標(biāo)題: Titlebook: Antifungal Drug Resistance; Methods and Protocol Damian J. Krysan,W. Scott Moye-Rowley Book 2023 The Editor(s) (if applicable) and The Auth [打印本頁] 作者: 挑染 時間: 2025-3-21 19:12
書目名稱Antifungal Drug Resistance影響因子(影響力)
書目名稱Antifungal Drug Resistance影響因子(影響力)學(xué)科排名
書目名稱Antifungal Drug Resistance網(wǎng)絡(luò)公開度
書目名稱Antifungal Drug Resistance網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Antifungal Drug Resistance被引頻次
書目名稱Antifungal Drug Resistance被引頻次學(xué)科排名
書目名稱Antifungal Drug Resistance年度引用
書目名稱Antifungal Drug Resistance年度引用學(xué)科排名
書目名稱Antifungal Drug Resistance讀者反饋
書目名稱Antifungal Drug Resistance讀者反饋學(xué)科排名
作者: BANAL 時間: 2025-3-21 22:37 作者: 固執(zhí)點好 時間: 2025-3-22 01:08
A Dual-Readout High-Throughput Screening Assay for Small Molecules Active Against ections, and yet treatment options are limited due to resistance to clinical antifungals and lack of broad-spectrum activity against molds. Technical challenges associated with molds have limited large-throughput screening efforts for anti-mold compounds: therefore, we adapted an assay for use with 作者: condescend 時間: 2025-3-22 07:47 作者: Pantry 時間: 2025-3-22 09:35 作者: Pantry 時間: 2025-3-22 14:29 作者: stroke 時間: 2025-3-22 18:53 作者: 一起 時間: 2025-3-22 23:29 作者: intellect 時間: 2025-3-23 05:07
Drug Target Elucidation Through Isolation and Analysis of Drug-Resistant Mutants in product screening, and drug repurposing efforts, can identify compounds with favorable in vitro antifungal activity. However, these approaches will often identify compounds with no known mechanism of action. Herein, we describe a method utilizing the human fungal pathogen . to identify antifungal d作者: tic-douloureux 時間: 2025-3-23 08:57
Chemical-Genetic Approaches for Exploring Mode of Action of Antifungal Compounds in the Fungal Pathorrently, antifungal drug classes available to treat fungal infections remain limited and the emergence of drug-resistant strains threatens antifungal efficacy, necessitating the discovery and development of additional therapeutics. The construction of the . double-barcoded heterozygous deletion coll作者: majestic 時間: 2025-3-23 11:42 作者: Asseverate 時間: 2025-3-23 14:46
Heterologous Expression of Candida Antifungal Target Genes in the Model Organism ecting resistance mechanisms. The influence of specific genes or gene alleles on a phenotype can initially be assessed within the model organism, .. . exhibits efficient rates of homologous recombination making it amendable for heterologous expression and represents a susceptible organism that can b作者: 規(guī)范就好 時間: 2025-3-23 19:25 作者: maintenance 時間: 2025-3-23 22:39
Transport across Membranes: Techniques for Measuring Efflux in Fungal Cellsux pumps or transporters. Drug efflux is a particularly common mechanism of resistance to azole antifungals, one of the most widely used classes of antifungal drugs. Here, we provide detailed protocols for two assays of small-molecule efflux activity: rhodamine 6G efflux and alanine-naphthylamide ac作者: Arteriography 時間: 2025-3-24 05:50 作者: gonioscopy 時間: 2025-3-24 08:00
Normal-incidence waves in a stack of layers,gal isolate may be resistant to clinically available antifungals, and they are also amendable for research purposes, as the microtiter trays can be prepared in different formats with different antifungal and investigational agent concentration ranges and with different growth media if necessary. Thi作者: 爭吵加 時間: 2025-3-24 14:28 作者: Derogate 時間: 2025-3-24 17:07 作者: Aqueous-Humor 時間: 2025-3-24 22:09 作者: Cultivate 時間: 2025-3-25 00:20
Copy Number Variation and Allele Ratio Analysis in , Using Whole Genome Sequencing Data of CNVs and allele ratios utilizing free, open-source visualization tools. We provide code to use with an example dataset (matched antifungal drug-sensitive and drug-resistant . isolates) and notes on how to expand this protocol to other fungal genomes.作者: 不容置疑 時間: 2025-3-25 05:16 作者: 未成熟 時間: 2025-3-25 08:38 作者: expound 時間: 2025-3-25 13:23
Damian J. Krysan,W. Scott Moye-RowleyIncludes cutting-edge techniques.Provides step-by-step detail essential for reproducible results.Contains key implementation advice from the experts作者: Institution 時間: 2025-3-25 18:03 作者: 元音 時間: 2025-3-25 21:31
Characterizing , Pdr1, a Hyperactive Transcription Factor Involved in Azole Resistancesteps are described that lead from a characterized plasmid-borne .-GOF allele to its integration into the yeast genome in a markerless manner. Pdr1-GOF strains constructed by this approach are suitable for virulence studies in an animal host.作者: CANDY 時間: 2025-3-26 01:52 作者: CLOWN 時間: 2025-3-26 05:05 作者: outrage 時間: 2025-3-26 08:54 作者: 肉身 時間: 2025-3-26 16:29 作者: 輕率看法 時間: 2025-3-26 19:48 作者: 發(fā)芽 時間: 2025-3-26 22:33
https://doi.org/10.1007/BFb0117709 drug. Even in entirely clonal populations, small subpopulations of yeast can grow in the presence of a drug, sometimes up to extremely high drug concentrations, such that they may be clinically relevant. Identifying and quantifying the incidence with which these subpopulations arise is an essential作者: heterogeneous 時間: 2025-3-27 01:24 作者: notice 時間: 2025-3-27 06:02 作者: 傀儡 時間: 2025-3-27 10:43
Elastic-Plastic Fracture Mechanics product screening, and drug repurposing efforts, can identify compounds with favorable in vitro antifungal activity. However, these approaches will often identify compounds with no known mechanism of action. Herein, we describe a method utilizing the human fungal pathogen . to identify antifungal d作者: 精美食品 時間: 2025-3-27 15:35 作者: Femish 時間: 2025-3-27 19:40 作者: GORGE 時間: 2025-3-27 22:42 作者: 范例 時間: 2025-3-28 03:45
https://doi.org/10.1007/978-3-540-45836-4h potential roles in the response to azole drugs. The strategy employed utilizes a plant-specific proteolysis pathway which allows for the rapid degradation of a target protein in the presence of the phytohormone, auxin. The steps taken to generate strains expressing the auxin-inducible plant F-box 作者: 匍匐前進 時間: 2025-3-28 06:45
https://doi.org/10.1007/978-3-319-14580-8ux pumps or transporters. Drug efflux is a particularly common mechanism of resistance to azole antifungals, one of the most widely used classes of antifungal drugs. Here, we provide detailed protocols for two assays of small-molecule efflux activity: rhodamine 6G efflux and alanine-naphthylamide ac作者: Ccu106 時間: 2025-3-28 12:17
Forces, Dislocations and Cracks biological activity. Altered accumulation of the drug is an important mechanism of antifungal drug resistance. The best characterized mechanism for altered accumulation is through the action of the drug efflux pump which actively transports the drugs out of the membrane, although this is not the on作者: Ligament 時間: 2025-3-28 17:05 作者: incredulity 時間: 2025-3-28 20:30 作者: 羽毛長成 時間: 2025-3-29 01:49
Antifungal Drug Resistance978-1-0716-3155-3Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: NICHE 時間: 2025-3-29 03:46 作者: 空洞 時間: 2025-3-29 08:36
https://doi.org/10.1007/BFb0117709ability to detect both lysis and inhibition of germination facilitates the identification of a wide range of compounds with different mechanisms of action, creating a strong screening platform for the identification of novel, anti-mold compounds.作者: 使顯得不重要 時間: 2025-3-29 13:00 作者: 改變 時間: 2025-3-29 18:11
A Dual-Readout High-Throughput Screening Assay for Small Molecules Active Against ability to detect both lysis and inhibition of germination facilitates the identification of a wide range of compounds with different mechanisms of action, creating a strong screening platform for the identification of novel, anti-mold compounds.作者: arsenal 時間: 2025-3-29 22:10
Antifungal Susceptibility Testing and Drug Discovery in the Dimorphic Fungus associated with quantifying some . strains which grow as aggregates of yeasts. We also describe antifungal susceptibility testing of . yeasts within macrophages to provide improved accuracy and better physiological relevance of antifungal susceptibility profiles.作者: Terminal 時間: 2025-3-30 02:40 作者: 驚奇 時間: 2025-3-30 06:42 作者: Kinetic 時間: 2025-3-30 08:49
https://doi.org/10.1007/BFb0117709 step in understanding how pathogenic yeast, such as . (i.e.., and others) as well as ., behave in response to antifungal therapeutics. Here we describe simple in vitro protocols for the quantification of drug responses with subpopulation resolution.作者: Prosaic 時間: 2025-3-30 14:13
Elastic-Plastic Fracture Mechanics a small number of changes that can be evaluated for association with drug resistance. Here, we provide a detailed protocol for the computational analysis of genome sequences to identify variants associated with drug resistance.作者: 鄙視 時間: 2025-3-30 18:11
1064-3745 expertsThis detailed volume aims to elucidate the molecular mechanisms that underlie antifungal resistance. The book highlights methods to identify and characterize antifungal activity, to define and characterize strains with altered responses to antifungal drugs, to investigate the genetic and mol作者: annexation 時間: 2025-3-31 00:02
https://doi.org/10.1007/BFb0117709phology of these important organisms. In this chapter, we describe a protocol for utilizing a bioluminescent . strain for identifying small molecules that potentiate the activity of the triazole antifungal drug fluconazole. The assay holds great promise for identifying small molecules with activity against filamentous fungal pathogens.作者: 熔巖 時間: 2025-3-31 02:59
Elastic-Plastic Fracture Mechanicsften identify compounds with no known mechanism of action. Herein, we describe a method utilizing the human fungal pathogen . to identify antifungal drug targets through the isolation of spontaneous resistant mutants, antifungal testing, whole-genome sequencing, and variant analysis.
