標(biāo)題: Titlebook: Amorphous Solid Dispersions; Theory and Practice Navnit Shah,Harpreet Sandhu,A. Waseem Malick Book 2014 Controlled Release Society 2014 amo [打印本頁(yè)] 作者: 我沒(méi)有辱罵 時(shí)間: 2025-3-21 16:40
書(shū)目名稱(chēng)Amorphous Solid Dispersions影響因子(影響力)
作者: 剛毅 時(shí)間: 2025-3-21 23:51
Book 2014ly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray d作者: 奴才 時(shí)間: 2025-3-22 02:03 作者: 長(zhǎng)處 時(shí)間: 2025-3-22 06:30
Allgemeine Konstitutionspathologief continuous manufacturing. Novel applications, such as devolatilization and development using quality by design, allow for the technology to support both drug substance and drug product manufacturing.作者: Painstaking 時(shí)間: 2025-3-22 11:30 作者: 厚臉皮 時(shí)間: 2025-3-22 14:17
,Das Alter und seine Identit?t, characterization as well as approaches applicable for stability predictions are discussed. Finally, some practical stability programs that are suitable at different stages of pharmaceutical research and development are introduced. The focus of this chapter is on physical stability of ASD with its chemical stability aspect briefly discussed.作者: Paraplegia 時(shí)間: 2025-3-22 19:03
Theoretical Considerations in Developing Amorphous Solid Dispersionsto their glass-forming ability and glass stability. In the main parts of this chapter, we review theoretical approaches to determine amorphous drug polymer miscibility and crystalline drug polymer solubility, as a prerequisite to develop amorphous solid dispersions (glass solutions).作者: FLAX 時(shí)間: 2025-3-22 21:49 作者: 奇怪 時(shí)間: 2025-3-23 03:30 作者: integrated 時(shí)間: 2025-3-23 05:31
Fundamentals of Amorphous Systems: Thermodynamic Aspectsamics and microscopic models, and their relationships to improved solubility/dissolution and physical stability are considered. In addition, the relationship between neat amorphous forms and glasses, especially as presented in the literature, is reviewed.作者: GNAW 時(shí)間: 2025-3-23 12:45 作者: NEG 時(shí)間: 2025-3-23 16:22
Theoretical Considerations in Developing Amorphous Solid Dispersionsn this book, the formulation scientist would benefit from a priori knowledge whether the amorphous route is a viable one for a given drug and how much solubility improvement, and hence increase in bioavailability, can be expected, and what forms of solid dispersion have been developed in the past. I作者: WAG 時(shí)間: 2025-3-23 18:36 作者: BUCK 時(shí)間: 2025-3-24 01:39
Excipients for Amorphous Solid Dispersionsis chapter illustrates the challenges associated with amorphous solid dispersion stability and the role that excipients play in stabilization of amorphous solid dispersions by influencing the physicochemical properties of the drug molecule of interest. The classification of various excipients is cat作者: 脆弱吧 時(shí)間: 2025-3-24 04:01
Miniaturized Screening Tools for Polymer and Process Evaluationompounds from pharmaceutical discovery in recent years. Although ASD has demonstrated drastic bioavailability enhancement, concerns over the physical instability remain as valid. By engineering amorphous solid dispersion with an appropriate polymer, the physical stability of ASD can be improved sign作者: Interferons 時(shí)間: 2025-3-24 08:22 作者: 保全 時(shí)間: 2025-3-24 12:01
HME for Solid Dispersions: Scale-Up and Late-Stage Developmentns. The proven scalability of the technology combined with the modular nature provides unmatched versatility. Extrusion has been utilized for dispersion manufacturing of commercial products across a range of scales and integrating with in-line monitoring technologies, it fully enables the benefits o作者: 勤勞 時(shí)間: 2025-3-24 17:44
Spray Drying: Scale-Up and Manufacturingss characterization techniques. Special attention is given to the selection of right scale of spray dryer for any given processes and product demands, and also to the ancillary equipment. The main concerns and challenges involved in the establishment of an industrial process are discussed and exempl作者: DOTE 時(shí)間: 2025-3-24 22:54 作者: 清澈 時(shí)間: 2025-3-25 01:48
MBP Technology: Composition and Design Considerationsuch as particle size reduction, use of solubilizers, and complexing agents, in addition to lipid formulations, have been conventionally used but with limited success. When such approaches fail to provide desired bioavailability, amorphous formulations can be used as an alternate approach. However, a作者: Junction 時(shí)間: 2025-3-25 03:50
MBP Technology: Process Development and Scale-Upecipitate with (ionic) polymers to increase the bioavailability of poorly soluble drugs. This chapter focuses on process development, scale-up, and its challenges for manufacturing of MBP on commercial scale. A preliminary formulation is established based on the physicochemical properties of API, sm作者: Grandstand 時(shí)間: 2025-3-25 10:02
Pharmaceutical Development of MBP Solid Dispersions: Case Studies technology has been applied to a number of poorly soluble compounds to enhance their biopharmaceutical performance in preclinical, toxicology, and clinical studies. MBP technology demonstrated its utility and versatility in preparing amorphous solid dispersions in various situations. Among the seve作者: 逢迎春日 時(shí)間: 2025-3-25 11:46 作者: 我不重要 時(shí)間: 2025-3-25 18:13
Structural Characterization of Amorphous Solid Dispersionspted that the physical stability, downstream processability, and performance of an ASD largely inherits its physical structure. The . and multi-methodological characterization of ASD microstructure require a range of analytical techniques working on diverse principles. This chapter presents a broad 作者: 啤酒 時(shí)間: 2025-3-25 20:18 作者: 致敬 時(shí)間: 2025-3-26 03:27 作者: 性冷淡 時(shí)間: 2025-3-26 07:32
Overview of Amorphous Solid Dispersion Technologies 1960s, the application of solid dispersion concept to solve solubility challenges in real world was limited and this was partly due to the lack of commercially viable processing technologies. However, in the past two decades this area has seen remarkable progress as the science and understanding of作者: 燒烤 時(shí)間: 2025-3-26 11:37 作者: GRAIN 時(shí)間: 2025-3-26 13:25 作者: Rankle 時(shí)間: 2025-3-26 18:23
Spray Drying: Scale-Up and Manufacturingd dispersion process for a late-stage candidate. The spray drying process was developed under a quality by design (QbD) approach at a large commercial-scale unit. The goal of this section is to highlight some important stages of the methodology (risk assessment, statistical and mechanistic modeling,作者: Albinism 時(shí)間: 2025-3-26 20:57 作者: 侵略者 時(shí)間: 2025-3-27 04:33
MBP Technology: Composition and Design Considerations many APIs, some compounds commonly referred to as “brickdust” were not readily amenable to these techniques either due to their high melting points and thermal instability or due to insufficient solubility in volatile organic solvents. An innovative technology, known as microprecipitated bulk powde作者: MANIA 時(shí)間: 2025-3-27 07:25 作者: 包裹 時(shí)間: 2025-3-27 09:28 作者: 缺陷 時(shí)間: 2025-3-27 17:05
Downstream Processing Considerationsplications for the four manufacturing technologies described in the previous chapters, namely hot-melt extrusion, spray drying, microprecipitated bulk powder, and mesoporous silica. Emphasis is placed on the selection of the formulation composition, the downstream manufacturing process, as well as t作者: dagger 時(shí)間: 2025-3-27 18:29
Structural Characterization of Amorphous Solid Dispersionsolecular level attributes of ASD are extensively discussed. Furthermore, brief accounts on the use of spectroscopic, microscopic, surface analytical, hyphenated, and some emerging techniques for the assessment of ASD microstructure are summarized.作者: PALMY 時(shí)間: 2025-3-28 00:36 作者: 得意牛 時(shí)間: 2025-3-28 05:47
2192-6204 the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems..Amorphous Solid Dispersions: Theory and Practice .is a valuable reference to pharmaceutical scientists inter978-1-4939-4866-6978-1-4939-1598-9Series ISSN 2192-6204 Series E-ISSN 2192-6212 作者: exclusice 時(shí)間: 2025-3-28 06:46
https://doi.org/10.1007/978-3-663-04643-1 1960s, the application of solid dispersion concept to solve solubility challenges in real world was limited and this was partly due to the lack of commercially viable processing technologies. However, in the past two decades this area has seen remarkable progress as the science and understanding of作者: forager 時(shí)間: 2025-3-28 14:26
https://doi.org/10.1007/978-3-662-56818-7tory aspects of these excipients also need to be considered for the development of successful products. In summary, excipients play a significant role in stabilizing amorphous solid dispersions, maximizing bioavailability, and overcoming absorption issues associated with poorly soluble drugs.作者: 連鎖 時(shí)間: 2025-3-28 15:16
Allgemeine Konstitutionspathologieniaturized experimental ASD screening methods, including solvent casting, solvent shift, coprecipitation, melt fusion, freeze drying, and spin coating. The criticality of understanding basic physicochemical properties of active pharmaceutical ingredient (API) in developing a successful ASD is discus作者: EXALT 時(shí)間: 2025-3-28 19:02 作者: OREX 時(shí)間: 2025-3-29 01:05
Allgemeine Konstitutionspathologie limits mobility and stabilizes amorphous drug; and (3) relative hydrophobicity, which limits plasticization of the SDD when stored at high relative humidity (RH) or in the presence of residual solvent from the spray-drying process..Spray drying has proven to be a robust and scalable method (from mi作者: radiograph 時(shí)間: 2025-3-29 04:29 作者: Adornment 時(shí)間: 2025-3-29 10:12
https://doi.org/10.1007/978-3-322-85317-2elopment approach helps to mitigate some risks associated with the MBP development, but the successful scale-up of process remains one of the most formidable challenges. From a simplistic approach, the MBP process can be considered as a solvent–antisolvent precipitation with rapid precipitation rate作者: anatomical 時(shí)間: 2025-3-29 13:11 作者: 印第安人 時(shí)間: 2025-3-29 15:45 作者: 談判 時(shí)間: 2025-3-29 20:22 作者: 沒(méi)血色 時(shí)間: 2025-3-30 00:28 作者: corpus-callosum 時(shí)間: 2025-3-30 06:35
Book 2014n the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol?, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems..Amorphous Solid Dispersions: Theory and Practice .is a valuable reference to pharmaceutical scientists inter作者: colloquial 時(shí)間: 2025-3-30 11:16
Amorphous Solid Dispersions978-1-4939-1598-9Series ISSN 2192-6204 Series E-ISSN 2192-6212 作者: Eructation 時(shí)間: 2025-3-30 13:17 作者: Insubordinate 時(shí)間: 2025-3-30 19:05 作者: DIS 時(shí)間: 2025-3-30 21:13
978-1-4939-4866-6Controlled Release Society 2014作者: Libido 時(shí)間: 2025-3-31 01:11 作者: 有發(fā)明天才 時(shí)間: 2025-3-31 07:08
Forschung und theoretische Rahmungo overcome this problem, much attention has been given to delivering drugs in formulations that supersaturate in the gastrointestinal (GI) fluids. One approach to achieve the supersaturation is to formulate drugs in amorphous forms. This chapter considers amorphous forms of the pure active pharmaceu作者: V洗浴 時(shí)間: 2025-3-31 12:04
