標(biāo)題: Titlebook: Anthracycline Antibiotics in Cancer Therapy; Proceedings of the I Franco M. Muggia,Charles W. Young,Stephen K. Carte Conference proceedings [打印本頁] 作者: Indigent 時間: 2025-3-21 17:03
書目名稱Anthracycline Antibiotics in Cancer Therapy影響因子(影響力)
書目名稱Anthracycline Antibiotics in Cancer Therapy影響因子(影響力)學(xué)科排名
書目名稱Anthracycline Antibiotics in Cancer Therapy網(wǎng)絡(luò)公開度
書目名稱Anthracycline Antibiotics in Cancer Therapy網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Anthracycline Antibiotics in Cancer Therapy被引頻次
書目名稱Anthracycline Antibiotics in Cancer Therapy被引頻次學(xué)科排名
書目名稱Anthracycline Antibiotics in Cancer Therapy年度引用
書目名稱Anthracycline Antibiotics in Cancer Therapy年度引用學(xué)科排名
書目名稱Anthracycline Antibiotics in Cancer Therapy讀者反饋
書目名稱Anthracycline Antibiotics in Cancer Therapy讀者反饋學(xué)科排名
作者: 填滿 時間: 2025-3-22 00:04 作者: Carminative 時間: 2025-3-22 02:50
978-94-009-7632-0Martinus Nijhoff Publishers, The Hague 1982作者: Mere僅僅 時間: 2025-3-22 05:26 作者: Bucket 時間: 2025-3-22 11:14
Einführung in die Algebraische Geometriesurvival of cancer patients which modern chemotherapy has made possible. It has been one of the intriguing results of cancer research that many active antineoplastic agents have been found to be carcinogenic. It is now well established that many antitumor substances are oncogenic in cells in culture作者: 遷移 時間: 2025-3-22 16:12 作者: 蜈蚣 時間: 2025-3-22 20:54 作者: PHONE 時間: 2025-3-22 23:01 作者: acclimate 時間: 2025-3-23 01:48 作者: 單調(diào)性 時間: 2025-3-23 06:33
Welche Organellen liegen im Zellplasma?). Exposure of cells in culture to anthracyclines at low concentrations (0.1–10 μM) produces marked inhibition of both DNA and RNA synthesis without appreciable effects on protein synthesis at comparable doses (4–13). In general, preribosomal RNA synthesis is thought to be more sensitive to inhibiti作者: 讓空氣進(jìn)入 時間: 2025-3-23 11:09
Wie ist ein Eiwei?molekül aufgebaut?e agent on DNA and chromosomes of cells in culture. Since the time of these early observations, a great deal more has been learned about Dm metabolic biotransformations in subcellular preparations. and through urinary and biliary excretion of these products.. The metabolism of Dm is now associated w作者: EVEN 時間: 2025-3-23 15:08 作者: nauseate 時間: 2025-3-23 18:05 作者: 踉蹌 時間: 2025-3-24 01:16
Einführung in die Allgemeine Biologie65 mg/kg) in rats .. None of these doses caused a significant increase in ethane formation, except a small elevation on the 2nd day after 45/kg. Treatment with 65 mg/kg was lethal within 24 hours, although no increase in ethane production was measured during the first 6 hours after administration. T作者: patriot 時間: 2025-3-24 03:07
Elementnamen und Elementsymbole,s the plasma membrane in order to exert its therapeutic effect by interference with the function of the DNA in the cell nucleus through intercalation (1). The transport mechanism by which doxorubicin enters the cell across the rate-limiting barrier is still under debate. It has been proposed that do作者: 粗糙 時間: 2025-3-24 09:13 作者: ACME 時間: 2025-3-24 13:10
https://doi.org/10.1007/978-3-0348-7636-0This volume is based upon papers presented at an International Symposium on Anthracycline Antibiotics in Cancer Therapy that was held in New York City, 16–18 September 1981. Cosponsors of the Symposium were New York University Post-Graduate Medical School and New York University Cancer Center.作者: Ringworm 時間: 2025-3-24 15:01 作者: SHRIK 時間: 2025-3-24 20:41 作者: 使入迷 時間: 2025-3-25 01:13 作者: 榮幸 時間: 2025-3-25 06:10
IntroductionWe are very furtunate to have the contributions of established leaders in the study of anthracycline mechanism of action who are continuing their enlightening studies. In addition, we have new and exciting voices to add to our knowledge of anthracycline actions.作者: enormous 時間: 2025-3-25 09:37
Free Radical DamageScientists have observed that a disproportionate number of natural products and synthetic products which contain quinone groups are cytotoxic both to tumors and to bacteria. From this vantage, proposals have been made that quinones are involved in a biochemically mediated reductive mechanism that plays a part in their cytotoxic action.作者: 放逐某人 時間: 2025-3-25 12:51
ke for granted the past, preferring research into totally new areas. However, the persistent development of fertile soil may yield surprising rewards for those who choose to build on the knowledge of the past--hence, this symposium on anthracycline antibiotics. Although the anthracycline antibiotics作者: conjunctiva 時間: 2025-3-25 18:00
https://doi.org/10.1007/978-3-642-70077-4 with nucleic acids have not provided satisfactory explanations for the differences observed in the therapeutic efficiency and spectrum of action of the various compounds; even new analogs and derivatives which display differing nuclear and DNA binding properties cannot have their characteristics reconciled with their cytotoxic activity (1–5).作者: Delude 時間: 2025-3-25 22:17 作者: 斗志 時間: 2025-3-26 02:35 作者: LIMIT 時間: 2025-3-26 06:10
Aufgaben des Zellkerns und des Plasmasrs immediately on either side of the intercalator, but rather is associated with the base pairs one removed from the intercalator. The unwinding effect of intercalation in DNA in intact cells would be expected to distort chromatin structure and could bring into play the action of topoisomerase enzymes which could relieve the distortion.作者: acheon 時間: 2025-3-26 11:28
Welche Organellen liegen im Zellplasma?ich, by reacting with intracellular macromolecules, could explain toxic effects of the drugs. Other mechanisms such as interaction with cell membranes may also contribute to the cycotoxicity of the anthracyclines (6).作者: Fester 時間: 2025-3-26 13:00
Consequences of DNA Intercalation: Protein-Associated DNA Strand Breaksrs immediately on either side of the intercalator, but rather is associated with the base pairs one removed from the intercalator. The unwinding effect of intercalation in DNA in intact cells would be expected to distort chromatin structure and could bring into play the action of topoisomerase enzymes which could relieve the distortion.作者: stress-test 時間: 2025-3-26 19:49 作者: Ingrained 時間: 2025-3-26 23:26 作者: prostate-gland 時間: 2025-3-27 02:43
Welche Organellen liegen im Zellplasma?s: Class I, those anthracyclines that yield similar IC. values for inhibition of DNA, total RNA, and nucleolar RNA synthesis ; and Class II, those that are selective for the inhibition of nucleolar RNA synthesis (0.1).作者: agnostic 時間: 2025-3-27 05:40 作者: 冰河期 時間: 2025-3-27 11:31
Einführung in die Allgemeine Biologiein doxorubicin cardiotoxicity. Thus, cardio-protection by α-tocopherol and other free radical scavengers may be due rather to the trap of free oxygen radicals than to the prevention of lipid peroxidation during doxorubicin metabolism.作者: 蜈蚣 時間: 2025-3-27 15:47
vieweg studium; Grundkurs Chemieitnessing similar concentrated efforts with the anthracycline antibiotics. Impressive therapeutic advances have been made in other biomedical research fields through this mixture of the empirical and rational approaches. We shall point out highlights of this interplay which is described in detail in the ensuing chapters.作者: Scintigraphy 時間: 2025-3-27 19:23
Anthracycline Antitumor Antibiotics: Their Carcinogenicity and their Mutagenicityon surgery as well as from the occurrence of second neoplasms after chemotherapy of a primary neoplasm, it can be suspected that many are also carcinogenic in man (4). This report attempts to consolidate the available data on the genotoxic effects of one important class of antitumor agents, i.e., the anthracycline antibiotics.作者: Expurgate 時間: 2025-3-27 22:20
Effects of Anthracyclines on Macromolecules and their Synthesess: Class I, those anthracyclines that yield similar IC. values for inhibition of DNA, total RNA, and nucleolar RNA synthesis ; and Class II, those that are selective for the inhibition of nucleolar RNA synthesis (0.1).作者: 最小 時間: 2025-3-28 05:20 作者: GLOSS 時間: 2025-3-28 07:53 作者: 讓空氣進(jìn)入 時間: 2025-3-28 10:35 作者: 一大塊 時間: 2025-3-28 15:26
Antitumor Activity of Anthracyclines: Experimental Studies). In this review, I will summarize the experience gained by studies on the antitumor activity of DNR, DX, and several new derivatives selected on the basis of interesting biological or pharmacological properties (3).作者: Entreaty 時間: 2025-3-28 18:54 作者: 食草 時間: 2025-3-28 23:13
Doxorubicin and Related Compounds. I. Physicochemical Characterization of the DNA Complexularly important in the case of the antitumor anthracyclines. Even though hundreds of new compounds have been made available for biological evaluation and a variety of pharmacological properties of the parent compounds have been investigated in different laboratories, programs aimed at the developme作者: 刪減 時間: 2025-3-29 04:36
Calcium Flux and Metabolism in the Pigeon Heart Following Doxorubicin Treatment: A Study of Acute Chl following doxorubicin treatment is interesting because several investigators have observed a decrease in the influx of calcium into mitochondria (7), red blood cells (8), and the guinea pig atria (9) in the presence of this anthracycline. These apparent conflicting reports may be explained by the 作者: 條約 時間: 2025-3-29 10:13
The Physicochemical Properties and Transmembraneous Transport of Doxorubicinxorubicin has been demonstrated to be an inhibitor of the Na,K-activated membrane-bound ATP’ase (5). Furthermore, in order to understand the transmembraneous transport mechanism of a compound, one must demonstrate how the physicochemical characteristics of the compound in the water phases on both si作者: Canvas 時間: 2025-3-29 14:15
Einführung in die Algebraische Geometrie). In this review, I will summarize the experience gained by studies on the antitumor activity of DNR, DX, and several new derivatives selected on the basis of interesting biological or pharmacological properties (3).作者: 我說不重要 時間: 2025-3-29 17:25
https://doi.org/10.1007/978-3-8349-9281-9gents can also represent a determinant of the therapeutic effectiveness of these compounds. In this connection, the term modulation emphasizes the concept that the effects of anticancer cytotoxic chemicals on the immune apparatus should not be viewed solely in terms of depression but rather in the l作者: 我不明白 時間: 2025-3-29 23:25 作者: 竊喜 時間: 2025-3-30 03:28 作者: 遣返回國 時間: 2025-3-30 05:22
Elementnamen und Elementsymbole,xorubicin has been demonstrated to be an inhibitor of the Na,K-activated membrane-bound ATP’ase (5). Furthermore, in order to understand the transmembraneous transport mechanism of a compound, one must demonstrate how the physicochemical characteristics of the compound in the water phases on both si作者: Frequency-Range 時間: 2025-3-30 12:14
Conference proceedings 1982 comas and a variety of other tumors that had been deemed - sistant to chemotherapy. These successes were tempered with the realization that the antitumor effect of anthracyclines could be achieved at times only at the very high price of risking cardiac decompensation and, almost invariably, with th作者: 小臼 時間: 2025-3-30 15:22 作者: 委派 時間: 2025-3-30 17:13
Franco M. Muggia,Charles W. Young,Stephen K. Carte作者: 災(zāi)難 時間: 2025-3-30 23:03
Antitumor Activity of Anthracyclines: Experimental Studiesss of daunorubicin (DNR) and doxorubicin (DX) and because of the rather large spectrum of antitumor activity of DX, which is active both against leukemias and solid tumors. Interest in this class of compounds has grown considerably from 1963, date of the first report on DNR (1), and many research gr作者: magenta 時間: 2025-3-31 04:14 作者: upstart 時間: 2025-3-31 09:02
The Immunological Activity of Anthracyclinesering on the two clinically most widely used compounds of the group, i.e. Doxorubicin (DX) and its earlier analog Daunorubicin (DM). An interest in the immunopharmacology of cancer chemotherapeutic agents finds its justification at different levels. In the first place, it is well accepted that drug-作者: debacle 時間: 2025-3-31 10:39
Doxorubicin and Related Compounds. I. Physicochemical Characterization of the DNA Complexrchers in this field of biophysical chemistry, although well aware of the different situation present in . systems (those that show a complexity of molecular structures in a dynamic state and in a polyphasic system as that represented by living cells), believe that information obtained at the molecu作者: 討好女人 時間: 2025-3-31 16:59 作者: Extricate 時間: 2025-3-31 17:38 作者: connoisseur 時間: 2025-3-31 23:44 作者: 敘述 時間: 2025-4-1 03:03
Biotransformations of Anthracyclines in the Smooth Endoplasmic Reticulum of Rat Livere agent on DNA and chromosomes of cells in culture. Since the time of these early observations, a great deal more has been learned about Dm metabolic biotransformations in subcellular preparations. and through urinary and biliary excretion of these products.. The metabolism of Dm is now associated w作者: anesthesia 時間: 2025-4-1 08:28
