作者: 清醒 時間: 2025-3-21 21:28 作者: 極少 時間: 2025-3-22 01:00
Farouk Musa Aliyu,Adegboyega Ojocontrol of ventilation have attracted much attention. Progress for many years was restricted to the whole animal and organ level, resulting in characterization of the stimulus-response characteristics of the CB with its afferent nerve supply during exposure to chemostimuli such as low PO. (hypoxia),作者: Duodenitis 時間: 2025-3-22 05:50
Abdulla Al Neaimi,Philip Lutaayaed effectors for O. sensing pathways, research has focussed on possible pathways coupling a reduction in hypoxia to altered ion channel activity. The most extensively studied systems are the K. channels which are inhibited by hypoxia in chemoreceptor tissues (carotid and neuroepithelial bodies). In 作者: 碎石 時間: 2025-3-22 09:55 作者: Ccu106 時間: 2025-3-22 16:04 作者: Frisky 時間: 2025-3-22 19:00
Abdulla Al Neaimi,Philip Lutaayagenous signalling molecule, with a variety of molecular targets, including ion channels. Here, we describe the effects of H.S on the large conductance, calcium-sensitive potassium channel (BK.). This channel contributes to carotid body glomus cell excitability and oxygen-sensitivity. The experiments作者: 最低點 時間: 2025-3-22 23:19 作者: 豐富 時間: 2025-3-23 02:28 作者: Blood-Vessels 時間: 2025-3-23 05:41
Amos Nungu,Bjorn Pehrson,Julianne Sansa-Otimnvolves either activation of AMP activated protein kinase (AMPK) or inhibition of carbon monoxide (CO) production by heme oxygenase 2 (HO-2). In the vasculature, L-type Ca. channels are also O. sensitive. Here, we have investigated the possible involvement of either AMPK or CO in the hypoxic inhibit作者: Gossamer 時間: 2025-3-23 11:44 作者: insidious 時間: 2025-3-23 13:57 作者: Vulnerable 時間: 2025-3-23 18:01
Nuove tecnologie a sostegno della didattica,reparations but the characterization of different PDE isoforms in CB has never been performed. PDE4 is one of the PDE families that uses cAMP as a specific substrate and changes its activity and affinity for drug inhibitors according to the degree of its phosphorylation. We investigated the effects 作者: 逃避現(xiàn)實 時間: 2025-3-23 23:01
https://doi.org/10.1007/978-88-470-0737-6 the idea being that two types of unusual cells could form synapse and provide a model for studies of chemotransduction. Calcium levels in the PGNs were measured in the presence of different chemical stimuli in the bath medium. Remarkably, the PGNs alone were not sensitive to hypoxia (10?torr), PCO 作者: inhibit 時間: 2025-3-24 02:53 作者: 新陳代謝 時間: 2025-3-24 09:50
Tian-hui Wang,Ang Li,Zheng Zhangeceptors, which are synaptically connected to the nerve terminals of the petrosal ganglion neurons. In response to hypoxia, hypercapnia and acidosis, glomus cells release one (or more) transmitter(s) which, acting on the nerve terminals of chemosensory neurons, increases the afferent discharge. Amon作者: Liability 時間: 2025-3-24 14:12 作者: follicular-unit 時間: 2025-3-24 15:05
https://doi.org/10.1007/978-3-030-63955-6investigated the hypothesis that this control is exerted via an interaction between adenosine A. and dopamine D. receptors present in chemoreceptor cells and if it is, the location of this interaction on the CB hypoxic transduction cascade. Experiments were performed . in CB from 3 months rats. The 作者: emission 時間: 2025-3-24 21:46
e-Learning, e-Education, and Online Trainingaction are not well understood. The goals of this study were: (1) to identify GABA. receptor subunits in the carotid body (CB) and petrosal ganglion (PG); (2) to test if BZs exert their effects through the GABA. receptor in the CB chemosensory unit. Tissues were taken from euthanized adult cats. RNA作者: Rheumatologist 時間: 2025-3-25 02:43 作者: 單獨 時間: 2025-3-25 05:33 作者: 毀壞 時間: 2025-3-25 09:12 作者: chandel 時間: 2025-3-25 13:55 作者: Intend 時間: 2025-3-25 16:00 作者: CANON 時間: 2025-3-25 22:27 作者: CURT 時間: 2025-3-26 02:57
https://doi.org/10.1007/978-88-470-0737-6. Taken together, these observations suggest that PGNs developed neurotransmission when in contact with PC-12 cells, as if the latter substituting for glomus cells, thus providing a model for chemotransduction studies. The reason for the insensitivity of PGNs alone to the chemical stimuli is unknown at this time.作者: expository 時間: 2025-3-26 06:19
https://doi.org/10.1007/978-3-030-63955-6well as, its metabolism and regulation; and at postsynaptic level in carotid sinus nerve activity. Additionally, a review on the effects of adenosine in ventilation was done. This review discusses evidence for a key role of adenosine in the hypoxic response of carotid body and emphasizes new research likely to be important in the future.作者: 遍及 時間: 2025-3-26 08:46
Calcium Sensitivity for Hypoxia in PGNs with PC-12 Cells in Co-Culture,. Taken together, these observations suggest that PGNs developed neurotransmission when in contact with PC-12 cells, as if the latter substituting for glomus cells, thus providing a model for chemotransduction studies. The reason for the insensitivity of PGNs alone to the chemical stimuli is unknown at this time.作者: Prologue 時間: 2025-3-26 14:18 作者: immunity 時間: 2025-3-26 19:08 作者: 蛤肉 時間: 2025-3-26 21:42
,Fifty Years of Progress in Carotid Body Physiology – ,,to their effects upon chemosensory nerve activity. Chemosensory neurons have been explored from generation of action potentials at peripheral nerve endings, passing to properties of perikarya at petrosal ganglia and finally at characterization of synaptic transmission at solitary tract nuclei. There作者: DOSE 時間: 2025-3-27 02:13 作者: 輕觸 時間: 2025-3-27 06:58
,Enzyme-Linked Acute Oxygen Sensing in Airway and Arterial Chemoreceptors – ,,onoxide, bilirubin and ferrous iron in the case of heme oxygenase), but the third responds to shifts in the AMP:ATP ratio, so responds to changes in O. levels more indirectly. We consider the evidence in favour of each of these systems, and highlight their differential importance in different system作者: disparage 時間: 2025-3-27 12:09 作者: MERIT 時間: 2025-3-27 17:36 作者: ostrish 時間: 2025-3-27 20:48
Hydrogen Sulfide Inhibits Human BKCa Channels,lthough 1?mM KCN completely suppressed CO-evoked channel activation, it was without effect on the H.S-induced channel inhibition, suggesting that the effects of CO and H.S were non-competitive. RT-PCR showed that mRNA for both of the H.S-producing enzymes, cystathionine-beta-synthase and cystathioni作者: 獸群 時間: 2025-3-27 22:19 作者: 拋棄的貨物 時間: 2025-3-28 02:13 作者: intoxicate 時間: 2025-3-28 07:27
Inhibition of L-Type Ca2+ Channels by Carbon Monoxide, prevented by the antioxidant MnTMPyP, but not by inhibition of NADPH oxidase (with either apocynin or diphenyleneiodonium), or xanthine oxidase (with allopurinol). Instead, inhibitors of complex III of the mitochondrial electron transport chain and a mitochondrial-targeted antioxidant (Mito Q), pre作者: AGONY 時間: 2025-3-28 11:04
Effects of the Polyamine Spermine on Arterial Chemoreception,or 10 minutes) and depolarization-evoked catecholamine release were partially suppressed by pre- (and co)-incubation with 500μM spermine. In dissociated type 1 glomus cells intracellular calcium concentration did not change following spermine treatment, but this polyamine did inhibit the depolarisat作者: ornithology 時間: 2025-3-28 18:03 作者: 拖債 時間: 2025-3-28 20:26 作者: blight 時間: 2025-3-29 02:55 作者: Liberate 時間: 2025-3-29 03:41
,Neurotransmitters in Carotid Body Function: The Case of Dopamine – ,,on the open question if the reported differences on its actions on the generation of afferent chemosensory activity reflect true species differences. The available data suggest that dopamine may play a modulatory role within the cat CB, while in the rabbit CB, dopamine is an excitatory transmitter. 作者: Landlocked 時間: 2025-3-29 09:21
The A2B-D2 Receptor Interaction that Controls Carotid Body Catecholamines Release Locates Between t propylnorapomorphine inhibits the release of CA evoked by ionomycin, being this effect totally reversed by NECA. The present results provide direct pharmacological evidence that A. and D. receptors interact to modulate the release of CA from rat CB between the steps of Ca. entry and increase in int作者: ESPY 時間: 2025-3-29 12:16
Benzodiazepines and GABA-GABAA Receptor System in the Cat Carotid Body,uring CB neural output using in vitro perfusion setup. Two BZs, midazolam and diazepam, decreased the CB neural response to hypoxia. With continuous application of bicuculline, a GABA. receptor antagonist, the effects of BZs were abolished. In conclusion, the GABA-GABA. receptor system is functionin作者: FID 時間: 2025-3-29 18:31
Julianne S. Sansa-Otim,Anthony Mileessive papers (1926, 1928, 1929), De Castro unravelled most of the histological secrets of this small structure and described the exact localisation of the “chemoreceptors” within the .. Indeed, his was the first description of cells specifically devoted to detect changes in the chemical composition作者: MELON 時間: 2025-3-29 22:14
Sarantorn Bisalbutra,Elisa Jimenoto their effects upon chemosensory nerve activity. Chemosensory neurons have been explored from generation of action potentials at peripheral nerve endings, passing to properties of perikarya at petrosal ganglia and finally at characterization of synaptic transmission at solitary tract nuclei. There作者: Proclaim 時間: 2025-3-30 01:09
Farouk Musa Aliyu,Adegboyega Ojorons, thin CB tissue slice preparations, and transgenic models. These preparations have contributed significantly, not only to our understanding of the transduction and neurotransmitter mechanisms that operate in the CB during sensory processing, but also to the identification and characterization o作者: delta-waves 時間: 2025-3-30 06:20 作者: 隱藏 時間: 2025-3-30 08:24
Abdulla Al Neaimi,Philip Lutaayasence of KCN the CO donor increased wild-type channel activity in a concentration-dependent manner, with an EC. of ca. 50μM. Single cysteine point mutations of residues C820, C995 and C1028 affected neither channel characteristics nor CO EC. values. In contrast, the CO sensitivity of the C911G mutat作者: 憤怒事實 時間: 2025-3-30 12:38
Farouk Musa Aliyu,Adegboyega Ojoak K. conductance in rat type I cells remains unclear, but shares similarities with TASK-1 and TASK-3. Recombinant TASK-1 was insensitive to AICAR. However, TASK-3 was inhibited by either AICAR or A-769662 in a manner which was reversed by compound C. These data highlight a role for AMPK in the modu作者: 技術(shù) 時間: 2025-3-30 19:03 作者: 和諧 時間: 2025-3-30 20:42
https://doi.org/10.1007/978-3-319-98827-6tion of DPPX to K. currents in rabbit CB chemoreceptor cells by using DPPX functional knockdown with siRNA. Our data suggest that DPPX proteins are integral components of K. currents, and that their association with Kv4 subunits modulate the pharmacological profile of the heteromultimers.作者: myopia 時間: 2025-3-31 01:58
Peterson Mwesiga,Julius Butime,Richard Okouoxic and 24 hours hypoxic cultured cells, acute hypoxic stimuli decreases NPo approximately 70% with no effects on current amplitude. On the other hand, in cultured cells subjected to 48 hours of hypoxia, NPo decreases near to 90% in response to acute hypoxia. We concluded that continuous hypoxic ex作者: 厚顏無恥 時間: 2025-3-31 07:56 作者: 圖表證明 時間: 2025-3-31 09:51 作者: 手勢 時間: 2025-3-31 14:43 作者: Ancestor 時間: 2025-3-31 18:16
Nuove tecnologie a sostegno della didattica,ypoxic conditions in the absence of PDE inhibitors. In both conditions, the E. calculated for IBMX was similar to that of the specific PDE4 inhibitors. Hypoxia shifted the concentration response curves to the left with the following rank order of potency IBMX> RO 20-1724=rolipram and increased E. by作者: Peculate 時間: 2025-3-31 23:13 作者: 史前 時間: 2025-4-1 04:56
Tian-hui Wang,Ang Li,Zheng Zhangon the open question if the reported differences on its actions on the generation of afferent chemosensory activity reflect true species differences. The available data suggest that dopamine may play a modulatory role within the cat CB, while in the rabbit CB, dopamine is an excitatory transmitter. 作者: headway 時間: 2025-4-1 09:45
https://doi.org/10.1007/978-3-030-63955-6 propylnorapomorphine inhibits the release of CA evoked by ionomycin, being this effect totally reversed by NECA. The present results provide direct pharmacological evidence that A. and D. receptors interact to modulate the release of CA from rat CB between the steps of Ca. entry and increase in int作者: 假設(shè) 時間: 2025-4-1 11:57
e-Learning, e-Education, and Online Traininguring CB neural output using in vitro perfusion setup. Two BZs, midazolam and diazepam, decreased the CB neural response to hypoxia. With continuous application of bicuculline, a GABA. receptor antagonist, the effects of BZs were abolished. In conclusion, the GABA-GABA. receptor system is functionin作者: Meager 時間: 2025-4-1 16:56
