標(biāo)題: Titlebook: Biopharmaceutics Applications in Drug Development; Rajesh Krishna,Lawrence Yu Book 2008 Springer-Verlag US 2008 absorption.bioequivalence. [打印本頁(yè)] 作者: Colossal 時(shí)間: 2025-3-21 18:14
書(shū)目名稱Biopharmaceutics Applications in Drug Development影響因子(影響力)
書(shū)目名稱Biopharmaceutics Applications in Drug Development影響因子(影響力)學(xué)科排名
書(shū)目名稱Biopharmaceutics Applications in Drug Development網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱Biopharmaceutics Applications in Drug Development網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱Biopharmaceutics Applications in Drug Development被引頻次
書(shū)目名稱Biopharmaceutics Applications in Drug Development被引頻次學(xué)科排名
書(shū)目名稱Biopharmaceutics Applications in Drug Development年度引用
書(shū)目名稱Biopharmaceutics Applications in Drug Development年度引用學(xué)科排名
書(shū)目名稱Biopharmaceutics Applications in Drug Development讀者反饋
書(shū)目名稱Biopharmaceutics Applications in Drug Development讀者反饋學(xué)科排名
作者: 蠟燭 時(shí)間: 2025-3-21 20:30 作者: avulsion 時(shí)間: 2025-3-22 00:46
Bioavailability and Bioequivalence,lay a significant role in the discovery, development, and regulation of new drug products. Additionally, bioequivalence studies are a crucial component of abbreviated new drug applications (ANDAs), leading to market access of safe, effective, and low cost generic drugs.作者: RADE 時(shí)間: 2025-3-22 07:16
fully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality, with specific focus on integration of regulatory considerations and case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs. .978-1-4419-4434-4978-0-387-72379-2作者: Rotator-Cuff 時(shí)間: 2025-3-22 10:34
Christian Werner,Volker Klein,Konradin Webervailability assessment, highlight issues regarding their utilities and limitations, and review challenges of improving some of these current dissolution methods, particularly those used for assessing . drug product performance. In this chapter, we first provide some background information on dissolu作者: 狂熱語(yǔ)言 時(shí)間: 2025-3-22 16:58 作者: 不透明性 時(shí)間: 2025-3-22 17:39
R. Bombach,B. Hemmerling,W. Kreutnerlay a significant role in the discovery, development, and regulation of new drug products. Additionally, bioequivalence studies are a crucial component of abbreviated new drug applications (ANDAs), leading to market access of safe, effective, and low cost generic drugs.作者: Heterodoxy 時(shí)間: 2025-3-22 23:47 作者: 牢騷 時(shí)間: 2025-3-23 01:58 作者: flavonoids 時(shí)間: 2025-3-23 09:31 作者: 詞根詞綴法 時(shí)間: 2025-3-23 10:10
Christian Werner,Volker Klein,Konradin Weberds has become one of the most important tests in drug product development and manufacturing, as well as in regulatory assessment of drug product quality. Not only can dissolution testing provide information regarding the rate and extent of drug absorption in the body, it can also assess the effects 作者: 套索 時(shí)間: 2025-3-23 16:30 作者: 虛假 時(shí)間: 2025-3-23 20:21 作者: 接合 時(shí)間: 2025-3-23 23:29
H. J. K?lsch,P. Rairoux,J. P. Wolf,L. W?steliver the drug at the right place at the right time and with the right dose with the optimal delivery characteristics. Basically, an excipient has to fulfill the same safety profile as a drug with the exception that it should not exert a therapeutic effect. Most excipients do comply with these requi作者: NOMAD 時(shí)間: 2025-3-24 03:53
Herbert Schneckenburger,Werner Schmidtinitial stages of drug discovery, numerous studies are performed to assess the pharmacological effectiveness of new chemical entities (NCEs) to select a lead compound(s) that offers the greatest promise for therapeutic efficacy. While the ability of a drug to bind to a therapeutic target is critical作者: notion 時(shí)間: 2025-3-24 09:18
R. Bombach,B. Hemmerling,W. Kreutnerug absorption have been discussed in previous chapters. This chapter will cover general methods to evaluate bioavailability and bioequivalence. Scientific principles as well as regulatory perspectives related to these two topics will be discussed. Historically, the development of sensitive and preci作者: 裝勇敢地做 時(shí)間: 2025-3-24 13:51
https://doi.org/10.1007/978-3-662-08252-2is a required performance test by many regulatory authorities for solid oral dosage forms, transdermal patches, stents, and oral suspensions. Dissolution testing is unique in that it is the only finished product test method in routine use that measures the effect of the formulation and physical prop作者: idiopathic 時(shí)間: 2025-3-24 17:18 作者: Fallibility 時(shí)間: 2025-3-24 22:50
H. G. Dahn,W. Lüdeker,K. P. Güntherssolution. Biological properties such as .max, or AUC have been used to correlate with . dissolution behavior such as percent drug release in order to establish IVIVC. IVIVC can be used to set product dissolution specifications; and as a surrogate for . bioequivalence in the case of any changes with作者: 母豬 時(shí)間: 2025-3-25 01:23
B. Fuchs,H.-P. Berlien,G. Müller,W. Gorischrally administered drug products, it is usually a correlation between the extent or rate of dissolution of a dosage form and its pharmacokinetic parameters, such as rate, duration, and extent of drug absorption. The physicochemical properties of dosage forms influence their . performance in many dif作者: commute 時(shí)間: 2025-3-25 06:11 作者: breadth 時(shí)間: 2025-3-25 10:45
978-1-4419-4434-4Springer-Verlag US 2008作者: CONE 時(shí)間: 2025-3-25 14:56
Rajesh Krishna,Lawrence Yudiscusses state of the art knowledge in biopharmaceutics.identifies key issues and opportunities in a distinct problem-solving approach作者: 閑蕩 時(shí)間: 2025-3-25 18:40
http://image.papertrans.cn/b/image/188319.jpg作者: 外觀 時(shí)間: 2025-3-25 22:38
Molecular and Physicochemical Properties Impacting OralAbsorptionofDrugs,ase of compliance, and cost-effectiveness. Not surprisingly, desirable oral bioavailability is one of the most important considerations for the successful development of bioactive molecules. Poor oral bioavailability affects drug performance and leads to high intra- and inter-patient variability.作者: 游行 時(shí)間: 2025-3-26 04:01
performance is a vital aspect of new drug development as it draws on interdisciplinary expertise from both pharmaceutics and pharmacokinetics disciplines. It is at the key interface that the discipline of biopharmaceutics has emerged. The past two decades have witnessed considerable advances in bio作者: Gourmet 時(shí)間: 2025-3-26 08:02
H. J. K?lsch,P. Rairoux,J. P. Wolf,L. W?stefulfill the same safety profile as a drug with the exception that it should not exert a therapeutic effect. Most excipients do comply with these requirements and do have the GRAS (generally regarded as safe, a system used by the US FDA) status when used in those amounts which are normally used to fabricate a drug delivery system.作者: 聯(lián)想記憶 時(shí)間: 2025-3-26 10:19 作者: 比目魚(yú) 時(shí)間: 2025-3-26 15:31
Excipients as Absorption Enhancers,fulfill the same safety profile as a drug with the exception that it should not exert a therapeutic effect. Most excipients do comply with these requirements and do have the GRAS (generally regarded as safe, a system used by the US FDA) status when used in those amounts which are normally used to fabricate a drug delivery system.作者: 單色 時(shí)間: 2025-3-26 19:17 作者: Criteria 時(shí)間: 2025-3-26 23:33 作者: 驚惶 時(shí)間: 2025-3-27 04:24
Introduction to Biopharmaceutics and its Role in Drug Development,of preparing, using, and administering drugs to living organisms or tissues. Inherent in the concept of biopharmaceutics as discussed here is the interdependence of biological aspects of the living organism (the patient) and the physical–chemical principles that govern the preparation and behavior of the medicinal agent or drug product.作者: 演講 時(shí)間: 2025-3-27 08:16
,In Vitro–In Vivo Correlation in Dosage Form Development: Case Studies,ferent ways (Li ., 2005). Through the establishment of a definitive relationship between certain physicochemical properties of a dosage form with the . appearance of its active component, one can establish . testing criteria which will predict, its . performance.作者: 壓倒性勝利 時(shí)間: 2025-3-27 10:59 作者: ascetic 時(shí)間: 2025-3-27 14:26
Einleitung: Laser in der Umweltme?techniking from initial clinical testing to final approval has remained disappointingly low. Greater than 90% of the compounds entering Phase-I clinical testing fail to reach the patients and as high as 50% entering Phase-III do not make the cut (Kola and Landis, 2004).作者: 滲入 時(shí)間: 2025-3-27 18:41 作者: 持久 時(shí)間: 2025-3-28 00:37
R. Bombach,B. Hemmerling,W. Kreutnerlity; (2) present examples from FDA-approved drug product labeling to show how food effects are considered in optimizing therapy; (3) distinguish between food effects on drug substance versus drug product; and (4) explain the role of food-effect studies in new and generic drug development.作者: 躲債 時(shí)間: 2025-3-28 02:14 作者: MITE 時(shí)間: 2025-3-28 07:31 作者: PALSY 時(shí)間: 2025-3-28 12:33
A Biopharmaceutical Classification System Approach to Dissolution: Mechanisms and Strategies,tors the impact of environmental storage conditions and manufacturing process upon the rate of drug release from the dosage form. These sensitivities have led to the use of the dissolution test as a measure of formulation bioperformance.作者: 少量 時(shí)間: 2025-3-28 17:45 作者: Foregery 時(shí)間: 2025-3-28 19:33
Book 2008 carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality, with specific focus on integration of regulatory considerations and case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs. .作者: blight 時(shí)間: 2025-3-29 00:41 作者: jeopardize 時(shí)間: 2025-3-29 04:27 作者: 前奏曲 時(shí)間: 2025-3-29 09:47 作者: 桶去微染 時(shí)間: 2025-3-29 15:25
Molecular and Physicochemical Properties Impacting OralAbsorptionofDrugs,ase of compliance, and cost-effectiveness. Not surprisingly, desirable oral bioavailability is one of the most important considerations for the successful development of bioactive molecules. Poor oral bioavailability affects drug performance and leads to high intra- and inter-patient variability.作者: Foreshadow 時(shí)間: 2025-3-29 15:43
Dissolution Testing,ds has become one of the most important tests in drug product development and manufacturing, as well as in regulatory assessment of drug product quality. Not only can dissolution testing provide information regarding the rate and extent of drug absorption in the body, it can also assess the effects 作者: BLA 時(shí)間: 2025-3-29 22:23
Drug Absorption Principles,the systemic circulation from the site of administration. Distribution of a drug includes all the processes that are involved from the time when the drug reaches the circulation to the time when it (or a metabolite of the drug) leaves the body. Metabolism involves all the biochemical processes that 作者: companion 時(shí)間: 2025-3-30 00:39 作者: 泥土謙卑 時(shí)間: 2025-3-30 07:26
Excipients as Absorption Enhancers,liver the drug at the right place at the right time and with the right dose with the optimal delivery characteristics. Basically, an excipient has to fulfill the same safety profile as a drug with the exception that it should not exert a therapeutic effect. Most excipients do comply with these requi作者: Left-Atrium 時(shí)間: 2025-3-30 10:24
IntestinalTransporters in Drug Absorption,initial stages of drug discovery, numerous studies are performed to assess the pharmacological effectiveness of new chemical entities (NCEs) to select a lead compound(s) that offers the greatest promise for therapeutic efficacy. While the ability of a drug to bind to a therapeutic target is critical作者: AVANT 時(shí)間: 2025-3-30 14:05
Bioavailability and Bioequivalence,ug absorption have been discussed in previous chapters. This chapter will cover general methods to evaluate bioavailability and bioequivalence. Scientific principles as well as regulatory perspectives related to these two topics will be discussed. Historically, the development of sensitive and preci
