標(biāo)題: Titlebook: Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease; Hoa Huu Phuc Nguyen,M. Angela Cenci Book 2015 The Editor(s) (if a [打印本頁] 作者: 時間 時間: 2025-3-21 17:36
書目名稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease影響因子(影響力)
書目名稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease影響因子(影響力)學(xué)科排名
書目名稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease網(wǎng)絡(luò)公開度
書目名稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease被引頻次
書目名稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease被引頻次學(xué)科排名
書目名稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease年度引用
書目名稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease年度引用學(xué)科排名
書目名稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease讀者反饋
書目名稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease讀者反饋學(xué)科排名
作者: Myelin 時間: 2025-3-21 23:50
Current Topics in Behavioral Neuroscienceshttp://image.papertrans.cn/b/image/182860.jpg作者: tinnitus 時間: 2025-3-22 02:49
https://doi.org/10.1007/978-3-662-46344-4Huntington; LRRK2; Parkin; Pink-1; Polyglutamine; animal models作者: judicial 時間: 2025-3-22 05:03 作者: 流浪者 時間: 2025-3-22 11:56
,Transgenic Rat Models of Huntington’s Disease,vel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.作者: 溺愛 時間: 2025-3-22 16:39 作者: 顛簸地移動 時間: 2025-3-22 17:16
Additional Insights From the Surveyvel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.作者: Coordinate 時間: 2025-3-23 00:52
https://doi.org/10.1007/978-3-319-28591-7ms. Symptoms progress over 15–20?years, and there are currently no disease-modifying therapies. The causative genetic mutation is an expanded CAG repeat in the . gene encoding the Huntingtin protein, and is inherited in an autosomal dominant manner. In this chapter we discuss the genetics, clinical 作者: Detonate 時間: 2025-3-23 02:55
Alexander Jokisch,Wilhelm Urban,Thomas Klugens of the brain. Therefore, the striatum which is preferentially degenerated and receives projections from the entire cortex also affects the regions to which it targets, especially the globus pallidus and substantia nigra pars reticulata. Additionally, the cerebral cortex is itself severely affecte作者: 蔓藤圖飾 時間: 2025-3-23 06:39
https://doi.org/10.1007/978-3-319-28591-7erative disorder. Its occurrence through generations of affected families was noted long before the basic genetic underpinnings of hereditary diseases was understood. The early classification of HD as a distinct hereditary neurodegenerative disorder allowed the study of this disease to lead the way 作者: 鳥籠 時間: 2025-3-23 11:38 作者: 逗它小傻瓜 時間: 2025-3-23 17:46 作者: 符合規(guī)定 時間: 2025-3-23 21:32
Comparing Results to Regression Resultsential neuronal loss in distinct brain regions. Mutant huntingtin causes late-onset neurological symptoms in patients in middle life, though the expression of mutant huntingtin is ubiquitous from early life. Thus, it is important to understand why mutant huntingtin selectively causes neuronal loss i作者: Incumbent 時間: 2025-3-23 23:07 作者: PURG 時間: 2025-3-24 05:21
Setting Up Research: Complicationsmmatory processes are exacerbated in Parkinson’s disease, including glial-mediated reactions, increased expression of proinflammatory substances, and lymphocytic infiltration, particularly in the substantia nigra. Neuroinflammation is also implicated in the neurodegeneration and consequent behaviora作者: HAIRY 時間: 2025-3-24 07:20 作者: Anthology 時間: 2025-3-24 13:06 作者: 單調(diào)女 時間: 2025-3-24 16:01
Comparing Results to Regression Resultsmon variation at the . genomic locus influences the risk of developing idiopathic PD. LRRK2 is a member of the ROCO protein family and contains multiple domains, including Ras-of-Complex (ROC) GTPase, kinase, and protein-protein interaction domains. In the last decade, the biochemical characterizati作者: lipids 時間: 2025-3-24 19:59 作者: 男學(xué)院 時間: 2025-3-25 01:55
Comparing Results to Regression Resultsrived induced pluripotent stem cells. We discuss how these models have contributed to understanding LRRK2 pathobiology and the advantages and limitations of each model for exploring aspects of .-associated PD.作者: 性行為放縱者 時間: 2025-3-25 07:19
,Modeling LRRK2 Pathobiology in Parkinson’s Disease: From Yeast to Rodents,rived induced pluripotent stem cells. We discuss how these models have contributed to understanding LRRK2 pathobiology and the advantages and limitations of each model for exploring aspects of .-associated PD.作者: 救護車 時間: 2025-3-25 11:16
Book 2015ing used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.作者: defuse 時間: 2025-3-25 12:50 作者: 松雞 時間: 2025-3-25 16:27 作者: 減少 時間: 2025-3-25 20:45
Setting Up Research: Complications or if some inflammatory features provide protective stress responses. Here, we compare and summarize findings on neuroinflammatory responses and effects on behavior in a wide range of toxin-based, inflammatory and genetic Parkinson’s disease animal models.作者: 不整齊 時間: 2025-3-26 02:18 作者: 失誤 時間: 2025-3-26 06:15
,Mouse Models of Huntington’s Disease,abnormalities in these systems impact on the behavioural readouts across the mouse lines and how these may correspond to the deficits observed in people. In addition, interpretational issues associated with the data from animal studies are discussed.作者: 無力更進 時間: 2025-3-26 09:26 作者: 惡心 時間: 2025-3-26 16:28 作者: 津貼 時間: 2025-3-26 18:44 作者: PAC 時間: 2025-3-26 22:20 作者: 玉米棒子 時間: 2025-3-27 03:13
,Therapeutic Strategies for Huntington’s Disease,gnitive, motor, and psychiatric impairment. This review focuses on the current state of therapeutic development for the treatment of HD, including the preclinical and clinical development of small molecules and molecular therapies.作者: insurgent 時間: 2025-3-27 06:28
Comparing Results to Regression Resultsgnitive, motor, and psychiatric impairment. This review focuses on the current state of therapeutic development for the treatment of HD, including the preclinical and clinical development of small molecules and molecular therapies.作者: 貪婪的人 時間: 2025-3-27 11:02 作者: 拖網(wǎng) 時間: 2025-3-27 14:57 作者: gastritis 時間: 2025-3-27 18:34
,Large Animal Models of Huntington’s Disease, patient brains. Since there are considerable species differences between small and large animals, large animal models of Huntington’s disease may allow one to identify the pathological features that are more similar to those in patients and also help uncover more effective therapeutic targets. This作者: Fretful 時間: 2025-3-27 23:16
,Viral Vector-Based Models of Parkinson’s Disease,ssion of α-synuclein are the most prevalent and extensively studied, and therefore the main focus of this chapter. Many efforts have been made to increase the expression levels of α-synuclein in the dopaminergic neurons. The best α-synuclein models currently available have been developed from a comb作者: 刺激 時間: 2025-3-28 02:48
Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits,ated using rodent models. There are currently several lines of transgenic mice overexpressing wild-type or mutated aSyn under various promoters. This review will provide an updated synopsis of the mouse lines available, summarize their cognitive deficits, and reflect on how deficits observed in thes作者: 獨裁政府 時間: 2025-3-28 08:28
Models of Multiple System Atrophy,nisms of neurodegeneration and GCIs formation, which is paralleled by a lack of therapeutic strategies. Two main types of rodent models have been generated to replicate different features of MSA neuropathology. On one hand, neurotoxin-based models have been produced to reproduce neuronal loss in sub作者: lipids 時間: 2025-3-28 12:27 作者: mosque 時間: 2025-3-28 17:37
,Symptomatic Models of Parkinson’s Disease and L-DOPA-Induced Dyskinesia in Non-human Primates,作者: 向下五度才偏 時間: 2025-3-28 19:57 作者: Anemia 時間: 2025-3-29 01:25 作者: HALO 時間: 2025-3-29 05:21 作者: objection 時間: 2025-3-29 07:38 作者: 改革運動 時間: 2025-3-29 12:27
Comparing Results to Regression Resultsssion of α-synuclein are the most prevalent and extensively studied, and therefore the main focus of this chapter. Many efforts have been made to increase the expression levels of α-synuclein in the dopaminergic neurons. The best α-synuclein models currently available have been developed from a comb作者: Pituitary-Gland 時間: 2025-3-29 15:59 作者: 牌帶來 時間: 2025-3-29 22:08
An Alternative Approach: LeibnizSystemnisms of neurodegeneration and GCIs formation, which is paralleled by a lack of therapeutic strategies. Two main types of rodent models have been generated to replicate different features of MSA neuropathology. On one hand, neurotoxin-based models have been produced to reproduce neuronal loss in sub作者: 一再遛 時間: 2025-3-30 01:48 作者: needle 時間: 2025-3-30 07:38
,The Neuropathology of Huntington’s Disease,ns of the brain. Therefore, the striatum which is preferentially degenerated and receives projections from the entire cortex also affects the regions to which it targets, especially the globus pallidus and substantia nigra pars reticulata. Additionally, the cerebral cortex is itself severely affecte
