標題: Titlebook: Biological Methylation and Drug Design; Experimental and Cli Ronald T. Borchardt,Cyrus R. Creveling,Per Magne U Book 1986 The Humana Press [打印本頁] 作者: 涌出 時間: 2025-3-21 18:32
書目名稱Biological Methylation and Drug Design影響因子(影響力)
書目名稱Biological Methylation and Drug Design影響因子(影響力)學科排名
書目名稱Biological Methylation and Drug Design網(wǎng)絡公開度
書目名稱Biological Methylation and Drug Design網(wǎng)絡公開度學科排名
書目名稱Biological Methylation and Drug Design被引頻次
書目名稱Biological Methylation and Drug Design被引頻次學科排名
書目名稱Biological Methylation and Drug Design年度引用
書目名稱Biological Methylation and Drug Design年度引用學科排名
書目名稱Biological Methylation and Drug Design讀者反饋
書目名稱Biological Methylation and Drug Design讀者反饋學科排名
作者: follicular-unit 時間: 2025-3-21 20:53 作者: Esophagitis 時間: 2025-3-22 02:54
Is There a Function for Protein Carboxylmethylation in the Nervous System? role of this enzyme are 1) the nature and specificity of relevant . protein substrates; 2) the stoichiometry of protein carboxylmethylation and 3) the rapid hydrolysis of carboxylmethylesters under conditions of neutral and basic pH (Billingsley and Lovenberg, 1985). Thus, two major schools of thou作者: VOK 時間: 2025-3-22 07:53 作者: Classify 時間: 2025-3-22 10:10 作者: exorbitant 時間: 2025-3-22 16:48 作者: 蘑菇 時間: 2025-3-22 19:27
Methylation of Phosphatidylethanolamine: Enzyme Characterization, Regulation and Physiological Functears. An introduction to the topic and its relationship to phospholipid metabolism has been published (Vance, 1985). A summary of the field until 1981 was published in the book originating from the 1981 Transmethylation Conference (Vance et al. 1982).作者: 慢慢啃 時間: 2025-3-22 22:13
Regulation of Phospholipid Methylation by Reversible Phosphorylationa?o et al., 1980). Similarly, glucagon produces a transient accumulation of radioactivity into phospholipids in rat hepatocytes prelabeled with (methyl–3H)-methionine (Schuller et al., 1985). Exogenous cyclic AMP (Casta?o et al., 1980) or chloropheny. thio-cyclic AMP (Pritchard et al., 1981), added 作者: assail 時間: 2025-3-23 02:52 作者: 斜谷 時間: 2025-3-23 09:01 作者: Cocker 時間: 2025-3-23 10:15
Tissue Specific DNA Methylation Patterns: Biochemistry of Formation and Possible Rolec expression have been studied in the past 8 years with respect to their methylation pattern (for recent review, see Razin and Szyf, 1984). Investigators took advantage of the restriction enzymes HpaII (CCGG) and HhaI (GCGC) that are inactive when the internal cytosine residue in their recognition s作者: 祖?zhèn)?nbsp; 時間: 2025-3-23 16:17
Regulation of Gene Expression by Site-Specific Promoter Methylationtter et al., 1978; Eick et al., 1983). Even the DNA of a symmetric recombinant (Deuring et al., 1981; Deuring & Doerfler, 1983) between the left terminus of adenovirus type 12 DNA and large amounts of human cell DNA, which was encapsidated into virus particles, was not methylated (Deuring et al., 19作者: Ingratiate 時間: 2025-3-23 20:57 作者: 西瓜 時間: 2025-3-24 00:04 作者: Herd-Immunity 時間: 2025-3-24 05:22
Relationship Between Methylation and Maturation of Ribosomal RNA in Prokaryotic and Eukaryotic Cells1 % of the total number) (Attardi and Amaldi, 1970 ; Hall, 1971), but the distribution of methyl groups in prokaryotic and eukaryotic ribosomal RNAs is strikingly different (see Table 1 of Maden, 1976 and Table 1 of Bj?rk, 1983). . 16 S and 23 S rRNAs contain a small number of 2′?0 methylated ribose作者: 弓箭 時間: 2025-3-24 06:37
Distribution of m6A in mRNA and its Possible Biological Roleethylated cap structures in translation and mRNA stability has been demonstrated (Both et al., 1975), the function of internal methylation of specific adenine residues, to form N.-methyladenosine (m.A), is not clear. It has been suggested that m.A serves some nuclear role in precursor processing and作者: Camouflage 時間: 2025-3-24 14:03
Ronald T. Borchardt,Cyrus R. Creveling,Per Magne U作者: 下邊深陷 時間: 2025-3-24 17:13 作者: 甜瓜 時間: 2025-3-24 20:30
Regulation of Phospholipid Methylation by Reversible Phosphorylation). Phospholipid methyltransferase has now been purified some 300-fold from rat liver (Pajares et al., 1983). The purified enzyme is activated by incubation with ATP and the catalytic subunit of cyclic AMP dependent protein kinase (cAMP-PK) (Varela et al., 1984). Under these conditions, only one prot作者: FOLLY 時間: 2025-3-25 00:59
Brain Phosphatidylcholine Pools as Possible Sources of Free Choline for Acetylcholine Synthesis choline-containing compounds (like PC) ., and liberate free choline from these larger molecules. Secondly, when labelled choline was infused intravenously into rats, specific radioactivities of free choline in the brain were found to be lower than those in the blood or liver, suggesting that unlabe作者: 漂亮 時間: 2025-3-25 06:35
Tissue Specific DNA Methylation Patterns: Biochemistry of Formation and Possible Rolequences. In most studies, when the pattern of methylation of a tissue specific gene has been correlated with the expression of the gene, an inverse correlation has been found (Yisraeli and Szyf, 1984). Many genes are under-methylated in the tissue of expression as compared to the extent of their met作者: ablate 時間: 2025-3-25 07:51 作者: ATRIA 時間: 2025-3-25 14:47
Carcinogenesis and DNA Hypomethylation in Methyl-Deficient Animals include other tumors and genes (Hoffman, 1984). Finally, dietary deprivation of the methyl donors methionine and choline had been shown to induce liver carcinomas in rats (Copeland and Salmon, 1946). Although these findings were accepted for a period of nearly 10 years, the subsequent demonstration作者: Ganglion 時間: 2025-3-25 18:24
Relationship Between Methylation and Maturation of Ribosomal RNA in Prokaryotic and Eukaryotic Cellse 28 S rRNA and present in the large subunit of eukaryotic (but not of prokaryotic) ribosomes, contains two 2′?0 methylated ribose residues (Nazar .., 1975a, b ; MacKay and Doolittle, 1981 ; Schnare and Gray, 1982). Whereas phosphodiester bonds adjacent to methylated bases in RNA display normal sens作者: ALTER 時間: 2025-3-25 23:13 作者: 清澈 時間: 2025-3-26 00:59
of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. Each plenary speaker at the symposium was requested to submit a chapter reviewing recen978-1-4612-9398-9978-1-4612-5012-8作者: Herpetologist 時間: 2025-3-26 07:24
Kleine ontwikkelingspsychologie IIIed some properties of two different enzymes. The first enzyme mainly methylates PtdEtn and the other enzyme forms PtdCho by adding two more methyl groups to monomethyl-PtdEtn. These enzymes have different kinetic parameters with respects to affinities for S-AdoMet, metal dependency and optimal pH.作者: 清楚說話 時間: 2025-3-26 12:13 作者: COLON 時間: 2025-3-26 13:28
Kleine ontwikkelingspsychologie III choline-containing compounds (like PC) ., and liberate free choline from these larger molecules. Secondly, when labelled choline was infused intravenously into rats, specific radioactivities of free choline in the brain were found to be lower than those in the blood or liver, suggesting that unlabe作者: PHIL 時間: 2025-3-26 19:30
,Interessen — Gemeinwohl — Gemeinsinn,quences. In most studies, when the pattern of methylation of a tissue specific gene has been correlated with the expression of the gene, an inverse correlation has been found (Yisraeli and Szyf, 1984). Many genes are under-methylated in the tissue of expression as compared to the extent of their met作者: ALTER 時間: 2025-3-26 21:17 作者: ARC 時間: 2025-3-27 01:23
https://doi.org/10.1007/978-3-322-99428-8 include other tumors and genes (Hoffman, 1984). Finally, dietary deprivation of the methyl donors methionine and choline had been shown to induce liver carcinomas in rats (Copeland and Salmon, 1946). Although these findings were accepted for a period of nearly 10 years, the subsequent demonstration作者: 引水渠 時間: 2025-3-27 07:04
https://doi.org/10.1007/978-3-662-66619-7e 28 S rRNA and present in the large subunit of eukaryotic (but not of prokaryotic) ribosomes, contains two 2′?0 methylated ribose residues (Nazar .., 1975a, b ; MacKay and Doolittle, 1981 ; Schnare and Gray, 1982). Whereas phosphodiester bonds adjacent to methylated bases in RNA display normal sens作者: 徹底檢查 時間: 2025-3-27 10:52
https://doi.org/10.1007/978-90-313-7590-5of these enzymes would function as components of reversible covalent modification systems to regulate the activity of various methyl-accepting proteins (Gagnon and Heisler, 1979; Paik and Kim, 1980; O’Dea et al., 1981). Although this does appear to be the case for a class of bacterial methyltransfer作者: Stricture 時間: 2025-3-27 13:55
Kleine ontwikkelingspsychologie IIbeen well established (Paik & Kim, 1980). It involves N-methylation of lysine, arginine, histidine, alanine, proline, and glutamine, O-methylation of glutamic and aspartic acid, and S-methylation of methionine and cysteine (Paik & Kim, 1985). As shown in Table I, methylated amino acids occur in high作者: Magnificent 時間: 2025-3-27 19:32
Kleine ontwikkelingspsychologie II role of this enzyme are 1) the nature and specificity of relevant . protein substrates; 2) the stoichiometry of protein carboxylmethylation and 3) the rapid hydrolysis of carboxylmethylesters under conditions of neutral and basic pH (Billingsley and Lovenberg, 1985). Thus, two major schools of thou作者: HPA533 時間: 2025-3-27 23:31 作者: geriatrician 時間: 2025-3-28 04:18 作者: Kinetic 時間: 2025-3-28 09:39 作者: 針葉樹 時間: 2025-3-28 11:57 作者: maudtin 時間: 2025-3-28 16:14 作者: archenemy 時間: 2025-3-28 22:23 作者: 袖章 時間: 2025-3-29 02:19
,Interessen — Gemeinwohl — Gemeinsinn,cytosine in DNA led to the suggestion that this minor base derived from post-replication modification of DNA (Romberg .., 1959). Subsequent studies showed that DNA modification in prokaryotes is part of the host range restriction system (Arber, 1968) and is also involved in strand selection in misma作者: 袖章 時間: 2025-3-29 04:30
,Interessen — Gemeinwohl — Gemeinsinn,c expression have been studied in the past 8 years with respect to their methylation pattern (for recent review, see Razin and Szyf, 1984). Investigators took advantage of the restriction enzymes HpaII (CCGG) and HhaI (GCGC) that are inactive when the internal cytosine residue in their recognition s作者: 字謎游戲 時間: 2025-3-29 11:14 作者: Herbivorous 時間: 2025-3-29 12:36 作者: pessimism 時間: 2025-3-29 19:35
,Brücke über die Simme in Garstatt, to show that tRNA modification serves as a mean to adapt cells to environmental changes, such as starvation or oxidation stress (Kersten, 1984; Buck & Ames, 1984). The metabolic control is triggered by specific alterations of tRNA modifications, caused by (i) changes in the levels or redox-state of作者: 分開如此和諧 時間: 2025-3-29 21:45 作者: Gustatory 時間: 2025-3-30 03:15
Kleiner Ratgeber für den Apothekenkaufethylated cap structures in translation and mRNA stability has been demonstrated (Both et al., 1975), the function of internal methylation of specific adenine residues, to form N.-methyladenosine (m.A), is not clear. It has been suggested that m.A serves some nuclear role in precursor processing and作者: daredevil 時間: 2025-3-30 07:41 作者: 結(jié)構(gòu) 時間: 2025-3-30 09:40 作者: delegate 時間: 2025-3-30 12:52 作者: albuminuria 時間: 2025-3-30 18:36
Experimental Biology and Medicinehttp://image.papertrans.cn/b/image/187405.jpg作者: Explosive 時間: 2025-3-30 22:14 作者: 突變 時間: 2025-3-31 01:42 作者: Bombast 時間: 2025-3-31 06:01
