publishing, Boston 1984 calcium [打印本頁(yè)] 作者: 孵化 時(shí)間: 2025-3-21 18:35
書(shū)目名稱Calcium Antagonists影響因子(影響力)
作者: Peristalsis 時(shí)間: 2025-3-21 21:59 作者: DEAF 時(shí)間: 2025-3-22 01:31
Action of Calcium Slow Channel Inhibitors on Cardiac and Vascular Smooth Muscle MembranesCa.-selective slow channels during the phase 2 of the action potential when these channels are presumably “open.” A number of organic compounds classified as calcium antagonists (1) were found to antagonize the extracellular Ca.-dependent contraction. These compounds are also referred to as “calcium作者: CLAIM 時(shí)間: 2025-3-22 07:10 作者: 污穢 時(shí)間: 2025-3-22 11:31
Antianginal Effects of Calcium Antagoniststo a patient provides the basis for their increasing use in patients disabled by angina pectoris due to either occlusive coronary artery disease or coronary artery spasm. As discussed elsewhere in this symposium, the relative selectivity of calcium blockers for vascular smooth muscle over cardiac mu作者: 閃光東本 時(shí)間: 2025-3-22 13:25
Clinical Electrophysiology of the Calcium Antagonistsvailable until Fleckenstein and colleagues (2) proposed the concept of calcium antagonism. A variety of substances were shown to be capable of inhibiting the transmembrane passage of calcium ions. Although this work had concentrated on the role of calcium in the myocardium the profound influence of 作者: 閃光東本 時(shí)間: 2025-3-22 17:50
Basic Features of The Frequency- and Voltage-Dependent Block By D600 of Calcium Channels in Ventricuoupling, sinoatrial rhythm, atrioventricular transmission, and certain patterns of dysrhythmia. A variety of organic agents, of which verapamil and D600 (methoxyverapamil) have been best studied, block Ca channels and thereby reduce I. in cardiac tissue (1–4). The consequences of this action include作者: CLAY 時(shí)間: 2025-3-22 23:15 作者: 無(wú)法破譯 時(shí)間: 2025-3-23 02:27 作者: Manifest 時(shí)間: 2025-3-23 09:31 作者: Intentional 時(shí)間: 2025-3-23 12:52 作者: META 時(shí)間: 2025-3-23 15:39
The Potentially Direct Role of Intracellular Calcium Overload in the Electrophysiology of Cardiac Isnnually in the United States. A substantial fraction of these deaths result from immediate effects of ischemia on the electrophysiological properties of ventricular myocardium. Within the first minute after coronary occlusion, there is a reduction in the resting potential of ischemic cells, together作者: connoisseur 時(shí)間: 2025-3-23 18:59
Mechanisms of the Beneficial Effects of Some Ca2+ Antagonists on the Ca2+-Paradox in Myocardiumentry of Ca. through slow calcium channels (1–3). These agents therefore can be seen to protect myocardium under pathophysiological conditions which are associated with a massive amount of Ca. entry and the occurrence of intracellular Ca. overload. Reperfusion of an isolated rat heart with a medium 作者: EXALT 時(shí)間: 2025-3-24 01:20 作者: conceal 時(shí)間: 2025-3-24 02:38 作者: CRAMP 時(shí)間: 2025-3-24 08:07 作者: 結(jié)構(gòu) 時(shí)間: 2025-3-24 11:11 作者: Congruous 時(shí)間: 2025-3-24 17:48
https://doi.org/10.1007/978-3-642-52615-200 (methoxyverapamil) have been best studied, block Ca channels and thereby reduce I. in cardiac tissue (1–4). The consequences of this action include a depression of the action potential plateau and contraction in ventricular muscle (3,5) as well as a reduction in the sinus rate and a prolongation of conduction time through the AV node (6).作者: Indecisive 時(shí)間: 2025-3-24 20:55 作者: Allodynia 時(shí)間: 2025-3-25 02:17 作者: 勉強(qiáng) 時(shí)間: 2025-3-25 07:04 作者: Inoperable 時(shí)間: 2025-3-25 11:00
Neue Aspekte der Wissenschaftstheoriechemic border, which may produce the initiating beat of ventricular fibrillation (1,2). Moreover, early depolarization of ischemic myocardium causes slowing of conduction, which could, in turn, produce arrhythmias by permitting re-entrant conduction within or around the infarct zone.作者: Altitude 時(shí)間: 2025-3-25 15:19
Neue Aspekte der betrieblichen Planung of the effect of calcium upon contraction in both cardiac and smooth muscle (3, 4, 5, 6, 7). Those interactions, in particular calcium binding to the cardiac sarcolemma and various other cell membranes, are the subject of this work.作者: 殺菌劑 時(shí)間: 2025-3-25 16:07
Effect of Nifedipine on Rat Papillary Muscle and Perfused Heart during cold ischemic arrest in cardiac surgery (Clark et al, 1979). It is thus more than of theoretical interest to know the dependence of the effect of nifedipine on frequency and temperature, two variables which are deeply involved in the calcium turnover of the heart muscle cell.作者: Corral 時(shí)間: 2025-3-25 21:32 作者: Dissonance 時(shí)間: 2025-3-26 00:10
The Effect of Verapamil on Lanthanum (La3+) Binding in the Isolated Rabbit Heart of the effect of calcium upon contraction in both cardiac and smooth muscle (3, 4, 5, 6, 7). Those interactions, in particular calcium binding to the cardiac sarcolemma and various other cell membranes, are the subject of this work.作者: 同時(shí)發(fā)生 時(shí)間: 2025-3-26 06:51 作者: Glycogen 時(shí)間: 2025-3-26 11:04
https://doi.org/10.1007/978-3-642-52615-2d explanations for such phenomena as the selective depression of conduction in ischemic myocardium, suppression of tachycardias, and the selective action of lidocaine on ventricular vs. atrial tissue (4).作者: foodstuff 時(shí)間: 2025-3-26 14:25 作者: jaunty 時(shí)間: 2025-3-26 20:10 作者: hurricane 時(shí)間: 2025-3-26 21:15
Evidence for a Modulated Receptor Mechanism of Calcium Channel Blockaded explanations for such phenomena as the selective depression of conduction in ischemic myocardium, suppression of tachycardias, and the selective action of lidocaine on ventricular vs. atrial tissue (4).作者: 亞當(dāng)心理陰影 時(shí)間: 2025-3-27 02:16
Calcium Antagonistic Agents: Uptake into Various Muscles and their Effects on Calcium Bindingpling of contraction from excitation. Their action can be greatly counteracted by increasing concentration of external calcium. Electrophysiological studies show that the mode of action of these drugs is due to a decrease of transmembrane conductance for calcium ions and, consequently, to a reduction of the slow inward calcium current.作者: 極深 時(shí)間: 2025-3-27 07:44
https://doi.org/10.1007/978-3-642-52615-2 smooth muscle than in cardiac muscle, producing vasodilation at low concentrations and negative inotropy at much higher concentrations. By virtue of this differential effect, some of these calcium antagonists have been found to be useful in the treatment of angina pectoris.作者: 期滿 時(shí)間: 2025-3-27 10:58
https://doi.org/10.1007/978-3-642-52615-2y effective in patients with typical exertional angina as well. This paper will review the clinical applications of the calcium blockers in patients with either coronary artery spasm or exertional angina due to occlusive coronary artery disease.作者: babble 時(shí)間: 2025-3-27 14:44 作者: 我們的面粉 時(shí)間: 2025-3-27 19:19
https://doi.org/10.1007/978-3-662-28386-8ectrogenic influx of calcium occurs during depolarization and has been described by Reuter (11) as a slow inward flow of current and is usually thought to be associated with the plateau of the transmembrane action potential.作者: 歡笑 時(shí)間: 2025-3-28 01:24
Action of Calcium Slow Channel Inhibitors on Cardiac and Vascular Smooth Muscle Membranes smooth muscle than in cardiac muscle, producing vasodilation at low concentrations and negative inotropy at much higher concentrations. By virtue of this differential effect, some of these calcium antagonists have been found to be useful in the treatment of angina pectoris.作者: impaction 時(shí)間: 2025-3-28 04:32
Antianginal Effects of Calcium Antagonistsy effective in patients with typical exertional angina as well. This paper will review the clinical applications of the calcium blockers in patients with either coronary artery spasm or exertional angina due to occlusive coronary artery disease.作者: 擴(kuò)張 時(shí)間: 2025-3-28 08:49
Effects of Calcium Antagonistic Drugs on Various Heart Tissues, Including Blockade of the Slow Channe drugs, like verapamil, methoxy-verapamil (D600), and nifedipine also block the slow Na. channels of young embryonic chick hearts, these drugs are more accurately described as “slow channel blockers” (Shigenobu et al., 1974; Lee & Tsien, 1983; Kojima & Sperelakis, 1983).作者: 神圣不可 時(shí)間: 2025-3-28 11:27 作者: ANTI 時(shí)間: 2025-3-28 18:19 作者: CRANK 時(shí)間: 2025-3-28 22:25
Clinical Electrophysiology of the Calcium Antagonistsofound importance in the generation and propagation of electrical activity in the SA and AV nodes. Although, in both the transitional cells of the SA node and the N cells of the AV node, sodium ions have a role in the initial generation of the action potential it is calcium which determines to a gre作者: irritation 時(shí)間: 2025-3-29 01:45
Mechanisms of the Beneficial Effects of Some Ca2+ Antagonists on the Ca2+-Paradox in Myocardiumum are far from clear. Some investigators have shown the protective effects of both verapamil and diltiazem against the Ca. -paradox related myocardial injury and have interpreted their results to mean that the massive Ca. -influx during Ca. -paradox is occurring through the slow calcium channels (1作者: MILL 時(shí)間: 2025-3-29 03:38
Comparative Effects of Ca Slow Channel Blockers on the Hamster Hereditary Cardiomyopathytary cardiomyopathy without changing the overall course of the generalized polymyopathy that prevails in these animals (7,9). Until now, the effectiveness of verapamil in hindering the progression of skeletal muscle changes has remained unexplained except for the fact that presumably Ca slow channel作者: Enthralling 時(shí)間: 2025-3-29 07:56 作者: 圓錐體 時(shí)間: 2025-3-29 15:10
https://doi.org/10.1007/978-3-642-52615-2l studies have provided considerable information about the influx of calcium through specific membrane pores, the transport mechanisms responsible for the extrusion of calcium are less well understood (2). It has been assumed that accumulation of calcium in injured cells reflects predominantly a pas作者: 現(xiàn)實(shí) 時(shí)間: 2025-3-29 18:40
https://doi.org/10.1007/978-3-642-52615-2ofound importance in the generation and propagation of electrical activity in the SA and AV nodes. Although, in both the transitional cells of the SA node and the N cells of the AV node, sodium ions have a role in the initial generation of the action potential it is calcium which determines to a gre作者: incite 時(shí)間: 2025-3-29 22:35
,über synthetisch-apriorische Urteile,um are far from clear. Some investigators have shown the protective effects of both verapamil and diltiazem against the Ca. -paradox related myocardial injury and have interpreted their results to mean that the massive Ca. -influx during Ca. -paradox is occurring through the slow calcium channels (1作者: d-limonene 時(shí)間: 2025-3-30 02:12
https://doi.org/10.1007/978-3-663-00199-7tary cardiomyopathy without changing the overall course of the generalized polymyopathy that prevails in these animals (7,9). Until now, the effectiveness of verapamil in hindering the progression of skeletal muscle changes has remained unexplained except for the fact that presumably Ca slow channel作者: Perceive 時(shí)間: 2025-3-30 04:43 作者: Congruous 時(shí)間: 2025-3-30 09:58 作者: 外露 時(shí)間: 2025-3-30 15:16 作者: 谷類 時(shí)間: 2025-3-30 17:36 作者: 連鎖 時(shí)間: 2025-3-30 23:03 作者: Nonconformist 時(shí)間: 2025-3-31 03:20 作者: leniency 時(shí)間: 2025-3-31 06:43 作者: STAT 時(shí)間: 2025-3-31 09:36
https://doi.org/10.1007/978-3-642-52615-2uscle cells through the voltage-dependent and time-dependent slow channels. Hence, these drugs are also known as Ca. entry blockers, slow channel blockers, or organic calcium antagonistis (to contrast with the inorganic calcium antagonists, such as Mn., Co., Mg., and La.). The organic structure of t作者: 拉開(kāi)這車床 時(shí)間: 2025-3-31 13:36 作者: 肌肉 時(shí)間: 2025-3-31 19:21
https://doi.org/10.1007/978-3-642-52615-2Ca.-selective slow channels during the phase 2 of the action potential when these channels are presumably “open.” A number of organic compounds classified as calcium antagonists (1) were found to antagonize the extracellular Ca.-dependent contraction. These compounds are also referred to as “calcium作者: 愛(ài)了嗎 時(shí)間: 2025-4-1 01:35 作者: demote 時(shí)間: 2025-4-1 05:22
https://doi.org/10.1007/978-3-642-52615-2to a patient provides the basis for their increasing use in patients disabled by angina pectoris due to either occlusive coronary artery disease or coronary artery spasm. As discussed elsewhere in this symposium, the relative selectivity of calcium blockers for vascular smooth muscle over cardiac mu
