標題: Titlebook: Biophysics of the Pancreatic β-Cell; Illani Atwater,Eduardo Rojas,Bernat Soria Book 1986 The Editor(s) (if applicable) and The Author(s), [打印本頁] 作者: T-cell 時間: 2025-3-21 16:58
書目名稱Biophysics of the Pancreatic β-Cell影響因子(影響力)
書目名稱Biophysics of the Pancreatic β-Cell影響因子(影響力)學科排名
書目名稱Biophysics of the Pancreatic β-Cell網(wǎng)絡公開度
書目名稱Biophysics of the Pancreatic β-Cell網(wǎng)絡公開度學科排名
書目名稱Biophysics of the Pancreatic β-Cell被引頻次
書目名稱Biophysics of the Pancreatic β-Cell被引頻次學科排名
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書目名稱Biophysics of the Pancreatic β-Cell年度引用學科排名
書目名稱Biophysics of the Pancreatic β-Cell讀者反饋
書目名稱Biophysics of the Pancreatic β-Cell讀者反饋學科排名
作者: spinal-stenosis 時間: 2025-3-21 20:31 作者: GEST 時間: 2025-3-22 04:20
Guatemala, an Alternation in Continuitysmitters. Examples include secretory granules from chromaffin cells,. pancreatic B-cells,. platelets. and mast cells. We have recently shown. that it is possible to obtain real-time measurements of the kinetics of secretion of vesicle contents by monitoring ATP release from stimulated medullary chro作者: Malleable 時間: 2025-3-22 06:02 作者: Cultivate 時間: 2025-3-22 10:22
https://doi.org/10.1007/978-94-007-0504-3e recent review by Henquin & Meissner.). Microelectrode recordings have shown that in the absence of glucose the β-cell is electrically silent. Increasing plasma glucose depolarises the membrane by an amount that is dependent on the glucose concentration and electrical activity is initiated when thi作者: 預測 時間: 2025-3-22 15:33
,Adult ESL Immigrant Learners …, the cell, mobilizes calcium from stores within the cell and thus triggers the exocytosis of insulin.. Calcium uptake occurs when glucose depolarizes the β-cell membrane to trigger periodic bursts of calcium action potentials.. The mechanisms which couple glucose metabolism to the depolarization hav作者: 截斷 時間: 2025-3-22 19:19 作者: 注意到 時間: 2025-3-22 22:13
https://doi.org/10.1007/978-3-031-46105-7 is to evoke membrane depolarization. followed by a cyclical pattern of electrical activity consisting of slow waves of depolarization with action potential-like spikes.. Tracer flux studies have indicated that glucose metabolism is associated with a decrease in membrane K. permeability. and Ashcrof作者: albuminuria 時間: 2025-3-23 01:47 作者: Stable-Angina 時間: 2025-3-23 06:22
https://doi.org/10.1007/978-3-031-56118-4al models of diabetes mellitus.. They all have hyperglycemia, hyperinsulinemia, and obesity as common metabolic characteristics.. Among these mouse mutants, particular attention has been paid to the homozygous diabetes mouse carrying the diabetes gene (commonly known as the db/db mouse), and the hom作者: 相同 時間: 2025-3-23 10:58
https://doi.org/10.1007/978-3-031-56118-4al events in “stimulus-release coupling”.. However, very recent development of patch clamp techniques. has made it possible to undertake a detailed characterization of membrane ionic conductances present in these cells, and to elucidate their precise role in the regulation of secretion. Among the di作者: Torrid 時間: 2025-3-23 17:06
(Mariana Rondón. 2013, Venezuela)ry cells which allows extracellular Ca. to penetrate them and trigger the catecholamine ejection process.” The formation accumulated since then can be summarized in the diagram of the sequence of events taking place during the secretory cycle depicted in Fig. 1.作者: slow-wave-sleep 時間: 2025-3-23 19:07 作者: 小故事 時間: 2025-3-23 22:41
https://doi.org/10.1007/978-3-031-56118-4e secretory and electrical responses are furthermore known to be closely correlated.. From membrane potential recordings obtained with conventional intracellular electrodes and from flux measurements at least three types of currents have been postulated..作者: figment 時間: 2025-3-24 05:58
Americanization and Resistance, The RINm5F cell line was developed from an insulinoma induced initially in a rat and then transplanted through mice before being established as a continuous cell line.. The secretion of insulin by RINm5F cells can be stimulated by secretagogues such as glyceraldehyde and L-alanine and by exposure t作者: 熒光 時間: 2025-3-24 08:57 作者: inclusive 時間: 2025-3-24 12:38 作者: 混雜人 時間: 2025-3-24 15:08
https://doi.org/10.1007/978-0-387-88347-2. We have recently been able to document in isolated pancreatic endocrine cells removed from normal rats that an increase in extracellular D-glucose concentration provokes a rapid and sustained increase in cytosolic Ca. activity.. Several factors could contribute to this increase in cytosolic Ca. co作者: florid 時間: 2025-3-24 19:52 作者: palliative-care 時間: 2025-3-25 01:13 作者: 品嘗你的人 時間: 2025-3-25 06:51
Glucose-Evoked Changes in [K+] and [Ca2+] in the Intercellular Spaces of the Mouse Islet of Langerhanvolves the cyclic activation of K-channels.. Furthermore, it is well documented that the action potentials during the bursts result from the activation of two voltage-gated membrane channels, Ca-channels. and K-channels.作者: 名義上 時間: 2025-3-25 08:30
Pharmacological Properties of the Chromaffin Cell Calcium Channelry cells which allows extracellular Ca. to penetrate them and trigger the catecholamine ejection process.” The formation accumulated since then can be summarized in the diagram of the sequence of events taking place during the secretory cycle depicted in Fig. 1.作者: GLIB 時間: 2025-3-25 15:28
Calcium and Potassium Currents Recorded from Pancreatic β-Cells Under Voltage Clamp Controle secretory and electrical responses are furthermore known to be closely correlated.. From membrane potential recordings obtained with conventional intracellular electrodes and from flux measurements at least three types of currents have been postulated..作者: 滔滔不絕地說 時間: 2025-3-25 17:26 作者: deforestation 時間: 2025-3-25 21:12
Effects of Verapamil and Nifedipine on Glucose-Induced Electrical Activity in Pancreatic β-Cellss thought to be triggered by an increase in the cytosolic calcium concentration which appears partially related to the gating of Ca-channels, located at the plasma membrane. Experiments with Ca-channel blockers have confirmed this hypothesis: D600, Verapamil and Nifedipine cause a dose-dependent inhibition of the glucose-induced insulin release..作者: jarring 時間: 2025-3-26 02:50
(Diego Lerman. 2002, Argentina)The development of the patch-clamp technique, nearly ten years ago, allowed electrical measurements to be made under voltage-clamp conditions on small cells unsuitable for two microeletrodes voltage-clamp techniques (see[14]).作者: 他姓手中拿著 時間: 2025-3-26 06:35 作者: Malaise 時間: 2025-3-26 10:27 作者: patriot 時間: 2025-3-26 15:03
Guatemala, an Alternation in Continuitysmitters. Examples include secretory granules from chromaffin cells,. pancreatic B-cells,. platelets. and mast cells. We have recently shown. that it is possible to obtain real-time measurements of the kinetics of secretion of vesicle contents by monitoring ATP release from stimulated medullary chromaffin cells using luciferin-luciferase.作者: 小步舞 時間: 2025-3-26 17:17 作者: 鋼筆記下懲罰 時間: 2025-3-27 00:22 作者: aspersion 時間: 2025-3-27 02:49 作者: Irrepressible 時間: 2025-3-27 07:33 作者: Urgency 時間: 2025-3-27 09:46
Thomas A. Arcury,Antonio J. Maríns thought to be triggered by an increase in the cytosolic calcium concentration which appears partially related to the gating of Ca-channels, located at the plasma membrane. Experiments with Ca-channel blockers have confirmed this hypothesis: D600, Verapamil and Nifedipine cause a dose-dependent inhibition of the glucose-induced insulin release..作者: Amplify 時間: 2025-3-27 16:40
https://doi.org/10.1007/978-1-4684-5314-0Calcium; biophysics; cells; membrane; regulation作者: 得罪人 時間: 2025-3-27 19:01
978-1-4684-5316-4The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: acrimony 時間: 2025-3-28 01:36 作者: Communicate 時間: 2025-3-28 03:50 作者: 吵鬧 時間: 2025-3-28 09:45 作者: 大方不好 時間: 2025-3-28 11:29 作者: Musket 時間: 2025-3-28 17:03 作者: 施魔法 時間: 2025-3-28 20:51 作者: NUL 時間: 2025-3-29 02:55 作者: 悶熱 時間: 2025-3-29 03:41
Pharmacological Control of 86Rb Efflux from Mouse Pancreatic Isletsd on a pharmacological basis., has been demonstrated recently by the patch clamp technique.. Elucidation of their respective physiological functions would be greatly facilitated by the availability of relatively specific inhibitors devoid of untoward effects in intact cells.作者: Camouflage 時間: 2025-3-29 10:23 作者: Hemiplegia 時間: 2025-3-29 13:13 作者: 有罪 時間: 2025-3-29 16:49
Contribution of Isotope Flux Studies to Understanding the Mechanism of the β-Cell Membranelity and/or an increase in the permeability of other ions such as Na. and/or Ca.. These changes in membrane potential play a key role in the function of various cell types, including the pancreatic β-cell, where they seem to initiate processes leading ultimately to insulin release.作者: 發(fā)誓放棄 時間: 2025-3-29 21:19 作者: Tincture 時間: 2025-3-30 03:44
Glucose Suppresses ATP-Inhibited K-Channels in Pancreatic β-Cellse K-channels which are open in low glucose and are closed by a process linked to glucose metabolism. As possibilities, it has been suggested that Ca-activated K-channels are closed by a glucose-induced fall of intracellular free Ca., or that K-channels are closed by metabolic proton production and intracellular acidification..作者: Nucleate 時間: 2025-3-30 04:31
Alberto Dávila,Marie T. Mora,Alma D. Haleslation and we have found them particularly suitable for patch clamp procedures. We have therefore investigated a new insulin-secreting cell line. using the patch-clamp technique in order to study potassium channels and their role in the control of insulin secretion.作者: connoisseur 時間: 2025-3-30 12:17 作者: tattle 時間: 2025-3-30 15:08 作者: 我怕被刺穿 時間: 2025-3-30 20:09 作者: Pedagogy 時間: 2025-3-30 22:18
Potassium Channels in Adrenocortical and Parathyroid Cellspotential duration, and thus the amount of Ca entry, but also because some of these channels are the target for the action of secretagogues and intracellular messengers. Different K- channels have been identified in β-cells (see this workshop) as well as in chromaffin. pituitary and adrenocortical cells..作者: 配偶 時間: 2025-3-31 03:01
Stimulation of Insulin Release by Organic Calcium-Agonistsent note refers to the stimulation of insulin release by organic calcium-agonists.. Our results support the view that the gating of Ca. channels represents an efficient modality for stimulation of insulin secretion.作者: 脫離 時間: 2025-3-31 08:49
https://doi.org/10.1007/978-94-007-0504-3s depolarisation exceeds a threshold level. There is considerable evidence that the initial slow depolarisation induced by glucose results from a decrease in the resting potassium permeability of the membrane. as a consequence of glucose metabolism.).作者: 努力趕上 時間: 2025-3-31 10:59 作者: semble 時間: 2025-3-31 14:08 作者: Rct393 時間: 2025-3-31 18:52 作者: DALLY 時間: 2025-3-31 22:06
Book 1986te the different characteristics of the a-cell ionic channels. To make this information available to the larger scientific community a record of the meeting has been assembled in this book. It is a collection of research papers by leading scientists at the meet- ing working on biophysical, biochemic作者: Gum-Disease 時間: 2025-4-1 02:48
Electrophysiological Measurements Show Marked Differences in the Properties of the Pancreatic β-Celle shown that the db/db β-cells exhibit a pattern of bursting or continuous electrical activity which is virtually insensitive to the concentration of the natural secretagogue D-glucose, thus suggesting an impairment of the db/db β-cell K.-permeability.. In pancreatic β-cells from normal mouse islets作者: Collected 時間: 2025-4-1 08:40
Voltage-Activated Ca2+ and K+ Currents in an Insulin-Secreting Cell Line (RINm5F)table negative membrane potential and that upon exposure to a secretagogue RINm5F cells depolarise and fire spike-potentials. In this study we examine in more detail the spike potentials and show them to result from voltage-activation of Ca-channels.作者: 無能力 時間: 2025-4-1 12:59
