標(biāo)題: Titlebook: Aromatase Inhibitors; Barrington J. A. Furr Book 2008Latest edition Birkh?user Basel 2008 Brustkrebs.Drogen.Treatment.biosynthesis.breast [打印本頁] 作者: MAXIM 時間: 2025-3-21 18:18
書目名稱Aromatase Inhibitors影響因子(影響力)
書目名稱Aromatase Inhibitors影響因子(影響力)學(xué)科排名
書目名稱Aromatase Inhibitors網(wǎng)絡(luò)公開度
書目名稱Aromatase Inhibitors網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Aromatase Inhibitors被引頻次
書目名稱Aromatase Inhibitors被引頻次學(xué)科排名
書目名稱Aromatase Inhibitors年度引用
書目名稱Aromatase Inhibitors年度引用學(xué)科排名
書目名稱Aromatase Inhibitors讀者反饋
書目名稱Aromatase Inhibitors讀者反饋學(xué)科排名
作者: 詼諧 時間: 2025-3-21 20:50 作者: 情感脆弱 時間: 2025-3-22 01:28
https://doi.org/10.1007/978-3-319-19393-9gen receptor (ER) with antioestrogens such as tamoxifen, by ovarian ablation using surgery, radiotherapy or luteinising hormone-releasing hormone analogs such as goserelin, or, in postmenopausal women, by blocking oestrogen production by inhibiting aromatase activity [.].作者: Little 時間: 2025-3-22 05:15
2296-6056 aromatase inhibitors.International authorship.Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrog作者: Onerous 時間: 2025-3-22 12:08
Urban Land Use Land Cover Changehe sole member of family 19 (see .). This haem protein is responsible for binding of the C19 androgenic steroid substrate and catalyzing the series of reactions leading to formation of the phenolic A ring characteristic of oestrogens.作者: 煩擾 時間: 2025-3-22 14:29 作者: STALL 時間: 2025-3-22 18:50
Management and Industrial Engineeringme. Whereas we now have data available comparing the effect of different compounds on total body aromatase inhibition, our understanding of the effects of these compounds at the tissue level, in particular with respect to local effects in the normal breast as well as breast tumour tissue, is still incomplete.作者: 小母馬 時間: 2025-3-22 23:35
Clinical pharmacology of aromatase inhibitors,me. Whereas we now have data available comparing the effect of different compounds on total body aromatase inhibition, our understanding of the effects of these compounds at the tissue level, in particular with respect to local effects in the normal breast as well as breast tumour tissue, is still incomplete.作者: arthroplasty 時間: 2025-3-23 02:14
Clinical studies with anastrozole,gen receptor (ER) with antioestrogens such as tamoxifen, by ovarian ablation using surgery, radiotherapy or luteinising hormone-releasing hormone analogs such as goserelin, or, in postmenopausal women, by blocking oestrogen production by inhibiting aromatase activity [.].作者: 洞穴 時間: 2025-3-23 09:15 作者: 他姓手中拿著 時間: 2025-3-23 09:45
Towards Sustainable Land Use in Asiat use of third-generation aromatase inhibitors has had a major therapeutic impact: emerging clinical evidence for some of them shows that they can achieve superior efficacy to tamoxifen, the gold standard of endocrine care for more than two decades.作者: MIRTH 時間: 2025-3-23 17:27
Kay Thwe Hlaing,Shigeko Haruyama,Saw Yu MayIn the USA, it is estimated that breast cancer will account for approximately 26% of all new cases of cancer in 2007 [.]. Although treatment has improved and death rates have declined in recent years, breast cancer still accounts for approximately 15% of all cancer-related deaths in women [.].作者: moribund 時間: 2025-3-23 20:03
The third-generation aromatase inhibitors: a clinical overview,In the USA, it is estimated that breast cancer will account for approximately 26% of all new cases of cancer in 2007 [.]. Although treatment has improved and death rates have declined in recent years, breast cancer still accounts for approximately 15% of all cancer-related deaths in women [.].作者: RALES 時間: 2025-3-24 00:20 作者: 笨拙的我 時間: 2025-3-24 03:47
Rahul Saxena,Mahipal Jadeja,Vikrant Bhatejaequence it might be expected that oestrogen deprivation will both prevent the appearance of these cancers and cause regression of established tumours [.]. This provides the rationale behind hormone prevention of breast cancer and endocrine management of the disease. Over the last 25 years hormone th作者: 大暴雨 時間: 2025-3-24 10:27
Rahul Saxena,Mahipal Jadeja,Vikrant Bhatejaaction by compounds interacting with oestrogen receptors (ERs; antioestrogens) and the inhibition of oestrogen synthesis by inhibitors of the enzyme, aromatase. Treatment with the antioestrogen, tamoxifen, has been an important therapeutic advance in breast cancer management for patients with ER-pos作者: micronized 時間: 2025-3-24 14:20
Management and Industrial Engineeringdirectly extrapolated to the . setting in humans. Thus a drug effect in the human body will depend on factors in addition to its effect on the target enzyme, like general pharmacokinetics, tissue penetration and cellular uptake. In contrast to the selective oestrogen receptor modulators (SERMs), for作者: 值得尊敬 時間: 2025-3-24 18:00
Management and Industrial Engineeringting, ablating or interfering with oestrogen activity. In young adult women, the ovary is the main source of oestrogen synthesis; after a cascade of biochemical steps, the conversion of androgen precursors (testosterone and androstenedione) into the corresponding oestrogens (oestradiol and oestrone,作者: 無辜 時間: 2025-3-24 21:46
Management and Industrial Engineeringer; nearly two thirds of these women were postmenopausal [.]. Current treatment options for breast cancer depend on disease characteristics (e.g., stage, sites of any metastases, hormone receptor status), patient characteristics (e.g., age, menopausal status), and patient preferences. Early breast c作者: 削減 時間: 2025-3-24 23:10 作者: FATAL 時間: 2025-3-25 04:04 作者: NAIVE 時間: 2025-3-25 08:29
Towards Sustainable Land Use in Asiat use of third-generation aromatase inhibitors has had a major therapeutic impact: emerging clinical evidence for some of them shows that they can achieve superior efficacy to tamoxifen, the gold standard of endocrine care for more than two decades.作者: 友好關(guān)系 時間: 2025-3-25 12:45 作者: Armory 時間: 2025-3-25 16:26
Milestones in Drug Therapyhttp://image.papertrans.cn/b/image/161734.jpg作者: 高興去去 時間: 2025-3-25 20:34 作者: 世俗 時間: 2025-3-26 00:20
978-3-7643-8692-4Birkh?user Basel 2008作者: ADORE 時間: 2025-3-26 07:36
Background and development of aromatase inhibitors,equence it might be expected that oestrogen deprivation will both prevent the appearance of these cancers and cause regression of established tumours [.]. This provides the rationale behind hormone prevention of breast cancer and endocrine management of the disease. Over the last 25 years hormone th作者: bromide 時間: 2025-3-26 12:22 作者: Ganglion-Cyst 時間: 2025-3-26 14:24 作者: grudging 時間: 2025-3-26 17:43 作者: 發(fā)怨言 時間: 2025-3-26 22:48 作者: Adenoma 時間: 2025-3-27 01:11
Clinical studies with anastrozole,sal women but ovarian oestrogen production diminishes with age. In postmenopausal women, oestrogens are synthesised by the aromatisation of androgen precursors in the skin, muscle, adipose and breast tissue, including malignant breast tumours [.]. Oestrogen action is inhibited by blocking the oestro作者: Finasteride 時間: 2025-3-27 07:46
Lessons from the ArKO mouse,t of the . gene). The P450 gene superfamily is a very large one, containing over 3000 members in some 350 families, of which cytochrome P450 arom is the sole member of family 19 (see .). This haem protein is responsible for binding of the C19 androgenic steroid substrate and catalyzing the series of作者: 卵石 時間: 2025-3-27 10:13
Possible additional therapeutic uses of aromatase inhibitors,t use of third-generation aromatase inhibitors has had a major therapeutic impact: emerging clinical evidence for some of them shows that they can achieve superior efficacy to tamoxifen, the gold standard of endocrine care for more than two decades.作者: Encapsulate 時間: 2025-3-27 13:38
Rahul Saxena,Mahipal Jadeja,Vikrant Bhatejarce of oestrogen whereas peripheral tissues such as fat, muscle and the tumour itself are more important in postmenopausal patients [.]. In using drugs to block biosynthesis, it is most attractive to employ agents which specifically affect oestrogen production irrespective of site. Mechanistically, 作者: chemoprevention 時間: 2025-3-27 21:16 作者: NAVEN 時間: 2025-3-28 00:25
Management and Industrial Engineeringtrone in peripheral tissues. Aromatase, the enzyme responsible for this conversion, is mainly present in adipose tissue, liver, placenta, muscle, skin and brain. Aromatase activity has also been identified in the epithelial and stromal components of the breast. Therefore, local synthesis of oestroge作者: 發(fā)生 時間: 2025-3-28 04:06 作者: Mammal 時間: 2025-3-28 09:39
2296-6056 eloped and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy..978-3-7643-8692-4978-3-7643-8693-1Series ISSN 2296-6056 Series E-ISSN 2296-6064 作者: 喚起 時間: 2025-3-28 13:29
Background and development of aromatase inhibitors,rce of oestrogen whereas peripheral tissues such as fat, muscle and the tumour itself are more important in postmenopausal patients [.]. In using drugs to block biosynthesis, it is most attractive to employ agents which specifically affect oestrogen production irrespective of site. Mechanistically, 作者: arthroplasty 時間: 2025-3-28 16:52
Aromatase inhibitors and models for breast cancer,onally cancer and increased risk of strokes [.], [.]. These agonist effects of tamoxifen were realized from its inception [.]. Because of these concerns, we proposed selective inhibition of aromatase to reduce oestrogen production as a different strategy that is unlikely to be associated with oestro作者: 噱頭 時間: 2025-3-28 21:35 作者: 佛刊 時間: 2025-3-29 01:24 作者: FOVEA 時間: 2025-3-29 05:07
10樓作者: COMMA 時間: 2025-3-29 10:50
10樓
