標(biāo)題: Titlebook: CNS Neuroprotection; Frank W. Marcoux (Vice President, Biology),Dennis Book 2002 Springer-Verlag Berlin Heidelberg 2002 Central Nervous S [打印本頁(yè)] 作者: SPARK 時(shí)間: 2025-3-21 16:53
書(shū)目名稱(chēng)CNS Neuroprotection影響因子(影響力)
作者: 吝嗇性 時(shí)間: 2025-3-21 23:52 作者: 議程 時(shí)間: 2025-3-22 03:51
Our World is a Narrative World,n the patient’s family, the health care system, and society in general. The National Head and Spinal Cord Injury Survey estimates the rate of occurrence of severe head injury at 200 per 100000 (. et al. 1996). Motor vehicle accidents are the primary cause of both brain and spinal cord injury, and young healthy males are the primary victims.作者: 挑剔小責(zé) 時(shí)間: 2025-3-22 04:41 作者: 晚來(lái)的提名 時(shí)間: 2025-3-22 10:12
Traumatic Central Nervous System Injuryn the patient’s family, the health care system, and society in general. The National Head and Spinal Cord Injury Survey estimates the rate of occurrence of severe head injury at 200 per 100000 (. et al. 1996). Motor vehicle accidents are the primary cause of both brain and spinal cord injury, and young healthy males are the primary victims.作者: FLIC 時(shí)間: 2025-3-22 13:11
,Introduction Narrative’s Lost Body,m in this pathologic sequence has prompted the development of glutamate and calcium receptor antagonists. Unfortunately, these strategies have not produced in humans the degree of protection observed in animal models of acute necrotic stroke (. and . 1999).作者: FLIC 時(shí)間: 2025-3-22 18:12 作者: 正面 時(shí)間: 2025-3-22 21:23
Narrationen in der politischen Bildunging specificity for blocking Ca. and Na. channels have proven to be neuroprotective in various animal models. Several of these have been studied in placebo-controlled clinical trials. Unfortunately, to date, none of these compounds has unequivocally reduced human brain damage from stroke, cardiac arrest, or head trauma.作者: 搖曳的微光 時(shí)間: 2025-3-23 03:21
Sodium and Calcium Channel Blockersing specificity for blocking Ca. and Na. channels have proven to be neuroprotective in various animal models. Several of these have been studied in placebo-controlled clinical trials. Unfortunately, to date, none of these compounds has unequivocally reduced human brain damage from stroke, cardiac arrest, or head trauma.作者: 落葉劑 時(shí)間: 2025-3-23 09:18 作者: judiciousness 時(shí)間: 2025-3-23 11:39 作者: 補(bǔ)助 時(shí)間: 2025-3-23 13:57
,Introduction Narrative’s Lost Body,ex vivo gene therapy. The direct injection of genes into the CNS using viral vectors or DNA-liposome suspensions is termed in vivo gene therapy. Ex vivo gene therapy is based on genetic modification of cells in vitro followed by the grafting of these cells into the CNS. Ex vivo approaches to gene therapy will be the focus of this review.作者: goodwill 時(shí)間: 2025-3-23 21:43
Limiting Apoptosis as a Strategy for CNS Neuroprotectionchromatin fragments (in a punctuate fashion) all over the nuclei. Eventually, the nuclei become leaky and ultimately the plasma membrane ruptures. At least under in vitro conditions, necrosis is rapid and the time course of cell death is usually within 1–5-h death (. and . 1995).作者: Delirium 時(shí)間: 2025-3-23 23:35
Ex Vivo Gene Therapy in the Central Nervous Systemex vivo gene therapy. The direct injection of genes into the CNS using viral vectors or DNA-liposome suspensions is termed in vivo gene therapy. Ex vivo gene therapy is based on genetic modification of cells in vitro followed by the grafting of these cells into the CNS. Ex vivo approaches to gene therapy will be the focus of this review.作者: 同步信息 時(shí)間: 2025-3-24 03:25
Narrating the Past through Theatreonotropic and metabotropic receptors (. et al. 1981; . and . 1987; . and . 1994). Under pathological conditions, glutamate receptor overactivation can trigger neuronal death, a phenomenon known as excitotoxicity (. and . 1957; . 1969). Incentive for developing practical methods for blocking excitoto作者: Lipoprotein 時(shí)間: 2025-3-24 07:30
https://doi.org/10.1057/9781137275424th (. and . 1995). Necrosis usually applies to cell death that occurs to a group of cells or part of an organ in vivo, but the term has more recently been applied to cells in culture. Necrosis is the form of cell death which usually occurs when cells were injured by extreme physical stress or chemic作者: aspect 時(shí)間: 2025-3-24 13:59
Introduction: A Decade under Construction,er the upregulation or induction of adhesion molecules and the release of biologically active substances, are collectively termed .. The inflammatory response is not antigen-specific and occurs following all modes of tissue injury, including traumatic, ischemic, and infectious insults. In infection,作者: 缺乏 時(shí)間: 2025-3-24 18:25 作者: 容易做 時(shí)間: 2025-3-24 22:23
Narratives and Pragmatic Arguments: Ivens’ ,ny different neurological disorders, with a focus on cerebral ischemia. I will not attempt to review the extensive literature supporting the involvement of calcium in ischemic injury to neurons (see . 1995; . and . 1996 for review), but rather will provide selected examples of such evidence, togethe作者: 魯莽 時(shí)間: 2025-3-25 02:03 作者: 樂(lè)意 時(shí)間: 2025-3-25 05:16 作者: Provenance 時(shí)間: 2025-3-25 11:19
Narrationen in der politischen Bildung trauma. Typically, neuroprotection is studied by acute drug treatment shortly after the insult in animal models of stroke, brain ischemia, or head trauma. The study of neuroprotection with organic cation channel blockers probably begins with nimodipine. This drug is a 1,4-dihydropyridine compound c作者: tooth-decay 時(shí)間: 2025-3-25 11:56
Methode ?Visionen und erste Schritte“ molecular oxygen is reduced to water, a small fraction (2%–5%) of the oxygen is converted to superoxide radical . by a one-electron reduction mechanism. Superoxide is further converted to hydrogen peroxide and related metabolites. Such semi-reduced species of oxygen (reactive oxygen species) are hi作者: Euthyroid 時(shí)間: 2025-3-25 16:03
Eva Clot-Siegrist,Federico Durante l).The current number of chemokines exceeds 50 related proteins. These proteins range in size from 68–120 amino acids (in the mature form) and can be segregated into at least four structural branches: C, C-C, C-X-C, and CXXXC according to variations in a shared cysteine motif. The largest branch, i作者: 裂縫 時(shí)間: 2025-3-25 23:35
,Introduction Narrative’s Lost Body,improved viral vector systems and suitable strategies for therapeutic intervention. Experimental gene therapy in animal models has been studied to prevent or slow the progression of chronic neurodegenerative diseases, to improve recovery after traumatic CNS injury and to kill malignant brain tumors.作者: 興奮過(guò)度 時(shí)間: 2025-3-26 02:45
,Introduction Narrative’s Lost Body, of vessel occlusion. Profound hypoperfusion produces neuronal necrosis in a matter of hour, resulting in plasma membrane rupture and subsequent release of synaptic and somal contents to the interstitial space. An appreciation for the role of elevated extracellular glutamate and intracellular calciu作者: FID 時(shí)間: 2025-3-26 05:22 作者: chronology 時(shí)間: 2025-3-26 09:45
Our World is a Narrative World,lity and death, particularly among young adults. The medical sequelae of central nervous system injury are substantial, resulting in large demands upon the patient’s family, the health care system, and society in general. The National Head and Spinal Cord Injury Survey estimates the rate of occurren作者: Individual 時(shí)間: 2025-3-26 12:56
Narrative Con/Texts in Dubliners acid, integral membrane precursor, the Alzheimer amyloid precursor protein (APP). The best evidence causally linking APP to Alzheimer’s disease has been provided by the discovery of mutations within the APP coding sequence that segregate with disease phenotypes in autosomal dominant forms of famili作者: 無(wú)聊的人 時(shí)間: 2025-3-26 18:34
Frank W. Marcoux (Vice President, Biology),Dennis Includes supplementary material: 作者: Genetics 時(shí)間: 2025-3-26 23:27 作者: 懶惰人民 時(shí)間: 2025-3-27 01:58
https://doi.org/10.1007/978-3-662-06274-6Central Nervous System; Chemokine; Gentherapie; Nervous System; Neurodegenerative Disease; Neuropharmakol作者: CONE 時(shí)間: 2025-3-27 07:03
978-3-642-07625-1Springer-Verlag Berlin Heidelberg 2002作者: 使入迷 時(shí)間: 2025-3-27 10:36 作者: Vasoconstrictor 時(shí)間: 2025-3-27 14:31
Narrating the Past through Theatretroke remains open, and there are other possible disease targets yet to be explored. Ongoing delineation of the cellular and molecular underpinnings of excitotoxicity has led to the progressive unveiling of countermeasures, aimed at attenuating presynaptic glutamate release, postsynaptic receptor ac作者: 自戀 時(shí)間: 2025-3-27 19:33
Introduction: A Decade under Construction, under normal circumstances, the blood-brain barrier (BBB) exists and the cerebral microvessels express few of the adhesion molecules required for leukocyte trafficking into the brain. But when the brain is injured, the BBB becomes compromised (. et al. 1996) and there is an upregulation of leukocyt作者: Phagocytes 時(shí)間: 2025-3-27 23:31 作者: pulmonary 時(shí)間: 2025-3-28 04:22 作者: Epidural-Space 時(shí)間: 2025-3-28 09:43 作者: 意外 時(shí)間: 2025-3-28 11:22
Methode ?Visionen und erste Schritte“ses are overwhelmed. The central nervous system is particularly sensitive to oxygen radical damage because of the high levels of polyunsaturated lipids present that, when peroxidized, compromise the integrity of neuronal cell membranes together with the specialized functions of those membranes.作者: adumbrate 時(shí)間: 2025-3-28 14:36 作者: adhesive 時(shí)間: 2025-3-28 19:47
Our World is a Narrative World, despite substantial effort and expense, no neuroprotective agent has yet been shown to improve clinical outcome in large, randomized multi-center trials. This review examines the data on neuroprotection in clinical stroke, with a focus on future directions for animal and human study.作者: 承認(rèn) 時(shí)間: 2025-3-29 00:25
Narrative Con/Texts in Dubliners or aggregability of A., consistent with a pathogenic role in AD. Other genetic loci for FAD have been discovered which are distinct from the immediate regulatory and coding regions of the APP gene, indicating that defects in molecules other than APP can also specify cerebral amyloidogenesis and FAD作者: 嘲笑 時(shí)間: 2025-3-29 05:58 作者: Psychogenic 時(shí)間: 2025-3-29 11:16
Book 2002lved in establishing the efficacy of these approaches through appropriate clinical trials. Section I, "Mechanistic Approaches to CNS Neuroprotection," reviews major injury mechanisms that have formed the basis for many past and present clinical trials conducted around the world. Dr. KIM and colleagu作者: faultfinder 時(shí)間: 2025-3-29 12:09
Blocking Excitotoxicitytroke remains open, and there are other possible disease targets yet to be explored. Ongoing delineation of the cellular and molecular underpinnings of excitotoxicity has led to the progressive unveiling of countermeasures, aimed at attenuating presynaptic glutamate release, postsynaptic receptor ac作者: Stress-Fracture 時(shí)間: 2025-3-29 17:28 作者: Lipoprotein 時(shí)間: 2025-3-29 21:26 作者: 天文臺(tái) 時(shí)間: 2025-3-30 00:59 作者: 共和國(guó) 時(shí)間: 2025-3-30 08:05 作者: gerontocracy 時(shí)間: 2025-3-30 11:48
Neuroprotection by Free Radical Scavengers and Other Antioxidantsses are overwhelmed. The central nervous system is particularly sensitive to oxygen radical damage because of the high levels of polyunsaturated lipids present that, when peroxidized, compromise the integrity of neuronal cell membranes together with the specialized functions of those membranes.作者: BRUNT 時(shí)間: 2025-3-30 12:26 作者: Absenteeism 時(shí)間: 2025-3-30 20:20
Stroke despite substantial effort and expense, no neuroprotective agent has yet been shown to improve clinical outcome in large, randomized multi-center trials. This review examines the data on neuroprotection in clinical stroke, with a focus on future directions for animal and human study.作者: HALO 時(shí)間: 2025-3-30 21:52
Neurohormonal Signalling Pathways and the Regulation of Alzheimer ,-Amyloid Metabolism Integrating B or aggregability of A., consistent with a pathogenic role in AD. Other genetic loci for FAD have been discovered which are distinct from the immediate regulatory and coding regions of the APP gene, indicating that defects in molecules other than APP can also specify cerebral amyloidogenesis and FAD作者: Buttress 時(shí)間: 2025-3-31 01:58 作者: 厚顏 時(shí)間: 2025-3-31 06:33
Limiting Apoptosis as a Strategy for CNS Neuroprotectionth (. and . 1995). Necrosis usually applies to cell death that occurs to a group of cells or part of an organ in vivo, but the term has more recently been applied to cells in culture. Necrosis is the form of cell death which usually occurs when cells were injured by extreme physical stress or chemic
